Search Results - "Lonskaya, Irina"

Ubiquitination increases parkin activity to promote autophagic α-synuclein clearance by Lonskaya, Irina, Desforges, Nicole M, Hebron, Michaeline L, Moussa, Charbel E-H

“…Parkinson's disease (PD) is a movement disorder associated with genetic and age related causes. Although autosomal recessive early onset PD linked to parkin…”
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Tyrosine kinase inhibition increases functional parkin‐Beclin‐1 interaction and enhances amyloid clearance and cognitive performance by Lonskaya, Irina, Hebron, Michaeline L., Desforges, Nicole M., Franjie, Alexander, Moussa, Charbel E.‐H.

“…Tyrosine kinase inhibitors (TKIs) are effective therapies for leukaemia. Alzheimer is a neurodegenerative disease characterized by accumulation of β‐amyloid…”
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Mechanisms of Unphosphorylated STAT3 Transcription Factor Binding to DNA by Timofeeva, Olga A., Chasovskikh, Sergey, Lonskaya, Irina, Tarasova, Nadya I., Khavrutskii, Lyuba, Tarasov, Sergey G., Zhang, Xueping, Korostyshevskiy, Valeriy R., Cheema, Amrita, Zhang, Lihua, Dakshanamurthy, Sivanesan, Brown, Milton L., Dritschilo, Anatoly

“…Phosphorylation of signal transducer and activator of transcription 3 (STAT3) on a single tyrosine residue in response to growth factors, cytokines,…”
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Tyrosine kinase inhibition reverses TDP‐43 effects on synaptic protein expression, astrocytic function and amino acid dis‐homeostasis by Heyburn, Lanier, Hebron, Michaeline L., Smith, Jacqueline, Winston, Charisse, Bechara, John, Li, Zhaoxia, Lonskaya, Irina, Burns, Mark P., Harris, Brent T., Moussa, Charbel E.‐H.

“…The trans‐activating response of DNA/RNA‐binding protein (TDP)‐43 pathology is associated with many neurodegenerative diseases via unknown mechanisms. Here, we…”
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Parkin-mediated reduction of nuclear and soluble TDP-43 reverses behavioral decline in symptomatic mice by Wenqiang, Chen, Lonskaya, Irina, Hebron, Michaeline L, Ibrahim, Zainab, Olszewski, Rafal T, Neale, Joseph H, Moussa, Charbel E-H

“…The transactivation DNA-binding protein (TDP)-43 binds to thousands of mRNAs, but the functional outcomes of this binding remain largely unknown. TDP-43 binds…”
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Methamphetamine‐associated cleavage of the synaptic adhesion molecule intercellular adhesion molecule‐5 by Conant, Katherine, Lonskaya, Irina, Szklarczyk, Arek, Krall, Caroline, Steiner, Joseph, Maguire‐Zeiss, Kathleen, Lim, Seung T.

“…J. Neurochem. (2011) 118, 521–532. Methamphetamine (MA) is a highly addictive psychostimulant that, used in excess, may be neurotoxic. Although the mechanisms…”
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Soluble ICAM-5, a product of activity dependent proteolysis, increases mEPSC frequency and dendritic expression of GluA1 by Lonskaya, Irina, Partridge, John, Lalchandani, Rupa R, Chung, Andrew, Lee, Taehee, Vicini, Stefano, Hoe, Hyang-Sook, Lim, Seung T, Conant, Katherine

“…Matrix metalloproteinases (MMPs) are zinc dependent endopeptidases that can be released from neurons in an activity dependent manner to play a role in varied…”
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Regulation of Poly(ADP-ribose) Polymerase-1 by DNA Structure-specific Binding by Lonskaya, Irina, Potaman, Vladimir N., Shlyakhtenko, Luda S., Oussatcheva, Elena A., Lyubchenko, Yuri L., Soldatenkov, Viatcheslav A.

“…Poly(ADP-ribose) polymerase-1 (PARP-1) is an intracellular sensor of DNA strand breaks and plays a critical role in cellular responses to DNA damage. In…”
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Fractalkine Mediates Communication between Pathogenic Proteins and Microglia : Implications of Anti-Inflammatory Treatments in Different Stages of Neurodegenerative Diseases by Desforges, Nicole M., Hebron, Michaeline L., Algarzae, Norah K., Lonskaya, Irina, Moussa, Charbel E.-H.

