Search Results - "Looijenga, LHJ"

OCT4: biological functions and clinical applications as a marker of germ cell neoplasia by Cheng, L, Sung, M-T, Cossu-Rocca, P, Jones, TD, MacLennan, GT, De Jong, J, Lopez-Beltran, A, Montironi, R, Looijenga, LHJ

“…Germ cell tumours (GCTs) are a heterogeneous group of neoplasms, which develop in the gonads as well as in extragonadal sites, that share morphological…”
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Differential expression of SOX17 and SOX2 in germ cells and stem cells has biological and clinical implications by de Jong, J, Stoop, H, Gillis, AJM, van Gurp, RJHLM, van de Geijn, G. JM, Boer, M. de, Hersmus, R, Saunders, PTK, Anderson, RA, Oosterhuis, JW, Looijenga, LHJ

“…Combined action of SOX and POU families of transcription factors plays major roles in embryonic development. In embryonic stem cells, the combination of SOX2…”
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Stem cell factor as a novel diagnostic marker for early malignant germ cells by Stoop, H, Honecker, F, van de Geijn, GJM, Gillis, AJM, Cools, MC, de Boer, M, Bokemeyer, C, Wolffenbuttel, KP, Drop, SLS, de Krijger, RR, Dennis, N, Summersgill, B, McIntyre, A, Shipley, J, Oosterhuis, JW, Looijenga, LHJ

“…Carcinoma in situ (CIS) of the testis is the pre-invasive stage of type II testicular germ cell tumours (TGCTs) of adolescents and adults. These tumours are…”
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A SRY-HMG box frame shift mutation inherited from a mosaic father with a mild form of testicular dysgenesis syndrome in Turner syndrome patient by Shahid, Mohammad, Dhillon, Varinderpal S, Khalil, Hesham Saleh, Haque, Shameemul, Batra, Swaraj, Husain, Syed Akhtar, Looijenga, L H J

“…Sex determining factor (SRY) located on the short arm of the Y chromosome, plays an important role in initiating male sex determination, resulting in…”
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Global Disorders of Sex Development Update since 2006: Perceptions, Approach and Care by Lee, Peter A, Nordenström, Anna, Houk, Christopher P, Ahmed, S Faisal, Auchus, Richard, Baratz, Arlene, Baratz Dalke, Katharine, Liao, Lih-Mei, Lin-Su, Karen, Looijenga, 3rd, Leendert H J, Mazur, Tom, Meyer-Bahlburg, Heino F L, Mouriquand, Pierre, Quigley, Charmian A, Sandberg, David E, Vilain, Eric, Witchel, Selma

“…The goal of this update regarding the diagnosis and care of persons with disorders of sex development (DSDs) is to address changes in the clinical approach…”
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Testicular germ-cell tumours in a broader perspective by Oosterhuis, J. Wolter, Looijenga, Leendert H. J

“…The germ-cell tumours are a fascinating group of neoplasms because of their unusual biology and the spectacular therapeutic results that have been obtained in…”
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Report From the International Society of Urological Pathology (ISUP) Consultation Conference on Molecular Pathology of Urogenital Cancers: IV: Current and Future Utilization of Molecular-Genetic Tests for Testicular Germ Cell Tumors by Looijenga, Leendert H.J., Van der Kwast, Theodorus H., Grignon, David, Egevad, Lars, Kristiansen, Glen, Kao, Chia-Sui, Idrees, Muhammad T.

“…The International Society of Urological Pathology (ISUP) organized a Consultation Conference in March 2019 dealing with applications of molecular pathology in…”
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Pathobiology of germ cell tumors - applying the gossip test by Looijenga, LHJ, Oosterhuis, J W

“…Residual mature teratoma, a frequent finding in clinical pathology since the introduction of cisplatin-based chemotherapy, put Wolter Oosterhuis on the track…”
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A Genetic Screen Implicates miRNA-372 and miRNA-373 As Oncogenes in Testicular Germ Cell Tumors by Voorhoeve, P. Mathijs, le Sage, Carlos, Schrier, Mariette, Gillis, Ad J.M., Stoop, Hans, Nagel, Remco, Liu, Ying-Poi, van Duijse, Josyanne, Drost, Jarno, Griekspoor, Alexander, Zlotorynski, Eitan, Yabuta, Norikazu, De Vita, Gabriella, Nojima, Hiroshi, Looijenga, Leendert H.J., Agami, Reuven

