Search Results - "Lopes, Susana S."

Symmetry-Breaking Cilia-Driven Flow in Embryogenesis by Smith, David J, Montenegro-Johnson, Thomas D, Lopes, Susana S

“…The systematic breaking of left-right body symmetry is a familiar feature of human physiology. In humans and many animals, this process originates with…”
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Left-Right Organizer Flow Dynamics: How Much Cilia Activity Reliably Yields Laterality? by Sampaio, Pedro, Ferreira, Rita R., Guerrero, Adán, Pintado, Petra, Tavares, Bárbara, Amaro, Joana, Smith, Andrew A., Montenegro-Johnson, Thomas, Smith, David J., Lopes, Susana S.

“…Internal organs are asymmetrically positioned inside the body. Embryonic motile cilia play an essential role in this process by generating a directional fluid…”
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Rab35 controls cilium length, function and membrane composition by Kuhns, Stefanie, Seixas, Cecília, Pestana, Sara, Tavares, Bárbara, Nogueira, Renata, Jacinto, Raquel, Ramalho, José S, Simpson, Jeremy C, Andersen, Jens S, Echard, Arnaud, Lopes, Susana S, Barral, Duarte C, Blacque, Oliver E

“…Rab and Arl guanine nucleotide‐binding (G) proteins regulate trafficking pathways essential for the formation, function and composition of primary cilia, which…”
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Zebrafish Motile Cilia as a Model for Primary Ciliary Dyskinesia by Pinto, Andreia L., Rasteiro, Margarida, Bota, Catarina, Pestana, Sara, Sampaio, Pedro, Hogg, Claire, Burgoyne, Thomas, Lopes, Susana S.

“…Zebrafish is a vertebrate teleost widely used in many areas of research. As embryos, they develop quickly and provide unique opportunities for research studies…”
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Usefulness of zebrafish larvae to evaluate drug-induced functional and morphological renal tubular alterations by Gorgulho, Rita, Jacinto, Raquel, Lopes, Susana S., Pereira, Sofia A., Tranfield, Erin M., Martins, Gabriel G., Gualda, Emilio J., Derks, Rico J. E., Correia, Ana C., Steenvoorden, Evelyne, Pintado, Petra, Mayboroda, Oleg A., Monteiro, Emilia C., Morello, Judit

“…Prediction and management of drug-induced renal injury (DIRI) rely on the knowledge of the mechanisms of drug insult and on the availability of appropriate…”
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Dand5 is involved in zebrafish tailbud cell movement by Bota, Catarina, Martins, Gabriel G, Lopes, Susana S

“…During vertebrate development, symmetry breaking occurs in the left-right organizer (LRO). The transfer of asymmetric molecular information to the lateral…”
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CiliarMove: new software for evaluating ciliary beat frequency helps find novel mutations by a Portuguese multidisciplinary team on primary ciliary dyskinesia by Sampaio, Pedro, da Silva, Mónica Ferro, Vale, Inês, Roxo-Rosa, Mónica, Pinto, Andreia, Constant, Carolina, Pereira, Luisa, Quintão, Carla M, Lopes, Susana S

“…Evaluation of ciliary beat frequency (CBF) performed by high-speed videomicroscopy analysis (HVMA) is one of the techniques required for the correct diagnosis…”
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Left-right function of dmrt2 genes is not conserved between zebrafish and mouse by Lourenço, Raquel, Lopes, Susana S, Saúde, Leonor

“…Members of the Dmrt family, generally associated with sex determination, were shown to be involved in several other functions during embryonic development…”
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Zebrafish Larvae Are a Suitable Model to Investigate the Metabolic Phenotype of Drug-Induced Renal Tubular Injury by Morello, Judit, Derks, Rico J E, Lopes, Susana S, Steenvoorden, Evelyne, Monteiro, Emilia C, Mayboroda, Oleg A, Pereira, Sofia A

“…Prevention and treatment of drug-induced renal injury (DIRI) rely on the availability of sensitive and specific biomarkers of early kidney injury and…”
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Pkd2 Affects Cilia Length and Impacts LR Flow Dynamics and Dand5 by Jacinto, Raquel, Sampaio, Pedro, Roxo-Rosa, Mónica, Pestana, Sara, Lopes, Susana S

“…The left-right (LR) field recognizes the importance of the mechanism involving the calcium permeable channel Polycystin-2. However, whether the early LR…”
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Unmasking the relevance of hemispheric asymmetries—Break on through (to the other side) by Esteves, Madalena, Lopes, Susana S., Almeida, Armando, Sousa, Nuno, Leite-Almeida, Hugo