“…The role of inflammation in neurodegenerative diseases has been widely demonstrated. Intraneuronal protein accumulation may regulate microglial activity via…”
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Nilotinib reverses loss of dopamine neurons and improves motor behavior via autophagic degradation of [alpha]-synuclein in Parkinson's disease models by Hebron, Michaeline L, Lonskaya, Irina, Moussa, Charbel E-H

“…Parkinson's disease is a movement disorder characterized by death of dopaminergic substantia nigra (SN) neurons and brain accumulation of alpha -synuclein. The…”
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Ubiquitin specific protease-13 independently regulates parkin ubiquitination and alpha-synuclein clearance in alpha-synucleinopathies by Liu, Xiaoguang, Hebron, Michaeline, Shi, Wangke, Lonskaya, Irina, Moussa, Charbel E-H

“…Abstract Ubiquitin specific proteases (USPs) are de-ubiquitinases (DUBs) that control protein ubiquitination cycle. The role of DUBs is poorly understood in…”
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Nilotinib-induced autophagic changes increase endogenous parkin level and ubiquitination, leading to amyloid clearance by Lonskaya, Irina, Hebron, Michaeline L., Desforges, Nicole M., Schachter, Joel B., Moussa, Charbel E-H

“…Alzheimer's disease (AD) is a neurodegenerative disorder associated with amyloid accumulation and autophagic changes. Parkin is an E3 ubiquitin ligase involved…”
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Tau deletion impairs intracellular β-amyloid-42 clearance and leads to more extracellular plaque deposition in gene transfer models by Lonskaya, Irina, Hebron, Michaeline, Chen, Wenqiang, Schachter, Joel, Moussa, Charbel

“…Tau is an axonal protein that binds to and regulates microtubule function. Hyper-phosphorylation of Tau reduces its binding to microtubules and it is…”
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Discoidin domain receptor inhibition reduces neuropathology and attenuates inflammation in neurodegeneration models by Hebron, Michaeline, Peyton, Margo, Liu, Xiaoguang, Gao, Xiaokong, Wang, Ruochong, Lonskaya, Irina, Moussa, Charbel E.-H.

“…The role of cell surface tyrosine kinase collagen-activated receptors known as discoidin domain receptors (DDRs) is unknown in neurodegenerative diseases. We…”
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Correction: Parkin ubiquitinates TAR-DNA binding protein-43 (TDP-43) and promotes its cytosolic accumulation via interaction with histone deacetylase 6 (HDAC6) by Hebron, Michaeline L., Lonskaya, Irina, Sharpe, Kaydee, Weerasinghe, Puwakdandawe P.K., Algarzae, Norah K., Shekoyan, Ashot R., Moussa, Charbel E.-H.

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Parkin Ubiquitinates Tar-DNA Binding Protein-43 (TDP-43) and Promotes Its Cytosolic Accumulation via Interaction with Histone Deacetylase 6 (HDAC6) by Hebron, Michaeline L., Lonskaya, Irina, Sharpe, Kaydee, Weerasinghe, Puwakdandawe P.K., Algarzae, Norah K., Shekoyan, Ashot R., Moussa, Charbel E.-H.

“…The importance of E3 ubiquitin ligases, involved in the degradation of misfolded proteins or promotion of protein-protein interaction, is increasingly…”
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[O1–14–02]: A NOVEL DISCOIDIN DOMAIN RECEPTOR INHIBITOR REDUCES NEUROPATHOLOGY AND ATTENUATES INFLAMMATION IN ALZHEIMER AND PARKINSON MODELS by E‐H Moussa, Charbel, Hebron, Michaeline, Lonskaya, Irina

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Tyrosine kinase inhibition facilitates autophagic SNCA/α-synuclein clearance by Hebron, Michaeline L., Lonskaya, Irina, Moussa, Charbel E.-H.

“…The effects of ABL1/ABL inhibition on clearance of SNCA/α-synuclein were evaluated in animal models of α-synucleinopathies. Parkinson disease (PD) is a…”
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Diminished parkin solubility and co-localization with intraneuronal amyloid-β are associated with autophagic defects in Alzheimer's disease by Lonskaya, Irina, Shekoyan, Ashot R, Hebron, Michaeline L, Desforges, Nicole, Algarzae, Norah K, Moussa, Charbel E-H

“…Alzheimer's disease (AD) is an aging disorder characterized by amyloid-β (Aβ) accumulation in extracellular plaques and formation of intracellular tangles…”
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Parkin reverses TDP‐43‐induced cell death and failure of amino acid homeostasis by Hebron, Michaeline, Chen, Wenqiang, Miessau, Matthew J., Lonskaya, Irina, Moussa, Charbel E.‐H.

“…The E3 ubiquitin ligase Parkin plays a central role in the pathogenesis of many neurodegenerative diseases. Parkin promotes specific ubiquitination and affects…”
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