Search Results - "Longo, Joseph"

Statins as Anticancer Agents in the Era of Precision Medicine by Longo, Joseph, van Leeuwen, Jenna E, Elbaz, Mohamad, Branchard, Emily, Penn, Linda Z

“…Statins are widely prescribed cholesterol-lowering drugs that inhibit HMG-CoA reductase (HMGCR), the rate-limiting enzyme of the mevalonate metabolic pathway…”
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Evaluating possible maternal effect lethality and genetic background effects in Naa10 knockout mice by Lyon, Gholson J, Longo, Joseph, Garcia, Andrew, Inusa, Fatima, Marchi, Elaine, Shi, Daniel, Dörfel, Max, Arnesen, Thomas, Aldabe, Rafael, Lyons, Scott, Nashat, Melissa A, Bolton, David

“…Amino-terminal (Nt-) acetylation (NTA) is a common protein modification, affecting approximately 80% of all human proteins. The human essential X-linked gene,…”
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Computational pharmacogenomic screen identifies drugs that potentiate the anti-breast cancer activity of statins by van Leeuwen, Jenna E., Ba-Alawi, Wail, Branchard, Emily, Cruickshank, Jennifer, Schormann, Wiebke, Longo, Joseph, Silvester, Jennifer, Gross, Peter L., Andrews, David W., Cescon, David W., Haibe-Kains, Benjamin, Penn, Linda Z., Gendoo, Deena M. A.

“…Statins, a family of FDA-approved cholesterol-lowering drugs that inhibit the rate-limiting enzyme of the mevalonate metabolic pathway, have demonstrated…”
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Acod1 expression in cancer cells promotes immune evasion through the generation of inhibitory peptides by Schofield, James H., Longo, Joseph, Sheldon, Ryan D., Albano, Emma, Ellis, Abigail E., Hawk, Mark A., Murphy, Sean, Duong, Loan, Rahmy, Sharif, Lu, Xin, Jones, Russell G., Schafer, Zachary T.

“…Targeting programmed cell death protein 1 (PD-1) is an important component of many immune checkpoint blockade (ICB) therapeutic approaches. However, ICB is not…”
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An actionable sterol-regulated feedback loop modulates statin sensitivity in prostate cancer by Longo, Joseph, Mullen, Peter J., Yu, Rosemary, van Leeuwen, Jenna E., Masoomian, Mehdi, Woon, Dixon T.S., Wang, Yuzhuo, Chen, Eric X., Hamilton, Robert J., Sweet, Joan M., van der Kwast, Theodorus H., Fleshner, Neil E., Penn, Linda Z.

“…The statin family of cholesterol-lowering drugs has been shown to induce tumor-specific apoptosis by inhibiting the rate-limiting enzyme of the mevalonate…”
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Cyclic AMP‐hydrolyzing phosphodiesterase inhibitors potentiate statin‐induced cancer cell death by Longo, Joseph, Pandyra, Aleksandra A., Stachura, Paweł, Minden, Mark D., Schimmer, Aaron D., Penn, Linda Z.

“…Dipyridamole, an antiplatelet drug, synergizes with statins to induce tumor‐specific apoptosis. Here, we took a pharmacological approach to dissect the…”
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Modelling the MYC-driven normal-to-tumour switch in breast cancer by Lourenco, Corey, Kalkat, Manpreet, Houlahan, Kathleen E, De Melo, Jason, Longo, Joseph, Done, Susan J, Boutros, Paul C, Penn, Linda Z

