Search Results - "Lopes, Marcela F."

From denial to hope: Brazil deals with a prolonged COVID-19 epidemic course by F Lopes, Marcela

“…Brazil must strengthen science-based education to improve human development and responses to future public health threats…”
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Immunopathogenesis in Trypanosoma cruzi infection: a role for suppressed macrophages and apoptotic cells by Vellozo, Natália S., Matos-Silva, Thayane C., Lopes, Marcela F.

“…During Trypanosoma cruzi infection, macrophages phagocytose parasites and remove apoptotic cells through efferocytosis. While macrophage 1 (M1) produces…”
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New Therapeutic Tools to Shape Monocyte Functional Phenotypes in Leishmaniasis by Vellozo, Natália S, Rigoni, Thaís S, Lopes, Marcela F

“…In the innate immunity to infection tissue-resident macrophages and inflammatory monocytes accumulate host-cell, effector, and efferocytosis functions. In…”
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All- Trans Retinoic Acid Promotes an M1- to M2-Phenotype Shift and Inhibits Macrophage-Mediated Immunity to Leishmania major by Vellozo, Natália S, Pereira-Marques, Sâmara T, Cabral-Piccin, Mariela P, Filardy, Alessandra A, Ribeiro-Gomes, Flávia L, Rigoni, Thaís S, DosReis, George A, Lopes, Marcela F

“…As key cells, able to host and kill parasites, inflammatory monocytes/macrophages are potential vaccine and therapeutic targets to improve immune responses in…”
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RANK Ligand Helps Immunity to Leishmania major by Skewing M2-Like Into M1 Macrophages by Rigoni, Thaís S, Vellozo, Natália S, Cabral-Piccin, Mariela, Fabiano-Coelho, Laryssa, Lopes, Ulisses G, Filardy, Alessandra A, DosReis, George A, Lopes, Marcela F

“…Macrophages host infection, which causes cutaneous Leishmaniasis in humans. In the murine model, resistance to infection depends on the host immunity mediated…”
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Trypanosoma cruzi Infection Induces Cellular Stress Response and Senescence-Like Phenotype in Murine Fibroblasts by Guimarães-Pinto, Kamila, Nascimento, Danielle Oliveira, Corrêa-Ferreira, Antonia, Morrot, Alexandre, Freire-de-Lima, Celio G, Lopes, Marcela F, DosReis, George A, Filardy, Alessandra A

“…infects and replicates within a wide variety of immune and non-immune cells. Here, we investigated early cellular responses induced in NIH-3T3 fibroblasts upon…”
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Axl receptor induces efferocytosis, dampens M1 macrophage responses and promotes heart pathology in Trypanosoma cruzi infection by Rigoni, Thaís S., Vellozo, Natália S., Guimarães-Pinto, Kamila, Cabral-Piccin, Mariela, Fabiano-Coelho, Laryssa, Matos-Silva, Thayane C., Filardy, Alessandra A., Takiya, Christina M., Lopes, Marcela F.

“…Adaptive immunity controls Trypanosoma cruzi infection, but the protozoan parasite persists and causes Chagas disease. T cells undergo apoptosis, and the…”
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Infection with Leishmania major induces a cellular stress response in macrophages by Filardy, Alessandra A, Costa-da-Silva, Ana Caroline, Koeller, Carolina M, Guimarães-Pinto, Kamila, Ribeiro-Gomes, Flávia L, Lopes, Marcela F, Heise, Norton, Freire-de-Lima, Célio G, Nunes, Marise P, DosReis, George A

“…We investigated early cellular responses induced by infection with Leishmania major in macrophages from resistant C57/BL6 mice. Infection increased production…”
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Myeloid-derived suppressor cells help protective immunity to Leishmania major infection despite suppressed T cell responses by Pereira, Wânia F., Ribeiro‐Gomes, Flávia L., Guillermo, Landi V. Costilla, Vellozo, Natália S., Montalvão, Fabrício, DosReis, George A., Lopes, Marcela F.

“…Infection with Leishmania major elicits myeloid‐derived suppressor cells, which kill Leishmania parasites despite suppressed T‐cell proliferation. Th1/Th2…”
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Pathogen-induced proapoptotic phenotype and high CD95 (Fas) expression accompany a suboptimal CD8+ T-cell response: reversal by adenoviral vaccine by Vasconcelos, José Ronnie, Bruña-Romero, Oscar, Araújo, Adriano F, Dominguez, Mariana R, Ersching, Jonatan, de Alencar, Bruna C G, Machado, Alexandre V, Gazzinelli, Ricardo T, Bortoluci, Karina R, Amarante-Mendes, Gustavo P, Lopes, Marcela F, Rodrigues, Mauricio M

