Search Results - "Lopes, Eloisi Caldas"

Paradigms for Precision Medicine in Epichaperome Cancer Therapy by Pillarsetty, Nagavarakishore, Jhaveri, Komal, Taldone, Tony, Caldas-Lopes, Eloisi, Punzalan, Blesida, Joshi, Suhasini, Bolaender, Alexander, Uddin, Mohammad M., Rodina, Anna, Yan, Pengrong, Ku, Anson, Ku, Thomas, Shah, Smit K., Lyashchenko, Serge, Burnazi, Eva, Wang, Tai, Lecomte, Nicolas, Janjigian, Yelena, Younes, Anas, Batlevi, Connie W., Guzman, Monica L., Roboz, Gail J., Koziorowski, Jacek, Zanzonico, Pat, Alpaugh, Mary L., Corben, Adriana, Modi, Shanu, Norton, Larry, Larson, Steven M., Lewis, Jason S., Chiosis, Gabriela, Gerecitano, John F., Dunphy, Mark P.S.

“…Alterations in protein-protein interaction networks are at the core of malignant transformation but have yet to be translated into appropriate diagnostic…”
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Extracellular vesicles in DLBCL provide abundant clues to aberrant transcriptional programming and genomic alterations by Rutherford, Sarah C., Fachel, Angela A., Li, Sheng, Sawh, Seema, Muley, Ashlesha, Ishii, Jennifer, Saxena, Ashish, Dominguez, Pilar M., Caldas Lopes, Eloisi, Agirre, Xabier, Chambwe, Nyasha, Correa, Fabian, Jiang, Yanwen, Richards, Kristy L., Betel, Doron, Shaknovich, Rita

“…The biological role of extracellular vesicles (EVs) in diffuse large B-cell lymphoma (DLBCL) initiation and progression remains largely unknown. We…”
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Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models by Caldas-Lopes, Eloisi, Cerchietti, Leandro, Ahn, James H, Clement, Cristina C, Robles, Ana I, Rodina, Anna, Moulick, Kamalika, Taldone, Tony, Gozman, Alexander, Guo, Yunke, Wu, Nian, de Stanchina, Elisa, White, Julie, Gross, Steven S, Ma, Yuliang, Varticovski, Lyuba, Melnick, Ari, Chiosis, Gabriela

“…Triple-negative breast cancers (TNBCs) are defined by a lack of expression of estrogen, progesterone, and HER2 receptors. Because of the absence of identified…”
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HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans by Marubayashi, Sachie, Koppikar, Priya, Taldone, Tony, Abdel-Wahab, Omar, West, Nathan, Bhagwat, Neha, Caldas-Lopes, Eloisi, Ross, Kenneth N, Gönen, Mithat, Gozman, Alex, Ahn, James H, Rodina, Anna, Ouerfelli, Ouathek, Yang, Guangbin, Hedvat, Cyrus, Bradner, James E, Chiosis, Gabriela, Levine, Ross L

“…JAK2 kinase inhibitors were developed for the treatment of myeloproliferative neoplasms (MPNs), following the discovery of activating JAK2 mutations in the…”
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Measuring the pharmacodynamic effects of a novel Hsp90 inhibitor on HER2/neu expression in mice using Zr-DFO-trastuzumab by Holland, Jason P, Caldas-Lopes, Eloisi, Divilov, Vadim, Longo, Valerie A, Taldone, Tony, Zatorska, Danuta, Chiosis, Gabriela, Lewis, Jason S

“…The positron-emitting radionuclide (89)Zr (t(1/2) = 3.17 days) was used to prepare (89)Zr-radiolabeled trastuzumab for use as a radiotracer for characterizing…”
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BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy by Cerchietti, Leandro C, Hatzi, Katerina, Caldas-Lopes, Eloisi, Yang, Shao Ning, Figueroa, Maria E, Morin, Ryan D, Hirst, Martin, Mendez, Lourdes, Shaknovich, Rita, Cole, Philip A, Bhalla, Kapil, Gascoyne, Randy D, Marra, Marco, Chiosis, Gabriela, Melnick, Ari

