Search Results - "Lopez, Charles D"

Colorectal Cancer Liver Metastasis: Evolving Paradigms and Future Directions by Zarour, Luai R, Anand, Sudarshan, Billingsley, Kevin G, Bisson, William H, Cercek, Andrea, Clarke, Michael F, Coussens, Lisa M, Gast, Charles E, Geltzeiler, Cristina B, Hansen, Lissi, Kelley, Katherine A, Lopez, Charles D, Rana, Shushan R, Ruhl, Rebecca, Tsikitis, V. Liana, Vaccaro, Gina M, Wong, Melissa H, Mayo, Skye C

“…In patients with colorectal cancer (CRC) that metastasizes to the liver, there are several key goals for improving outcomes including early detection,…”
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Exploratory Analyses of Circulating Neoplastic-Immune Hybrid Cells as Prognostic Biomarkers in Advanced Intrahepatic Cholangiocarcinoma by Patel, Ranish K, Parappilly, Michael S, Walker, Brett S, Heussner, Robert T, Fung, Alice, Chang, Young Hwan, Kardosh, Adel, Lopez, Charles D, Mayo, Skye C, Wong, Melissa H

“…Existing clinical biomarkers do not reliably predict treatment response or disease progression in patients with advanced intrahepatic cholangiocarcinoma (ICC)…”
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Randomized phase II study of the Bruton tyrosine kinase inhibitor acalabrutinib, alone or with pembrolizumab in patients with advanced pancreatic cancer by Overman, Michael, Javle, Milind, Davis, Richard E, Vats, Pankaj, Kumar-Sinha, Chandan, Xiao, Lianchun, Mettu, Niharika B, Parra, Edwin R, Benson, Al B, Lopez, Charles D, Munugalavadla, Veerendra, Patel, Priti, Tao, Lin, Neelapu, Sattva, Maitra, Anirban

“…BackgroundThe immunosuppressive desmoplastic stroma of pancreatic cancer represents a major hurdle to developing an effective immune response. Preclinical…”
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Alternative splicing of Apoptosis Stimulating Protein of TP53-2 (ASPP2) results in an oncogenic isoform promoting migration and therapy resistance in soft tissue sarcoma (STS) by Tsintari, Vasileia, Walter, Bianca, Fend, Falko, Overkamp, Mathis, Rothermundt, Christian, Lopez, Charles D., Schittenhelm, Marcus M., Kampa-Schittenhelm, Kerstin M.

“…Abstract Background Metastatic soft tissue sarcoma (STS) are a heterogeneous group of malignancies which are not curable with chemotherapy alone. Therefore,…”
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Neoadjuvant immunotherapy leads to complete pathologic response in locally advanced colon cancer by Sandow, Lyndsey, Tsikitis, Liana, Lopez, Charles D., Brinkerhoff, Brian, Kardosh, Adel, Pegna, Guillaume, Chen, Emerson Y.

“…Key Clinical Message Immunotherapy is considered first line in patients with dMMR metastatic colorectal cancer (CRC). Recent studies have also shown promising…”
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Effect of Time to Surgery of Colorectal Liver Metastases on Survival by Chen, Emerson Y., Mayo, Skye C., Sutton, Thomas, Kearney, Matthew R., Kardosh, Adel, Vaccaro, Gina M., Billingsley, Kevin G., Lopez, Charles D.

“…Purpose Resection of liver-only colorectal liver metastases (CRLM) with perioperative chemotherapy is potentially curative. Specific primary tumor and liver…”
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Implementing a comprehensive translational oncology platform: from molecular testing to actionability by Mitri, Zahi I, Parmar, Swapnil, Johnson, Brett, Kolodzie, Annette, Keck, Jamie M, Morris, Max, Guimaraes, Alexander R, Beckett, Brooke R, Borate, Uma, Lopez, Charles D, Kemmer, Kathleen A, Alumkal, Joshi J, Beer, Tomasz M, Corless, Christopher L, Mills, Gordon B, Gray, Joe W, Bergan, Raymond C

“…In order to establish the workflows required to implement a real-time process involving multi-omic analysis of patient samples to support precision-guided…”
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N terminus of ASPP2 binds to Ras and enhances Ras/Raf/MEK/ERK activation to promote oncogene-induced senescence by Wang, Zhiping, Liu, Yuangang, Takahashi, Maho, Van Hook, Kathryn, Kampa-Schittenhelm, Kerstin M., Sheppard, Brett C., Sears, Rosalie C., Stork, Philip J. S., Lopez, Charles D.

