Search Results - "Lopes, Dahabada H. J"

Lysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid Proteins by Sinha, Sharmistha, Lopes, Dahabada H. J, Du, Zhenming, Pang, Eric S, Shanmugam, Akila, Lomakin, Aleksey, Talbiersky, Peter, Tennstaedt, Annette, McDaniel, Kirsten, Bakshi, Reena, Kuo, Pei-Yi, Ehrmann, Michael, Benedek, George B, Loo, Joseph A, Klärner, Frank-Gerrit, Schrader, Thomas, Wang, Chunyu, Bitan, Gal

“…Amyloidoses are diseases characterized by abnormal protein folding and self-assembly, for which no cure is available. Inhibition or modulation of abnormal…”
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Molecular Tweezers Inhibit Islet Amyloid Polypeptide Assembly and Toxicity by a New Mechanism by Lopes, Dahabada H. J, Attar, Aida, Nair, Gayatri, Hayden, Eric Y, Du, Zhenming, McDaniel, Kirsten, Dutt, Som, Bandmann, Heinz, Bravo-Rodriguez, Kenny, Mittal, Sumit, Klärner, Frank-Gerrit, Wang, Chunyu, Sanchez-Garcia, Elsa, Schrader, Thomas, Bitan, Gal

“…In type-2 diabetes (T2D), islet amyloid polypeptide (IAPP) self-associates into toxic assemblies causing islet β-cell death. Therefore, preventing IAPP…”
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Induction of Methionine-Sulfoxide Reductases Protects Neurons from Amyloid β-Protein Insults in Vitro and in Vivo by Moskovitz, Jackob, Maiti, Panchanan, Lopes, Dahabada H. J, Oien, Derek B, Attar, Aida, Liu, Tingyu, Mittal, Shivina, Hayes, Jane, Bitan, Gal

“…Self-assembly of amyloid β-protein (Aβ) into toxic oligomers and fibrillar polymers is believed to cause Alzheimer’s disease (AD). In the AD brain, a high…”
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Peripherally derived angiotensin converting enzyme-enhanced macrophages alleviate Alzheimer-related disease by Koronyo-Hamaoui, Maya, Sheyn, Julia, Hayden, Eric Y, Li, Songlin, Fuchs, Dieu-Trang, Regis, Giovanna C, Lopes, Dahabada H J, Black, Keith L, Bernstein, Kenneth E, Teplow, David B, Fuchs, Sebastien, Koronyo, Yosef, Rentsendorj, Altan

“…Targeted overexpression of angiotensin-converting enzyme (ACE), an amyloid-β protein degrading enzyme, to brain resident microglia and peripheral…”
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A Key Role for Lysine Residues in Amyloid β-Protein Folding, Assembly, and Toxicity by Sinha, Sharmistha, Lopes, Dahabada H. J, Bitan, Gal

“…A combination of hydrophobic and electrostatic interactions is important in initiating the aberrant self-assembly process that leads to formation of toxic…”
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C-Terminal Tetrapeptides Inhibit Aβ42-Induced Neurotoxicity Primarily through Specific Interaction at the N-Terminus of Aβ42 by Li, Huiyuan, Du, Zhenming, Lopes, Dahabada H. J, Fradinger, Erica A, Wang, Chunyu, Bitan, Gal

“…Inhibition of amyloid β-protein (Aβ)-induced toxicity is a promising therapeutic strategy for Alzheimer’s disease (AD). Previously, we reported that the…”
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Tranilast Binds to Aβ Monomers and Promotes Aβ Fibrillation by Connors, Christopher R, Rosenman, David J, Lopes, Dahabada H. J, Mittal, Shivina, Bitan, Gal, Sorci, Mirco, Belfort, Georges, Garcia, Angel, Wang, Chunyu

“…The antiallergy and potential anticancer drug tranilast has been patented for treating Alzheimer’s disease (AD), in which amyloid β-protein (Aβ) plays a key…”
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Angiotensin-converting enzyme overexpression in myelomonocytes prevents Alzheimer's-like cognitive decline by Bernstein, Kenneth E, Koronyo, Yosef, Salumbides, Brenda C, Sheyn, Julia, Pelissier, Lindsey, Lopes, Dahabada H J, Shah, Kandarp H, Bernstein, Ellen A, Fuchs, Dieu-Trang, Yu, Jeff J-Y, Pham, Michael, Black, Keith L, Shen, Xiao Z, Fuchs, Sebastien, Koronyo-Hamaoui, Maya

“…Cognitive decline in patients with Alzheimer's disease (AD) is associated with elevated brain levels of amyloid β protein (Aβ), particularly neurotoxic…”
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A Two-Step Strategy for Structure-Activity Relationship Studies of N-Methylated Aβ42 C-Terminal Fragments as Aβ42 Toxicity Inhibitors by Li, Huiyuan, Zemel, Reeve, Lopes, Dahabada H. J., Monien, Bernhard H., Bitan, Gal

“…Neurotoxic Aβ42 oligomers are believed to be the main cause of Alzheimer’s disease. Previously, we found that the C‐terminal fragments (CTFs), Aβ(30–42) and…”
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A Two-Step Strategy for Structure-Activity Relationship Studies of N-Methylated A[beta]42 C-Terminal Fragments as A[beta]42 Toxicity Inhibitors by Li, Huiyuan, Zemel, Reeve, Lopes, Dahabada H. J, Monien, Bernhard H, Bitan, Gal

“…Neurotoxic A[beta]42 oligomers are believed to be the main cause of Alzheimer's disease. Previously, we found that the C-terminal fragments (CTFs),…”
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Redesigning the Folding Energetics of a Model Three-helix Bundle Protein by Site-directed Mutagenesis by Lopes, Dahabada H.J., Chapeaurouge, Alex, Manderson, Gavin A., Johansson, Jonas S., Ferreira, Sérgio T.

“…Because of their limited size and complexity, de novo designed proteins are particularly useful for the detailed investigation of folding thermodynamics and…”
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Amyloidogenicity and Cytotoxicity of Recombinant Mature Human Islet Amyloid Polypeptide (rhIAPP) by Dahabada H. J. Lopes, Christian Colin, Theri L. Degaki, Ana Christina V. de Sousa, Marcelo N. N. Vieira, Adriano Sebollela, Ana M. Blanco Martinez, Carlos Bloch, Jr, Sérgio T. Ferreira, Mari C. Sogayar

“…Pancreatic amyloid plaques formed by the pancreatic islet amyloid polypeptide (IAPP) are present in more than 95% of type II diabetes mellitus patients, and…”
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Application of photochemical cross-linking to the study of oligomerization of amyloidogenic proteins by Lopes, Dahabada H J, Sinha, Sharmistha, Rosensweig, Clark, Bitan, Gal

“…Assembly of amyloidogenic proteins into toxic oligomers and fibrils is an important pathogenic feature of over 30 amyloid-related diseases. Understanding the…”
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A two-step strategy for SAR studies of N- methylated Aβ42 C-terminal fragments as Aβ42 toxicity inhibitors by Li, Huiyuan, Zemel, Reeve, Lopes, Dahabada H. J., Monien, Bernhard H., Bitan, Gal

“…Neurotoxic Aβ42 oligomers are believed to be the main cause of Alzheimer’s disease. Previously, we found that the C-terminal fragments (CTFs), Aβ(30–42) and…”
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