Search Results - "Lopez‐Castejon, Gloria"

Control of the inflammasome by the ubiquitin system by Lopez‐Castejon, Gloria

“…Inflammation is the body’s response to danger. One of the first immune cell types to encounter danger is the macrophage. Macrophages sense danger signals such…”
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NLRP3 inflammasome triggers interleukin‐37 release from human monocytes by Gritsenko, Anna, Díaz‐Pino, Rodrigo, López‐Castejón, Gloria

“…IL‐37 is an anti‐inflammatory member of the IL‐1 family that dampens inflammation associated with many noncommunicable diseases. However, mechanisms of IL‐37…”
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Bafilomycin A1 enhances NLRP3 inflammasome activation in human monocytes independent of lysosomal acidification by Yu, Shi, Green, Jack, Wellens, Rose, Lopez‐Castejon, Gloria, Brough, David

“…The NLRP3 inflammasome drives inflammation in response to tissue damage and infection by promoting the processing and release of IL‐1β. Human monocytes have an…”
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The inflammasomes, immune guardians at defence barriers by Palazon‐Riquelme, Pablo, Lopez‐Castejon, Gloria

“…Summary As a result of its strategic location, the epithelium is constantly exposed to a wide variety of pathogen and danger signals. Traditionally, the…”
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Microglia and macrophages differentially modulate cell death after brain injury caused by oxygen-glucose deprivation in organotypic brain slices by Girard, Sylvie, Brough, David, Lopez-Castejon, Gloria, Giles, James, Rothwell, Nancy J., Allan, Stuart M.

“…Macrophage can adopt several phenotypes, process call polarization, which is crucial for shaping inflammatory responses to injury. It is not known if…”
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NLRP3 at the crossroads between immune/inflammatory responses and enteric neuroplastic remodelling in a mouse model of diet‐induced obesity by Pellegrini, Carolina, Fornai, Matteo, Benvenuti, Laura, Colucci, Rocchina, Caputi, Valentina, Palazon‐Riquelme, Pablo, Giron, Maria Cecilia, Nericcio, Anna, Garelli, Francesca, D'Antongiovanni, Vanessa, Segnani, Cristina, Ippolito, Chiara, Nannipieri, Monica, Lopez‐Castejon, Gloria, Pelegrin, Pablo, Haskó, György, Bernardini, Nunzia, Blandizzi, Corrado, Antonioli, Luca

“…Background and Purpose Enteric neurogenic/inflammation contributes to bowel dysmotility in obesity. We examined the role of NLRP3 in colonic neuromuscular…”
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P2X7 receptor‐dependent tuning of gut epithelial responses to infection by Huang, Szu‐Wei, Walker, Catherine, Pennock, Joanne, Else, Kathryn, Muller, Werner, Daniels, Michael JD, Pellegrini, Carolina, Brough, David, Lopez‐Castejon, Gloria, Cruickshank, Sheena M

“…Infection and injury of the gut are associated with cell damage and release of molecules such as extracellular adenosine 5′‐triphosphate (ATP), which is…”
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Pathophysiology of NSAID-Associated Intestinal Lesions in the Rat: Luminal Bacteria and Mucosal Inflammation as Targets for Prevention by Colucci, Rocchina, Pellegrini, Carolina, Fornai, Matteo, Tirotta, Erika, Antonioli, Luca, Renzulli, Cecilia, Ghelardi, Emilia, Piccoli, Elena, Gentile, Daniela, Benvenuti, Laura, Natale, Gianfranco, Fulceri, Federica, Palazón-Riquelme, Pablo, López-Castejón, Gloria, Blandizzi, Corrado, Scarpignato, Carmelo

“…Non-steroidal anti-inflammatory drugs (NSAIDs) can damage the small intestine, mainly through an involvement of enteric bacteria. This study examined the…”
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Two Zinc Uptake Systems Contribute to the Full Virulence of Listeria monocytogenes during Growth In Vitro and In Vivo by Corbett, David, Wang, Jiahui, Schuler, Stephanie, Lopez-Castejon, Gloria, Glenn, Sarah, Brough, David, Andrew, Peter W, Cavet, Jennifer S, Roberts, Ian S

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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The NLRP3-inflammasome as a sensor of organelle dysfunction by Seoane, Paula I, Lee, Bali, Hoyle, Christopher, Yu, Shi, Lopez-Castejon, Gloria, Lowe, Martin, Brough, David