“…MHC class Ia-restricted CD8(+) T cells are important mediators of the adaptive immune response against infections caused by intracellular microorganisms…”
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Antibody Repertoires Identify β-Tubulin as a Host Protective Parasite Antigen in Mice Infected With Trypanosoma cruzi by Montalvão, Fabricio, Nascimento, Danielle Oliveira, Nunes, Marise P, Koeller, Carolina M, Morrot, Alexandre, Lery, Leticia Miranda S, Bisch, Paulo M, Teixeira, Santuza M R, Vasconcellos, Rita, Freire-de-Lima, Leonardo, Lopes, Marcela F, Heise, Norton, DosReis, George A, Freire-de-Lima, Célio Geraldo

“…Few studies investigate the major protein antigens targeted by the antibody diversity of infected mice with . To detect global IgG antibody specificities, sera…”
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The Importance of Apoptosis for Immune Regulation in Chagas Disease by DosReis, George A, Lopes, Marcela F

“…Host cell apoptosis plays an important immune regulatory role in parasitic infections. Infection of mice with Trypanosoma cruzi , the causative agent of Chagas…”
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Inhibition of caspase-8 activity promotes protective Th1- and Th2-mediated immunity to Leishmania major infection by Pereira‐Manfro, Wânia F., Ribeiro‐Gomes, Flávia L., Filardy, Alessandra Almeida, Vellozo, Natália S., Guillermo, Landi V. C., Silva, Elisabeth M., Siegel, Richard M., DosReis, George A., Lopes, Marcela F.

“…T cell expression of caspase‐8 inhibitor vFLIP provides a Th1 cytokine environment, along with a protective Th2 response that increases immunity to Leishmania…”
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Intracellular protozoan parasites and apoptosis: diverse strategies to modulate parasite–host interactions by Lüder, Carsten G.K, Gross, Uwe, Lopes, Marcela F

“…Programmed cell death (apoptosis) is an important regulator of the host's response during infection with a variety of intracellular protozoan parasites…”
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The Fas death pathway controls coordinated expansions of type 1 CD8 and type 2 CD4 T cells in Trypanosoma cruzi infection by Guillermo, Landi V. Costilla, Silva, Elisabeth M., Ribeiro‐Gomes, Flávia L., De Meis, Juliana, Pereira, Wânia F., Yagita, Hideo, DosReis, George A., Lopes, Marcela F.

“…We investigated the role of the Fas ligand (FasL)/Fas death pathway on apoptosis and cytokine production by T cells in Trypanosoma cruzi infection. Anti‐FasL,…”
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Apoptosis differentially regulates mesenteric and subcutaneous lymph node immune responses to Trypanosoma cruzi by de Meis, Juliana, Ferreira, Lidia M.S, Guillermo, Landi V.C, Silva, Elisabeth M, DosReis, George A, Lopes, Marcela F

“…Infection with Trypanosoma cruzi causes expansion of subcutaneous (SLN) and atrophy of mesenteric (MLN) lymph nodes. Here we show that excision of MLN…”
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Caspase inhibition reduces lymphocyte apoptosis and improves host immune responses to Trypanosoma cruzi infection by Silva, Elisabeth M., Guillermo, Landi V. C., Ribeiro‐Gomes, Flávia L., De Meis, Juliana, Nunes, Marise P., Senra, Juliana F. V., Soares, Milena B. P., DosReis, George A., Lopes, Marcela F.

“…In experimental Chagas’ disease, lymphocytes from mice infected with Trypanosoma cruzi show increased apoptosis in vivo and in vitro. Treatment with a…”
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Immunity to Protozoan Parasites by Lujan, Hugo D., Zamboni, Dario S., Lopes, Marcela F., Rodrigues, Mauricio M.

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Neutrophils Activate Macrophages for Intracellular Killing of Leishmania major through Recruitment of TLR4 by Neutrophil Elastase by Ribeiro-Gomes, Flavia L, Moniz-de-Souza, Maria Carolina A, Alexandre-Moreira, Magna S, Dias, Wagner B, Lopes, Marcela F, Nunes, Marise P, Lungarella, Giuseppe, DosReis, George A

“…We investigated the role of neutrophil elastase (NE) in interactions between murine inflammatory neutrophils and macrophages infected with the parasite…”
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Inhibition of caspase-8 activity reduces IFN-gamma expression by T cells from Leishmania major infection by Pereira, Wânia F, Guillermo, Landi V C, Ribeiro-Gomes, Flávia L, Lopes, Marcela F

“…Following infection with Leishmania major, T cell activation and apoptosis can be detected in draining lymph nodes of C57BL/6-infected mice. We investigated…”
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