Search Results - "Looker, Brian E"

Synthesis and Structure−Activity Relationships of Long-acting β2 Adrenergic Receptor Agonists Incorporating Metabolic Inactivation: An Antedrug Approach by Procopiou, Panayiotis A, Barrett, Victoria J, Bevan, Nicola J, Biggadike, Keith, Box, Philip C, Butchers, Peter R, Coe, Diane M, Conroy, Richard, Emmons, Amanda, Ford, Alison J, Holmes, Duncan S, Horsley, Helen, Kerr, Fern, Li-Kwai-Cheung, Anne-Marie, Looker, Brian E, Mann, Inderjit S, McLay, Iain M, Morrison, Valerie S, Mutch, Peter J, Smith, Claire E, Tomlin, Paula

“…A series of saligenin β2 adrenoceptor agonist antedrugs having high clearance were prepared by reacting a protected saligenin oxazolidinone with protected…”
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The discovery of quinoline based single-ligand human H 1 and H 3 receptor antagonists by Procopiou, Panayiotis A, Ancliff, Rachael A, Gore, Paul M, Hancock, Ashley P, Hodgson, Simon T, Holmes, Duncan S, Keeling, Steven P, Looker, Brian E, Parr, Nigel A, Rowedder, James E, Slack, Robert J

“…A novel series of potent quinoline-based human H and H bivalent histamine receptor antagonists, suitable for intranasal administration for the potential…”
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Discovery of a rapidly metabolized, long-acting β(2) adrenergic receptor agonist with a short onset time incorporating a sulfone group suitable for once-daily dosing by Procopiou, Panayiotis A, Barrett, Victoria J, Biggadike, Keith, Butchers, Peter R, Craven, Andrew, Ford, Alison J, Guntrip, Stephen B, Holmes, Duncan S, Hughes, Sara C, Jones, Anne E, Looker, Brian E, Mutch, Peter J, Ruston, Mark, Needham, Deborah, Smith, Claire E

“…A series of novel, potent, and selective human β2 adrenoceptor agonists incorporating a sulfone moiety on the terminal right-hand-side phenyl ring of…”
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Identification of selective 8-(piperidin-4-yloxy)quinoline sulfone and sulfonamide histamine H1 receptor antagonists for use in allergic rhinitis by Procopiou, Panayiotis A., Ford, Alison J., Gore, Paul M., Hancock, Ashley P., Hodgson, Simon T., Holmes, Duncan S., Looker, Brian E., Vile, Sadie, Clark, Kenneth L., Saunders, Ken A., Slack, Robert J., Watts, Clarissa J.

“…Selective human H1 histamine receptor antagonist pA2=9.3 with 24h duration of action. [Display omitted] A series of potent, selective and long-acting…”
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Identification of selective 8-(piperidin-4-yloxy)quinoline sulfone and sulfonamide histamine H 1 receptor antagonists for use in allergic rhinitis by Procopiou, Panayiotis A, Ford, Alison J, Gore, Paul M, Hancock, Ashley P, Hodgson, Simon T, Holmes, Duncan S, Looker, Brian E, Vile, Sadie, Clark, Kenneth L, Saunders, Ken A, Slack, Robert J, Watts, Clarissa J

“…A series of potent, selective and long-acting quinoline-based sulfonamide human H histamine receptor antagonists, designed for once-daily intranasal…”
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The discovery of quinoline based single-ligand human H1 and H3 receptor antagonists by Procopiou, Panayiotis A., Ancliff, Rachael A., Gore, Paul M., Hancock, Ashley P., Hodgson, Simon T., Holmes, Duncan S., Keeling, Steven P., Looker, Brian E., Parr, Nigel A., Rowedder, James E., Slack, Robert J.

