Search Results - "Lonigro, R."

The neuronal repellent SLIT2 is a target for repression by EZH2 in prostate cancer by Yu, J, Cao, Q, Yu, J, Wu, L, Dallol, A, Li, J, Chen, G, Grasso, C, Cao, X, Lonigro, R J, Varambally, S, Mehra, R, Palanisamy, N, Wu, J Y, Latif, F, Chinnaiyan, A M

“…The neuronal repellent SLIT2 is repressed in a number of cancer types primarily through promoter hypermethylation. SLIT2, however, has not been studied in…”
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A thyroid‐specific nuclear protein essential for tissue‐specific expression of the thyroglobulin promoter by Civitareale, D., Lonigro, R., Sinclair, A.J., Di Lauro, R.

“…A rat thyroglobulin promoter fragment, capable of directing thyroid‐specific transcription, binds at least three different factors, TTF‐1, TTF‐2 and UFA, which…”
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TTF-1 gene expression in human lung tumours by Fabbro, D., Di Loreto, C., Stamerra, O., Beltrami, C. Alberto, Lonigro, R., Damante, G.

“…Tissue-specific transcription factors control cell determination and differentiation. TTF-1 is a tissue-specific transcription factor expressed in the thyroid…”
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A versatile method for gene dosage quantification: multiplex PCR and single base extension for copy number and gene-conversion identification of SMN genes by Radovic, S, Dubsky De Wittenau, G, Mandl, N, Betto, E, Curcio, F, Morgante, M, Lonigro, I R

“…A comparison of the individual genomes within a species demonstrates that structural variation, including copy number variation (CNV), is a major contributor…”
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The thyroid transcription factor‐1 gene is a candidate target for regulation by Hox proteins by Guazzi, S., Lonigro, R., Pintonello, L., Boncinelli, E., Di Lauro, R., Mavilio, F.

“…Vertebrate Hox homeobox genes are transcription factors which regulate antero‐posterior axial identity in embryogenesis, presumably through activation and/or…”
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Thyroid-Specific Gene Expression Is Differentially Influenced by Intracellular Glutathione Level in FRTL-5 Cells by Lonigro, R., Donnini, D., Fabbro, D., Perrella, G., Damante, G., Ambesi Impiombato, F. S., Curcio, F.

“…Abstract Alteration of the redox potential has been proposed as a mechanism influencing gene expression. Reduced glutathione (GSH) is one of the cellular…”
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APE/Ref-1 is controlled by both redox and cAMP-dependent mechanisms in rat thyroid cells by Tell, G, Pines, A, Pandolfi, M, D'Elia, A V, Donnini, D, Lonigro, R, Manzini, G, Russo, D, Di Loreto, C, Damante, G

“…APE/Ref-1 is a multifunctional protein possessing both redox and DNA repair functions. Through its redox activity, APE/Ref-1 controls the DNA-binding function…”
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Abstract PD9-12: Integrative molecular profiling of breast cancer brain metastasis and patient-derived xenograft organoids from resected breast cancer brain metastases to interrogate and prioritize therapeutic personalized strategies by Morikawa, A, Robinson, DR, Soellner, M, Wu, Y-M, Lonigro, R, Gilani, R, Cheng, X, Lachacz, E, Thomas, D, McMurray, K, Smerage, J, Henry, NL, Heth, J, Chinnaiyan, A, Hayes, DF, Merajver, S

“…Background: Breast cancer brain metastasis (BM) is an area of unmet need in metastatic breast cancer patients. Novel therapeutic interventions to help prevent…”
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Abstract P2-09-26: Frequency and mechanisms of elevated somatic mutation burden in metastatic breast cancer and response to immune checkpoint blockade by Cobain, EF, Robinson, DR, Wu, Y-M, Lonigro, R, Vats, P, Rabban, E, Kumar-Sinha, C, Schott, AF, Smerage, JB, Morikawa, A, Burness, ML, Van Poznak, CH, Griggs, J, Wicha, M, Hayes, DF, Chinnaiyan, AM

“…Background: Immune checkpoint blockade (ICB) is effective in the treatment of various malignancies. Thus far, however, results in breast cancer have been…”
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Definition of the DNA-Binding Specificity of TTF-1 Homeodomain by Chromatographic Selection of Binding Sequences by Fabbro, D., Tell, G., Pellizzari, L., Leonardi, A., Pucillo, C., Lonigro, R., Damante, G.

