Search Results - "Lopez‐Canul, Martha"

Melatonin MT1 and MT2 Receptors Exhibit Distinct Effects in the Modulation of Body Temperature across the Light/Dark Cycle by López-Canul, Martha, Min, Seung Hyun, Posa, Luca, De Gregorio, Danilo, Bedini, Annalida, Spadoni, Gilberto, Gobbi, Gabriella, Comai, Stefano

“…Melatonin (MLT) is a neurohormone that regulates many physiological functions including sleep, pain, thermoregulation, and circadian rhythms. MLT acts mainly…”
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Antidepressant actions of ketamine engage cell-specific translation via eIF4E by Aguilar-Valles, Argel, De Gregorio, Danilo, Matta-Camacho, Edna, Eslamizade, Mohammad J., Khlaifia, Abdessattar, Skaleka, Agnieszka, Lopez-Canul, Martha, Torres-Berrio, Angelica, Bermudez, Sara, Rurak, Gareth M., Simard, Stephanie, Salmaso, Natalina, Gobbi, Gabriella, Lacaille, Jean-Claude, Sonenberg, Nahum

“…Effective pharmacotherapy for major depressive disorder remains a major challenge, as more than 30% of patients are resistant to the first line of treatment…”
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Effects of Chronic Exposure to Low-Dose delta-9-Tetrahydrocannabinol in Adolescence and Adulthood on Serotonin/Norepinephrine Neurotransmission and Emotional Behavior by De Gregorio, Danilo, Dean Conway, Joshua, Canul, Martha-Lopez, Posa, Luca, Bambico, Francis Rodriguez, Gobbi, Gabriella

“…Abstract Background Chronic exposure to D9-tetrahydrocannabinol (THC), the main pharmacological component of cannabis, during adolescence has been shown to be…”
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Antinociceptive properties of selective MT2 melatonin receptor partial agonists by López-Canul, Martha, Comai, Stefano, Domínguez-López, Sergio, Granados-Soto, Vinicio, Gobbi, Gabriella

“…Melatonin is a neurohormone involved in the regulation of both acute and chronic pain whose mechanism is still not completely understood. We have recently…”
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Supraspinal melatonin MT2 receptor agonism alleviates pain via a neural circuit that recruits mu opioid receptors by Posa, Luca, De Gregorio, Danilo, Lopez‐Canul, Martha, He, Qianzi, Darcq, Emmanuel, Rullo, Laura, Pearl‐Dowler, Leora, Luongo, Livio, Candeletti, Sanzio, Romualdi, Patrizia, Kieffer, Brigitte Lina, Gobbi, Gabriella

“…Melatonin, through its G protein‐coupled receptor (GPCR) (MTNR1B gene) MT2, is implicated in analgesia, but the relationship between MT2 receptors and the…”
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Nociceptive responses in melatonin MT2 receptor knockout mice compared to MT1 and double MT1/MT2 receptor knockout mice by Posa, Luca, Lopez‐Canul, Martha, Rullo, Laura, De Gregorio, Danilo, Dominguez‐Lopez, Sergio, Kaba Aboud, Matthew, Caputi, Francesca Felicia, Candeletti, Sanzio, Romualdi, Patrizia, Gobbi, Gabriella

“…Melatonin, a neurohormone that binds to two G protein‐coupled receptors MT1 and MT2, is involved in pain regulation, but the distinct role of each receptor has…”
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The ventral hippocampus is required for behavioral flexibility but not for allocentric/egocentric learning by Torres-Berrío, Angélica, Vargas-López, Viviana, López-Canul, Martha

“…•Allocentric or egocentric spatial strategies do not involve ventral hippocampus function.•Inactivation of the ventral hippocampus impairs the ability to shift…”
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Selective melatonin MT2 receptor ligands relieve neuropathic pain through modulation of brainstem descending antinociceptive pathways by Lopez-Canul, Martha, Palazzo, Enza, Dominguez-Lopez, Sergio, Luongo, Livio, Lacoste, Baptiste, Comai, Stefano, Angeloni, Debora, Fraschini, Franco, Boccella, Serena, Spadoni, Gilberto, Bedini, Annalida, Tarzia, Giorgio, Maione, Sabatino, Granados-Soto, Vinicio, Gobbi, Gabriella

“…Neuropathic pain is an important public health problem for which only a few treatments are available. Preclinical studies show that melatonin (MLT), a…”
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Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain by De Gregorio, Danilo, McLaughlin, Ryan J., Posa, Luca, Ochoa-Sanchez, Rafael, Enns, Justine, Lopez-Canul, Martha, Aboud, Matthew, Maione, Sabatino, Comai, Stefano, Gobbi, Gabriella

“…Clinical studies indicate that cannabidiol (CBD), the primary nonaddictive component of cannabis that interacts with the serotonin (5-HT)1A receptor, may…”
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Electrophysiological characterization of dopamine neuronal activity in the ventral tegmental area across the light-dark cycle by Domínguez-López, Sergio, Howell, Rebecca Dean, López-Canúl, Martha Graciela, Leyton, Marco, Gobbi, Gabriella

“…ABSTRACT Direct evidence that dopamine (DA) neurotransmission varies during the 24 h of the day is lacking. Here, we have characterized the firing activity of…”
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Anti-allodynic and medullary modulatory effects of a single dose of delta-9-tetrahydrocannabinol (THC) in neuropathic rats tolerant to morphine by Pearl-Dowler, Leora, Posa, Luca, Lopez-Canul, Martha, Teggin, Alexandra, Gobbi, Gabriella

