Search Results - "Loo, R."

Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43 by Jiang, Yi Xiao, Cao, Qin, Sawaya, Michael R., Abskharon, Romany, Ge, Peng, DeTure, Michael, Dickson, Dennis W., Fu, Janine Y., Ogorzalek Loo, Rachel R., Loo, Joseph A., Eisenberg, David S.

“…Frontotemporal lobar degeneration (FTLD) is the third most common neurodegenerative condition after Alzheimer’s and Parkinson’s diseases 1 . FTLD typically…”
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An integrated native mass spectrometry and top-down proteomics method that connects sequence to structure and function of macromolecular complexes by Li, Huilin, Nguyen, Hong Hanh, Ogorzalek Loo, Rachel R., Campuzano, Iain D. G., Loo, Joseph A.

“…Mass spectrometry (MS) has become a crucial technique for the analysis of protein complexes. Native MS has traditionally examined protein subunit arrangements,…”
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Added Value of Internal Fragments for Top-Down Mass Spectrometry of Intact Monoclonal Antibodies and Antibody–Drug Conjugates by Wei, Benqian, Lantz, Carter, Liu, Weijing, Viner, Rosa, Ogorzalek Loo, Rachel R., Campuzano, Iain D. G., Loo, Joseph A.

“…Monoclonal antibodies (mAbs) and antibody–drug conjugates (ADCs) are two of the most important therapeutic drug classes that require extensive…”
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GeSn/Ge heterostructure short-wave infrared photodetectors on silicon by Gassenq, A, Gencarelli, F, Van Campenhout, J, Shimura, Y, Loo, R, Narcy, G, Vincent, B, Roelkens, G

“…A surface-illuminated photoconductive detector based on Ge0.91Sn0.09 quantum wells with Ge barriers grown on a silicon substrate is demonstrated…”
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Salt Bridge Rearrangement (SaBRe) Explains the Dissociation Behavior of Noncovalent Complexes by Loo, Rachel R. Ogorzalek, Loo, Joseph A.

“…Native electrospray ionization-mass spectrometry, with gas-phase activation and solution compositions that partially release subcomplexes, can elucidate…”
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What Protein Charging (and Supercharging) Reveal about the Mechanism of Electrospray Ionization by Ogorzalek Loo, Rachel R., Lakshmanan, Rajeswari, Loo, Joseph A.

“…Understanding the charging mechanism of electrospray ionization is central to overcoming shortcomings such as ion suppression or limited dynamic range, and…”
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Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions by Jiang, Jiansen, Chan, Henry, Cash, Darian D., Miracco, Edward J., Loo, Rachel R. Ogorzalek, Upton, Heather E., Cascio, Duilio, Johnson, Reid O'Brien, Collins, Kathleen, Loo, Joseph A., Zhou, Z. Hong, Feigon, Juli

“…Telomerase helps maintain telomeres by processive synthesis of telomere repeat DNA at their 3'-ends, using an integral telomerase RNA (TER) and telomerase…”
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Enhancing sensitivity of liquid chromatography–mass spectrometry of peptides and proteins using supercharging agents by Nshanian, Michael, Lakshmanan, Rajeswari, Chen, Hao, Loo, Rachel R. Ogorzalek, Loo, Joseph A.

“…[Display omitted] •New supercharging agents, tetraethylsulfamide and 2-methyl-2-oxazoline, identified.•Using supercharging agents rescues LC–MS TFA-induced ion…”
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ClipsMS: An Algorithm for Analyzing Internal Fragments Resulting from Top-Down Mass Spectrometry by Lantz, Carter, Zenaidee, Muhammad A, Wei, Benqian, Hemminger, Zachary, Ogorzalek Loo, Rachel R, Loo, Joseph A

“…Top-down mass spectrometry (TD-MS) of peptides and proteins results in product ions that can be correlated to polypeptide sequence. Fragments can either be…”
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Towards understanding the formation of internal fragments generated by collisionally activated dissociation for top-down mass spectrometry by Wei, Benqian, Zenaidee, Muhammad A., Lantz, Carter, Ogorzalek Loo, Rachel R., Loo, Joseph A.

“…Top-down mass spectrometry (TD-MS) generates fragment ions that returns information on the polypeptide amino acid sequence. In addition to terminal fragments,…”
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Structural Characterization of a Thrombin-Aptamer Complex by High Resolution Native Top-Down Mass Spectrometry by Zhang, Jiang, Loo, Rachel R. Ogorzalek, Loo, Joseph A.

