Search Results - "Lopez, Bernard L."

Withaferin A Prevents Myocardial Ischemia/Reperfusion Injury by Upregulating AMP-Activated Protein Kinase-Dependent B-Cell Lymphoma2 Signaling by Guo, Rui, Gan, Lu, Lau, Wayne Bond, Yan, Zheyi, Xie, Dina, Gao, Erhe, Christopher, Theodore A, Lopez, Bernard L., Ma, Xinliang, Wang, Yajing

“…Background:Withaferin A (WFA), an anticancer constituent of the plant Withania somnifera, inhibits tumor growth in association with apoptosis induction…”
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miRNA-Mediated Suppression of a Cardioprotective Cardiokine as a Novel Mechanism Exacerbating Post-MI Remodeling by Sleep Breathing Disorders by Du, Yunhui, Wang, Xiao, Li, Linyi, Hao, Wenjing, Zhang, Huina, Li, Yu, Qin, Yanwen, Nie, Shaoping, Christopher, Theodore A., Lopez, Bernard L., Lau, Wayne Bond, Wang, Yajing, Ma, Xin-Liang, Wei, Yongxiang

“…Obstructive sleep apnea-hypopnea syndrome, a sleep breathing disorder in which chronic intermittent hypoxia (CIH) is the primary pathology, is associated with…”
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C1q/TNF-Related Proteins, A Family of Novel Adipokines, Induce Vascular Relaxation Through the Adiponectin Receptor-1/AMPK/eNOS/Nitric Oxide Signaling Pathway by Zheng, Qijun, Yuan, Yuexing, Yi, Wei, Lau, Wayne Bond, Wang, Yajing, Wang, Xiaoliang, Sun, Yang, Lopez, Bernard L, Christopher, Theodore A, Peterson, Jonathan M, Wong, G William, Yu, Shiqiang, Yi, Dinghua, Ma, Xin-Liang

“…OBJECTIVE—Reduced plasma adiponectin (APN) in diabetic patients is associated with endothelial dysfunction. However, APN knockout animals manifest modest…”
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Adiponectin cardioprotection after myocardial ischemia/reperfusion involves the reduction of oxidative/nitrative stress by LING TAO, ERHE GAO, MA, Xin L, XIANGYING JIAO, YUEXING YUAN, SHUZHUANG LI, CHRISTOPHER, Theodore A, LOPEZ, Bernard L, KOCH, Walter, CHAN, Lawrence, GOLDSTEIN, Barry J

“…Several clinical studies have demonstrated that levels of adiponectin are significantly reduced in patients with type 2 diabetes and that adiponectin levels…”
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AMP-Activated Protein Kinase Deficiency Enhances Myocardial Ischemia/Reperfusion Injury but Has Minimal Effect on the Antioxidant/Antinitrative Protection of Adiponectin by YAJING WANG, ERHE GAO, MA, Xin-Liang, LING TAO, BOND LAU, Wayne, YUEXIN YUAN, GOLDSTEIN, Barry J, LOPEZ, Bernard L, CHRISTOPHER, Theodore A, TIAN, Rong, KOCH, Walter

“…Diabetes increases the morbidity/mortality of ischemic heart disease, but the underlying mechanisms are incompletely understood. Deficiency of both…”
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Adiponectin improves endothelial function in hyperlipidemic rats by reducing oxidative/nitrative stress and differential regulation of eNOS/iNOS activity by Li, Rong, Wang, Wen-Qing, Zhang, Haifeng, Yang, Xinchung, Fan, Qian, Christopher, Theodore A, Lopez, Bernard L, Tao, Ling, Goldstein, Barry J, Gao, Feng, Ma, Xin L

“…Plasma adiponectin level is significantly reduced in patients with metabolic syndrome, and vascular dysfunction is an important pathological event in these…”
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C1q/TNF-related protein 5 contributes to diabetic vascular endothelium dysfunction through promoting Nox-1 signaling by Liu, Jing, Meng, Zhijun, Gan, Lu, Guo, Rui, Gao, Jia, Liu, Caihong, Zhu, Di, Liu, Demin, Zhang, Ling, Zhang, Zhen, Xie, Dina, Jiao, Xiangying, Lau, Wayne Bond, Lopez, Bernard L., Christopher, Theodore A., Ma, Xinliang, Cao, Jimin, Wang, Yajing

“…Dysregulated adipokine profiles contribute to the pathogenesis of diabetic cardiovascular complications. Endothelial cell (EC) dysfunction, a common…”
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High glucose/High Lipids impair vascular adiponectin function via inhibition of caveolin-1/AdipoR1 signalsome formation by Liu, Gai-Zhen, Liang, Bin, Lau, Wayne Bond, Wang, Yang, Zhao, Jianli, Li, Rui, Wang, Xi, Yuan, Yuexing, Lopez, Bernard L., Christopher, Theodore A., Xiao, Chuanshi, Ma, Xin-Liang, Wang, Yajing

“…Reduced levels of adiponectin (APN) contribute to cardiovascular injury in the diabetic population. Recent studies demonstrate elevated circulating APN levels…”
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C1q/TNF-Related Protein 3 Prevents Diabetic Retinopathy via AMPK-Dependent Stabilization of Blood-Retinal Barrier Tight Junctions by Yan, Zheyi, Wang, Chunfang, Meng, Zhijun, Gan, Lu, Guo, Rui, Liu, Jing, Bond Lau, Wayne, Xie, Dina, Zhao, Jianli, Lopez, Bernard L, Christopher, Theodore A, Naik, Ulhas P, Ma, Xinliang, Wang, Yajing

