Search Results - "Look, Maxime"

Four miRNAs associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer by Foekens, John A, Sieuwerts, Anieta M, Smid, Marcel, Look, Maxime P, de Weerd, Vanja, Boersma, Antonius W.M, Klijn, Jan G.M, Wiemer, Erik A.C, Martens, John W.M

“…In this study, we quantified 249 mature micro-RNA (miRNA) transcripts in estrogen receptor-positive (ER⁺) primary breast tumors of patients with lymph…”
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Multilevel mixed effects parametric survival models using adaptive Gauss-Hermite quadrature with application to recurrent events and individual participant data meta-analysis by Crowther, Michael J., Look, Maxime P., Riley, Richard D.

“…Multilevel mixed effects survival models are used in the analysis of clustered survival data, such as repeated events, multicenter clinical trials, and…”
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LAMP3 is involved in tamoxifen resistance in breast cancer cells through the modulation of autophagy by Nagelkerke, Anika, Sieuwerts, Anieta M, Bussink, Johan, Sweep, Fred C G J, Look, Maxime P, Foekens, John A, Martens, John W M, Span, Paul N

“…Lysosome-associated membrane protein 3 (LAMP3) is a member of the LAMP-family of proteins, which are involved in the process of autophagy. Autophagy is induced…”
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Multivariate meta-analysis of individual participant data helped externally validate the performance and implementation of a prediction model by Snell, Kym I.E, Hua, Harry, Debray, Thomas P.A, Ensor, Joie, Look, Maxime P, Moons, Karel G.M, Riley, Richard D

“…Abstract Objectives Our aim was to improve meta-analysis methods for summarizing a prediction model's performance when individual participant data are…”
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Tumor cell migration screen identifies SRPK1 as breast cancer metastasis determinant by van Roosmalen, Wies, Le Dévédec, Sylvia E, Golani, Ofra, Smid, Marcel, Pulyakhina, Irina, Timmermans, Annemieke M, Look, Maxime P, Zi, Di, Pont, Chantal, de Graauw, Marjo, Naffar-Abu-Amara, Suha, Kirsanova, Catherine, Rustici, Gabriella, Hoen, Peter A C 't, Martens, John W M, Foekens, John A, Geiger, Benjamin, van de Water, Bob

“…Tumor cell migration is a key process for cancer cell dissemination and metastasis that is controlled by signal-mediated cytoskeletal and cell matrix adhesion…”
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Evidence synthesis combining individual patient data and aggregate data: a systematic review identified current practice and possible methods by Riley, Richard D, Simmonds, Mark C, Look, Maxime P

“…Abstract Objective Meta-analysis of individual patient data (IPD) is the “gold-standard” for synthesizing evidence across several studies. Some studies,…”
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Application of circulating tumor DNA in prospective clinical oncology trials – standardization of preanalytical conditions by Dessel, Lisanne F., Beije, Nick, Helmijr, Jean C.A., Vitale, Silvia R., Kraan, Jaco, Look, Maxime P., Wit, Ronald, Sleijfer, Stefan, Jansen, Maurice P.H.M., Martens, John W.M., Lolkema, Martijn P.

“…Circulating tumor DNA (ctDNA) has emerged as a potential new biomarker with diagnostic, predictive, and prognostic applications for various solid tumor types…”
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MicroRNA-30c expression level is an independent predictor of clinical benefit of endocrine therapy in advanced estrogen receptor positive breast cancer by Rodríguez-González, F. Germán, Sieuwerts, Anieta M., Smid, Marcel, Look, Maxime P., Meijer-van Gelder, Marion E., de Weerd, Vanja, Sleijfer, Stefan, Martens, John W. M., Foekens, John A.

“…MicroRNAs (miRNAs) are small RNA molecules that modulate gene expression and which have been implicated in cancer. We evaluated whether five candidate…”
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The 29.5 kb APOBEC3B Deletion Polymorphism Is Not Associated with Clinical Outcome of Breast Cancer by Liu, Jingjing, Sieuwerts, Anieta M, Look, Maxime P, van der Vlugt-Daane, Michelle, Meijer-van Gelder, Marion E, Foekens, John A, Hollestelle, Antoinette, Martens, John W M

“…Increased APOBEC3B mRNA levels are associated with a hypermutator phenotype and poor prognosis in ER-positive breast cancer patients. In addition, a 29.5 kb…”
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Individual participant data meta‐analysis for external validation, recalibration, and updating of a flexible parametric prognostic model by Ensor, Joie, Snell, Kym I. E., Debray, Thomas P. A., Lambert, Paul C., Look, Maxime P., Mamas, Mamas A., Moons, Karel G. M., Riley, Richard D.

“…Individual participant data (IPD) from multiple sources allows external validation of a prognostic model across multiple populations. Often this reveals poor…”
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Association of an Extracellular Matrix Gene Cluster with Breast Cancer Prognosis and Endocrine Therapy Response by Helleman, Jozien, Jansen, Maurice P H M, Ruigrok-Ritstier, Kirsten, van Staveren, Iris L, Look, Maxime P, Meijer-van Gelder, Marion E, Sieuwerts, Anieta M, Klijn, Jan G M, Sleijfer, Stefan, Foekens, John A, Berns, Els M J J

“…Purpose: We previously discovered an extracellular matrix (ECM) gene cluster associated with resistance to first-line tamoxifen therapy of patients with…”
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Comparative Proteome Analysis Revealing an 11-Protein Signature for Aggressive Triple-Negative Breast Cancer by NING QING LIU, STINGL, Christoph, MANGIA, Anita, PARADISO, Angelo, DIRIX, Luc Y, VAN LAERE, Steven J, LUIDER, Theo M, MARTENS, John W. M, FOEKENS, John A, UMAR, Arzu, LOOK, Maxime P, SMID, Marcel, BRAAKMAN, René B. H, DE MARCHI, Tommaso, SIEUWERTS, Anieta M, SPAN, Paul N, SWEEP, Fred C. G. J, LINDERHOLM, Barbro K

