Search Results - "Loo, Jennifer K"

Mitochondrial Inhibition Augments the Efficacy of Imatinib by Resetting the Metabolic Phenotype of Gastrointestinal Stromal Tumor by Vitiello, Gerardo A, Medina, Benjamin D, Zeng, Shan, Bowler, Timothy G, Zhang, Jennifer Q, Loo, Jennifer K, Param, Nesteene J, Liu, Mengyuan, Moral, Alec J, Zhao, Julia N, Rossi, Ferdinand, Antonescu, Cristina R, Balachandran, Vinod P, Cross, Justin R, DeMatteo, Ronald P

“…Imatinib dramatically reduces gastrointestinal stromal tumor (GIST) F-FDG uptake, providing an early indicator of treatment response. Despite decreased glucose…”
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Csf1r or Mer inhibition delays liver regeneration via suppression of Kupffer cells by Santamaria-Barria, Juan A, Zeng, Shan, Greer, Jonathan B, Beckman, Michael J, Seifert, Adrian M, Cohen, Noah A, Zhang, Jennifer Q, Crawley, Megan H, Green, Benjamin L, Loo, Jennifer K, Maltbaek, Joanna H, DeMatteo, Ronald P

“…Murine Kupffer cells (KCs) comprise CD11bhi and F4/80hi subsets. Tissue-resident macrophages are known to express the tyrosine kinase receptors…”
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Association between neighbourhood walkability and metabolic risk factors influenced by physical activity: a cross-sectional study of adults in Toronto, Canada by Loo, C K Jennifer, Greiver, Michelle, Aliarzadeh, Babak, Lewis, Daniel

“…ObjectiveTo determine whether neighbourhood walkability is associated with clinical measures of obesity, hypertension, diabetes and dyslipidaemia in an urban…”
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Differential immune profiles distinguish the mutational subtypes of gastrointestinal stromal tumor by Vitiello, Gerardo A, Bowler, Timothy G, Liu, Mengyuan, Medina, Benjamin D, Zhang, Jennifer Q, Param, Nesteene J, Loo, Jennifer K, Goldfeder, Rachel L, Chibon, Frederic, Rossi, Ferdinand, Zeng, Shan, DeMatteo, Ronald P

“…Gastrointestinal stromal tumor (GIST) is the most common human sarcoma, frequently characterized by an oncogenic mutation in the KIT or platelet-derived growth…”
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PD-1/PD-L1 Blockade Enhances T-cell Activity and Antitumor Efficacy of Imatinib in Gastrointestinal Stromal Tumors by Seifert, Adrian M, Zeng, Shan, Zhang, Jennifer Q, Kim, Teresa S, Cohen, Noah A, Beckman, Michael J, Medina, Benjamin D, Maltbaek, Joanna H, Loo, Jennifer K, Crawley, Megan H, Rossi, Ferdinand, Besmer, Peter, Antonescu, Cristina R, DeMatteo, Ronald P

“…Tyrosine kinase inhibitors are effective in gastrointestinal stromal tumors (GISTs) but often are of transient benefit as resistance commonly develops…”
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Combined KIT and CTLA-4 Blockade in Patients with Refractory GIST and Other Advanced Sarcomas: A Phase Ib Study of Dasatinib plus Ipilimumab by D'Angelo, Sandra P, Shoushtari, Alexander N, Keohan, Mary Louise, Dickson, Mark A, Gounder, Mrinal M, Chi, Ping, Loo, Jennifer K, Gaffney, Leigh, Schneider, Lee, Patel, Zarine, Erinjeri, Joseph Patrick, Bluth, Mark J, Sjoberg, Ana, Streicher, Howard, Takebe, Naoko, Qin, Li-Xuan, Antonescu, Cristina, DeMatteo, Ronald P, Carvajal, Richard D, Tap, William D

“…A phase Ib study of dasatinib plus ipilimumab in patients with gastrointestinal stromal tumor (GIST) and other sarcomas was performed on the basis of…”
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Multiple intratumoral sources of kit ligand promote gastrointestinal stromal tumor by Tieniber, Andrew D., Rossi, Ferdinando, Hanna, Andrew N., Liu, Marion, Etherington, Mark S., Loo, Jennifer K., Param, Nesteene, Zeng, Shan, Do, Kevin, Wang, Laura, DeMatteo, Ronald P.

