Search Results - "Lopes, Luiz Gonzaga França"

New nitrosyl ruthenium complexes with combined activities for multiple cardiovascular disorders by Gouveia Júnior, Florêncio Sousa, Silveira, João Alison de Moraes, Holanda, Thais Muratori, Marinho, Aline Diogo, Ridnour, Lisa A, Wink, David A, de Siqueira, Rodrigo José Bezerra, Monteiro, Helena Serra Azul, Sousa, Eduardo Henrique Silva de, Lopes, Luiz Gonzaga de França

“…Nitrosyl ruthenium complexes are promising platforms for nitric oxide (NO) and nitroxyl (HNO) release, which exert their therapeutic application. In this…”
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Further Insights into the Oxidative Pathway of Thiocarbonyl-Type Antitubercular Prodrugs: Ethionamide, Thioacetazone, and Isoxyl by de Freitas Paulo, Tércio, Duhayon, Carine, de França Lopes, Luiz Gonzaga, Silva Sousa, Eduardo Henrique, Chauvin, Remi, Bernardes-Génisson, Vania

“…A chemical activation study of the thiocarbonyl-type antitubercular prodrugs, ethionamide (ETH), thioacetazone (TAZ), and isoxyl (ISO), was performed…”
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When NO. Is not Enough: Chemical Systems, Advances and Challenges in the Development of NO. and HNO Donors for Old and Current Medical Issues by Muniz Carvalho, Edinilton, Silva Sousa, Eduardo Henrique, Bernardes‐Génisson, Vania, Gonzaga de França Lopes, Luiz

“…Nitric oxide (NO.) has been widely studied as an active agent of many physiological and pathological processes. Currently, NO. divides attention with its…”
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Novel ruthenium complexes as potential drugs for Chagas's disease: enzyme inhibition and in vitro/in vivo trypanocidal activity by Silva, Jean Jerley Nogueira, Guedes, Paulo Marcos Matta, Zottis, Aderson, Balliano, Tatiane Luciano, Nascimento Silva, Francisco Ordelei, França Lopes, Luiz Gonzaga, Ellena, Javier, Oliva, Glaucius, Andricopulo, Adriano Defini, Franco, Douglas Wagner, Silva, João Santana

“…Background and purpose:  The discovery of the pharmacological functions of nitric oxide has led to the development of NO donor compounds as therapeutic agents…”
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Pentacyanoferrate(II) complex of pyridine-4- and pyrazine-2-hydroxamic acid as source of HNO: investigation of anti-tubercular and vasodilation activities by Carvalho, Edinilton Muniz, de Freitas Paulo, Tercio, Saquet, Alix Sournia, Abbadi, Bruno Lopes, Macchi, Fernanda Souza, Bizarro, Cristiano Valim, de Morais Campos, Rafael, Ferreira, Talles Luann Abrantes, do Nascimento, Nilberto Robson Falcão, Lopes, Luiz Gonzaga França, Chauvin, Remi, Sousa, Eduardo Henrique Silva, Bernardes-Génisson, Vania

“…A pharmacophore design approach, based on the coordination chemistry of an intimate molecular hybrid of active metabolites of pro-drugs, known to release…”
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The Role of Ruthenium Compounds in Neurologic Diseases: A Minireview by Gama Justi, Fátima Virgínia, Araújo Matos, Gabriella, de Sá Roriz Caminha, Juan, Rodrigues Roque, Cássia, Muniz Carvalho, Edinilton, Soares Campelo, Márcio Wilker, Belayev, Ludmila, Gonzaga de França Lopes, Luiz, Barreto Oriá, Reinaldo

“…Ruthenium compounds, nitric oxide donors in biologic systems, have emerged as a promising therapeutic alternative to conventional drugs in anticancer…”
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Anti-asthmatic effect of nitric oxide metallo-donor FOR811A [cis-[Ru(bpy)2(2-MIM)(NO)](PF6)3] in the respiratory mechanics of Swiss mice by Costa, Paula Priscila Correia, Waller, Stefanie Bressan, Dos Santos, Gilvan Ribeiro, Gondim, Fladimir de Lima, Serra, Daniel Silveira, Cavalcante, Francisco Sales Ávila, Gouveia Júnior, Florêncio Sousa, de Paula Júnior, Valdir Ferreira, Sousa, Eduardo Henrique Silva, Lopes, Luiz Gonzaga de França, Ribeiro, Wesley Lyeverton Correia, Monteiro, Helena Serra Azul

