Search Results - "Lord, Caleb"

The atypical antipsychotic olanzapine causes weight gain by targeting serotonin receptor 2C by Lord, Caleb C, Wyler, Steven C, Wan, Rong, Castorena, Carlos M, Ahmed, Newaz, Mathew, Dias, Lee, Syann, Liu, Chen, Elmquist, Joel K

“…Atypical antipsychotics such as olanzapine often induce excessive weight gain and type 2 diabetes. However, the mechanisms underlying these drug-induced…”
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Mammalian alpha beta hydrolase domain (ABHD) proteins: Lipid metabolizing enzymes at the interface of cell signaling and energy metabolism by Lord, Caleb C., Thomas, Gwynneth, Brown, J. Mark

“…Dysregulation of lipid metabolism underlies many chronic diseases such as obesity, diabetes, cardiovascular disease, and cancer. Therefore, understanding…”
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Serotonergic Control of Metabolic Homeostasis by Wyler, Steven C, Lord, Caleb C, Lee, Syann, Elmquist, Joel K, Liu, Chen

“…New treatments are urgently needed to address the current epidemic of obesity and diabetes. Recent studies have highlighted multiple pathways whereby serotonin…”
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POMC neurons expressing leptin receptors coordinate metabolic responses to fasting via suppression of leptin levels by Caron, Alexandre, Dungan Lemko, Heather M, Castorena, Carlos M, Fujikawa, Teppei, Lee, Syann, Lord, Caleb C, Ahmed, Newaz, Lee, Charlotte E, Holland, William L, Liu, Chen, Elmquist, Joel K

“…Leptin is critical for energy balance, glucose homeostasis, and for metabolic and neuroendocrine adaptations to starvation. A prevalent model predicts that…”
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Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity by Schreiber, Renate, Hofer, Peter, Taschler, Ulrike, Voshol, Peter J., Rechberger, Gerald N., Kotzbeck, Petra, Jaeger, Doris, Preiss-Landl, Karina, Lord, Caleb C., Brown, J. Mark, Haemmerle, Guenter, Zimmermann, Robert, Vidal-Puig, Antonio, Zechner, Rudolf

“…Adipose triglyceride lipase (ATGL) initiates intracellular triglyceride (TG) catabolism. In humans, ATGL deficiency causes neutral lipid storage disease with…”
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Acyl-ghrelin Is Permissive for the Normal Counterregulatory Response to Insulin-Induced Hypoglycemia by Shankar, Kripa, Gupta, Deepali, Mani, Bharath K, Findley, Brianna G, Lord, Caleb C, Osborne-Lawrence, Sherri, Metzger, Nathan P, Pietra, Claudio, Liu, Chen, Berglund, Eric D, Zigman, Jeffrey M

“…Insulin-induced hypoglycemia leads to far-ranging negative consequences in patients with diabetes. Components of the counterregulatory response (CRR) system…”
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Regulation of Hepatic Triacylglycerol Metabolism by CGI-58 Does Not Require ATGL Co-activation by Lord, Caleb C., Ferguson, Daniel, Thomas, Gwynneth, Brown, Amanda L., Schugar, Rebecca C., Burrows, Amy, Gromovsky, Anthony D., Betters, Jenna, Neumann, Chase, Sacks, Jessica, Marshall, Stephanie, Watts, Russell, Schweiger, Martina, Lee, Richard G., Crooke, Rosanne M., Graham, Mark J., Lathia, Justin D., Sakaguchi, Takuya F., Lehner, Richard, Haemmerle, Guenter, Zechner, Rudolf, Brown, J. Mark

“…Adipose triglyceride lipase (ATGL) and comparative gene identification 58 (CGI-58) are critical regulators of triacylglycerol (TAG) turnover. CGI-58 is thought…”
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Ghrelin Receptor Agonist Rescues Excess Neonatal Mortality in a Prader-Willi Syndrome Mouse Model by Rodriguez, Juan A, Bruggeman, Emily C, Mani, Bharath K, Osborne-Lawrence, Sherri, Lord, Caleb C, Roseman, Henry F, Viroslav, Hannah L, Vijayaraghavan, Prasanna, Metzger, Nathan P, Gupta, Deepali, Shankar, Kripa, Pietra, Claudio, Liu, Chen, Zigman, Jeffrey M