“…Neuropathic pain (NP) is often treated with opioids, the prolonged use of which causes tolerance to their analgesic effect and can potentially cause death by…”
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Melatonin MT1 receptor as a novel target in neuropsychopharmacology: MT1 ligands, pathophysiological and therapeutic implications, and perspectives by Comai, Stefano, Lopez-Canul, Martha, De Gregorio, Danilo, Posner, Ada, Ettaoussi, Mohamed, Guarnieri, Fabrizia Claudia, Gobbi, Gabriella

“…[Display omitted] Melatonin (MLT), a neuromodulator mainly acting through two G-protein coupled receptors MT1 and MT2, regulates many brain functions,…”
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Repeated lysergic acid diethylamide (LSD) reverses stress-induced anxiety-like behavior, cortical synaptogenesis deficits and serotonergic neurotransmission decline by De Gregorio, Danilo, Inserra, Antonio, Enns, Justine P, Markopoulos, Athanasios, Pileggi, Michael, El Rahimy, Youssef, Lopez-Canul, Martha, Comai, Stefano, Gobbi, Gabriella

“…Lysergic acid diethylamide (LSD) is a serotonergic psychedelic compound receiving increasing interest due to putative anxiolytic and antidepressant properties…”
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Lysergic acid diethylamide (LSD) promotes social behavior through mTORC1 in the excitatory neurotransmission by De Gregorio, Danilo, Popic, Jelena, Enns, Justine P., Inserra, Antonio, Skalecka, Agnieszka, Markopoulos, Athanasios, Posa, Luca, Lopez-Canul, Martha, Qianzi, He, Lafferty, Christopher K., Britt, Jonathan P., Comai, Stefano, Aguilar-Valles, Argel, Sonenberg, Nahum, Gobbi, Gabriella

“…Clinical studies have reported that the psychedelic lysergic acid diethylamide (LSD) enhances empathy and social behavior (SB) in humans, but its mechanism of…”
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Lysergic acid diethylamide differentially modulates the reticular thalamus, mediodorsal thalamus, and infralimbic prefrontal cortex: An in vivo electrophysiology study in male mice by Inserra, Antonio, De Gregorio, Danilo, Rezai, Tamim, Lopez-Canul, Martha Graciela, Comai, Stefano, Gobbi, Gabriella

“…Background: The reticular thalamus gates thalamocortical information flow via finely tuned inhibition of thalamocortical cells in the mediodorsal thalamus…”
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Supraspinal melatonin MT 2 receptor agonism alleviates pain via a neural circuit that recruits mu opioid receptors by Posa, Luca, De Gregorio, Danilo, Lopez‐Canul, Martha, He, Qianzi, Darcq, Emmanuel, Rullo, Laura, Pearl‐Dowler, Leora, Luongo, Livio, Candeletti, Sanzio, Romualdi, Patrizia, Kieffer, Brigitte Lina, Gobbi, Gabriella

“…Melatonin, through its G protein‐coupled receptor (GPCR) (MTNR1B gene) MT 2 , is implicated in analgesia, but the relationship between MT 2 receptors and the…”
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Nociceptive responses in melatonin MT 2 receptor knockout mice compared to MT 1 and double MT 1 /MT 2 receptor knockout mice by Posa, Luca, Lopez‐Canul, Martha, Rullo, Laura, De Gregorio, Danilo, Dominguez‐Lopez, Sergio, Kaba Aboud, Matthew, Caputi, Francesca Felicia, Candeletti, Sanzio, Romualdi, Patrizia, Gobbi, Gabriella

“…Melatonin, a neurohormone that binds to two G protein‐coupled receptors MT 1 and MT 2, is involved in pain regulation, but the distinct role of each receptor…”
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Effects of chronic exposure to low doses of Δ9- tetrahydrocannabinol in adolescence and adulthood on serotonin/norepinephrine neurotransmission and emotional behaviors by De Gregorio, Danilo, Dean Conway, Joshua, Canul, Martha-Lopez, Posa, Luca, Bambico, Francis Rodriguez, Gobbi, Gabriella

“…Chronic exposure to the Δ9-tetrahydrocannabinol (THC), the main cannabis pharmacological component, during adolescence has been shown to be associated with an…”
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Melatonin MT 1 receptor as a novel target in neuropsychopharmacology: MT 1 ligands, pathophysiological and therapeutic implications, and perspectives by Comai, Stefano, Lopez-Canul, Martha, De Gregorio, Danilo, Posner, Ada, Ettaoussi, Mohamed, Guarnieri, Fabrizia Claudia, Gobbi, Gabriella

“…Melatonin (MLT), a neuromodulator mainly acting through two G-protein coupled receptors MT and MT , regulates many brain functions, including circadian…”
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Nociceptive responses in MT 2 receptor knockout mice compared to MT 1 and double MT 1 /MT 2 receptor knockout mice by Posa, Luca, Lopez-Canul, Martha, Rullo, Laura, De Gregorio, Danilo, Dominguez-Lopez, Sergio, Aboud, Matthew Kaba, Felicia Caputi, Francesca, Candeletti, Sanzio, Romualdi, Patrizia, Gobbi, Gabriella

“…Melatonin, a neurohormone that binds to two G-protein coupled receptors MT and MT is involved in pain regulation, but the distinct role of each receptor has…”
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