Search Results - "Lord, B. I."

CD34+AC133+ Cells Isolated from Cord Blood are Highly Enriched in Long‐Term Culture‐Initiating Cells, NOD/SCID‐Repopulating Cells and Dendritic Cell Progenitors by de Wynter, E. A., Buck, D., Hart, C., Heywood, R., Coutinho, L. H., Clayton, A., Rafferty, J. A., Burt, D., Guenechea, G., Bueren, J. A., Gagen, D., Fairbairn, L. J., Lord, B. I., Testa, N. G.

“…The AC133 antigen is a novel antigen selectively expressed on a subset of CD34+ cells in human fetal liver, bone marrow, and blood as demonstrated by flow…”
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Stimulation and inhibition of proliferation in the small intestinal crypts of the mouse after in vivo administration of growth factors by Potten, C S, Owen, G, Hewitt, D, Chadwick, C A, Hendry, H, Lord, B I, Woolford, L B

“…The effects of epidermal growth factor (EGF), transforming growth factor alpha (TGF alpha), insulin-like growth factor (IGF) I and II, acidic fibroblast growth…”
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Transplantation Potential of Peripheral Blood Stem Cells Induced by Granulocyte Colony-Stimulating Factor by Molineux, G., Pojda, Z., Hampson, I.N., Lord, B.I., Dexter, T.M.

“…The major effect of granulocyte colony-stimulating factor (G-CSF) is to induce neutrophilia in previously untreated animals or after chemotherapy or marrow…”
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Tumour induction by methyl-nitroso-urea following preconceptional paternal contamination with plutonium-239 by LORD, B. I, WOOLFORD, L. B, WANG, L, STONES, V. A, MCDONALD, D, LORIMORE, S. A, PAPWORTH, D, WRIGHT, E. G, SCOTT, D

“…We have investigated the possibility that transgenerational effects from preconceptional paternal irradiation (PPI) may render offspring more vulnerable to…”
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The Kinetics of Human Granulopoiesis Following Treatment with Granulocyte Colony-Stimulating Factor in vivo by Lord, B. I., Bronchud, M. H., Owens, S., Chang, J., Howell, A., Souza, L., Dexter, T. M.

“…Cell proliferation in the bone marrow and blood of two patients with metastatic breast cancer who were treated with granulocyte colony-stimulating factor was…”
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Mobilization of early hematopoietic progenitor cells with BB-10010 : a genetically engineered variant of human macrophage inflammatory protein-1α by LORD, B. I, WOOLFORD, L. B, WOOD, L. M, CZAPLEWSKI, L. G, MCCOURT, M, HUNTER, M. G, EDWARDS, R. M

“…BB-10010 is a genetically engineered variant of human macrophage inflammatory protein-1 alpha with improved solution properties. We show here that it mobilizes…”
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Transgenerational susceptibility to leukaemia induction resulting from preconception, paternal irradiation by LORD, B. I.

“…The clustered excess of childhood leukaemia and non-Hodgkin's lymphoma at Seascale, close to the nuclear reprocessing plant at Sellafield in the UK is well…”
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Myeloid Cell Kinetics in Mice Treated With Recombinant Interleukin-3, Granulocyte Colony-Stimulating Factor (CSF), or Granulocyte-Macrophage CSF In Vivo by Lord, B.I., Molineux, G., Pojda, Z., Souza, L.M., Mermod, J.-J., Dexter, T.M.

“…Myeloid cell kinetics in mice treated with pure hematopoietic growth factors have been investigated using tritiated thymidine labeling and autoradiography…”
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Hemopoietic Damage and Induction of Leukemia in Offspring due to Preconception Paternal Irradiation from Incorporated Plutonium-239 by Lord, B. I., Hoyes, K. P.

“…Preconception paternal irradiation has been implicated in a localized excess of childhood leukemia and non-Hodgkin's lymphoma close to a nuclear reprocessing…”
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Gamma-Ray-Induced Cell Killing and Chromosome Abnormalities in the Bone Marrow of p53-Deficient Mice by Wang, L., Cui, Y., Lord, B. I., Roberts, S. A., Potten, C. S., Hendry, J. H., Scott, D.

