Search Results - "Lopez, Juan D"
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Past, present and future of therapeutic strategies against amyloid-β peptides in Alzheimer’s disease: a systematic review
Published in Ageing research reviews (01-12-2021)“…Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease in ageing, affecting around 46 million people worldwide but few treatments are…”
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Efficacy and safety of anti-amyloid-β monoclonal antibodies in current Alzheimer's disease phase III clinical trials: A systematic review and interactive web app-based meta-analysis
Published in Ageing research reviews (01-09-2023)“…The risk-benefit profile of anti-Aβ monoclonal antibodies (mAbs) in Alzheimer’s disease (AD) remains unclear, especially concerning their safety and overall…”
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Targeting epigenetics: A novel promise for Alzheimer’s disease treatment
Published in Ageing research reviews (01-09-2023)“…So far, the search for a cure for Alzheimer Disease (AD) has been unsuccessful. The only approved drugs attenuate some symptoms, but do not halt the progress…”
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Systematic review and meta analysis of cross immunity and the smokers paradox in COVID19
Published in Scientific reports (17-10-2024)“…COVID-19 pandemic, caused by the novel SARS-CoV-2 virus, has raised significant interest in understanding potential cross-immunity mechanisms. Recent evidence…”
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Therapeutic potential of targeting G protein-gated inwardly rectifying potassium (GIRK) channels in the central nervous system
Published in Pharmacology & therapeutics (Oxford) (01-07-2021)“…G protein-gated inwardly rectifying potassium channels (Kir3/GirK) are important for maintaining resting membrane potential, cell excitability and inhibitory…”
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Amyloid-β(25-35) Modulates the Expression of GirK and KCNQ Channel Genes in the Hippocampus
Published in PloS one (28-07-2015)“…During early stages of Alzheimer's disease (AD), synaptic dysfunction induced by toxic amyloid-β (Aβ) is present before the accumulation of histopathological…”
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Anti-amyloid antibodies in Alzheimer's disease: what did clinical trials teach us?
Published in Neural regeneration research (01-04-2025)Get full text
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8
Geographic and Temporal Variation in Moth Chemical Communication
Published in Evolution (01-08-2009)“…In moth pheromone communication signals, both quantitative and qualitative intraspecific differences have been found across geographic regions. Such variation…”
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Cytokine Release Syndrome (CRS) and Nicotine in COVID-19 Patients: Trying to Calm the Storm
Published in Frontiers in immunology (11-06-2020)“…SARS-CoV-2 is a new coronavirus that has caused a worldwide pandemic. It causes severe acute respiratory syndrome (COVID-19), which is fatal in many cases, and…”
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Impairments of Synaptic Plasticity Induction Threshold and Network Oscillatory Activity in the Hippocampus Underlie Memory Deficits in a Non-Transgenic Mouse Model of Amyloidosis
Published in Biology (Basel, Switzerland) (01-07-2020)“…In early Alzheimer disease (AD) models synaptic failures and upstreaming aberrant patterns of network synchronous activity result in hippocampal-dependent…”
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Monitoring of Power Over Fiber Signals Using Intercore Crosstalk in ARoF 5G NR Transmission
Published in Journal of lightwave technology (01-12-2023)“…Power over Fiber (PoF) needs safe and resilient operation of the infrastructure. In this article, we propose a new crosstalk-based remote monitoring technique…”
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Cardiac paraganglioma: implications and impacts of a rare disease-a case report
Published in European heart journal : case reports (01-03-2024)“…Tumour-producing catecholamines arise in the adrenal medulla (pheochromocytomas), as well as in extra-adrenal chromaffin cells (paragangliomas). The origin can…”
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Safe Zones and Trajectory of Femoral Pin Placement in Robotic Total Knee Arthroplasty
Published in Arthroplasty today (01-10-2023)“…Robotic-assisted total knee arthroplasty may result in array pin-related complications. Lack of knowledge on ideal pin placement results in varied insertion…”
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Effect of Emamectin Benzoate on Mortality, Proboscis Extension, Gustation and Reproduction of the Corn Earworm, Helicoverpa zea
Published in Journal of insect science (Tucson, Ariz.) (2010)“…Newly emerged corn earworm adults, Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) require a carbohydrate source from plant or other exudates and nectars for…”
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Amyloid-β induces synaptic dysfunction through G protein-gated inwardly rectifying potassium channels in the fimbria-CA3 hippocampal synapse
Published in Frontiers in cellular neuroscience (25-07-2013)“…Last evidences suggest that, in Alzheimer's disease (AD) early stage, Amyloid-β (Aβ) peptide induces an imbalance between excitatory and inhibitory…”
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Clinical characteristics and respiratory care in hospitalized vaccinated SARS-CoV-2 patients
Published in EClinicalMedicine (01-06-2022)“…The main objective of the present study was to analyze both clinical characteristics and evolution during hospitalization of a cohort of patients admitted for…”
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TRP channels and neural persistent activity
Published in Advances in experimental medicine and biology (01-01-2011)“…One of the integrative properties of the nervous system is its capability to, by transient motor commands or brief sensory stimuli, evoke persistent neuronal…”
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Effect of Racemic, (+)- and (−)-Gossypol on Survival and Development of Heliothis virescens Larvae
Published in Environmental entomology (01-10-2008)“…Gossypol is a constituent of the lysigenous foliar glands of cotton plants and is also found in glands in cottonseed. Gossypol exists as enantiomers because of…”
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Hippocampal long‐term synaptic depression and memory deficits induced in early amyloidopathy are prevented by enhancing G‐protein‐gated inwardly rectifying potassium channel activity
Published in Journal of neurochemistry (01-05-2020)“…Hippocampal synaptic plasticity disruption by amyloid‐β (Aβ) peptides + thought to be responsible for learning and memory impairments in Alzheimer's disease…”
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Effect of Racemic and (+)- and (-)-Gossypol on the Survival and Development of Helicoverpa zea Larvae
Published in Journal of chemical ecology (01-05-2006)“…Gossypol is a sesquiterpene that occurs naturally in seed and other parts of the cotton plant. Because of restricted rotation around the binaphthyl bond, it…”
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