Search Results - "Lopez, Daniel H"

Immune Landscape in Tumor Microenvironment: Implications for Biomarker Development and Immunotherapy by Pérez-Romero, Karim, Rodríguez, Ramón M, Amedei, Amedeo, Barceló-Coblijn, Gwendolyn, Lopez, Daniel H

“…Integration of the tumor microenvironment as a fundamental part of the tumorigenic process has undoubtedly revolutionized our understanding of cancer biology…”
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Tissue-selective alteration of ethanolamine plasmalogen metabolism in dedifferentiated colon mucosa by Lopez, Daniel H., Bestard-Escalas, Joan, Garate, Jone, Maimó-Barceló, Albert, Fernández, Roberto, Reigada, Rebeca, Khorrami, Sam, Ginard, Daniel, Okazaki, Toshiro, Fernández, José A., Barceló-Coblijn, Gwendolyn

“…Human colon lipid analysis by imaging mass spectrometry (IMS) demonstrates that the lipid fingerprint is highly sensitive to a cell's pathophysiological state…”
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Ins and Outs of Interpreting Lipidomic Results by Bestard-Escalas, Joan, Maimó-Barceló, Albert, Pérez-Romero, Karim, Lopez, Daniel H., Barceló-Coblijn, Gwendolyn

“…Membrane lipids are essential for life; however, research on how cells regulate cell lipid composition has been falling behind for quite some time. One reason…”
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2-hydroxy arachidonic acid: a new non-steroidal anti-inflammatory drug by Lopez, Daniel H, Fiol-deRoque, Maria A, Noguera-Salvà, Maria A, Terés, Silvia, Campana, Federica, Piotto, Stefano, Castro, José A, Mohaibes, Raheem J, Escribá, Pablo V, Busquets, Xavier

“…Nonsteroidal anti-inflammatory drugs (NSAIDs) are a family of COX1 and COX2 inhibitors used to reduce the synthesis of pro-inflammatory mediators. In addition,…”
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Sustained activation of sphingomyelin synthase by 2-hydroxyoleic acid induces sphingolipidosis in tumor cells by Martin, Maria Laura, Liebisch, Gerhard, Lehneis, Stefan, Schmitz, Gerd, Alonso-Sande, María, Bestard-Escalas, Joan, Lopez, Daniel H, García-Verdugo, José Manuel, Soriano-Navarro, Mario, Busquets, Xavier, Escribá, Pablo V, Barceló-Coblijn, Gwendolyn

“…The mechanism of action of 2-hydroxyoleic acid (2OHOA), a potent antitumor drug, involves the rapid and specific activation of sphingomyelin synthase (SMS),…”
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Program for the Epidemiological Evaluation of Stroke in Tandil, Argentina (PREVISTA) Study: Rationale and Design by Sposato, Luciano A., Coppola, Mariano L., Altamirano, Juan, Guerrero, Brenda Borrego, Casanova, Jorge, De Martino, Maximiliano, Díaz, Alejandro, Feigin, Valery L., Funaro, Fernando, Gradillone, María E., Lewin, María L., Lopes, Renato D., López, Daniel H., Louge, Mariel, Maccarone, Patricia, Martens, Cecilia, Miguel, Marcelo, Rabinstein, Alejandro, Morasso, Hernán, Riccio, Patricia M., Saposnik, Gustavo, Silva, Damián, Suasnabar, Ramón, Truelsen, Thomas, Uzcudun, Araceli, Viviani, Carlos A., Bahit, M. Cecilia

“…The availability of population-based epidemiological data on the incident risk of stroke is very scarce in Argentina and other Latin American countries. In…”
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Confirmation of sub-cellular resolution using oversampling imaging mass spectrometry by Maimó-Barceló, Albert, Garate, Jone, Bestard-Escalas, Joan, Fernández, Roberto, Berthold, Luzie, Lopez, Daniel H., Fernández, José Andrés, Barceló-Coblijn, Gwendolyn

“…The use of oversampling in MALDI (matrix-assisted laser desorption/ionization) imaging mass spectrometry (IMS) to improve lateral resolution is a common…”
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Imaging mass spectrometry increased resolution using 2-mercaptobenzothiazole and 2,5-diaminonaphtalene matrices: application to lipid distribution in human colon by Garate, Jone, Fernández, Roberto, Lage, Sergio, Bestard-Escalas, Joan, Lopez, Daniel H., Reigada, Rebeca, Khorrami, Sam, Ginard, Daniel, Reyes, José, Amengual, Isabel, Barceló-Coblijn, Gwendolyn, Fernández, José A.

“…Imaging mass spectrometry is becoming a reference technique in the field of lipidomics, due to its ability to map the distribution of hundreds of species in a…”
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Common and Differential Traits of the Membrane Lipidome of Colon Cancer Cell Lines and their Secreted Vesicles: Impact on Studies Using Cell Lines by Bestard-Escalas, Joan, Maimó-Barceló, Albert, Lopez, Daniel H, Reigada, Rebeca, Guardiola-Serrano, Francisca, Ramos-Vivas, José, Hornemann, Thorsten, Okazaki, Toshiro, Barceló-Coblijn, Gwendolyn