“…Diverse pathogen- and damage-associated stresses drive inflammation via activation of the multimolecular NLRP3-inflammasome complex. How the effects of diverse…”
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Canonical and Non-Canonical Activation of NLRP3 Inflammasome at the Crossroad between Immune Tolerance and Intestinal Inflammation by Pellegrini, Carolina, Antonioli, Luca, Lopez-Castejon, Gloria, Blandizzi, Corrado, Fornai, Matteo

“…Several lines of evidence point out the relevance of nucleotide-binding oligomerization domain leucine rich repeat and pyrin domain-containing protein 3…”
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Chloride regulates dynamic NLRP3-dependent ASC oligomerization and inflammasome priming by Green, Jack P., Yu, Shi, Martín-Sánchez, Fátima, Pelegrin, Pablo, Lopez-Castejon, Gloria, Lawrence, Catherine B., Brough, David

“…The NLRP3 inflammasome is an important regulator of inflammation and immunity. It is a multimolecular platform formed within cells that facilitates the…”
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Current status of inflammasome blockers as anti-inflammatory drugs by López-Castejón, Gloria, Pelegrín, Pablo

“…The inflammasomes have emerged as key mediators of inflammation and immunity, yet clinical application of this knowledge has been limited by a lack of specific…”
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Priming Is Dispensable for NLRP3 Inflammasome Activation in Human Monocytes In Vitro by Gritsenko, Anna, Yu, Shi, Martin-Sanchez, Fatima, Diaz-Del-Olmo, Ines, Nichols, Eva-Maria, Davis, Daniel M, Brough, David, Lopez-Castejon, Gloria

“…Interleukin (IL)-18 and IL-1β are potent pro-inflammatory cytokines that contribute to inflammatory conditions such as rheumatoid arthritis and Alzheimer's…”
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Apoptosis-associated speck-like protein containing a CARD forms specks but does not activate caspase-1 in the absence of NLRP3 during macrophage swelling by Compan, Vincent, Martín-Sánchez, Fátima, Baroja-Mazo, Alberto, López-Castejón, Gloria, Gomez, Ana I, Verkhratsky, Alexei, Brough, David, Pelegrín, Pablo

“…Apoptosis-associated speck-like protein containing a C-terminal caspase recruitment domain (ASC) is a key adaptor molecule required for the inflammatory…”
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Sphingosine regulates the NLRP3‐inflammasome and IL‐1β release from macrophages by Luheshi, Nadia M., Giles, James A., Lopez‐Castejon, Gloria, Brough, David

“…Interleukin‐1β (IL‐1β) is a pro‐inflammatory cytokine that regulates inflammatory responses to injury and infection. IL‐1β secretion requires the protease…”
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NLRP3-Inflammasome Activating DAMPs Stimulate an Inflammatory Response in Glia in the Absence of Priming Which Contributes to Brain Inflammation after Injury by Savage, Catherine Diane, Lopez-Castejon, Gloria, Denes, Adam, Brough, David

“…Inflammation in the absence of infection (sterile inflammation) contributes to acute injury and chronic disease. Cerebral ischemia is a devastating condition…”
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Proximity labelling of pro-interleukin-1α reveals evolutionary conserved nuclear interactions by Wellens, Rose, Tapia, Victor S., Seoane, Paula I., Bennett, Hayley, Adamson, Antony, Coutts, Graham, Rivers-Auty, Jack, Lowe, Martin, Green, Jack P., Lopez-Castejon, Gloria, Brough, David, Hoyle, Christopher

“…Interleukin-1α is a suggested dual-function cytokine that diverged from interleukin-1β in mammals potentially by acquiring additional biological roles that…”
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Deubiquitinases: Novel Therapeutic Targets in Immune Surveillance? by Lopez-Castejon, Gloria, Edelmann, Mariola J.

“…Inflammation is a protective response of the organism to tissue injury or infection. It occurs when the immune system recognizes Pathogen-Associated Molecular…”
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P2X7 Receptor-Mediated Release of Cathepsins from Macrophages Is a Cytokine-Independent Mechanism Potentially Involved in Joint Diseases by Lopez-Castejon, Gloria, Theaker, Jill, Pelegrin, Pablo, Clifton, Andrew D., Braddock, Martin, Surprenant, Annmarie

“…The ATP-gated P2X7 receptor (P2X7R) is a promising therapeutic target in chronic inflammatory diseases with highly specific antagonists currently under…”
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