Search Results - "Looman, Maaike W. G."

DC-SCRIPT Regulates IL-10 Production in Human Dendritic Cells by Modulating NF-κBp65 Activation by Søndergaard, Jonas Nørskov, Poghosyan, Susanna, Hontelez, Saartje, Louche, Pauline, Looman, Maaike W G, Ansems, Marleen, Adema, Gosse J

“…The balance between tolerance and immunity is important for the outcome of an infection or cancer, and dendritic cells (DCs) are key regulators of this…”
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Saponin-based adjuvants enhance antigen cross-presentation in human CD11c + CD1c + CD5 − CD163 + conventional type 2 dendritic cells by Ho, Nataschja I, Huis in 't Veld, Lisa G M, van Eck van der Sluijs, Jesper, Heuts, Branco M H, Looman, Maaike W G, Kers-Rebel, Esther D, van den Dries, Koen, Dolstra, Harry, Martens, Joost H A, Hobo, Willemijn, Adema, Gosse J

“…Background Adjuvants are key for effective vaccination against cancer and chronic infectious diseases. Saponin-based adjuvants (SBAs) are unique among…”
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Identification and Characterization of DC-SCRIPT, a Novel Dendritic Cell-Expressed Member of the Zinc Finger Family of Transcriptional Regulators by Triantis, Vassilis, Trancikova, Dagmar Eleveld, Looman, Maaike W. G, Hartgers, Franca C, Janssen, Richard A. J, Adema, Gosse J

“…Dendritic cells (DC) compose a heterogeneous population of cells that hold a leading role in initiating and directing immune responses. Although their function…”
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Dendritic Cells Actively Limit Interleukin-10 Production Under Inflammatory Conditions via DC-SCRIPT and Dual-Specificity Phosphatase 4 by Søndergaard, Jonas Nørskov, van Heeringen, Simon J, Looman, Maaike W G, Tang, Chunling, Triantis, Vassilis, Louche, Pauline, Janssen-Megens, Eva M, Sieuwerts, Anieta M, Martens, John W M, Logie, Colin, Stunnenberg, Hendrik G, Ansems, Marleen, Adema, Gosse J

“…Dendritic cell (DC)-based immunotherapy makes use of the DC's ability to direct the adaptive immune response toward activation or inhibition. DCs perform this…”
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The dendritic cell-derived protein DC-STAMP is highly conserved and localizes to the endoplasmic reticulum by Eleveld‐Trancikova, Dagmar, Triantis, Vassilis, Moulin, Veronique, Looman, Maaike W. G., Wijers, Mietske, Fransen, Jack A. M., Lemckert, Angelique A. C., Havenga, Menzo J. E., Figdor, Carl G., Janssen, Richard A. J., Adema, Gosse J.

“…Recently, we described the molecular identification of dendritic cell‐specific TrAnsMembrane protein (DC‐STAMP), a multimembrane‐spanning protein…”
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DC-SCRIPT is a novel regulator of the tumor suppressor gene CDKN2B and induces cell cycle arrest in ERα-positive breast cancer cells by Ansems, Marleen, Søndergaard, Jonas Nørskov, Sieuwerts, Anieta M., Looman, Maaike W. G., Smid, Marcel, de Graaf, Annemarie M. A., de Weerd, Vanja, Zuidscherwoude, Malou, Foekens, John A., Martens, John W. M., Adema, Gosse J.

“…Breast cancer is one of the most common causes of cancer-related deaths in women. The estrogen receptor (ERα) is well known for having growth promoting effects…”
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DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes activated during DC maturation by Eleveld-Trancikova, Dagmar, Sanecka, Anna, van Hout-Kuijer, Maaike A., Looman, Maaike W.G., Hendriks, Ilona A.M., Jansen, Bastiaan J.H., Adema, Gosse J.

“…Dendritic cells (DCs) are the professional antigen-presenting cells (APC) which efficiently prime the immune response or induce tolerance. We recently…”
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Nuclear receptor expression patterns in murine plasmacytoid and conventional dendritic cells by Karthaus, Nina, Hontelez, Saartje, Looman, Maaike W.G., van Spriel, Annemiek B., Ansems, Marleen, Adema, Gosse J.

“…•Nuclear receptor mRNA was analyzed in plasmacytoid and conventional dendritic cells.•pDC and cDC express the same NR repertoire in vitro and in vivo.•DC…”
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Analysis of genes regulated by the transcription factor LUMAN identifies ApoA4 as a target gene in dendritic cells by Sanecka, Anna, Ansems, Marleen, van Hout-Kuijer, Maaike A., Looman, Maaike W.G., Prosser, Amy C., Welten, Suzanne, Gilissen, Christian, Sama, Iziah E., Huynen, Martijn A., Veltman, Joris A., Jansen, Bastiaan J.H., Eleveld-Trancikova, Dagmar, Adema, Gosse J.

“…► Retroviral overexpression of the active form of LUMAN in D2SC/1 cell line. ► Analysis of differentially expressed genes using microarray. ► Identification…”
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Vitamin D Controls Murine and Human Plasmacytoid Dendritic Cell Function by Karthaus, Nina, van Spriel, Annemiek B., Looman, Maaike W.G., Chen, Shuo, Spilgies, Lisanne M., Lieben, Liesbet, Carmeliet, Geert, Ansems, Marleen, Adema, Gosse J.

