Search Results - "Lord, J. J."

PARP inhibitors: Synthetic lethality in the clinic by Lord, Christopher J., Ashworth, Alan

“…PARP inhibitors (PARPi), a cancer therapy targeting poly(ADP-ribose) polymerase, are the first clinically approved drugs designed to exploit synthetic…”
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Synthetic lethal therapies for cancer: what’s next after PARP inhibitors? by Ashworth, Alan, Lord, Christopher J.

“…The genetic concept of synthetic lethality has now been validated clinically through the demonstrated efficacy of poly(ADP-ribose) polymerase (PARP) inhibitors…”
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Mechanisms of resistance to therapies targeting BRCA-mutant cancers by Lord, Christopher J, Ashworth, Alan

“…Synthetic lethality describes a situation in which defects in either one of two genes are not detrimental, but combining defects in the two genes is lethal…”
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Conflicts between being a “Good Farmer” and freshwater policy: A New Zealand case study by Walton, S., Lord, J. M., Lord, A. J., Kahui, V.

“…Strategies that motivate agrifood producers to adopt more sustainable practices are a critical component for a sustainable future. This case study examines…”
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Genetic Interactions in Cancer Progression and Treatment by Ashworth, Alan, Lord, Christopher J., Reis-Filho, Jorge S.

“…As cancer cell genomes are unveiled at a breathtaking pace, the genetic principles at play in cancer are emerging in all their complexity, prompting the…”
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SuperPlots: Communicating reproducibility and variability in cell biology by Lord, Samuel J, Velle, Katrina B, Mullins, R Dyche, Fritz-Laylin, Lillian K

“…P values and error bars help readers infer whether a reported difference would likely recur, with the sample size n used for statistical tests representing…”
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Effectiveness, safety and acceptability of no‐test medical abortion (termination of pregnancy) provided via telemedicine: a national cohort study by Aiken, ARA, Lohr, PA, Lord, J, Ghosh, N, Starling, J

“…Objective To compare outcomes before and after implementation of medical abortion (termination of pregnancy) without ultrasound via telemedicine. Design Cohort…”
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Synthetic Lethality and Cancer Therapy: Lessons Learned from the Development of PARP Inhibitors by Lord, Christopher J, Tutt, Andrew N.J, Ashworth, Alan

“…The genetic concept of synthetic lethality, in which the combination or synthesis of mutations in multiple genes results in cell death, provides a framework to…”
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Ricin trafficking in cells by Spooner, Robert A, Lord, J Michael

“…The heterodimeric plant toxin ricin binds exposed galactosyls at the cell surface of target mammalian cells, and, following endocytosis, is transported in…”
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Tankyrase-targeted therapeutics: expanding opportunities in the PARP family by Riffell, Jenna L., Lord, Christopher J., Ashworth, Alan

“…Key Points The tankyrases TANK1 and TANK2 are members of the poly(ADP-ribose) polymerase (PARP) superfamily of enzymes that catalyse the transfer of many…”
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Structural basis for allosteric PARP-1 retention on DNA breaks by Zandarashvili, Levani, Langelier, Marie-France, Velagapudi, Uday Kiran, Hancock, Mark A, Steffen, Jamin D, Billur, Ramya, Hannan, Zain M, Wicks, Andrew J, Krastev, Dragomir B, Pettitt, Stephen J, Lord, Christopher J, Talele, Tanaji T, Pascal, John M, Black, Ben E

“…The success of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors (PARPi) to treat cancer relates to their ability to trap PARP-1 at the site of a DNA break…”
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Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance by Zatreanu, Diana, Robinson, Helen M. R., Alkhatib, Omar, Boursier, Marie, Finch, Harry, Geo, Lerin, Grande, Diego, Grinkevich, Vera, Heald, Robert A., Langdon, Sophie, Majithiya, Jayesh, McWhirter, Claire, Martin, Niall M. B., Moore, Shaun, Neves, Joana, Rajendra, Eeson, Ranzani, Marco, Schaedler, Theresia, Stockley, Martin, Wiggins, Kimberley, Brough, Rachel, Sridhar, Sandhya, Gulati, Aditi, Shao, Nan, Badder, Luned M., Novo, Daniela, Knight, Eleanor G., Marlow, Rebecca, Haider, Syed, Callen, Elsa, Hewitt, Graeme, Schimmel, Joost, Prevo, Remko, Alli, Christina, Ferdinand, Amanda, Bell, Cameron, Blencowe, Peter, Bot, Chris, Calder, Mathew, Charles, Mark, Curry, Jayne, Ekwuru, Tennyson, Ewings, Katherine, Krajewski, Wojciech, MacDonald, Ellen, McCarron, Hollie, Pang, Leon, Pedder, Chris, Rigoreau, Laurent, Swarbrick, Martin, Wheatley, Ed, Willis, Simon, Wong, Ai Ching, Nussenzweig, Andre, Tijsterman, Marcel, Tutt, Andrew, Boulton, Simon J., Higgins, Geoff S., Pettitt, Stephen J., Smith, Graeme C. M., Lord, Christopher J.