“…We aimed at evaluating the anti-asthmatic effect of cis-[Ru(bpy)2(2-MIM)(NO)](PF6)3 (FOR811A), a nitrosyl-ruthenium compound, in a murine model of allergic…”
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Drug discovery targeting heme-based sensors and their coupled activities by Sousa, Eduardo Henrique Silva, Lopes, Luiz Gonzaga de França, Gonzalez, Gonzalo, Gilles-Gonzalez, Marie-Alda

“…Heme-based sensors have emerged during the last 20years as being a large family of proteins that occur in all kingdoms of life. A myriad of biological…”
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Minimal Functionalization of Ruthenium Compounds with Enhanced Photoreactivity against Hard-to-Treat Cancer Cells and Resistant Bacteria by Oliveira, Geângela de Fátima Sousa, Gouveia, Florencio Sousa, Andrade, Alexandre Lopes, de Vasconcelos, Mayron Alves, Teixeira, Edson Holanda, Palmeira-Mello, Marcos V., Batista, Alzir A., Lopes, Luiz Gonzaga de França, de Carvalho, Idalina Maria Moreira, Sousa, Eduardo Henrique Silva

“…Metallocompounds have emerged as promising new anticancer agents, which can also exhibit properties to be used in photodynamic therapy. Here, we prepared two…”
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NitroprussideExpanding the Potential Use of an Old Drug Using Nanoparticles by da Silva Filho, Pedro Martins, Paz, Iury Araújo, Nascimento, Nilberto Robson Falcão do, Abreu, Dieric S., Lopes, Luiz Gonzaga de França, Sousa, Eduardo Henrique Silva, Longhinotti, Elisane

“…For more than 70 years, sodium nitroprusside (SNP) has been used to treat severe hypertension in hospital emergency settings. During this time, a few other…”
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Oxygen triggers signal transduction in the DevS (DosS) sensor of Mycobacterium tuberculosis by modulating the quaternary structure by Lobão, Josiane Bezerra da Silva, Gondim, Ana C. S., Guimarães, Wellinson G., Gilles‐Gonzalez, Marie‐Alda, Lopes, Luiz Gonzaga de França, Sousa, Eduardo H. S.

“…A major challenge to the control and eventual eradication of Mycobacterium tuberculosis infection is this pathogen's prolonged dormancy. The heme‐based oxygen…”
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An unusual bidentate methionine ruthenium(II) complex: photo-uncaging and antimicrobial activity by de Sousa, Aurideia P., Gondim, Ana C. S., Sousa, Eduardo H. S., de Vasconcelos, Mayron A., Teixeira, Edson H., Bezerra, Beatriz Pinheiro, Ayala, Alejandro Pedro, Martins, Patrícia H. R., Lopes, Luiz Gonzaga de França, Holanda, Alda K. M.

“…The cis -[Ru(bpy) 2 (Met)](PF 6 ) 2 complex, where Met =  l -methionine and bpy = 2,2′-bipyridine, was prepared and fully characterized. This complex was…”
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Nitric oxide and Brazilian propolis combined accelerates tissue repair by modulating cell migration, cytokine production and collagen deposition in experimental leishmaniasis by Miranda, Milena Menegazzo, Panis, Carolina, Cataneo, Allan Henrique Depieri, da Silva, Suelen Santos, Kawakami, Natalia Yoshie, Lopes, Luiz Gonzaga de França, Morey, Alexandre Tadachi, Yamauchi, Lucy Megumi, Andrade, Célia Guadalupe Tardelli de Jesus, Cecchini, Rubens, da Silva, Jean Jerley Nogueira, Sforcin, José Maurício, Conchon-Costa, Ivete, Pavanelli, Wander Rogério

“…The fact that drugs currently used in the treatment of Leishmania are highly toxic and associated with acquired resistance has promoted the search for new…”
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Thionicotinamide SAM on Gold: Adsorption Studies and Electroactivity by de Freitas Paulo, Tércio, de Oliveira Pinheiro, Solange, Da Silva, Maria Aparecida S., de França Lopes, Luiz Gonzaga, Pinheiro, Lucidalva S., Aquino, Gil F. A., Temperini, Márcia Laudelina Arruda, de Lima Neto, Pedro, Diógenes, Izaura Cirino Nogueira