“…The impairment of the inner blood-retinal barrier (iBRB) increases the pathological development of diabetic retinopathy (DR), a severe complication in diabetic…”
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Methylglyoxal increases cardiomyocyte ischemia-reperfusion injury via glycative inhibition of thioredoxin activity by Wang, Xiao-Liang, Lau, Wayne B, Yuan, Yue-Xing, Wang, Ya-Jing, Yi, Wei, Christopher, Theodore A, Lopez, Bernard L, Liu, Hui-Rong, Ma, Xin-Liang

“…Diabetes mellitus (DM) is closely related to cardiovascular morbidity and mortality, but the specific molecular basis linking DM with increased vulnerability…”
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Cardioprotective Effects of Thioredoxin in Myocardial Ischemia and the Reperfusion Role of S-Nitrosation by Tao, Ling, Gao, Erhe, Bryan, Nathan S., Qu, Yan, Liu, Hui-Rong, Hu, Aihua, Christopher, Theodore A., Lopez, Bernard L., Yodoi, Junji, Koch, Walter J., Feelisch, Martin, Ma, Xin L., Ignarro, Louis J.

“…Apoptosis contributes to myocardial ischemia/reperfusion (MI/R) injury, and both thioredoxin (Trx) and nitric oxide have been shown to exert antiapoptotic…”
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Cardioprotective effect of adiponectin is partially mediated by its AMPK-independent antinitrative action by Wang, Yajing, Tao, Ling, Yuan, Yuexin, Lau, Wayne Bond, Li, Rong, Lopez, Bernard L, Christopher, Theodore A, Tian, Rong, Ma, Xin-Liang

“…Adiponectin (APN) exerts its metabolic regulation largely through AMP-dependent protein kinase (AMPK). However, the role of AMPK in APN's antiapoptotic effect…”
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Sickle Cell Disease in the Emergency Department by Lovett, Paris B., MD, MBA, Sule, Harsh P., MD, MPP, Lopez, Bernard L., MD, MS

“…Acute painful episodes are the most common reason for emergency department visits among patients with sickle cell disease (SCD). Early and aggressive pain…”
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Inhibition of p38 mitogen-activated protein kinase decreases cardiomyocyte apoptosis and improves cardiac function after myocardial ischemia and reperfusion by MA, X. L, KUMAR, S, FENG GAO, LOUDEN, C. S, LOPEZ, B. L, CHRISTOPHER, T. A, CHUANLIN WANG, LEE, J. C, FEUERSTEIN, G. Z, YUE, T.-L

“…Activation of p38 mitogen-activated protein kinase (MAPK) plays an important role in apoptotic cell death. The role of p38 MAPK in myocardial injury caused by…”
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Nitrative thioredoxin inactivation as a cause of enhanced myocardial ischemia/reperfusion injury in the aging heart by Zhang, Hangxiang, Tao, Ling, Jiao, Xiangying, Gao, Erhe, Lopez, Bernard L., Christopher, Theodore A., Koch, Walter, Ma, Xin L.

“…Several recent studies have demonstrated that thioredoxin (Trx) is an important antiapoptotic/cytoprotective molecule. The present study was designed to…”
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Role of Omi/HtrA2 in apoptotic cell death after myocardial ischemia and reperfusion by LIU, Hui-Rong, GAO, Erhe, ZERVOS, Antonis S, MA, Xin L, AIHUA HU, LING TAO, YAN QU, MOST, Patrick, KOCH, Walter J, CHRISTOPHER, Theodore A, LOPEZ, Bernard L, ALNEMRI, Emad S

“…Omi/HtrA2 is a proapoptotic mitochondrial serine protease involved in caspase-dependent as well as caspase-independent cell death. However, the role of…”
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Acquired Bleeding Disorders by Hurwitz, Alisheba, MD, Massone, Richard, MD, Lopez, Bernard L., MD, MS

“…Emergency medicine practitioners treat bleeding patients on a regular basis. Disorders of hemostasis are an additional challenge in these patients but can be…”
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Acquired Bleeding Disorders by Hurwitz, Alisheba, Massone, Richard, Lopez, Bernard L.

“…Emergency medicine practitioners treat bleeding patients on a regular basis. Disorders of hemostasis are an additional challenge in these patients but can be…”
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Role of iNOS-derived reactive nitrogen species and resultant nitrative stress in leukocytes-induced cardiomyocyte apoptosis after myocardial ischemia/reperfusion by Wang, Xiao-Liang, Liu, Hui-Rong, Tao, Lin, Liang, Feng, Yan, Li, Zhao, Rong-Rui, Lopez, Bernard L, Christopher, Theodore A, Ma, Xin-Liang

“…Polymorphonuclear leukocyte (PMN) accumulation/activation has been implicated as a primary mechanism underlying MI/R injury. Recent studies have demonstrated…”
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Withaferin A inhibits apoptosis via activated Akt-mediated inhibition of oxidative stress by Yan, Zheyi, Guo, Rui, Gan, Lu, Lau, Wayne Bond, Cao, Xiaoming, Zhao, Jianli, Ma, Xinliang, Christopher, Theodore A., Lopez, Bernard L., Wang, Yajing

“…Withaferin A (WFA), a withanolide derived from medicinal plant Withania somnifera, possesses anti-tumorigenic and immunomodulatory activities against various…”
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