“…Native mass spectrometry (MS) with electrospray ionization (ESI) has evolved as an invaluable tool for the characterization of intact native proteins and…”
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Elucidating the molecular programming of a nonlinear non-ribosomal peptide synthetase responsible for fungal siderophore biosynthesis by Jenner, Matthew, Hai, Yang, Nguyen, Hong H., Passmore, Munro, Skyrud, Will, Kim, Junyong, Garg, Neil K., Zhang, Wenjun, Ogorzalek Loo, Rachel R., Tang, Yi

“…Siderophores belonging to the ferrichrome family are essential for the viability of fungal species and play a key role for virulence of numerous pathogenic…”
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Improving Proteome Coverage and Sample Recovery with Enhanced FASP (eFASP) for Quantitative Proteomic Experiments by Erde, Jonathan, Loo, Rachel R Ogorzalek, Loo, Joseph A

“…Enhanced Filter Aided Sample Preparation (eFASP) incorporates plastics passivation and digestion-enhancing surfactants into the traditional FASP workflow to…”
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Internal Fragments Generated by Electron Ionization Dissociation Enhance Protein Top-Down Mass Spectrometry by Zenaidee, Muhammad A, Lantz, Carter, Perkins, Taylor, Jung, Wonhyuek, Loo, Rachel R. Ogorzalek, Loo, Joseph A

“…Top-down proteomics by mass spectrometry (MS) involves the mass measurement of an intact protein followed by subsequent activation of the protein to generate…”
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Insight into the autoproteolysis mechanism of the RsgI9 anti‐σ factor from Clostridium thermocellum by Takayesu, Allen, Mahoney, Brendan J., Goring, Andrew K., Jessup, Tobie, Ogorzalek Loo, Rachel R., Loo, Joseph A., Clubb, Robert T.

“…Clostridium thermocellum is a potential microbial platform to convert abundant plant biomass to biofuels and other renewable chemicals. It efficiently degrades…”
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Internal Fragments Enhance Middle-Down Mass Spectrometry Structural Characterization of Monoclonal Antibodies and Antibody-Drug Conjugates by Wei, Benqian, Lantz, Carter, Ogorzalek Loo, Rachel R., Campuzano, Iain D. G., Loo, Joseph A.

“…Monoclonal antibodies (mAbs) and antibody-drug conjugates (ADCs) are important large biotherapeutics (∼150 kDa) and high structural complexity that require…”
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Top-down mass spectrometry and assigning internal fragments for determining disulfide bond positions in proteins by Wei, Benqian, Zenaidee, Muhammad A, Lantz, Carter, Williams, Brad J, Totten, Sarah, Ogorzalek Loo, Rachel R, Loo, Joseph A

“…Disulfide bonds in proteins have a substantial impact on protein structure, stability, and biological activity. Localizing disulfide bonds is critical for…”
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Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils by Abskharon, Romany, Pan, Hope, Sawaya, Michael R, Seidler, Paul M, Olivares, Eileen J, Chen, Yu, Murray, Kevin A, Zhang, Jeffrey, Lantz, Carter, Bentzel, Megan, Boyer, David R, Cascio, Duilio, Nguyen, Binh A, Hou, Ke, Cheng, Xinyi, Pardon, Els, Williams, Christopher K, Nana, Alissa L, Vinters, Harry V, Spina, Salvatore, Grinberg, Lea T, Seeley, William W, Steyaert, Jan, Glabe, Charles G, Ogorzalek Loo, Rachel R, Loo, Joseph A, Eisenberg, David S

“…Despite much effort, antibody therapies for Alzheimer's disease (AD) have shown limited efficacy. Challenges to the rational design of effective antibodies…”
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Multi-Domain Interventions for Dementia Prevention–A Systematic Review by Castro, C.B., Costa, L.M., Dias, C.B., Chen, J., Hillebrandt, H., Gardener, S.L., Brown, B.M., Loo, R.L., Garg, M.L., Rainey-Smith, S.R., Martins, Ralph N., Sohrabi, Hamid R.

“…There is a growing incidence of cognitive decline and dementia associated with the ageing population. Lifestyle factors such as diet, physical activity, and…”
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New Reagents for Increasing ESI Multiple Charging of Proteins and Protein Complexes by Lomeli, Shirley H., Peng, Ivory X., Yin, Sheng, Ogorzalek Loo, Rachel R., Loo, Joseph A.

“…The addition of m-nitrobenzyl alcohol ( m-NBA) was shown previously (Lomeli et al., J. Am. Soc. Mass Spectrom. 2009, 20, 593–596) to enhance multiple charging…”
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