“…In the current study, we sought to determine the significance of the ghrelin system in Prader-Willi Syndrome (PWS). PWS is characterized by hypotonia and…”
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Assessing human carcinogenicity risk of agrochemicals without the rodent cancer bioassay by Goetz, Amber, Ryan, Natalia, Sauve-Ciencewicki, Alaina, Lord, Caleb C, Hilton, Gina M, Wolf, Douglas C

“…The rodent cancer bioassays are conducted for agrochemical safety assessment yet they often do not inform regulatory decision-making. As part of a…”
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Hepatocyte toll-like receptor 4 deficiency protects against alcohol-induced fatty liver disease by Jia, Lin, Chang, Xiuli, Qian, Shuwen, Liu, Chen, Lord, Caleb C., Ahmed, Newaz, Lee, Charlotte E., Lee, Syann, Gautron, Laurent, Mitchell, Mack C., Horton, Jay D., Scherer, Philipp E., Elmquist, Joel K.

“…Recent studies have suggested a critical role for toll-like receptor 4 (TLR4) in the development of alcoholic liver disease. As TLR4 is widely expressed…”
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Gαi/o-coupled Htr2c in the paraventricular nucleus of the hypothalamus antagonizes the anorectic effect of serotonin agents by Yoo, Eun-Seon, Li, Li, Jia, Lin, Lord, Caleb C., Lee, Charlotte E., Birnbaum, Shari G., Vianna, Claudia R., Berglund, Eric D., Cunningham, Kathryn A., Xu, Yong, Sohn, Jong-Woo, Liu, Chen

“…The anorexigenic effect of serotonergic compounds has largely been attributed to activation of serotonin 2C receptors (Htr2cs). Using mouse genetic models in…”
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CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance[S] by Brown, J. Mark, Betters, Jenna L., Lord, Caleb, Ma, Yinyan, Han, Xianlin, Yang, Kui, Alger, Heather M., Melchior, John, Sawyer, Janet, Shah, Ramesh, Wilson, Martha D., Liu, Xiuli, Graham, Mark J., Lee, Richard, Crooke, Rosanne, Shulman, Gerald I., Xue, Bingzhong, Shi, Hang, Yu, Liqing

“…Mutations of Comparative Gene Identification-58 (CGI-58) in humans cause triglyceride (TG) accumulation in multiple tissues. Mice genetically lacking CGI-58…”
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Deletion of CGI-58 or adipose triglyceride lipase differently affects macrophage function and atherosclerosis[S] by Goeritzer, Madeleine, Schlager, Stefanie, Radovic, Branislav, Madreiter, Corina T., Rainer, Silvia, Thomas, Gwynneth, Lord, Caleb C., Sacks, Jessica, Brown, Amanda L., Vujic, Nemanja, Obrowsky, Sascha, Sachdev, Vinay, Kolb, Dagmar, Chandak, Prakash G., Graier, Wolfgang F., Sattler, Wolfgang, Brown, J. Mark, Kratky, Dagmar

“…Cellular TG stores are efficiently hydrolyzed by adipose TG lipase (ATGL). Its coactivator comparative gene identification-58 (CGI-58) strongly increases…”
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CGI-58/ABHD5-Derived Signaling Lipids Regulate Systemic Inflammation and Insulin Action by LORD, Caleb C, BETTERS, Jenna L, LEE, Richard G, CROOKE, Rosanne M, GRAHAM, Mark J, PARKS, John S, BRASAEMLE, Dawn L, FESSLER, Michael B, BROWN, H. Alex, BROWN, J. Mark, IVANOVA, Pavlina T, MILNE, Stephen B, MYERS, David S, MADENSPACHER, Jennifer, THOMAS, Gwynneth, CHUNG, Soonkyu, MINGXIA LIU, DAVIS, Matthew A

