Search Results - "Lopez Ríos, Fernando"

Molecular effects of lapatinib in patients with HER2 positive ductal carcinoma in situ by Estévez, Laura G, Suarez-Gauthier, Ana, García, Elena, Miró, Cristina, Calvo, Isabel, Fernández-Abad, María, Herrero, Mercedes, Marcos, Manuel, Márquez, Cristina, Lopez Ríos, Fernando, Perea, Sofía, Hidalgo, Manuel

“…Human epidermal growth factor receptor 2 (HER2) amplification is frequent in ductal carcinoma in situ (DCIS) of the breast and is associated with poorly…”
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Programmed Death-Ligand 1 Immunohistochemistry Testing: A Review of Analytical Assays and Clinical Implementation in Non-Small-Cell Lung Cancer by Büttner, Reinhard, Gosney, John R, Skov, Birgit Guldhammer, Adam, Julien, Motoi, Noriko, Bloom, Kenneth J, Dietel, Manfred, Longshore, John W, López-Ríos, Fernando, Penault-Llorca, Frédérique, Viale, Giuseppe, Wotherspoon, Andrew C, Kerr, Keith M, Tsao, Ming-Sound

“…Purpose Three programmed death-1/programmed death-ligand 1 (PD-L1) inhibitors are currently approved for treatment of non-small-cell lung cancer (NSCLC)…”
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Implementing TMB measurement in clinical practice: considerations on assay requirements by Büttner, Reinhard, Longshore, John W, López-Ríos, Fernando, Merkelbach-Bruse, Sabine, Normanno, Nicola, Rouleau, Etienne, Penault-Llorca, Frédérique

“…Clinical evidence demonstrates that treatment with immune checkpoint inhibitor immunotherapy agents can have considerable benefit across multiple tumours…”
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Prognostic value of KIT expression in small cell lung cancer by López-Martin, Ana, Ballestín, Claudio, Garcia-Carbonero, Rocío, Castaño, Angel, Lopez-Ríos, Fernando, López-Encuentra, Angel, Sánchez-Cespedes, Montserrat, Castellano, Daniel, Bartolomé, Adela, Cortés-Funes, Hernan, Paz-Ares, Luis

“…Summary Background Small cell lung cancer (SCLC) is a very aggressive disease, with poor survival rates despite standard treatment with combination…”
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A direct pancreatic cancer xenograft model as a platform for cancer stem cell therapeutic development by Jimeno, Antonio, Feldmann, Georg, Suárez-Gauthier, Ana, Rasheed, Zeshaan, Solomon, Anna, Zou, Gang-Ming, Rubio-Viqueira, Belen, García-García, Elena, López-Ríos, Fernando, Matsui, William, Maitra, Anirban, Hidalgo, Manuel

“…There is an enormous gap between the antiproliferative and in vivo antitumor efficacy of gemcitabine in cell line-based models and its clinical efficacy. This…”
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Optimizing tissue stewardship in non‐small cell lung cancer to support molecular characterization and treatment selection: statement from a working group of thoracic pathologists by Kerr, Keith M, Bubendorf, Lukas, Lopez‐Rios, Fernando, Khalil, Farah, Roy‐Chowdhuri, Sinchita, Joubert, Philippe, Hartmann, Arndt, Guerini‐Rocco, Elena, Yatabe, Yasushi, Hofman, Paul, Cooper, Wendy A, Dacic, Sanja

“…Many patients with non‐small cell lung cancer do not receive guideline‐recommended, biomarker‐directed therapy, despite the potential for improved clinical…”
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Accurate identification of ALK positive lung carcinoma patients: novel FDA-cleared automated fluorescence in situ hybridization scanning system and ultrasensitive immunohistochemistry by Conde, Esther, Suárez-Gauthier, Ana, Benito, Amparo, Garrido, Pilar, García-Campelo, Rosario, Biscuola, Michele, Paz-Ares, Luis, Hardisson, David, de Castro, Javier, Camacho, M Carmen, Rodriguez-Abreu, Delvys, Abdulkader, Ihab, Ramirez, Josep, Reguart, Noemí, Salido, Marta, Pijuán, Lara, Arriola, Edurne, Sanz, Julián, Folgueras, Victoria, Villanueva, Noemí, Gómez-Román, Javier, Hidalgo, Manuel, López-Ríos, Fernando