“…Gastrointestinal stromal tumor (GIST) is the most common human sarcoma and is typically driven by a single mutation in the Kit or PDGFRA receptor. While highly…”
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Oncogenic kinase inhibition limits Batf3-dependent dendritic cell development and antitumor immunity by Medina, Benjamin D, Liu, Mengyuan, Vitiello, Gerardo A, Seifert, Adrian M, Zeng, Shan, Bowler, Timothy, Zhang, Jennifer Q, Cavnar, Michael J, Loo, Jennifer K, Param, Nesteene J, Maltbaek, Joanna H, Rossi, Ferdinand, Balachandran, Vinod, DeMatteo, Ronald P

“…Gastrointestinal stromal tumor (GIST) is driven by an activating mutation in the proto-oncogene. Using a mouse model of GIST and human specimens, we show that…”
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The V654A second-site KIT mutation increases tumor oncogenesis and STAT activation in a mouse model of gastrointestinal stromal tumor by Zhang, Jennifer Q., Bosbach, Benedikt, Loo, Jennifer K., Vitiello, Gerardo A., Zeng, Shan, Seifert, Adrian M., Medina, Benjamin D., Param, Nesteene J., Maltbaek, Joanna H., Rossi, Ferdinand, Antonescu, Cristina R., Besmer, Peter, DeMatteo, Ronald P.

“…Gastrointestinal stromal tumor (GIST) is the most common human sarcoma and arises in the gastrointestinal tract. Most GISTs are caused by activating mutations…”
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Wnt/β-catenin Signaling Contributes to Tumor Malignancy and Is Targetable in Gastrointestinal Stromal Tumor by Zeng, Shan, Seifert, Adrian M, Zhang, Jennifer Q, Cavnar, Michael J, Kim, Teresa S, Balachandran, Vinod P, Santamaria-Barria, Juan A, Cohen, Noah A, Beckman, Michael J, Medina, Benjamin D, Rossi, Ferdinand, Crawley, Megan H, Loo, Jennifer K, Maltbaek, Joanna H, Besmer, Peter, Antonescu, Cristina R, DeMatteo, Ronald P

“…Gastrointestinal stromal tumor (GIST) is the most common type of sarcoma and usually harbors either a or mutation. However, the molecular basis for tumor…”
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Macrophages and CD8 + T Cells Mediate the Antitumor Efficacy of Combined CD40 Ligation and Imatinib Therapy in Gastrointestinal Stromal Tumors by Zhang, Jennifer Q, Zeng, Shan, Vitiello, Gerardo A, Seifert, Adrian M, Medina, Benjamin D, Beckman, Michael J, Loo, Jennifer K, Santamaria-Barria, Juan, Maltbaek, Joanna H, Param, Nesteene J, Moral, John A, Zhao, Julia N, Balachandran, Vinod, Rossi, Ferdinand, Antonescu, Cristina R, DeMatteo, Ronald P

“…Tyrosine kinase inhibition of gastrointestinal stromal tumors (GIST) is effective but typically culminates in resistance and is rarely curative. Immunotherapy…”
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ETV4 collaborates with Wnt/β-catenin signaling to alter cell cycle activity and promote tumor aggressiveness in gastrointestinal stromal tumor by Zeng, Shan, Seifert, Adrian M, Zhang, Jennifer Q, Kim, Teresa S, Bowler, Timothy G, Cavnar, Michael J, Medina, Benjamin D, Vitiello, Gerardo A, Rossi, Ferdinand, Loo, Jennifer K, Param, Nesteene J, DeMatteo, Ronald P

“…Gastrointestinal stromal tumor (GIST) is the most common sarcoma, often resulting from a or platelet-derived growth factor receptor alpha ( ) mutation. The…”
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Opioid-related deaths in Northern Ontario in the early COVID-19 pandemic period by Nunn, Alexandra, Perri, Amanda M, Gordon, Hilary, Harding, John P D, Loo, C K Jennifer, Tuinema, John

“…In the first year of pandemic measures, opioid-related deaths across Ontario's (ON) 34 public health units (PHUs) increased by 60%. Death rates for all seven…”
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Examining the impact of cycle lanes on cyclist-motor vehicle collisions in the city of Toronto by Bhatia, Deepit, Richmond, Sarah A., Loo, C.K. Jennifer, Rothman, Linda, Macarthur, Colin, Howard, Andrew

“…To examine whether implementation of painted cycle lanes in Toronto, Canada is associated with a reduction in cycle-motor vehicle collisions (CMVCs). A…”
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Do questions reflecting indoor air pollutant exposure from a questionnaire predict direct measure of exposure in owner-occupied houses? by Loo, C K Jennifer, Foty, Richard G, Wheeler, Amanda J, Miller, J David, Evans, Greg, Stieb, David M, Dell, Sharon D

“…Home characteristic questions are used in epidemiological studies and clinical settings to assess potentially harmful exposures in the home. The objective of…”
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