“…B cell lymphoma 6 (BCL6), which encodes a transcriptional repressor, is a critical oncogene in diffuse large B cell lymphomas (DLBCLs). Although a…”
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Targeting heat shock protein 90 with non‐quinone inhibitors: A novel chemotherapeutic approach in human hepatocellular carcinoma by Breinig, Marco, Caldas‐Lopes, Eloisi, Goeppert, Benjamin, Malz, Mona, Rieker, Ralf, Bergmann, Frank, Schirmacher, Peter, Mayer, Matthias, Chiosis, Gabriela, Kern, Michael André

“…The inhibition of heat shock protein 90 (Hsp90) has emerged as a promising antineoplastic strategy in diverse human malignancies. Hsp90 has been predicted to…”
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Approaches to Targeting Cancer Stem Cells in Solid Tumors by Caldas-Lopes, Eloisi, Gomez-Arteaga, Alexandra, Guzman, Monica L

“…CSCs are a population of self-renewing and tumor repopulating cells that have been observed in hematologic and solid tumors and their presence contributes to…”
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A Hyperactive Signalosome in Acute Myeloid Leukemia Drives Addiction to a Tumor-Specific Hsp90 Species by Zong, Hongliang, Gozman, Alexander, Caldas-Lopes, Eloisi, Taldone, Tony, Sturgill, Eric, Brennan, Sarah, Ochiana, Stefan O., Gomes-DaGama, Erica M., Sen, Siddhartha, Rodina, Anna, Koren, John, Becker, Michael W., Rudin, Charles M., Melnick, Ari, Levine, Ross L., Roboz, Gail J., Nimer, Stephen D., Chiosis, Gabriela, Guzman, Monica L.

“…Acute myeloid leukemia (AML) is a heterogeneous and fatal disease with an urgent need for improved therapeutic regimens given that most patients die from…”
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Pre-clinical efficacy of PU-H71, a novel HSP90 inhibitor, alone and in combination with bortezomib in Ewing sarcoma by Ambati, Srikanth R., Lopes, Eloisi Caldas, Kosugi, Kohji, Mony, Ullas, Zehir, Ahmet, Shah, Smit K., Taldone, Tony, Moreira, Andre L., Meyers, Paul A., Chiosis, Gabriela, Moore, Malcolm A.S.

“…Ewing sarcoma is characterized by multiple deregulated pathways that mediate cell survival and proliferation. Heat shock protein 90 (HSP90) is a critical…”
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Heat shock protein-90 inhibitors: a chronicle from geldanamycin to today's agents by Chiosis, Gabriela, Caldas Lopes, Eloisi, Solit, David

“…Heat shock protein (Hsp)90 is a chaperone with essential roles in maintaining transformation and in elevating the survival and growth potential of cancer…”
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Disruption of mitochondrial membrane potential during apoptosis induced by PSC 833 and CsA in multidrug-resistant lymphoid leukemia by Bustamante, Juanita, Caldas Lopes, Eloisi, Garcia, Mariana, Di Libero, Eugenia, Alvarez, Elida, Hajos, Silvia E

“…Previous findings from our laboratory demonstrated that when used at low concentration (0.1 μg ml −1), CsA as well as its analog PSC 833 were able to revert…”
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Qpctl Inhibition, By Targeting the Inflammatory Tumor Microenvironment, Constitutes a Novel Therapeutic Approach for Diffuse Large B-Cell Lymphoma by Di Siervi, Nicolas, Mullender, Jasper, Revuelta, María Victoria, Zamponi, Nahuel, Caldas-Lopes, Eloisi, Isshiki, Yusuke, Béguelin, Wendy, Scheepstra, Marcel, Evers, Bastiaan, Wuerthner, Jens, Cerchietti, Leandro

“…We have previously described that diffuse large B-cell lymphomas (DLBCL) harboring an inflammatory and immunosuppressive microenvironment (i.e., IN-LME) carry…”
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Abstract 7586: TOX loss-of-function(TOXLOF)results in BCR hyperactivation andenhanced responses to BCR-targeting in diffuse large B cell lymphomas (DLBCL) by Lopes, Eloisi Caldas, Revuelta, Maria, Marullo, Rossella, Cerchietti, Leandro