“…The homeodomain of the thyroid transcription factor-1 (TTF-1HD) shows a peculiar DNA-binding specificity, preferentially recognizing sequences having the…”
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Molecular events in the differentiation of the thyroid gland by DI LAURO, R, DAMANTE, G, DE FELICE, M, ARNONE, M. I, SATO, K, LONIGRO, R, ZANNINI, M

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Role of Transcriptional Co-Repressor CtBP1 in Prostate Cancer Progression by Wang, R, Asangani, IA, Chakravarthi, BVSK, Ateeq, B, Lonigro, R J, Cao, Q, Mani, R-S, Camacho, D F, McGregor, N, Schumann, TEW, Jing, X, Menawat, R, Tomlins, SA, Zheng, H

“…Transcriptional repressors and co-repressors play a critical role in cellular homeostasis and are frequently altered in cancer. C-terminal Binding Protein 1…”
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Detection of Somatic Copy Number Alterations in Cancer Employing Targeted Exome Capture Sequencing by Lonigro, R J, Grasso, C S, Robinson, DR, Jing, X, Wu, Y-M, Cao, X, Quist, MJ, Tomlins, SA, Pienta, K J, Chinnaiyan, A M

“…The research community at large is expending considerable resources to sequence the coding region of the genomes of tumors and other human diseases using…”
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Distribution of tightly bound non-histone proteins in chromatin fractions obtained by DNAase II digestion by Lonigro, R I, Altieri, F, Allegra, P, Caiafa, P

“…Digestion of pig liver chromatin with DNAse II afforded three different fractions which were characterized in terms of their DNA, RNA and tightly bound…”
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A simple multiplex real-time PCR methodology for the SMN1 gene copy number quantification by Passon, Nadia, Pozzo, Federico, Molinis, Cristiano, Bregant, Elisa, Gellera, Cinzia, Damante, Giuseppe, Lonigro, Renata I

“…Spinal muscular atrophy (SMA) is an autosomal recessive disease caused, in about 95% of SMA cases, by homozygous deletion of the survival motor neuron 1 (SMN1)…”
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Governing equations of motion for the otolith organs and their response to a step change in velocity of the skull by Grant, J W, Best, W A, LoNigro, R

“…The otolith organs are the linear motion sensors of the inner ear. They comprise an overdamped second-order system and respond to gravity and skull…”
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Missense mutations of human homeoboxes: A review by D'Elia, Angela V., Tell, Gianluca, Paron, Igor, Pellizzari, Lucia, Lonigro, Renata, Damante, Giuseppe

“…The homeodomain (encoded by the homeobox) is the DNA‐binding domain of a large variety of transcriptional regulators involved in controlling cell fate…”
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Correlations between individual clinical manifestations and CTG repeat amplification in myotonic dystrophy by Marchini, Corrado, Lonigro, Renata, Verriello, Lorenzo, Pellizzari, Lucia, Bergonzi, Paolo, Damante, Giuseppe

“…Myotonic dystrophy (DM) is a multisystemic disease caused by the expansion of a CTG repeat, located in the 3′‐untranslated region of the DMPK gene. The number…”
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Distribution of tissue‐specific tightly bound non‐histone proteins in the first level of repeating chromatin structures by ALTIERI, Fabio, ALLEGRA, Paola, LONIGRO, Renata I., SCARPA, Sigfrido, CAIAFA, Paola

“…Non‐histone proteins, tightly bound to DNA, have been extracted from whole chromatin and core particles prepared from pig liver or kidney. We have investigated…”
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Nestin Is a Neuroepithelial Target Gene of Thyroid Transcription Factor-1, a Homeoprotein Required for Forebrain Organogenesis by Lonigro, Renata, Donnini, Deborah, Zappia, Emanuela, Damante, Giuseppe, Bianchi, Marco E., Guazzi, Stefania

“…Thyroid transcription factor-1 (TTF-1, also known as NKX2.1 and T/EBP), a transcription factor belonging to the NKX-2 family of homeodomain-containing genes,…”
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