“…Mutations of comparative gene identification 58 (CGI-58) in humans cause Chanarin-Dorfman syndrome, a rare autosomal recessive disease in which excess…”
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Intestinal SR-BI does not impact cholesterol absorption or transintestinal cholesterol efflux in mice by Bura, Kanwardeep S., Lord, Caleb, Marshall, Stephanie, McDaniel, Allison, Thomas, Gwyn, Warrier, Manya, Zhang, Jun, Davis, Matthew A., Sawyer, Janet K., Shah, Ramesh, Wilson, Martha D., Dikkers, Arne, Tietge, Uwe J.F., Collet, Xavier, Rudel, Lawrence L., Temel, Ryan E., Brown, J.Mark

“…Reverse cholesterol transport (RCT) can proceed through the classic hepatobiliary route or through the nonbiliary transintestinal cholesterol efflux (TICE)…”
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Distinct roles for α-β hydrolase domain 5 (ABHD5/CGI-58) and adipose triglyceride lipase (ATGL/PNPLA2) in lipid metabolism and signaling by Lord, Caleb C., Brown, J. Mark

“…Catabolism of stored triacylglycerol (TAG) from cytoplasmic lipid droplets is critical for providing energy substrates, membrane building blocks and signaling…”
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Adipose-selective overexpression of ABHD5/CGI-58 does not increase lipolysis or protect against diet-induced obesity by Caviglia, Jorge M., Betters, Jenna L., Dapito, Dianne-Helerie, Lord, Caleb C., Sullivan, Sean, Chua, Streamson, Yin, Terry, Sekowski, Anna, Mu, Haiyan, Shapiro, Lawrence, Brown, J. Mark, Brasaemle, Dawn L.

“…Adipose triglyceride lipase (ATGL) catalyzes the first step of triacylglycerol hydrolysis in adipocytes. Abhydrolase domain 5 (ABHD5) increases ATGL activity…”
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Combined Therapy of Dietary Fish Oil and Stearoyl-CoA Desaturase 1 Inhibition Prevents the Metabolic Syndrome and Atherosclerosis by Brown, J Mark, Chung, Soonkyu, Sawyer, Janet K, Degirolamo, Chiara, Alger, Heather M, Nguyen, Tam M, Zhu, Xuewei, Duong, My-Ngan, Brown, Amanda L, Lord, Caleb, Shah, Ramesh, Davis, Matthew A, Kelley, Kathryn, Wilson, Martha D, Madenspacher, Jennifer, Fessler, Michael B, Parks, John S, Rudel, Lawrence L

“…BACKGROUND—Stearoyl-CoA desaturase 1 (SCD1) is a critical regulator of energy metabolism and inflammation. We have previously reported that inhibition of SCD1…”
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The Serine Hydrolase ABHD6 Is a Critical Regulator of the Metabolic Syndrome by Thomas, Gwynneth, Betters, Jenna L., Lord, Caleb C., Brown, Amanda L., Marshall, Stephanie, Ferguson, Daniel, Sawyer, Janet, Davis, Matthew A., Melchior, John T., Blume, Lawrence C., Howlett, Allyn C., Ivanova, Pavlina T., Milne, Stephen B., Myers, David S., Mrak, Irina, Leber, Vera, Heier, Christoph, Taschler, Ulrike, Blankman, Jacqueline L., Cravatt, Benjamin F., Lee, Richard G., Crooke, Rosanne M., Graham, Mark J., Zimmermann, Robert, Brown, H. Alex, Brown, J. Mark

“…The serine hydrolase α/β hydrolase domain 6 (ABHD6) has recently been implicated as a key lipase for the endocannabinoid 2-arachidonylglycerol (2-AG) in the…”
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Abstract P1001: Comprehensive “Tool Box” For Delineating Adrenergic Receptor Function by Elmquist, Joel, Caron, Alexander, Wyler, Steven, Lee, Syann, Choi, Yun-Hee, Lord, Caleb, Liu, Chen, Fujikawa, Teppei

“…Abstract only Sympathetic regulation of the cardiovascular system is required to maintain cardiac output and vascular tone in response to varied physiological…”
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