“…Colorectal cancer (CRC) is the fourth leading cause of cancer death in the world. Despite the screening programs, its incidence in the population below the 50s…”
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First-Ever Stroke and Transient Ischemic Attack Incidence and 30-Day Case-Fatality Rates in a Population-Based Study in Argentina by Bahit, M Cecilia, Coppola, Mariano L, Riccio, Patricia M, Cipriano, Lauren E, Roth, Gregory A, Lopes, Renato D, Feigin, Valery L, Borrego Guerrero, Brenda, De Martino, Maximiliano, Díaz, Alejandro, Ferrante, Daniel, Funaro, Fernando, Lavados, Pablo, Lewin, M Laura, López, Daniel H, Macarrone, Patricia, Marciello, Rafael, Marino, Diego, Martens, Cecilia, Martínez, Paula, Odriozola, Guillermo, Rabinstein, Alejandro A, Saposnik, Gustavo, Silva, Damián, Suasnabar, Ramón, Truelsen, Thomas, Uzcudun, Araceli, Viviani, Carlos A, Sposato, Luciano A

“…BACKGROUND AND PURPOSE—Epidemiological data about stroke are scarce in low- and middle-income Latin-American countries. We investigated annual incidence of…”
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Optimized Protocol To Analyze Changes in the Lipidome of Xenografts after Treatment with 2‑Hydroxyoleic Acid by Fernández, Roberto, Garate, Jone, Lage, Sergio, Terés, Silvia, Higuera, Mónica, Bestard-Escalas, Joan, Martin, M. Laura, López, Daniel H, Guardiola-Serrano, Francisca, Escribá, Pablo V, Barceló-Coblijn, Gwendolyn, Fernández, José A

“…Xenografts are a popular model for the study of the action of new antitumor drugs. However, xenografts are highly heterogeneous structures, and therefore it is…”
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A Drastic Shift in Lipid Adducts in Colon Cancer Detected by MALDI-IMS Exposes Alterations in Specific K + Channels by Garate, Jone, Maimó-Barceló, Albert, Bestard-Escalas, Joan, Fernández, Roberto, Pérez-Romero, Karim, Martínez, Marco A, Payeras, Mª Antònia, Lopez, Daniel H, Fernández, José Andrés, Barceló-Coblijn, Gwendolyn

“…Even though colorectal cancer (CRC) is one of the most preventable cancers, it is one of the deadliest, and recent data show that the incidence in people <50…”
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Identification of Biomarkers of Necrosis in Xenografts Using Imaging Mass Spectrometry by Fernández, Roberto, Garate, Jone, Lage, Sergio, Terés, Silvia, Higuera, Mónica, Bestard-Escalas, Joan, López, Daniel H., Guardiola-Serrano, Francisca, Escribá, Pablo V., Barceló-Coblijn, Gwendolyn, Fernández, José A.

“…Xenografts are commonly used to test the effect of new drugs on human cancer. However, because of their heterogeneity, analysis of the results is often…”
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Analysis of the Lipidome of Xenografts Using MALDI-IMS and UHPLC-ESI-QTOF by Fernández, Roberto, Lage, Sergio, Abad-García, Beatriz, Barceló-Coblijn, Gwendolyn, Terés, Silvia, López, Daniel H., Guardiola-Serrano, Francisca, Martín, M. Laura, Escribá, Pablo V., Fernández, José A.

“…Human tumor xenografts in immunodeficient mice are a very popular model to study the development of cancer and to test new drug candidates. Among the…”
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Sustained activation of sphingomyelin synthase by 2-hydroxyoleic acid induces sphingolipidosis in tumor cells1[S] by Martin, Maria Laura, Liebisch, Gerhard, Lehneis, Stefan, Schmitz, Gerd, Alonso-Sande, María, Bestard-Escalas, Joan, Lopez, Daniel H., García-Verdugo, José Manuel, Soriano-Navarro, Mario, Busquets, Xavier, Escribá, Pablo V., Barceló-Coblijn, Gwendolyn

“…The mechanism of action of 2-hydroxyoleic acid (2OHOA), a potent antitumor drug, involves the rapid and specific activation of sphingomyelin synthase (SMS),…”
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Extracellular Acidification Induces Human Neutrophil Activation by Trevani, Analia S, Andonegui, Graciela, Giordano, Mirta, Lopez, Daniel H, Gamberale, Romina, Minucci, Fernando, Geffner, Jorge R

“…In the current work, we evaluated the effect of extracellular acidification on neutrophil physiology. Neutrophils suspended in bicarbonate-buffered RPMI 1640…”
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Magnetic Graphene Nanosheet-Based Microfluidic Device for Homogeneous Real-Time Electronic Monitoring of Pyrophosphatase Activity Using Enzymatic Hydrolysate-Induced Release of Copper Ion by Lin, Youxiu, Zhou, Qian, Li, Juan, Shu, Jian, Qiu, Zhenli, Lin, Yuping, Tang, Dianping

“…A novel flow-through microfluidic device based on a magneto-controlled graphene sensing platform was designed for homogeneous electronic monitoring of…”
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Lipids as clinical drugs, lipids as drug targets by Escribá, Pablo V., Busquets, Xavier, Terés, Silvia, Lladó, Victoria, Barceó-Coblijn, Gwendolyn, Lopez, Daniel H., López, David

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2-Hydroxy Arachidonic Acid: A New Non-Steroidal Anti-Inflammatory Drug: e72052 by Lopez, Daniel H, Fiol-deRoque, Maria A, Noguera-Salva, Maria A, Teres, Silvia, Campana, Federica, Piotto, Stefano, Castro, Jose A, Mohaibes, Raheem J, Escriba, Pablo V, Busquets, Xavier

“…Background Nonsteroidal anti-inflammatory drugs (NSAIDs) are a family of COX1 and COX2 inhibitors used to reduce the synthesis of pro-inflammatory mediators…”
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Inhibition of human neutrophil apoptosis by platelets by Andonegui, G, Trevani, AS, Lopez, DH, Raiden, S, Giordano, M, Geffner, JR

“…In the absence of appropriate stimuli, polymorphonuclear neutrophils rapidly undergo characteristic changes indicative of programmed cell death or apoptosis…”
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