“…DLBCL originate from germinal center B cells (GCB). The ABC-DLBCL subtype, characterized by activation of B-cell receptor (BCR) signaling and downstream NF-kB…”
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The epichaperome is an integrated chaperome network that facilitates tumour survival by Rodina, Anna, Wang, Tai, Yan, Pengrong, Gomes, Erica DaGama, Dunphy, Mark P. S., Pillarsetty, Nagavarakishore, Koren, John, Gerecitano, John F., Taldone, Tony, Zong, Hongliang, Caldas-Lopes, Eloisi, Alpaugh, Mary, Corben, Adriana, Riolo, Matthew, Beattie, Brad, Pressl, Christina, Peter, Radu I., Xu, Chao, Trondl, Robert, Patel, Hardik J., Shimizu, Fumiko, Bolaender, Alexander, Yang, Chenghua, Panchal, Palak, Farooq, Mohammad F., Kishinevsky, Sarah, Modi, Shanu, Lin, Oscar, Chu, Feixia, Patil, Sujata, Erdjument-Bromage, Hediye, Zanzonico, Pat, Hudis, Clifford, Studer, Lorenz, Roboz, Gail J., Cesarman, Ethel, Cerchietti, Leandro, Levine, Ross, Melnick, Ari, Larson, Steven M., Lewis, Jason S., Guzman, Monica L., Chiosis, Gabriela

“…Chaperomes are dynamic assemblies of proteins that regulate cellular homeostasis but specific cellular stresses remodel chaperome components into a stable…”
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A novel tetrazole analogue of resveratrol is a potent anticancer agent by Bommagani, Shobanbabu, Penthala, Narsimha Reddy, Balasubramaniam, Meenakshisundaram, Kuravi, Sudhakiranmayi, Caldas-Lopes, Eloisi, Guzman, Monica L., Balusu, Ramesh, Crooks, Peter A.

“…[Display omitted] •Tetrazolylresveratrols exhibit anti-cancer activity against human cancer cells.•Tetrazolylresveratrols are cytotoxic against MV4-11 cells…”
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Ligaria cuneifolia flavonoid fractions modulate cell growth of normal lymphocytes and tumor cells as well as multidrug resistant cells by Cerdá Zolezzi, Paula, Fernández, Teresa, Aulicino, Paula, Cavaliere, Victoria, Greczanik, Sofía, Caldas Lopes, Eloisi, Wagner, Marcelo, Ricco, Rafael, Gurni, Alberto, Hajos, Silvia, Álvarez, Elida

“…Flavonoids are ubiquitous compounds present in plant extracts. They represent a major active component of the plant extract and are often known for their…”
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Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90 by Moulick, Kamalika, Ahn, James H, Zong, Hongliang, Rodina, Anna, Cerchietti, Leandro, Gomes DaGama, Erica M, Caldas-Lopes, Eloisi, Beebe, Kristin, Perna, Fabiana, Hatzi, Katerina, Vu, Ly P, Zhao, Xinyang, Zatorska, Danuta, Taldone, Tony, Smith-Jones, Peter, Alpaugh, Mary, Gross, Steven S, Pillarsetty, Nagavarakishore, Ku, Thomas, Lewis, Jason S, Larson, Steven M, Levine, Ross, Erdjument-Bromage, Hediye, Guzman, Monica L, Nimer, Stephen D, Melnick, Ari, Neckers, Len, Chiosis, Gabriela

“…The inhibitor PU-H71 preferentially targets tumor-enriched Hsp90 complexes. Affinity purification using PU-H71 reveals cancer-specific protein networks in…”
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Abstract 5155: Orally bioavailable aurora-kinase B inhibitor (MK7) as a potential therapeutic approach in multiple myeloma by Contreras, Jorge, Lopes, Eloisi Caldas, Monge, Jorge, Jayabalan, David, Gunaganti, Naresh, Frett, Brendan, Li, Hong-yu, Coleman, Morton, Niesvizky, Ruben, Guzman, Monica L.

“…Multiple myeloma (MM) is a plasma cell malignancy diagnosed in approximately 30 thousand patients per year and accounts for nearly 12 thousand deaths in the US…”
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Abstract 272: Novel role for eIF4E in homing of acute myeloid leukemia cells by Martinez, Leandro M., Lopes, Eloisi Caldas, Sugita, Mayumi, Gasiorek, Jadwiga, Alilovic, Kata, Borden, Katherine L., Guzman, Monica L.

“…Acute myeloid leukemia (AML) remains with dismal outcomes, mostly attributed to the inability of therapies to eliminate leukemia stem cells (LSCs) leading to…”
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