Randomized Trial of Platelet-Transfusion Thresholds in Neonates

Randomized Trial of Platelet-Transfusion Thresholds in Neonates

The rate of death or major bleeding was significantly higher among preterm infants with severe thrombocytopenia assigned to transfusions at higher platelet-count thresholds (50,000 per cubic millimeter) than among those assigned to lower thresholds (25,000 per cubic millimeter).

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Bibliographic Details
Published in:The New England journal of medicine Vol. 380; no. 3; pp. 242 - 251
Main Authors: Curley, Anna, Stanworth, Simon J, Willoughby, Karen, Fustolo-Gunnink, Susanna F, Venkatesh, Vidheya, Hudson, Cara, Deary, Alison, Hodge, Renate, Hopkins, Valerie, Lopez Santamaria, Beatriz, Mora, Ana, Llewelyn, Charlotte, D’Amore, Angela, Khan, Rizwan, Onland, Wes, Lopriore, Enrico, Fijnvandraat, Karin, New, Helen, Clarke, Paul, Watts, Timothy
Format: Journal Article
Language:English
Published: United States Massachusetts Medical Society 17-01-2019
Subjects:
Age
Birth weight
Bleeding
Blood platelets
Death
Evidence-based medicine
Female
Gestational age
Health services
Hemorrhage
Hemorrhage - etiology
Hemorrhage - prevention & control
Humans
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases - mortality
Infant, Premature, Diseases - therapy
Infants
Male
Medical research
Neonates
Newborn babies
Platelet Count
Platelet Transfusion
Platelets
Premature birth
R&D
Research & development
Thrombocytopenia
Thrombocytopenia - complications
Thrombocytopenia - mortality
Thrombocytopenia - therapy
United Kingdom > UK
Ireland
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Description
Summary:The rate of death or major bleeding was significantly higher among preterm infants with severe thrombocytopenia assigned to transfusions at higher platelet-count thresholds (50,000 per cubic millimeter) than among those assigned to lower thresholds (25,000 per cubic millimeter).
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-News-2
ObjectType-Feature-3
content type line 23
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMoa1807320