Search Results - "Lopez, Kyle E."
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Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis
Published in Nature structural & molecular biology (01-05-2020)“…The ClpAP complex is a conserved bacterial protease that unfolds and degrades proteins targeted for destruction. The ClpA double-ring hexamer powers substrate…”
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Journal Article -
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Robust Sequence Determinants of α‑Synuclein Toxicity in Yeast Implicate Membrane Binding
Published in ACS chemical biology (21-08-2020)“…Protein conformations are shaped by cellular environments, but how environmental changes alter the conformational landscapes of specific proteins in vivo…”
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Journal Article