Search Results - "Lopez‐Ramirez, Alejandro"

β1 integrin monoclonal antibody treatment ameliorates cerebral cavernous malformations by McCurdy, Sara, Lin, Jenny, Shenkar, Robert, Moore, Thomas, Lightle, Rhonda, Faurobert, Eva, Lopez‐Ramirez, Miguel‐Alejandro, Awad, Issam, Ginsberg, Mark H.

“…β1 integrins are important in blood vessel formation and function, finely tuning the adhesion of endothelial cells to each other and to the extracellular…”
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Role of caspases in cytokine-induced barrier breakdown in human brain endothelial cells by Lopez-Ramirez, M Alejandro, Fischer, Roman, Torres-Badillo, Claudia C, Davies, Heather A, Logan, Karen, Pfizenmaier, Klaus, Male, David K, Sharrack, Basil, Romero, Ignacio A

“…During neuroinflammation, cytokines such as TNF-α and IFN-γ secreted by activated leukocytes and/or CNS resident cells have been shown to alter the phenotype…”
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MicroRNAs regulate human brain endothelial cell-barrier function in inflammation: implications for multiple sclerosis by Reijerkerk, Arie, Lopez-Ramirez, M Alejandro, van Het Hof, Bert, Drexhage, Joost A R, Kamphuis, Wouter W, Kooij, Gijs, Vos, Joost B, van der Pouw Kraan, Tineke C T M, van Zonneveld, Anton J, Horrevoets, Anton J, Prat, Alexandre, Romero, Ignacio A, de Vries, Helga E

“…Blood-brain barrier (BBB) dysfunction is a major hallmark of many neurological diseases, including multiple sclerosis (MS). Using a genomics approach, we…”
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Rap1 binding and a lipid-dependent helix in talin F1 domain promote integrin activation in tandem by Gingras, Alexandre R, Lagarrigue, Frederic, Cuevas, Monica N, Valadez, Andrew J, Zorovich, Marcus, McLaughlin, Wilma, Lopez-Ramirez, Miguel Alejandro, Seban, Nicolas, Ley, Klaus, Kiosses, William B, Ginsberg, Mark H

“…Rap1 GTPases bind effectors, such as RIAM, to enable talin1 to induce integrin activation. In addition, Rap1 binds directly to the talin1 F0 domain (F0);…”
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FOXO3 targets are reprogrammed as Huntington's disease neural cells and striatal neurons face senescence with p16INK4a increase by Voisin, Jessica, Farina, Francesca, Naphade, Swati, Fontaine, Morgane, Tshilenge, Kizito‐Tshitoko, Galicia Aguirre, Carlos, Lopez‐Ramirez, Alejandro, Dancourt, Julia, Ginisty, Aurélie, Sasidharan Nair, Satish, Lakshika Madushani, Kuruwitage, Zhang, Ningzhe, Lejeune, François‐Xavier, Verny, Marc, Campisi, Judith, Ellerby, Lisa M., Neri, Christian

“…Neurodegenerative diseases (ND) have been linked to the critical process in aging—cellular senescence. However, the temporal dynamics of cellular senescence in…”
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FOXO3 targets are reprogrammed as Huntington's disease neural cells and striatal neurons face senescence with p16 INK4a increase by Voisin, Jessica, Farina, Francesca, Naphade, Swati, Fontaine, Morgane, Tshilenge, Kizito-Tshitoko, Galicia Aguirre, Carlos, Lopez-Ramirez, Alejandro, Dancourt, Julia, Ginisty, Aurélie, Sasidharan Nair, Satish, Lakshika Madushani, Kuruwitage, Zhang, Ningzhe, Lejeune, François-Xavier, Verny, Marc, Campisi, Judith, Ellerby, Lisa M, Neri, Christian