“…Endogenous small RNAs (miRNAs) regulate gene expression by mechanisms conserved across metazoans. While the number of verified human miRNAs is still expanding,…”
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Development of malignant germ cells - the genvironmental hypothesis by Looijenga, LHJ, Van Agthoven, T, Biermann, K

“…Human germ cell tumors are of interest because of their epidemiology, clinic and pathobiology. Histologically, they are subdivided into various elements, with…”
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High-throughput microRNAome analysis in human germ cell tumours by Gillis, AJM, Stoop, HJ, Hersmus, R, Oosterhuis, JW, Sun, Y, Chen, C, Guenther, S, Sherlock, J, Veltman, I, Baeten, J, van der Spek, PJ, de Alarcon, P, Looijenga, LHJ

“…Testicular germ cell tumours (GCTs) of adolescents and adults can be subdivided into seminomas (referred to as dysgerminomas of the ovary) and non-seminomas,…”
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Intragenic ERBB2 kinase mutations in tumours by Stephens, Philip, Hunter, Chris, Bignell, Graham, Edkins, Sarah, Davies, Helen, Teague, Jon, Stevens, Claire, O'Meara, Sarah, Smith, Raffaella, Parker, Adrian, Barthorpe, Andy, Blow, Matthew, Brackenbury, Lisa, Butler, Adam, Clarke, Oliver, Cole, Jennifer, Dicks, Ed, Dike, Angus, Drozd, Anja, Edwards, Ken, Forbes, Simon, Foster, Rebecca, Gray, Kristian, Greenman, Chris, Halliday, Kelly, Hills, Katy, Kosmidou, Vivienne, Lugg, Richard, Menzies, Andy, Perry, Janet, Petty, Robert, Raine, Keiran, Ratford, Lewis, Shepherd, Rebecca, Small, Alexandra, Stephens, Yvonne, Tofts, Calli, Varian, Jennifer, West, Sofie, Widaa, Sara, Yates, Andrew, Brasseur, Francis, Cooper, Colin S., Flanagan, Adrienne M., Knowles, Margaret, Leung, Suet Y., Louis, David N., Looijenga, Leendert H. J., Malkowicz, Bruce, Pierotti, Marco A., Teh, Bin, Chenevix-Trench, Georgia, Weber, Barbara L., Yuen, Siu T., Harris, Grace, Goldstraw, Peter, Nicholson, Andrew G., Futreal, P. Andrew, Wooster, Richard, Stratton, Michael R.

“…The protein-kinase family is the most frequently mutated gene family found in human cancer and faulty kinase enzymes are being investigated as promising…”
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The pluripotency homeobox gene NANOG is expressed in human germ cell tumors by Hart, Adam H., Hartley, Lynne, Parker, Karen, Ibrahim, Marilyn, Looijenga, Leendert H.J., Pauchnik, Marija, Chow, Chung Wo, Robb, Lorraine

“…BACKGROUND The NANOG gene, a member of the homeobox family of DNA binding transcription factors, was recently identified in a screen for pluripotency‐promoting…”
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Management of Gonads in Adults with Androgen Insensitivity: An International Survey by Tack, Lloyd J W, Maris, Ellen, Looijenga, Leendert H J, Hannema, Sabine E, Audi, Laura, Köhler, Birgit, Holterhus, Paul-Martin, Riedl, Stefan, Wisniewski, Amy, Flück, Christa E, Davies, Justin H, T'Sjoen, Guy, Lucas-Herald, Angela K, Evliyaoglu, Olcay, Krone, Nils, Iotova, Violeta, Marginean, Otilia, Balsamo, Antonio, Verkauskas, Gilvydas, Weintrob, Naomi, Ellaithi, Mona, Nordenström, Anna, Verrijn Stuart, Annemarie, Kluivers, Kirsten B, Wolffenbuttel, Katja P, Ahmed, S Faisal, Cools, Martine

“…Complete and partial androgen insensitivity syndrome (CAIS, PAIS) are associated with an increased risk of gonadal germ cell cancer (GGCC). Recent guidelines…”
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DNA methylation profiles delineate epigenetic heterogeneity in seminoma and non-seminoma by Brait, M, Maldonado, L, Begum, S, Loyo, M, Wehle, D, Tavora, F F, Looijenga, L H J, Kowalski, J, Zhang, Z, Rosenbaum, E, Halachmi, S, Netto, G J, Hoque, M O