“…STM and impedance results of the self‐assembled monolayer (SAM) formed with thionicotinamide (TNA) on gold indicate the presence of defects that increase with…”
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Preconditioning with a Novel Metallopharmaceutical NO Donor in Anesthetized Rats Subjected to Brain Ischemia/Reperfusion by Campelo, Marcio Wilker Soares, Oriá, Reinaldo Barreto, de França Lopes, Luiz Gonzaga, Brito, Gerly Anne de Castro, dos Santos, Armenio Aguiar, de Vasconcelos, Raquel Cavalcante, da Silva, Francisco Ordelei Nascimento, Nobrega, Beatrice Nuto, Bento-Silva, Moisés Tolentino, de Vasconcelos, Paulo Roberto Leitão

“…Rut-bpy is a novel nitrosyl–ruthenium complex releasing NO into the vascular system. We evaluated the effect of Rut-bpy (100 mg/kg) on a rat model of brain…”
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New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory by Macêdo, Clóvis Ney Pinheiro, Braga, Francisco Evanilso Silva, Campelo, Ana Paula Bomfim Soares, Diniz, Gabriel Maia, Lopes, Luiz Gonzaga de França, Kubrusly, Marcos, Campelo, Marcio Wilker Soares

“…To evaluate the effect of Rut-bpy (Cis-[Ru(bpy)2(SO3)(NO)]PF 6), a novel nitric oxide donor, able to modulate the histological changes caused by the NASID…”
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Antimicrobial activity and antibiotic synergy of a biphosphinic ruthenium complex against clinically relevant bacteria by Andrade, Alexandre Lopes, de Vasconcelos, Mayron Alves, Arruda, Francisco Vassiliepe de Sousa, do Nascimento Neto, Luiz Gonzaga, Carvalho, José Marcos da Silveira, Gondim, Ana Claudia Silva, Lopes, Luiz Gonzaga de França, Sousa, Eduardo Henrique Silva, Teixeira, Edson Holanda

“…The aim of this study was to investigate the antibacterial activity, antibiotic-associated synergy, and anti-biofilm activity of the ruthenium complex,…”
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Antihypertensive potential of cis-[Ru(bpy)2(ImN)(NO)]3+, a ruthenium-based nitric oxide donor by Costa, Paula Priscila Correia, Campos, Rafael, Cabral, Pedro Henrique Bezerra, Gomes, Victor Martins, Santos, Cláudia Ferreira, Waller, Stefanie Bressan, de Sousa, Eduardo Henrique Silva, LOPES, Luiz Gonzaga de França, Fonteles, Manasses Claudino, do Nascimento, Nilberto Robson Falcão

“…The aim of this study was to investigate the antihypertensive properties of cis-[Ru(bpy)2ImN(NO)]3+ (FOR0811) in normotensive and in Nω–nitro-L-arginine methyl…”
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Thiol-Activated HNO Release from a Ruthenium Antiangiogenesis Complex and HIF-1α Inhibition for Cancer Therapy by Silva Sousa, Eduardo Henrique, Ridnour, Lisa A, Gouveia, Florêncio S, Silva da Silva, Carlos Daniel, Wink, David A, de França Lopes, Luiz Gonzaga, Sadler, Peter J

“…Metallonitrosyl complexes are promising as nitric oxide (NO) donors for the treatment of cardiovascular, endothelial, and pathogenic diseases, as well as…”
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Experimental Chemotherapy in Paracoccidioidomycosis Using Ruthenium NO Donor by Pavanelli, Wander Rogério, da Silva, Jean Jerley Nogueira, Panis, Carolina, Cunha, Thiago Mattar, Costa, Ivete Conchon, de Menezes, Maria Claudia Noronha Dutra, de Abreu Oliveira, Francisco José, de França Lopes, Luiz Gonzaga, Cecchini, Rubens, de Queiroz Cunha, Fernando, Watanabe, Maria Angélica Ehara, Itano, Eiko Nakagawa

“…Paracoccidioidomycosis (PCM) is a granulomatous disease caused by a dimorphic fungus, Paracoccidioides brasiliensis (Pb) . To determine the influence of nitric…”
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