“…3-(8-(4-(4-(3-(Azepan-1-yl)propoxy)phenethyl)piperazin-1-yl)-6-butylquinolin-2-yl)propanoic acid; pA2=8.8 for H1 receptor; pKi=9.1 for H3 receptor. [Display…”
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Discovery of a Rapidly Metabolized, Long-Acting β2 Adrenergic Receptor Agonist with a Short Onset Time Incorporating a Sulfone Group Suitable for Once-Daily Dosing by Procopiou, Panayiotis A, Barrett, Victoria J, Biggadike, Keith, Butchers, Peter R, Craven, Andrew, Ford, Alison J, Guntrip, Stephen B, Holmes, Duncan S, Hughes, Sara C, Jones, Anne E, Looker, Brian E, Mutch, Peter J, Ruston, Mark, Needham, Deborah, Smith, Claire E

“…A series of novel, potent, and selective human β2 adrenoceptor agonists incorporating a sulfone moiety on the terminal right-hand-side phenyl ring of…”
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Design of Phthalazinone Amide Histamine H 1 Receptor Antagonists for Use in Rhinitis by Procopiou, Panayiotis A, Ford, Alison J, Gore, Paul M, Looker, Brian E, Hodgson, Simon T, Holmes, Duncan S, Vile, Sadie, Clark, Kenneth L, Saunders, Ken A, Slack, Robert J, Rowedder, James E, Watts, Clarissa J

“…The synthesis of potent amide-containing phthalazinone H histamine receptor antagonists is described. Three analogues , , and were equipotent with azelastine…”
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Design of Phthalazinone Amide Histamine H1 Receptor Antagonists for Use in Rhinitis by Procopiou, Panayiotis A, Ford, Alison J, Gore, Paul M, Looker, Brian E, Hodgson, Simon T, Holmes, Duncan S, Vile, Sadie, Clark, Kenneth L, Saunders, Ken A, Slack, Robert J, Rowedder, James E, Watts, Clarissa J

“…The synthesis of potent amide-containing phthalazinone H1 histamine receptor antagonists is described. Three analogues 3e, 3g, and 9g were equipotent with…”
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The Discovery of Phthalazinone-Based Human H1 and H3 Single-Ligand Antagonists Suitable for Intranasal Administration for the Treatment of Allergic Rhinitis by Procopiou, Panayiotis A, Browning, Christopher, Buckley, Jennifer M, Clark, Kenneth L, Fechner, Lise, Gore, Paul M, Hancock, Ashley P, Hodgson, Simon T, Holmes, Duncan S, Kranz, Michael, Looker, Brian E, Morriss, Karen M. L, Parton, Daniel L, Russell, Linda J, Slack, Robert J, Sollis, Steven L, Vile, Sadie, Watts, Clarissa J

“…A series of potent phthalazinone-based human H1 and H3 bivalent histamine receptor antagonists, suitable for intranasal administration for the potential…”
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Synthesis and Structure−Activity Relationships of Long-acting β2 Adrenergic Receptor Agonists Incorporating Arylsulfonamide Groups by Procopiou, Panayiotis A, Barrett, Victoria J, Bevan, Nicola J, Biggadike, Keith, Butchers, Peter R, Coe, Diane M, Conroy, Richard, Edney, Dean D, Field, Rita N, Ford, Alison J, Guntrip, Stephen B, Looker, Brian E, McLay, Iain M, Monteith, Michael J, Morrison, Valerie S, Mutch, Peter J, Richards, Stephen A, Sasse, Rosemary, Smith, Claire E

“…A series of saligenin alkoxyalkylphenylsulfonamide β2 adrenoceptor agonists were prepared by reacting a protected saligenin oxazolidinone with alkynyloxyalkyl…”
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discovery of long-acting saligenin β₂ adrenergic receptor agonists incorporating a urea group by Procopiou, Panayiotis A, Barrett, Victoria J, Ford, Alison J, Looker, Brian E, Lunniss, Gillian E, Needham, Deborah, Smith, Claire E, Somers, Graham

“…A series of novel, potent and selective human β₂ adrenoceptor agonists incorporating a urea moiety on the terminal right-hand side phenyl ring of…”
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The discovery of long-acting saligenin β2 adrenergic receptor agonists incorporating hydantoin or uracil rings by Procopiou, Panayiotis A., Barrett, Victoria J., Bevan, Nicola J., Butchers, Peter R., Conroy, Richard, Emmons, Amanda, Ford, Alison J., Jeulin, Séverine, Looker, Brian E., Lunniss, Gillian E., Morrison, Valerie S., Mutch, Peter J., Perciaccante, Rossana, Ruston, Mark, Smith, Claire E., Somers, Graham