“…Background: It remains important to understand the biology and identify biomarkers for less studied cancers like testicular cancer. The purpose of this study…”
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POU5F1 (OCT3/4) identifies cells with pluripotent potential in human germ cell tumors by LOOIJENGA, Leendert H. J, STOOP, Hans, HONECKER, Friedemann, BOKEMEYER, Carsten, PERLMAN, Elizabeth J, SCHNEIDER, Dominik T, KONONEN, Juha, SAUTER, Guido, OOSTERHUIS, J. Wolter, DE LEEUW, Hubert P. J. C, DE GOUVEIA BRAZAO, Carlos A, GILLIS, Ad J. M, VAN ROOZENDAAL, Kees E. P, VAN ZOELEN, Everardus J. J, WEBER, Rob F. A, WOLFFENBUTTEL, Katja P, VAN DEKKEN, Herman

“…Human germ cell tumors (GCTs) may have variable histology and clinical behavior, depending on factors such as sex of the patient, age at clinical diagnosis,…”
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Role of stem cell proteins and microRNAs in embryogenesis and germ cell cancer by Eini, Ronak, Dorssers, Lambert C J, Looijenga, Leendert H J

“…Embryonic stem (ES) cells are pluripotent cells derived from the inner cell mass of the blastocyst. These cells can proliferate indefinitely and differentiate…”
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Molecular characterization of hiwi, a human member of the piwi gene family whose overexpression is correlated to seminomas by DAN QIAO, ZEEMAN, Anne-Marie, WEI DENG, LOOIJENGA, Leendert H. J, HAIFAN LIN

“…The piwi family genes are highly conserved during evolution and play essential roles in stem cell self-renewal, gametogenesis, and RNA interference in diverse…”
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FOXL2 and SOX9 as parameters of female and male gonadal differentiation in patients with various forms of disorders of sex development (DSD) by Hersmus, R, Kalfa, N, de Leeuw, B, Stoop, H, Oosterhuis, JW, de Krijger, R, Wolffenbuttel, KP, Drop, SLS, Veitia, RA, Fellous, M, Jaubert, F, Looijenga, LHJ

“…The transcription factors SOX9 and FOXL2 are required for male and female mammalian gonadal development. We have used specific antibodies to investigate the…”
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Pancreatic cyst surveillance imposes low psychological burden by Overbeek, Kasper A., Kamps, Anne, van Riet, Priscilla A., Di Marco, Mariacristina, Zerboni, Giulia, van Hooft, Jeanin E., Carrara, Silvia, Ricci, Claudio, Gonda, Tamas A., Schoon, Erik, Polkowski, Marcin, Beyer, Georg, Honkoop, Pieter, van der Waaij, Laurens A., Casadei, Riccardo, Capurso, Gabriele, Erler, Nicole S., Bruno, Marco J., Bleiker, Eveline M.A., Cahen, Djuna L., Bruno, M.J., Cahen, D.L., van Riet, P.A., Overbeek, K.A., Levink, I.J.M., Koopmann, B., Besselink, M.G.H., del Chiaro, M., Lerch, M.M., Wallace, M.B., van Ballegooijen, M., Biermann, K., Bleiker, E.M.A., Bollen, T.H.L., Fockens, P., de Kok, I.M.C.M., Looijenga, L.H.J., Peppelenbosch, M.P., Verhagen-Oldenampsen, J.H.E., Arcidiacono, P.G., Capurso, G., Bergmann, J., van Berkel, A., Beyer, G., Bijlsma, R., Braat, H., Cahen, D.L., Carrara, S., Czakó, L., van Erp-van der Steen, H., Ganesh, S., van Geenen, E., Gonda, T., Hoge, C., Honkoop, P., van Hooft, J.E., Jansen, J., Larghi, A., van Leeuwenburgh, I., Laukkarinen, J., Lelyveld, N., Lerch, M., di Marco, M.C., Ricci, C., Casadei, R., Rau, E.P., Perk, L., Polkowski, M., Pukitits, A., Quispel, R., Radenkovic, D., Seicean, A., Schwartz, T., Schoon, E.J., van Soest, E., Tan, A., Venneman, N.G., Vos, P., Voorburg, A., van der Waaij, L.A., Wallace, M.B., Wijkerslooth, L.R.H., Zerboni, G., Capurso, G., della Fave, G., Zonderhuis, B.

“…For the currently recommended pancreatic cyst surveillance to be feasible, participant adherence is a prerequisite. Our objective was to evaluate the…”
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