“…The ASPP2 (also known as 53BP2L) tumor suppressor is a proapoptotic member of a family of p53 binding proteins that functions in part by enhancing…”
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Phase 2 study of preoperative chemotherapy with nab‐paclitaxel and gemcitabine followed by chemoradiation for borderline resectable or node‐positive pancreatic ductal adenocarcinoma by Chen, Emerson Y., Kardosh, Adel, Nabavizadeh, Nima, Foster, Bryan, Mayo, Skye C., Billingsley, Kevin G., Gilbert, Erin W., Lanciault, Christian, Grossberg, Aaron, Bensch, Kenneth G., Maynard, Erin, Anderson, Eric C., Sheppard, Brett C., Thomas, Charles R., Lopez, Charles D., Vaccaro, Gina M.

“…Background Neoadjuvant treatment with nab‐paclitaxel and gemcitabine for potentially operable pancreatic adenocarcinoma has not been well studied in a…”
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Efficacy and safety of maintenance therapy with pamiparib versus placebo for advanced gastric cancer responding to first‐line platinum‐based chemotherapy: Phase 2 study results by Ciardiello, Fortunato, Bang, Yung‐Jue, Cervantes, Andrés, Dvorkin, Mikhail, Lopez, Charles D., Metges, Jean‐Philippe, Sánchez Ruiz, Antonio, Calvo, Mariona, Strickland, Andrew H., Kannourakis, George, Muro, Kei, Kawakami, Hisato, Wei, Jia, Borg, Christophe, Zhu, Zhaoyin, Gupta, Neal, Pelham, Robert J., Shen, Lin

“…Background Poly (ADP‐ribose) polymerase (PARP) inhibitors (PARPi) are approved for the treatment of various solid tumors. In gastric cancer, genes commonly…”
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Attenuated expression of apoptosis stimulating protein of p53-2 (ASPP2) in human acute leukemia is associated with therapy failure by Schittenhelm, Marcus M, Illing, Barbara, Ahmut, Figen, Rasp, Katharina Henriette, Blumenstock, Gunnar, Döhner, Konstanze, Lopez, Charles D, Kampa-Schittenhelm, Kerstin M

“…Inactivation of the p53 pathway is a universal event in human cancers and promotes tumorigenesis and resistance to chemotherapy. Inactivating p53 mutations are…”
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ASPP2κ Is Expressed In Human Colorectal Carcinoma And Promotes Chemotherapy Resistance And Tumorigenesis by Rieger, Ingmar, Tsintari, Vasileia, Overkamp, Mathis, Fend, Falko, Lopez, Charles D., Schittenhelm, Marcus M., Kampa-Schittenhelm, Kerstin M.

“…Alternative splicing is a common physiologic mechanism to generate numerous distinct gene products from one gene locus, which can result in unique gene…”
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New insights into the expanding complexity of the tumor suppressor ASPP2 by Kampa, Kerstin M., Bonin, Michael, Lopez, Charles D.