“…To identify approaches to target DNA repair vulnerabilities in cancer, we discovered nanomolar potent, selective, low molecular weight (MW), allosteric…”
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PARP inhibition enhances tumor cell-intrinsic immunity in ERCC1-deficient non-small cell lung cancer by Chabanon, Roman M, Muirhead, Gareth, Krastev, Dragomir B, Adam, Julien, Morel, Daphné, Garrido, Marlène, Lamb, Andrew, Hénon, Clémence, Dorvault, Nicolas, Rouanne, Mathieu, Marlow, Rebecca, Bajrami, Ilirjana, Cardeñosa, Marta Llorca, Konde, Asha, Besse, Benjamin, Ashworth, Alan, Pettitt, Stephen J, Haider, Syed, Marabelle, Aurélien, Tutt, Andrew Nj, Soria, Jean-Charles, Lord, Christopher J, Postel-Vinay, Sophie

“…The cyclic GMP-AMP synthase/stimulator of IFN genes (cGAS/STING) pathway detects cytosolic DNA to activate innate immune responses. Poly(ADP-ribose) polymerase…”
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Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance by Pettitt, Stephen J., Krastev, Dragomir B., Brandsma, Inger, Dréan, Amy, Song, Feifei, Aleksandrov, Radoslav, Harrell, Maria I., Menon, Malini, Brough, Rachel, Campbell, James, Frankum, Jessica, Ranes, Michael, Pemberton, Helen N., Rafiq, Rumana, Fenwick, Kerry, Swain, Amanda, Guettler, Sebastian, Lee, Jung-Min, Swisher, Elizabeth M., Stoynov, Stoyno, Yusa, Kosuke, Ashworth, Alan, Lord, Christopher J.

“…Although PARP inhibitors (PARPi) target homologous recombination defective tumours, drug resistance frequently emerges, often via poorly understood mechanisms…”
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The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin by Krastev, Dragomir B., Li, Shudong, Sun, Yilun, Wicks, Andrew J., Hoslett, Gwendoline, Weekes, Daniel, Badder, Luned M., Knight, Eleanor G., Marlow, Rebecca, Pardo, Mercedes Calvo, Yu, Lu, Talele, Tanaji T., Bartek, Jiri, Choudhary, Jyoti S., Pommier, Yves, Pettitt, Stephen J., Tutt, Andrew N. J., Ramadan, Kristijan, Lord, Christopher J.

“…Poly (ADP-ribose) polymerase (PARP) inhibitors elicit antitumour activity in homologous recombination-defective cancers by trapping PARP1 in a chromatin-bound…”
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ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A by Williamson, Chris T., Miller, Rowan, Pemberton, Helen N., Jones, Samuel E., Campbell, James, Konde, Asha, Badham, Nicholas, Rafiq, Rumana, Brough, Rachel, Gulati, Aditi, Ryan, Colm J., Francis, Jeff, Vermulen, Peter B., Reynolds, Andrew R., Reaper, Philip M., Pollard, John R., Ashworth, Alan, Lord, Christopher J.

“…Identifying genetic biomarkers of synthetic lethal drug sensitivity effects provides one approach to the development of targeted cancer therapies. Mutations in…”
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Targeted therapy for cancer using PARP inhibitors by Lord, Christopher J, Ashworth, Alan

“…Poly (ADP-ribose) Polymerase (PARP) has a well-established role in DNA repair processes, and small molecule inhibitors of PARP have been developed as…”
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A genetic screen using the PiggyBac transposon in haploid cells identifies Parp1 as a mediator of olaparib toxicity by Pettitt, Stephen J, Rehman, Farah L, Bajrami, Ilirjana, Brough, Rachel, Wallberg, Fredrik, Kozarewa, Iwanka, Fenwick, Kerry, Assiotis, Ioannis, Chen, Lina, Campbell, James, Lord, Christopher J, Ashworth, Alan

“…Genetic perturbation screens have the potential to dissect a wide range of cellular phenotypes. Such screens have historically been difficult in diploid…”
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Dysregulation of leukocyte trafficking in ageing: Causal factors and possible corrective therapies by Hopkin, S., Lord, J.M., Chimen, M.

“…[Display omitted] Ageing is a universal biological phenomenon that is accompanied by the development of chronic, low-grade inflammation and remodelling of the…”
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THE ROLE OF SUBSURFACE FLOWS IN SOLAR SURFACE CONVECTION: MODELING THE SPECTRUM OF SUPERGRANULAR AND LARGER SCALE FLOWS by Lord, J W, Cameron, R H, Rast, M P, Rempel, M, Roudier, T

“…We model the solar horizontal velocity power spectrum at scales larger than granulation using a two-component approximation to the mass continuity equation…”
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