“…Resistance to the lethal effects of ionizing radiation has been demonstrated in a wide variety of cell types with defects in the p53 gene (thymocytes, splenic…”
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Modification of murine adult haemopoiesis and response to methyl nitrosourea following exposure to radiation at different developmental stages by HOYES, K. P, HENDRY, J. H, LORD, B. I

“…Purpose: To investigate the hypothesis that the developmental phase at which an individual encounters radiation damage affects its long-term sensitivity to a…”
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BB-10010: An Active Variant of Human Macrophage Inflammatory Protein-1α With Improved Pharmaceutical Properties by Hunter, M.G., Bawden, L., Brotherton, D., Craig, S., Cribbes, S., Czaplewski, L.G., Dexter, T.M., Drummond, A.H., Gearing, A.H., Heyworth, C.M., Lord, B.I., McCourt, M., Varley, P.G., Wood, L.M., Edwards, R.M., Lewis, P.J.

“…The stem cell inhibitor, macrophage inflammatory protein-1α (MIP-1α) or LD78, protects multipotent hematopoietic progenitors in murine models from the…”
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Clinical effects of human macrophage inflammatory protein-1 alpha MIP-1α (LD78) administration to humans: a phase I study in cancer patients and normal healthy volunteers with the genetically engineered variant, BB-10010 by Marshall, E, Howell, A.H, Powles, R, Hunter, M.G, Edwards, M, Wood, L.M, Czaplewski, L, Puttick, R, Warrington, S, Boyce, M, Testa, N, Dexter, T.M, Lord, B.I, Millar, A

“…BB-10010 is a genetically engineered variant of human macrophage inflammatory protein-1 alpha (hMIP-1α) with improved pharmaceutical formulation properties…”
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BB-10010/MIP-1α in vivo maintains haemopoietic recovery following repeated cycles of sublethal irradiation by LORD, B. I, MARSHALL, E, WOOLFORD, L. B, HUNTER, M. G

“…Macrophage inflammatory protein-1 alpha (MIP-1 alpha) is an inhibitor of stem cell proliferation affording protection against damage from agents that express…”
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Macrophage-Inflammatory Protein Protects Multipotent Hematopoietic Cells From the Cytotoxic Effects of Hydroxyurea In Vivo by Lord, B.l., Dexter, T.M., Clements, J.M., Hunter, M.A., Gearing, A.J.H.

“…Macrophage inflammatory protein-1 α (MIP-1α) has been assessed for its potential in vivo to protect hematopoietic progenitor cells from the cytotoxic effects…”
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Continuous infusion of macrophage inflammatory protein MIP-1α enhances leucocyte recovery and haemopoietic progenitor cell mobilization after cyclophosphamide by MARSHALL, E, WOOLFORD, L. B, LORD, B. I

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Proliferation of spleen colony forming units (CFU-S8, CFU-S13) and cells with marrow repopulating ability by Lord, B I, Woolford, L B

“…The practicalities of gene transfer therapy using retroviral vector systems require both that host cells be as primitive as possible and that those cells be…”
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Gamma Irradiation of the Fetus Damages the Developing Hemopoietic Microenvironment Rather Than the Hemopoietic Progenitor Cells by F-T. Yang, Lord, B. I., Hendry, J. H.

“…Hemopoiesis is the product of two components: the hemopoietic tissue and the regulatory stromal microenvironment in which it resides. Plutonium-239,…”
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Induction of lympho-haemopoietic malignancy: impact of preconception paternal irradiation by LORD, B. I.

“…Purpose: To investigate the effects of preconception paternal irradiation (PPI) from injected 239Pu on the susceptibility to induction of lympho-haemopoietic…”
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Characterisation of the differential response of normal and CML haemopoietic progenitor cells to macrophage inflammatory protein-1α by DÜRIG, J, TESTA, N. G, LORD, B. I, KASPER, C, CHANG, J, TELFORD, N, DEXTER, T. M, HEYWORTH, C. M

“…The clonogenic cells of chronic myeloid leukaemia (CML), unlike normal haemopoietic colony forming cells (CFC), are resistant to the growth inhibitory effects…”
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