Search Results - "Lopez‐Bailon, Luis"
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Beyond the antibody: B cells as a target for bacterial infection
Published in Journal of leukocyte biology (01-05-2019)“…It is well established that B cells play an important role during infections beyond antibody production. B cells produce cytokines and are APCs for T cells…”
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Salmonella Promotes Its Own Survival in B Cells by Inhibiting Autophagy
Published in Cells (Basel, Switzerland) (29-06-2022)“…Salmonella is a Gram-negative bacterium known to be the major cause of gastrointestinal diseases and systemic infections. During infection of murine B cells,…”
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Harnessing γδ T Cells against Human Gynecologic Cancers
Published in Life (Basel, Switzerland) (29-02-2024)“…Immuno-oncology has traditionally focused on conventional MHC-restricted αβ T cells. Yet, unconventional γδ T cells, which kill tumor cells in an…”
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Unraveling spontaneous humoral immune responses against human cancer: A road to novel immunotherapies
Published in Journal of leukocyte biology (04-11-2024)“…In immuno-oncology, the focus has traditionally been on αβ T cells, and immune checkpoint inhibitors that primarily target PD-1 or CTLA4 in these lymphocytes…”
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Targeting intracellular oncoproteins with dimeric IgA promotes expulsion from the cytoplasm and immune-mediated control of epithelial cancers
Published in Immunity (Cambridge, Mass.) (14-11-2023)“…Dimeric IgA (dIgA) can move through cells via the IgA/IgM polymeric immunoglobulin receptor (PIGR), which is expressed mainly on mucosal epithelia. Here, we…”
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Novel tumor-specific Vd1/3 gd CAR T cells effectively control solid tumors
Published in The Journal of immunology (1950) (01-05-2024)“…Abstract Chimeric Antigen Receptor (CAR) T cell therapy has proven to be successful in treating hematological malignancies. However, its effectiveness against…”
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Vgd1 and Vgd3 T cells are abundant gd T cells populations in high-grade serous ovarian carcinoma, non-small/small cell lung cancer, and show a heterogeneous g-chain usage
Published in The Journal of immunology (1950) (01-05-2024)“…Abstract γδ T cells, in contrast to the conventional MHC-restricted αβ, recognize and kill tumor cells in an MHC-unrestricted manner, highlighting their…”
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Presence of SARS-CoV-2-specific T cells before vaccination in the Mexican population
Published in Journal of leukocyte biology (28-06-2024)“…The immune response to SARS-CoV-2 has been extensively studied following the pandemic outbreak in 2020; however, the presence of specific T cells against…”
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IFN‐γ stimulates Paneth cell secretion through necroptosis mTORC1 dependent
Published in European journal of immunology (01-09-2024)“…Immune mediators affect multiple biological functions of intestinal epithelial cells (IECs) and, like Paneth and Paneth‐like cells, play an important role in…”
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Abstract 6346: IgG engineered to target PIGR-mediated transcytosis specifically targets intracellular oncoproteins and abrogated tumor growth
Published in Cancer research (Chicago, Ill.) (22-03-2024)“…Abstract Despite their long half-life, therapeutic antibodies are considered ineffective against intracellular antigens due to their perceived inability to…”
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Abstract 4438: Time restricted eating improves antitumor immune responses via modulation of insulin-like growth factor 1 in patients with head and neck cancer
Published in Cancer research (Chicago, Ill.) (22-03-2024)“…Abstract Background- Treatment of metastatic head and neck cancer remains an area of unmet need with median survival less than a year. We tested the efficacy…”
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