“…•Brain asymmetry is ubiquitous, but its biological significance remains elusive.•We provide historical and evolutionary context.•Laterality development and…”
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Crosstalk between cilia and autophagy: implication for human diseases by Morleo, Manuela, Vieira, Helena L.A., Pennekamp, Petra, Palma, Alessandro, Bento-Lopes, Liliana, Omran, Heymut, Lopes, Susana S., Barral, Duarte C., Franco, Brunella

“…Macroautophagy/autophagy is a self-degradative process necessary for cells to maintain their energy balance during development and in response to nutrient…”
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Imbalanced mitochondrial function provokes heterotaxy via aberrant ciliogenesis by Burkhalter, Martin D, Sridhar, Arthi, Sampaio, Pedro, Jacinto, Raquel, Burczyk, Martina S, Donow, Cornelia, Angenendt, Max, Hempel, Maja, Walther, Paul, Pennekamp, Petra, Omran, Heymut, Lopes, Susana S, Ware, Stephanie M, Philipp, Melanie

“…About 1% of all newborns are affected by congenital heart disease (CHD). Recent findings identify aberrantly functioning cilia as a possible source for CHD…”
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Leukocyte tyrosine kinase functions in pigment cell development by Lopes, Susana S, Yang, Xueyan, Müller, Jeanette, Carney, Thomas J, McAdow, Anthony R, Rauch, Gerd-Jörg, Jacoby, Arie S, Hurst, Laurence D, Delfino-Machín, Mariana, Haffter, Pascal, Geisler, Robert, Johnson, Stephen L, Ward, Andrew, Kelsh, Robert N

“…A fundamental problem in developmental biology concerns how multipotent precursors choose specific fates. Neural crest cells (NCCs) are multipotent, yet the…”
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Current methods to analyze lysosome morphology, positioning, motility and function by Barral, Duarte C., Staiano, Leopoldo, Guimas Almeida, Cláudia, Cutler, Dan F., Eden, Emily R., Futter, Clare E., Galione, Antony, Marques, André R. A., Medina, Diego Luis, Napolitano, Gennaro, Settembre, Carmine, Vieira, Otília V., Aerts, Johannes M. F. G., Atakpa‐Adaji, Peace, Bruno, Gemma, Capuozzo, Antonella, De Leonibus, Elvira, Di Malta, Chiara, Escrevente, Cristina, Esposito, Alessandra, Grumati, Paolo, Hall, Michael J., Teodoro, Rita O., Lopes, Susana S., Luzio, J. Paul, Monfregola, Jlenia, Montefusco, Sandro, Platt, Frances M., Polishchuck, Roman, De Risi, Maria, Sambri, Irene, Soldati, Chiara, Seabra, Miguel C.

“…Since the discovery of lysosomes more than 70 years ago, much has been learned about the functions of these organelles. Lysosomes were regarded as exclusively…”
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Notch signalling regulates left-right asymmetry through ciliary length control by Lopes, Susana S, Lourenço, Raquel, Pacheco, Luís, Moreno, Nuno, Kreiling, Jill, Saúde, Leonor

“…The importance of cilia in embryonic development and adult physiology is emphasized by human ciliopathies. Despite its relevance, molecular signalling pathways…”
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Primary ciliary dyskinesia due to CCNO mutations : a genotype‐phenotype correlation contribution by Henriques, Ana Raquel, Constant, Carolina, Descalço, Andreia, Pinto, Andreia, Moura Nunes, J., Sampaio, Pedro, Lopes, Susana S., Pereira, Luísa, Bandeira, Teresa

“…© 2021 Wiley Periodicals LLC Primary ciliary dyskinesia (PCD) is genetically and clinically heterogeneous. CCNO mutations are associated with chronic…”
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Arl13b and the non-muscle myosin heavy chain IIA are required for circular dorsal ruffle formation and cell migration by Casalou, Cristina, Seixas, Cecília, Portelinha, Ana, Pintado, Petra, Barros, Mafalda, Ramalho, José S, Lopes, Susana S, Barral, Duarte C

“…The Arf-like protein Arl13b has been implicated in ciliogenesis and Sonic hedgehog signaling. Furthermore, we have previously shown that it regulates endocytic…”
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Editorial: The Cytoskeleton and Cellular Compartmentation: Cilia as Specialized Cellular Domains by Garcia-Gonzalo, Francesc R., Soares, Helena, Lopes, Susana S., Inoue, Takanari

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Zebrafish colourless encodes sox10 and specifies non-ectomesenchymal neural crest fates by Dutton, K A, Pauliny, A, Lopes, S S, Elworthy, S, Carney, T J, Rauch, J, Geisler, R, Haffter, P, Kelsh, R N

“…Waardenburg-Shah syndrome combines the reduced enteric nervous system characteristic of Hirschsprung’s disease with reduced pigment cell number, although the…”
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