“…Neurodegenerative diseases (ND) have been linked to the critical process in aging-cellular senescence. However, the temporal dynamics of cellular senescence in…”
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MicroRNA‐155 negatively affects blood–brain barrier function during neuroinflammation by Lopez‐Ramirez, Miguel Alejandro, Wu, Dongsheng, Pryce, Gareth, Simpson, Julie E., Reijerkerk, Arie, King‐Robson, Josh, Kay, Oliver, Vries, Helga E., Hirst, Mark C., Sharrack, Basil, Baker, David, Male, David Kingsley, Michael, Gregory J., Romero, Ignacio Andres

“…ABSTRACT Blood–brain barrier (BBB) dysfunction is a hallmark of neurological conditions such as multiple sclerosis (MS) and stroke. However, the molecular…”
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A Dicer-miR-107 Interaction Regulates Biogenesis of Specific miRNAs Crucial for Neurogenesis by Ristori, Emma, Lopez-Ramirez, Miguel Alejandro, Narayanan, Anand, Hill-Teran, Guillermina, Moro, Albertomaria, Calvo, Charles-Félix, Thomas, Jean-Léon, Nicoli, Stefania

“…Dicer controls the biogenesis of microRNAs (miRNAs) and is essential for neurogenesis. Recent reports show that the levels and substrate selectivity of DICER…”
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Inhibition of the HEG1–KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells by Lopez‐Ramirez, Miguel Alejandro, McCurdy, Sara, Li, Wenqing, Haynes, Mark K., Hale, Preston, Francisco, Karol, Oukoloff, Killian, Bautista, Matthew, Choi, Chelsea H.J., Sun, Hao, Gongol, Brendan, Shyy, John Y., Ballatore, Carlo, Sklar, Larry A., Gingras, Alexandre R.

“…ABSTRACT The transmembrane protein heart of glass1 (HEG1) directly binds to and recruits Krev interaction trapped protein 1 (KRIT1) to endothelial junctions to…”
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Astrocytes propel neurovascular dysfunction during cerebral cavernous malformation lesion formation by Lopez-Ramirez, Miguel Alejandro, Lai, Catherine Chinhchu, Soliman, Shady Ibrahim, Hale, Preston, Pham, Angela, Estrada, Esau J, McCurdy, Sara, Girard, Romuald, Verma, Riya, Moore, Thomas, Lightle, Rhonda, Hobson, Nicholas, Shenkar, Robert, Poulsen, Orit, Haddad, Gabriel G, Daneman, Richard, Gongol, Brendan, Sun, Hao, Lagarrigue, Frederic, Awad, Issam A, Ginsberg, Mark H

“…Cerebral cavernous malformations (CCMs) are common neurovascular lesions caused by loss-of-function mutations in 1 of 3 genes, including KRIT1 (CCM1), CCM2,…”
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Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice by Lopez-Ramirez, Miguel Alejandro, Pham, Angela, Girard, Romuald, Wyseure, Tine, Hale, Preston, Yamashita, Atsuki, Koskimäki, Janne, Polster, Sean, Saadat, Laleh, Romero, Ignacio A., Esmon, Charles T., Lagarrigue, Frederic, Awad, Issam A., Mosnier, Laurent O., Ginsberg, Mark H.

“…Cerebral cavernous malformations (CCMs) are common brain vascular dysplasias that are prone to acute and chronic hemorrhage with significant clinical sequelae…”
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Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations by Lopez-Ramirez, Miguel Alejandro, Fonseca, Gregory, Zeineddine, Hussein A, Girard, Romuald, Moore, Thomas, Pham, Angela, Cao, Ying, Shenkar, Robert, de Kreuk, Bart-Jan, Lagarrigue, Frederic, Lawler, Jack, Glass, Christopher K, Awad, Issam A, Ginsberg, Mark H

“…mutations are the most common cause of cerebral cavernous malformation (CCM). Acute gene inactivation in mouse brain microvascular endothelial cells (BMECs)…”
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Lectin-type oxidized LDL receptor-1 as a potential therapeutic target for cerebral cavernous malformations treatment by Ashok, Karthik, Martinez, Tyra, Sesen, Julie, Nasim, Sana, Lang, Shih-Shan, Heuer, Gregory, Tucker, Alexander, Lopez-Ramirez, Miguel Alejandro, Smith, Edward R, Ghalali, Aram