“…Clinical outcome of patients with triple-negative breast cancer (TNBC) is highly variable. This study aims to identify and validate a prognostic protein…”
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Phosphoserine aminotransferase 1 is associated to poor outcome on tamoxifen therapy in recurrent breast cancer by De Marchi, Tommaso, Timmermans, Mieke A., Sieuwerts, Anieta M., Smid, Marcel, Look, Maxime P., Grebenchtchikov, Nicolai, Sweep, Fred C. G. J., Smits, Jan G., Magdolen, Viktor, van Deurzen, Carolien H. M., Foekens, John A., Umar, Arzu, Martens, John W.

“…In a previous study, we detected a significant association between phosphoserine aminotransferase 1 (PSAT1) hyper-methylation and mRNA levels to outcome to…”
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IGF1R signaling drives antiestrogen resistance through PAK2/PIX activation in luminal breast cancer by Zhang, Yinghui, Wester, Lynn, He, Jichao, Geiger, Tamar, Moerkens, Marja, Siddappa, Ram, Helmijr, Jean A., Timmermans, Mieke M., Look, Maxime P., van Deurzen, Caroline H. M., Martens, John W. M., Pont, Chantal, de Graauw, Marjo, Danen, Erik H. J., Berns, Els M. J. J., Meerman, John H. N., Jansen, Maurice P. H. M., van de Water, Bob

“…Antiestrogen resistance in estrogen receptor positive (ER + ) breast cancer is associated with increased expression and activity of insulin-like growth factor…”
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High TWIST1 mRNA expression is associated with poor prognosis in lymph node-negative and estrogen receptor-positive human breast cancer and is co-expressed with stromal as well as ECM related genes by Riaz, Muhammad, Sieuwerts, Anieta M, Look, Maxime P, Timmermans, Mieke A, Smid, Marcel, Foekens, John A, Martens, John W M

“…The TWIST homolog 1 (TWIST1) is a transcription factor that induces epithelial to mesenchymal transition (EMT), a key process in metastasis. The purpose of…”
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KLF6-SV1 drives breast cancer metastasis and is associated with poor survival by Hatami, Raheleh, Sieuwerts, Anieta M, Izadmehr, Sudeh, Yao, Zhong, Qiao, Rui Fang, Papa, Luena, Look, Maxime P, Smid, Marcel, Ohlssen, Jessica, Levine, Alice C, Germain, Doris, Burstein, David, Kirschenbaum, Alexander, DiFeo, Analisa, Foekens, John A, Narla, Goutham

“…Metastasis is the major cause of cancer mortality. A more thorough understanding of the mechanisms driving this complex multistep process will aid in the…”
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Prospects of Targeting the Gastrin Releasing Peptide Receptor and Somatostatin Receptor 2 for Nuclear Imaging and Therapy in Metastatic Breast Cancer by Dalm, Simone U, Schrijver, Willemijne A M E, Sieuwerts, Anieta M, Look, Maxime P, Ziel-van der Made, Angelique C J, de Weerd, Vanja, Martens, John W, van Diest, Paul J, de Jong, Marion, van Deurzen, Carolien H M

“…The gastrin releasing peptide receptor (GRPR) and the somatostatin receptor 2 (SSTR2) are overexpressed on primary breast cancer (BC), making them ideal…”
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Relevance of Breast Cancer Antiestrogen Resistance Genes in Human Breast Cancer Progression and Tamoxifen Resistance by VAN AGTHOVEN, Ton, SIEUWERTS, Anieta M, MEIJER-VAN GELDER, Marion E, LOOK, Maxime P, SMID, Marcel, VELDSCHOLTE, Jos, SLEIJFER, Stefan, FOEKENS, John A, DORSSERS, Lambert C. J

“…We have previously identified a set of breast cancer antiestrogen resistance (BCAR) genes causing estrogen independence and tamoxifen resistance in vitro using…”
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CCAT2, a novel long non-coding RNA in breast cancer: expression study and clinical correlations by Redis, Roxana S, Sieuwerts, Anieta M, Look, Maxime P, Tudoran, Oana, Ivan, Cristina, Spizzo, Riccardo, Zhang, Xinna, de Weerd, Vanja, Shimizu, Masayoshi, Ling, Hui, Buiga, Rares, Pop, Victor, Irimie, Alexandru, Fodde, Riccardo, Bedrosian, Isabella, Martens, John W M, Foekens, John A, Berindan-Neagoe, Ioana, Calin, George A

“…The clinical outcome of BC patients receiving the same treatment is known to vary considerably and thus, there is a compelling need to identify novel…”
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Molecular Classification of Tamoxifen-Resistant Breast Carcinomas by Gene Expression Profiling by JANSEN, Maurice P. H. M, FOEKENS, John A, KLIJN, Jan G. M, BERNS, Els M. J. J, VAN STAVEREN, Iris L, DIRKZWAGER-KIEL, Maaike M, RITSTIER, Kirsten, LOOK, Maxime P, MEIJER-VAN GELDER, Marion E, SIEUWERTS, Anieta M, PORTENGEN, Henk, DORSSERS, Lambert C. J

“…To discover a set of markers predictive for the type of response to endocrine therapy with the antiestrogen tamoxifen using gene expression profiling. The…”
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