Search Results - "Lordo, Matthew R."
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Single-cell RNA sequencing identifies a population of human liver-type ILC1s
Published in Cell reports (Cambridge) (31-01-2023)“…Group 1 innate lymphoid cells (ILCs) comprise a heterogeneous family of cytotoxic natural killer (NK) cells and ILC1s. We identify a population of “liver-type”…”
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Effects of epigenetic therapy on natural killer cell function and development in hematologic malignancy
Published in Journal of leukocyte biology (02-05-2023)“…Epigenetic therapy is an emerging field in the treatment of human cancer, including hematologic malignancies. This class of therapeutic agents approved by the…”
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Acute Myeloid Leukemia Alters Group 1 Innate Lymphoid Cell Differentiation from a Common Precursor
Published in The Journal of immunology (1950) (15-09-2021)“…NK cells are known to be developmentally blocked and functionally inhibited in patients with acute myeloid leukemia (AML), resulting in poor clinical outcomes…”
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Adipocyte CD1d Gene Transfer Induces T Cell Expansion and Adipocyte Inflammation in CD1d Knockout Mice
Published in The Journal of immunology (1950) (01-05-2022)“…CD1d, a lipid Ag-presenting molecule for invariant NKT (iNKT) cells, is abundantly expressed on adipocytes and regulates adipose homeostasis through iNKT…”
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Unraveling the Role of Innate Lymphoid Cells in AcuteMyeloid Leukemia
Published in Cancers (17-01-2021)“…Over the past 50 years, few therapeutic advances have been made in treating acute myeloid leukemia (AML), an aggressive form of blood cancer, despite vast…”
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Identification and Targeting of the Developmental Blockade in Extranodal Natural Killer/T-cell Lymphoma
Published in Blood cancer discovery (01-03-2022)“…Extranodal natural killer/T-cell lymphoma (ENKTL) is an aggressive, rare lymphoma of natural killer (NK) cell origin with poor clinical outcomes. Here we used…”
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Type 3 Innate Lymphoid Cells Protect Leukemic Blasts from Natural Killer Cell Cytotoxicity in Acute Myeloid Leukemia
Published in Blood (15-11-2022)Get full text
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ILC3 Expansion in Acute Myeloid Leukemia
Published in The Journal of immunology (1950) (01-05-2022)“…At homeostasis, type 3 innate lymphoid cells (ILC3s) are tissue-resident and have key roles in maintaining mucosal immunity. Recently, the expansion of ILC3s…”
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9
Unraveling the Role of Innate Lymphoid Cells in Acute Myeloid Leukemia
Published in Cancers (17-01-2021)“…Over the past 50 years, few therapeutic advances have been made in treating acute myeloid leukemia (AML), an aggressive form of blood cancer, despite vast…”
Get full text
Journal Article