“…Cerebral cavernous malformations (CCMs) are pathologic lesions comprised of clusters of thin-walled capillaries characterized by abnormal proliferation,…”
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Regulation of brain endothelial barrier function by microRNAs in health and neuroinflammation by Lopez‐Ramirez, Miguel Alejandro, Reijerkerk, Arie, Vries, Helga E., Romero, Ignacio Andres

“…ABSTRACT Brain endothelial cells constitute the major cellular element of the highly specialized blood‐brain barrier (BBB) and thereby contribute to CNS…”
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MicroRNA-155 contributes to shear-resistant leukocyte adhesion to human brain endothelium in vitro by Cerutti, Camilla, Soblechero-Martin, Patricia, Wu, Dongsheng, Lopez-Ramirez, Miguel Alejandro, de Vries, Helga, Sharrack, Basil, Male, David Kingsley, Romero, Ignacio Andres

“…Increased leukocyte adhesion to brain endothelial cells forming the blood-brain barrier (BBB) precedes extravasation into the central nervous system (CNS) in…”
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Cytokine-induced changes in the gene expression profile of a human cerebral microvascular endothelial cell-line, hCMEC/D3 by Lopez-Ramirez, Miguel Alejandro, Male, David Kingsley, Wang, Chunfang, Sharrack, Basil, Wu, Dongsheng, Romero, Ignacio Andres

“…The human cerebral microvascular endothelial cell line, hCMEC/D3, has been used extensively to model the blood-brain barrier (BBB) in vitro. Recently, we…”
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Polarized P-glycoprotein expression by the immortalised human brain endothelial cell line, hCMEC/D3, restricts apical-to-basolateral permeability to rhodamine 123 by Tai, Leon M, Reddy, P. Sreekanth, Lopez-Ramirez, M. Alejandro, Davies, Heather A, Male, A. David K, Loughlin, A. Jane, Romero, Ignacio A

“…Abstract P-glycoprotein (P-gp) expression at the blood–brain barrier prevents unwanted blood-borne toxins and signalling molecules from entering the brain…”
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Mayan Traditional Knowledge on Weather Forecasting: Who Contributes to Whom in Coping With Climate Change? by Camacho-Villa, Tania Carolina, Martinez-Cruz, Tania Eulalia, Ramírez-López, Alejandro, Hoil-Tzuc, Matias, Terán-Contreras, Silvia

“…Despite international commitments to integrate indigenous peoples and their Traditional Ecological Knowledge (TEK) in actions combating climate change, their…”
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Brain transcriptomic, metabolic and mitohormesis properties associated with N-propargylglycine treatment: A prevention strategy against neurodegeneration by Teramayi, Fadzai, Bons, Joanna, Scott, Madeleine, Scott, Gary K., Loureiro, Ashley, Lopez-Ramirez, Alejandro, Schilling, Birgit, Ellerby, Lisa M., Benz, Christopher C.

“…[Display omitted] •Treatment of HD or control mice with N-propargylglycine (N-PPG) induced mitohormesis.•Metabolomics revealed increased levels of proline,…”
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Modulating FKBP5/FKBP51 and autophagy lowers HTT (huntingtin) levels by Bailus, Barbara J., Scheeler, Stephen M., Simons, Jesse, Sanchez, Maria A., Tshilenge, Kizito-Tshitoko, Creus-Muncunill, Jordi, Naphade, Swati, Lopez-Ramirez, Alejandro, Zhang, Ningzhe, Lakshika Madushani, Kuruwitage, Moroz, Stanislav, Loureiro, Ashley, Schreiber, Katherine H., Hausch, Felix, Kennedy, Brian K., Ehrlich, Michelle E., Ellerby, Lisa M.

“…Current disease-modifying therapies for Huntington disease (HD) focus on lowering mutant HTT (huntingtin; mHTT) levels, and the immunosuppressant drug…”
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