“…Based on the excellent results of the clinical trials with ALK-inhibitors, the importance of accurately identifying ALK positive lung cancer has never been…”
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A comparison of EGFR mutation testing methods in lung carcinoma: direct sequencing, real-time PCR and immunohistochemistry by Angulo, Bárbara, Conde, Esther, Suárez-Gauthier, Ana, Plaza, Carlos, Martínez, Rebeca, Redondo, Pilar, Izquierdo, Elisa, Rubio-Viqueira, Belén, Paz-Ares, Luis, Hidalgo, Manuel, López-Ríos, Fernando

“…The objective of this study is to compare two EGFR testing methodologies (a commercial real-time PCR kit and a specific EGFR mutant immunohistochemistry), with…”
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The challenge of NSCLC diagnosis and predictive analysis on small samples. Practical approach of a working group by Thunnissen, Erik, Kerr, Keith M, Herth, Felix J.F, Lantuejoul, Sylvie, Papotti, Mauro, Rintoul, Robert C, Rossi, Giulio, Skov, Birgit G, Weynand, Birgit, Bubendorf, Lukas, Katrien, Grünberg, Johansson, Leif, López-Ríos, Fernando, Ninane, Vincent, Olszewski, Włodzimierz, Popper, Helmut, Jaume, Sauleda, Schnabel, Philipp, Thiberville, Luc, Laenger, Florian

“…Highlights ► The diagnosis of lung cancer involves the identification and complete classification of malignancy. ► New therapeutic options require specific…”
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Concordance in the estimation of tumor percentage in non-small cell lung cancer using digital pathology by Carretero-Barrio, Irene, Pijuan, Lara, Illarramendi, Adrián, Curto, Daniel, López-Ríos, Fernando, Estébanez-Gallo, Ángel, Castellvi, Josep, Granados-Aparici, Sofía, Compañ-Quilis, Desamparados, Noguera, Rosa, Esteban-Rodríguez, Isabel, Sánchez-Güerri, Ignacio, Ramos-Guerra, Ana Delia, Ortuño, Juan Enrique, Garrido, Pilar, Ledesma-Carbayo, María Jesús, Benito, Amparo, Palacios, José

“…The incorporation of digital pathology in clinical practice will require the training of pathologists in digital skills. Our study aimed to assess the…”
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Global gene expression profiling of pleural mesotheliomas : Overexpression of aurora kinases and P16/CDKN2A deletion as prognostic factors and critical evaluation of microarray-based prognostic prediction by LOPEZ-RIOS, Fernando, CHUAI, Shannon, RUSCH, Valerie, OLSHEN, Adam B, LADANYI, Marc, FLORES, Raja, SHIMIZU, Shigeki, OHNO, Takatoshi, WAKAHARA, Kazuhiko, ILLEI, Peter B, HUSSAIN, Sanaa, KRUG, Lee, ZAKOWSKI, Maureen F

“…Most gene expression profiling studies of mesothelioma have been based on relatively small sample numbers, limiting their statistical power. We did Affymetrix…”
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Loss of the mitochondrial bioenergetic capacity underlies the glucose avidity of carcinomas by LOPEZ-RIOS, Fernando, SANCHEZ-ARAGO, Maria, GARCIA-GARCIA, Elena, ORTEGA, Alvaro D, BERRENDERO, José R, POZO-RODRIGUEZ, Francisco, LOPEZ-ENCUENTRA, Angel, BALLESTIN, Claudio, CUEZVA, José M

“…The down-regulation of the catalytic subunit of the mitochondrial H+-ATP synthase (beta-F1-ATPase) is a hallmark of most human carcinomas. This characteristic…”
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External Quality Assessment for KRAS Testing Is Needed: Setup of a European Program and Report of the First Joined Regional Quality Assessment Rounds by Bellon, Ellen, Ligtenberg, Marjolijn J.L., Tejpar, Sabine, Cox, Karen, Hertogh, Gert, Stricker, Karin, Edsjö, Anders, Gorgoulis, Vassilis, Höfler, Gerald, Jung, Andreas, Kotsinas, Athanassios, Laurent‐Puig, Pierre, López‐Ríos, Fernando, Hansen, Tine Plato, Rouleau, Etienne, Vandenberghe, Peter, Krieken, Johan J.M., Dequeker, Elisabeth

