Search Results - "Lopez McDonald, Melanie"

Cycloguanil and Analogues Potently Target DHFR in Cancer Cells to Elicit Anti-Cancer Activity by Brown, Jennifer I, Wang, Peng, Wong, Alan Y L, Petrova, Boryana, Persaud, Rosanne, Soukhtehzari, Sepideh, Lopez McDonald, Melanie, Hanke, Danielle, Christensen, Josephine, Iliev, Petar, Wang, Weiyuan, Everton, Daniel K, Williams, Karla C, Frank, David A, Kanarek, Naama, Page, Brent D G

“…Dihydrofolate reductase (DHFR) is an established anti-cancer drug target whose inhibition disrupts folate metabolism and STAT3-dependent gene expression…”
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The complementary roles of STAT3 and STAT1 in cancer biology: insights into tumor pathogenesis and therapeutic strategies by Wang, Weiyuan, Lopez McDonald, Melanie Cristina, Kim, Christine, Ma, Mirielle, Pan, Zetao Tommy, Kaufmann, Charlotte, Frank, David A

“…STATs are a family of transcription factors that regulate many critical cellular processes such as proliferation, apoptosis, and differentiation. Dysregulation…”
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Oncogenic STAT Transcription Factors as Targets for Cancer Therapy: Innovative Strategies and Clinical Translation by Wang, Weiyuan, Lopez McDonald, Melanie Cristina, Hariprasad, Rajashree, Hamilton, Tiara, Frank, David A

“…Despite advances in our understanding of molecular aspects of oncogenesis, cancer remains a leading cause of death. The malignant behavior of a cancer cell is…”
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Use of an Integrated Functional Quantitation of Modulation of Transcriptional Pathways (IFQ) Assay in Untreated Mantle Cell Lymphoma Patients by Gerber, Drew, Lopez-McDonald, Melanie, Wang, Weiyuan, Koff, Jean L., Churnetski, Michael, O'Leary, Colin B, Cohen, Jonathon B., Frank, David A.

“…Background: Mantle cell lymphoma (MCL) is an extremely heterogenous cancer, with substantial variation in clinical presentation and genetic makeup among…”
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