Search Results - "Longo, Lawrence D"

Antenatal maternal hypoxia: criterion for fetal growth restriction in rodents by Jang, Eeun Amy, Longo, Lawrence D, Goyal, Ravi

“…Rodents are a useful model for life science research. Accumulating evidence suggests that the offspring of mice and rats suffer from similar disorders as…”
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Metabolic Profiles in Ovine Carotid Arteries with Developmental Maturation and Long-Term Hypoxia by Goyal, Ravi, Longo, Lawrence D

“…Long-term hypoxia (LTH) is an important stressor related to health and disease during development. At different time points from fetus to adult, we are exposed…”
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Acclimatization to long-term hypoxia: gene expression in ovine carotid arteries by Goyal, Ravi, Longo, Lawrence D

“…Exposure to acute high-altitude hypoxia is associated with an increase in cerebral blood flow (CBF) as a consequence of low arterial O2 tension. However, in…”
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Microarray gene expression analysis in ovine ductus arteriosus during fetal development and birth transition by Goyal, Ravi, Goyal, Dipali, Longo, Lawrence D., Clyman, Ronald I.

“…Background: Patent ductus arteriosus (PDA) in the newborn is the most common congenital heart anomaly and is significantly more common in preterm infants…”
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Pulmonary artery smooth muscle cell proliferation and migration in fetal lambs acclimatized to high-altitude long-term hypoxia: role of histone acetylation by Yang, Qiwei, Lu, Ziyan, Ramchandran, Ramaswamy, Longo, Lawrence D, Raj, J Usha

“…High-altitude long-term hypoxia (LTH) is known to induce pulmonary arterial smooth muscle cell (PASMC) proliferation in the fetus, leading to pulmonary…”
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Maternal protein deprivation: sexually dimorphic programming of hypertension in the mouse by Goyal, Ravi, Longo, Lawrence D

“…Epidemiological data in humans and experiments in laboratory animals have demonstrated that the developmental programming of hypertension may occur as a…”
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Macrophage gene expression associated with remodeling of the prepartum rat cervix: microarray and pathway analyses by Dobyns, Abigail E, Goyal, Ravi, Carpenter, Lauren Grisham, Freeman, Tom C, Longo, Lawrence D, Yellon, Steven M

“…As the critical gatekeeper for birth, prepartum remodeling of the cervix is associated with increased resident macrophages (Mφ), proinflammatory processes, and…”
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Antenatal maternal long-term hypoxia: acclimatization responses with altered gene expression in ovine fetal carotid arteries by Goyal, Ravi, Van Wickle, Jonathan, Goyal, Dipali, Matei, Nathanael, Longo, Lawrence D

“…In humans and other species, long-term hypoxia (LTH) during pregnancy can lead to intrauterine growth restriction with reduced body/brain weight, dysregulation…”
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Long-Term High-Altitude Hypoxia and Alpha Adrenoceptor-Dependent Pulmonary Arterial Contractions in Fetal and Adult Sheep by Moretta, Dafne, Papamatheakis, Demosthenes G, Morris, Daniel P, Giri, Paresh C, Blood, Quintin, Murray, Samuel, Ramzy, Marian, Romero, Monica, Vemulakonda, Srilakshmi, Lauw, Sidney, Longo, Lawrence D, Zhang, Lubo, Wilson, Sean M

“…Autonomic innervation of the pulmonary vasculature triggers vasomotor contractility predominately through activation of alpha-adrenergic receptors (α-ARs) in…”
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Temporal Dissection of Rate Limiting Transcriptional Events Using Pol II ChIP and RNA Analysis of Adrenergic Stress Gene Activation by Morris, Daniel P, Lei, Beilei, Longo, Lawrence D, Bomsztyk, Karol, Schwinn, Debra A, Michelotti, Gregory A

“…In mammals, increasing evidence supports mechanisms of co-transcriptional gene regulation and the generality of genetic control subsequent to RNA polymerase II…”
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Increased Carbon Monoxide Clearance during Exercise in Humans by ZAVORSKY, Gerald S, SMOLIGA, James M, LONGO, Lawrence D, UHRANOWSKY, Kathy A, CADMAN, Christopher R, DUFFIN, James, FISHER, Joseph A

“…Hyperventilation increases the clearance of carbon monoxide (CO) from blood; thus, we hypothesized that CO elimination would be enhanced with exercise…”
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Role of Rho kinases in PKG-mediated relaxation of pulmonary arteries of fetal lambs exposed to chronic high altitude hypoxia by Gao, Yuansheng, Portugal, Ada D, Negash, Sewite, Zhou, Weilin, Longo, Lawrence D, Usha Raj, J

“…An increase in Rho kinase (ROCK) activity is implicated in chronic hypoxia-induced pulmonary hypertension. In the present study, we determined the role of…”
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Sir Joseph Barcroft: one victorian physiologist's contributions to a half century of discovery by Longo, Lawrence D.

“…During the first half of the 20th Century, Joseph Barcroft, KBE, FRS of Cambridge University became a world leader in respiratory physiology. He determined the…”
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Fetal cerebral blood flow, electrocorticographic activity, and oxygenation: responses to acute hypoxia by Stephen J. Lee, Douglas P. Hatran, Takuji Tomimatsu, Jorge Pereyra Peña, Grant McAuley, Lawrence D. Longo

“…Arterial blood gases are critical in regulation of cerebral blood flow (CBF) and cerebral metabolic rate for O 2 (CMRO 2 ). However, the relation of these…”
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Role of KATP and L-type Ca2+ channel activities in regulation of ovine uterine vascular contractility: effect of pregnancy and chronic hypoxia by Xiao, Daliao, PhD, Longo, Lawrence D., MD, Zhang, Lubo, PhD

“…Objective Our objective was to determine whether the pregnancy and high altitude long-term hypoxia-mediated changes in uterine artery contractility were…”
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Cerebral artery alpha-1 AR subtypes: high altitude long-term acclimatization responses by Goyal, Ravi, Goyal, Dipali, Chu, Nina, Van Wickle, Jonathan, Longo, Lawrence D

“…In response to hypoxia and other stress, the sympathetic (adrenergic) nervous system regulates arterial contractility and blood flow, partly through…”
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Cerebral blood flow and oxygenation in ovine fetus: responses to superimposed hypoxia at both low and high altitude by Peňa, Jorge Pereyra, Tomimatsu, Takuji, Hatran, Douglas P., McGill, Lisa L., Longo, Lawrence D.

“…For the fetus, although the roles of arterial blood gases are recognized to be critical in the regulation of cerebral blood flow (CBF) and cerebral…”
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A challenge for the 21st century: whither physician-scientists in obstetrics, gynecology, and the reproductive sciences? by Longo, Lawrence D., MD, Jaffe, Robert B., MD

“…As we begin a new century, research in obstetrics and gynecology and its subspecialties face a crisis. Federal support to academic departments of obstetrics…”
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Exercise Guidelines in Pregnancy: New Perspectives by Zavorsky, Gerald S., Longo, Lawrence D.

“…In 2002, the American College of Obstetricians and Gynecologists published exercise guidelines for pregnancy, which suggested that in the absence of medical or…”
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Brain renin-angiotensin system: fetal epigenetic programming by maternal protein restriction during pregnancy by Goyal, Ravi, Goyal, Dipali, Leitzke, Arthur, Gheorghe, Ciprian P, Longo, Lawrence D

“…Maternal protein malnutrition during pregnancy can lead to significant alterations in the systemic renin-angiotensin system (RAS) in the fetus. All components…”
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