“…Topical application of the vitamin D (VitD) analog calcipotriol is a highly effective standard treatment modality of psoriatic skin lesions. However, the…”
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Molecular characterization of the murine homologue of the DC-derived protein DC-SCRIPT by Triantis, Vassilis, Moulin, Veronique, Looman, Maaike W. G., Hartgers, Franca C., Janssen, Richard A. J., Adema, Gosse J.

“…Dendritic cell‐specific transcript (DC‐SCRIPT) is a putative DC zinc (Zn) finger‐type transcription factor described recently in humans. Here, we illustrate…”
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DC-SCRIPT deficiency delays mouse mammary gland development and branching morphogenesis by Tang, Chunling, van den Bijgaart, Renske J.E., Looman, Maaike W.G., Tel-Karthaus, Nina, de Graaf, Annemarie M.A., Gilfillan, Susan, Colonna, Marco, Ansems, Marleen, Adema, Gosse J.

“…Mammary glands are unique organs in which major adaptive changes occur in morphogenesis and development after birth. Breast cancer is the most common cancer…”
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DC-SCRIPT affects mammary organoids branching morphogenesis by modulating the FGFR1-pERK signaling axis by Tang, Chunling, van den Bijgaart, Renske J.E., Looman, Maaike W.G., Triantis, Vassilis, Nørskov Søndergaard, Jonas, Ansems, Marleen, Adema, Gosse J.

“…Loss of expression of the transcription regulator DC-SCRIPT (Zfp366) is a prominent prognostic event in estrogen receptor-positive breast cancer patients…”
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Anti-GD2 mAb and Vorinostat synergize in the treatment of neuroblastoma by Kroesen, Michiel, Büll, Christian, Gielen, Paul R., Brok, Ingrid C., Armandari, Inna, Wassink, Melissa, Looman, Maaike W. G., Boon, Louis, den Brok, Martijn H., Hoogerbrugge, Peter M., Adema, Gosse J.

“…Neuroblastoma (NBL) is a childhood malignancy of the sympathetic nervous system. For high-risk NBL patients, the mortality rate is still over 50%, despite…”
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OS9 interacts with DC-STAMP and modulates its intracellular localization in response to TLR ligation by Jansen, Bastiaan J.H., Eleveld-Trancikova, Dagmar, Sanecka, Anna, van Hout-Kuijer, Maaike, Hendriks, Ilona A.M., Looman, Maaike G.W., Leusen, Jeanette H.W., Adema, Gosse J.

“…Dendritic cell-specific transmembrane protein (DC-STAMP) has been first identified as an EST in a cDNA library of human monocyte-derived dendritic cells (DC)…”
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DC‐STAMP, a novel multimembrane‐spanning molecule preferentially expressed by dendritic cells by Hartgers, Franca C., Vissers, Joost L. M., Looman, Maaike W. G., Zoelen, Claudia van, Huffine, Connie, Figdor, Carl G., Adema, Gosse J.

“…Dendritic cells (DC) are unique in their ability to present antigen to naive T cells, and therefore play a central role in the initiation of immune responses…”
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DC-SCRIPT is a novel regulator of the tumor suppressor gene CDKN2B and induces cell cycle arrest in ER[alpha]-positive breast cancer cells by Ansems, Marleen, Søndergaard, Jonas Nørskov, Sieuwerts, Anieta M, Looman, Maaike W; G, Smid, Marcel, de Graaf, Annemarie M; A, de Weerd, Vanja, Zuidscherwoude, Malou, Foekens, John A, Martens, John W; M, Adema, Gosse J

“…Breast cancer is one of the most common causes of cancer-related deaths in women. The estrogen receptor (ER[alpha]) is well known for having growth promoting…”
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A comparison of genomic structures and expression patterns of two closely related flanking genes in a critical lung cancer region at 3p21.3 by Timmer, T, Terpstra, P, van den Berg, A, Veldhuis, P M, Ter Elst, A, Voutsinas, G, Hulsbeek, M M, Draaijers, T G, Looman, M W, Kok, K, Naylor, S L, Buys, C H

“…In the search for a tumour suppressor gene in the 3p21.3 region we isolated two genes, RBM5 and RBM6. Gene RBM5 maps to the region which is homozygously…”
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MSH2 and MLH1 mutations in sporadic replication error-positive colorectal carcinoma as assessed by two-dimensional DNA electrophoresis by Wu, Ying, Nyström-Lahti, Minna, Osinga, Jan, Looman, Maaike W. G., Peltomäki, Päivi, Aaltonen, Lauri A., de la Chapelle, Albert, Hofstra, Robert M. W., Buys, Charles H. C. M.

“…Replication errors (RER) are frequently seen in both sporadic and hereditary forms of colorectal cancer. In hereditary nonpolyposis colorectal cancer (HNPCC),…”
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Improvement of fragment and primer selection for mutation detection by denaturing gradient gel electrophoresis by Wu, Ying, Hayes, Vanessa M., Osinga, Jan, Mulder, Inge M., Looman, Maaike W. G., Buys, Charles H. C. M., Hofstra, Robert M. W.

“…Denaturing gradient gel electrophoresis (DGGE) is one of the most powerful methods for mutation detection currently available. For successful application the…”
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