“…A series of novel, potent and selective human β2 adrenoceptor agonists incorporating a hydantoin or a uracil ring on the right-hand side phenyl ring of…”
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4-Acyl-1-(4-aminoalkoxyphenyl)-2-ketopiperazines as a Novel Class of Non-Brain-Penetrant Histamine H3 Receptor Antagonists by Procopiou, Panayiotis A, Ancliff, Rachael A, Bamford, Mark J, Browning, Christopher, Connor, Helen, Davies, Susannah, Fogden, Yvonne C, Hodgson, Simon T, Holmes, Duncan S, Looker, Brian E, Morriss, Karen M. L, Parr, Christopher A, Pickup, Elizabeth A, Sehmi, Sanjeet S, White, Gemma V, Watts, Clarissa J, Wilson, David M, Woodrow, Michael D

“…A series of ketopiperazines were prepared and evaluated for their activity as histamine H3 antagonists. From investigation of the tertiary basic center in the…”
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The Discovery of Phthalazinone-Based Human H 1 and H 3 Single-Ligand Antagonists Suitable for Intranasal Administration for the Treatment of Allergic Rhinitis by Procopiou, Panayiotis A., Browning, Christopher, Buckley, Jennifer M., Clark, Kenneth L., Fechner, Lise, Gore, Paul M., Hancock, Ashley P., Hodgson, Simon T., Holmes, Duncan S., Kranz, Michael, Looker, Brian E., Morriss, Karen M. L., Parton, Daniel L., Russell, Linda J., Slack, Robert J., Sollis, Steven L., Vile, Sadie, Watts, Clarissa J.

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The discovery of long-acting saligenin β 2 adrenergic receptor agonists incorporating a urea group by Procopiou, Panayiotis A., Barrett, Victoria J., Ford, Alison J., Looker, Brian E., Lunniss, Gillian E., Needham, Deborah, Smith, Claire E., Somers, Graham

“…A series of novel, potent and selective human β 2 adrenoceptor agonists incorporating a urea moiety on the terminal right-hand side phenyl ring of (…”
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Discovery of a Rapidly Metabolized, Long-Acting β 2 Adrenergic Receptor Agonist with a Short Onset Time Incorporating a Sulfone Group Suitable for Once-Daily Dosing by Procopiou, Panayiotis A., Barrett, Victoria J., Biggadike, Keith, Butchers, Peter R., Craven, Andrew, Ford, Alison J., Guntrip, Stephen B., Holmes, Duncan S., Hughes, Sara C., Jones, Anne E., Looker, Brian E., Mutch, Peter J., Ruston, Mark, Needham, Deborah, Smith, Claire E.

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The discovery of long-acting saligenin [beta] sub(2 adrenergic receptor agonists incorporating a urea group) by Procopiou, Panayiotis A, Barrett, Victoria J, d, Alison J, Looker, Brian E, Lunniss, Gillian E, Needham, Deborah, Smith, Claire E, Somers, Graham

“…A series of novel, potent and selective human [beta] sub(2 adrenoceptor agonists incorporating a urea moiety on the terminal right-hand side phenyl ring of…”
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4-Acyl-1-(4-aminoalkoxyphenyl)-2-ketopiperazines as a Novel Class of Non-Brain-Penetrant Histamine H 3 Receptor Antagonists by Procopiou, Panayiotis A., Ancliff, Rachael A., Bamford, Mark J., Browning, Christopher, Connor, Helen, Davies, Susannah, Fogden, Yvonne C., Hodgson, Simon T., Holmes, Duncan S., Looker, Brian E., Morriss, Karen M. L., Parr, Christopher A., Pickup, Elizabeth A., Sehmi, Sanjeet S., White, Gemma V., Watts, Clarissa J., Wilson, David M., Woodrow, Michael D.

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The discovery of long-acting saligenin beta sub(2 adrenergic receptor agonists incorporating hydantoin or uracil rings) by Procopiou, Panayiotis A, Barrett, Victoria J, Bevan, Nicola J, Butchers, Peter R, Conroy, Richard, Emmons, Amanda, d, Alison J, Jeulin, Severine, Looker, Brian E, Lunniss, Gillian E, Morrison, Valerie S, Mutch, Peter J, Perciaccante, Rossana, Ruston, Mark, Smith, Claire E, Somers, Graham, Xepfqmjboitfns-Sanmltnesa-N, InChiKey

“…A series of novel, potent and selective human beta sub(2 adrenoceptor agonists incorporating a hydantoin or a uracil ring on the right-hand side phenyl ring of…”
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