“…Apoptosis Stimulating Protein of p53-2, ASPP2, aka 53BP2L, (encoded by TP53BP2) is a pro-apoptotic member of a family of p53 binding proteins. ASPP2 expression…”
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Apoptosis-stimulating protein of p53 (ASPP2) heterozygous mice are tumor-prone and have attenuated cellular damage-response thresholds by Kampa, Kerstin M, Acoba, Jared D, Chen, Dexi, Gay, Joel, Lee, Hunjoo, Beemer, Kelly, Padiernos, Emerson, Boonmark, Nataya, Zhu, Zhiyi, Fan, Alice C, Bailey, Alexis S, Fleming, William H, Corless, Christopher, Felsher, Dean W, Naumovski, Louie, Lopez, Charles D

“…The expression of ASPP2 (53BP2L), a proapoptotic member of a family of p53-binding proteins, is frequently suppressed in many human cancers. Accumulating…”
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E2F1 Regulates the Base Excision Repair Gene XRCC1 and Promotes DNA Repair by Chen, Dexi, Yu, Zhiyong, Zhu, Zhiyi, Lopez, Charles D.

“…The E2F1 transcription factor activates S-phase-promoting genes, mediates apoptosis, and stimulates DNA repair through incompletely understood mechanisms…”
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Randomized Phase III Study of FOLFOX Alone or With Pegilodecakin as Second-Line Therapy in Patients With Metastatic Pancreatic Cancer That Progressed After Gemcitabine (SEQUOIA) by Hecht, J Randolph, Lonardi, Sara, Bendell, Johanna, Sim, Hao-Wen, Macarulla, Teresa, Lopez, Charles D, Van Cutsem, Eric, Muñoz Martin, Andres J, Park, Joon Oh, Greil, Richard, Wang, Hong, Hozak, Rebecca R, Gueorguieva, Ivelina, Lin, Yong, Rao, Sujata, Ryoo, Baek-Yeol

“…SEQUOIA compared efficacy and safety of adding pegilodecakin (PEG), a pegylated recombinant human interleukin (IL)-10, with folinic acid, fluorouracil, and…”
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ASO Author Reflections: Is It Time to Re-evaluate Floxuridine Dosing for Hepatic Arterial Infusion? by Schwantes, Issac R., Patel, Ranish K., Kardosh, Adel, Lopez, Charles D., Mayo, Skye C.

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Activation of PP2A and Inhibition of mTOR Synergistically Reduce MYC Signaling and Decrease Tumor Growth in Pancreatic Ductal Adenocarcinoma by Allen-Petersen, Brittany L, Risom, Tyler, Feng, Zipei, Wang, Zhiping, Jenny, Zina P, Thoma, Mary C, Pelz, Katherine R, Morton, Jennifer P, Sansom, Owen J, Lopez, Charles D, Sheppard, Brett, Christensen, Dale J, Ohlmeyer, Michael, Narla, Goutham, Sears, Rosalie C

“…In cancer, kinases are often activated and phosphatases suppressed, leading to aberrant activation of signaling pathways driving cellular proliferation,…”
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Cell fusion potentiates tumor heterogeneity and reveals circulating hybrid cells that correlate with stage and survival by Gast, Charles E, Silk, Alain D, Zarour, Luai, Riegler, Lara, Burkhart, Joshua G, Gustafson, Kyle T, Parappilly, Michael S, Roh-Johnson, Minna, Goodman, James R, Olson, Brennan, Schmidt, Mark, Swain, John R, Davies, Paige S, Shasthri, Vidya, Iizuka, Shinji, Flynn, Patrick, Watson, Spencer, Korkola, James, Courtneidge, Sara A, Fischer, Jared M, Jaboin, Jerry, Billingsley, Kevin G, Lopez, Charles D, Burchard, Julja, Gray, Joe, Coussens, Lisa M, Sheppard, Brett C, Wong, Melissa H

“…High lethality rates associated with metastatic cancer highlight an urgent medical need for improved understanding of biologic mechanisms driving metastatic…”
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Hepatectomy is associated with improved oncologic outcomes in recurrent colorectal liver metastases: A propensity-matched analysis by Sutton, Thomas L., Wong, Liam H., Walker, Brett S., Dewey, Elizabeth N., Eil, Robert, Lopez, Charles D., Kardosh, Adel, Chen, Emerson Y., Rocha, Flavio G., Billingsley, Kevin G., Mayo, Skye C.

“…Following resection of colorectal liver metastasis, most patients have disease recurrence, most commonly intrahepatic. Although the role of resection in…”
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