“…Learning Objectives After completing this course, the reader will be able to: Identify the most frequent errors made in KRAS testing in this study and the…”
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Antitumor activity and molecular effects of the novel heat shock protein 90 inhibitor, IPI-504, in pancreatic cancer by Song, Dongweon, Chaerkady, Raghothama, Tan, Aik Choon, García-García, Elena, Nalli, Anuradha, Suárez-Gauthier, Ana, López-Ríos, Fernando, Zhang, Xian Feng, Solomon, Anna, Tong, Jeffrey, Read, Margaret, Fritz, Christian, Jimeno, Antonio, Pandey, Akhilesh, Hidalgo, Manuel

“…Targeting Hsp90 is an attractive strategy for anticancer therapy because the diversity and relevance of biological processes are regulated by these proteins in…”
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Evidence against a role for SV40 infection in human mesotheliomas and high risk of false-positive PCR results owing to presence of SV40 sequences in common laboratory plasmids by López-Ríos, Fernando, Illei, Peter B, Rusch, Valerie, Ladanyi, Marc

“…PCR-based evidence of infection by simian virus 40 (SV40) has been reported in varying proportions of pleural mesotheliomas and other tumours, but data are…”
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Pulmonary vascular remodeling in pulmonary hypertension due to chronic heart failure by Delgado, Juan F., Conde, Esther, Sánchez, Violeta, López-Ríos, Fernando, Gómez-Sánchez, Miguel A., Escribano, Pilar, Sotelo, Teresa, de la Cámara, Agustín Gómez, Cortina, José, de la Calzada, Carlos S.

“…Pulmonary hypertension (PHT) associated with chronic heart failure (CHF) is a risk factor of right ventricular failure after heart transplantation (HT). Our…”
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Determining the profiles and parameters for gene amplification testing of growth factor receptors in lung cancer by Pros, Eva, Lantuejoul, Sylvie, Sanchez‐Verde, Lydia, Castillo, Sandra D, Bonastre, Ester, Suarez‐Gauthier, Ana, Conde, Esther, Cigudosa, Juan C, Lopez‐Rios, Fernando, Torres‐Lanzas, Juan, Castellví, Josep, Cajal, Santiago Ramon y, Brambilla, Elisabeth, Sanchez‐Cespedes, Montse

“…Growth factor receptors (GFRs) are amenable to therapeutic intervention in cancer and it is important to select patients appropriately. One of the mechanisms…”
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Hybridization for human epidermal growth factor receptor 2 testing in gastric carcinoma: a comparison of fluorescence in-situ hybridization with a novel fully automated dual-colour silver in-situ hybridization method by García-García, Elena, Gómez-Martín, Carlos, Angulo, Bárbara, Conde, Esther, Suárez-Gauthier, Ana, Adrados, Magdalena, Perna, Cristian, Rodríguez-Peralto, José Luis, Hidalgo, Manuel, López-Ríos, Fernando

“…García‐García E, Gómez‐Martín C, Angulo B, Conde E, Suárez‐Gauthier A, Adrados M, Perna C, Rodríguez‐Peralto J L, Hidalgo M & López‐Ríos F 
(2011)…”
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The use of P63 immunohistochemistry for the identification of squamous cell carcinoma of the lung by Conde, Esther, Angulo, Bárbara, Redondo, Pilar, Toldos, Oscar, García-García, Elena, Suárez-Gauthier, Ana, Rubio-Viqueira, Belén, Marrón, Carmen, García-Luján, Ricardo, Sánchez-Céspedes, Montse, López-Encuentra, Angel, Paz-Ares, Luis, López-Ríos, Fernando

“…While some targeted agents should not be used in squamous cell carcinomas (SCCs), other agents might preferably target SCCs. In a previous microarray study,…”
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The ALK translocation in advanced non-small-cell lung carcinomas: preapproval testing experience at a single cancer centre by Conde, Esther, Angulo, Bárbara, Izquierdo, Elisa, Muñoz, Luna, Suárez-Gauthier, Ana, Plaza, Carlos, Dominguez, Nuria, Torres, Maribel, Madrigal, Luis, Rubio-Viqueira, Belén, Belda-Iniesta, Cristobal, Hidalgo, Manuel, López-Ríos, Fernando

“…Aims To study the ALK translocation in patients with advanced non‐small‐cell lung carcinomas (NSCLCs) seen at a European cancer centre, and its association…”
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