“…The potent MYC oncoprotein is deregulated in many human cancers, including breast carcinoma, and is associated with aggressive disease. To understand the…”
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P238: Discovery of the phenotypic landscape and mechanistic understanding of NAA10-related and NAA15-related neurodevelopmental syndromes, using mouse models and iPSCs by Lyon, Gholson, Vedaie, Marall, Beisheim, Travis, Park, Agnes, Marchi, Elaine, Gottlieb, Leah, Starr, Lois, Sandomirsky, Katherine, Cheng, Hanyin, Preddy, Isabelle, Tseng, Marcellus, Li, Quan, Wang, Kai, Gavin, Maureen, Amble, Karen, Marmorstein, Ronen, Herr-Israel, Ellen, Harpell, Randie, Nashat, Melissa, Ma, Ning, Belbachir, Nadjet, Wu, Joseph, Hsieh, Tzung-Chien, Krawitz, Peter, Rope, Alan, Monsma, Frederick, Wesely, Josephine, Chen, Yu-Ren, Hunter, Christopher, Bauer, Lauren, Rusielewicz, Tom, Kneeland, Stephen, Lutz, Cat, Snow, Kathy, Murray, Steve, Gropman, Andrea, Whitehead, Matthew, Garcia, Andrew, Inusa, Fatima, Longo, Joseph, Fleischer, Nicole, Bolton, David, Reese, Martin, Hu, Yu

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The interplay between cell signalling and the mevalonate pathway in cancer by Mullen, Peter J., Yu, Rosemary, Longo, Joseph, Archer, Michael C., Penn, Linda Z.

“…Key Points Mevalonate (MVA) pathway metabolites are essential for cancer cell survival and growth. Expression of the genes encoding MVA pathway enzymes is…”
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Vitamin C protects low-density lipoprotein from homocysteine-mediated oxidation by Alul, Rushdi H, Wood, Michael, Longo, Joseph, Marcotte, Anthony L, Campione, Allan L, Moore, Michael K, Lynch, Sean M

“…Homocysteine, an atherogenic amino acid, promotes iron-dependent oxidation of low-density lipoprotein (LDL). We investigated whether vitamin C, a physiological…”
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Demonstration of INCC6 for advanced list-mode data acquisition and analysis using ALMM by Ogren, Kristofer Bengtt, Henzlova, Daniela Constance, Longo, Joseph Francis, Rael, Carlos D.

“…The International Neutron Coincidence Counting (INCC) software plays an important role in nuclear safeguards and nuclear material control and accounting…”
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Comparison of CFD and EFD for the Series 60 C B = 0.6 in steady drift motion by Tahara, Yusuke, Longo, Joseph, Stern, Frederick

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Statin Concentration in Prostatic Tissue is Subtype- and Dose-dependent by Chavarriaga, Julian, Penn, Linda Z., Khurram, Najia, Lajkosz, Katherine, Longo, Joseph, Chen, Eric, Fleshner, Neil, van der Kwast, Theodorus, Hamilton, Robert J.

“…To evaluate for the first time, comparative serum and prostate tissue concentrations of lipophilic and hydrophilic statins. After reviewing all patients who…”
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Carbon source availability drives nutrient utilization in CD8+ T cells by Kaymak, Irem, Luda, Katarzyna M., Duimstra, Lauren R., Ma, Eric H., Longo, Joseph, Dahabieh, Michael S., Faubert, Brandon, Oswald, Brandon M., Watson, McLane J., Kitchen-Goosen, Susan M., DeCamp, Lisa M., Compton, Shelby E., Fu, Zhen, DeBerardinis, Ralph J., Williams, Kelsey S., Sheldon, Ryan D., Jones, Russell G.

“…How environmental nutrient availability impacts T cell metabolism and function remains poorly understood. Here, we report that the presence of physiologic…”
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Benchmark CFD validation data for surface combatant 5415 in PMM maneuvers – Part II: Phase-averaged stereoscopic PIV flow field measurements by Yoon, Hyunse, Longo, Joseph, Toda, Yasuyuki, Stern, Frederick

“…Part II of this two-part paper presents computational fluid dynamics (CFD) benchmark local flow field measurements for a surface combatant in dynamic…”
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Statin-Induced Cancer Cell Death Can Be Mechanistically Uncoupled from Prenylation of RAS Family Proteins by Yu, Rosemary, Longo, Joseph, van Leeuwen, Jenna E, Mullen, Peter J, Ba-Alawi, Wail, Haibe-Kains, Benjamin, Penn, Linda Z

“…The statin family of drugs preferentially triggers tumor cell apoptosis by depleting mevalonate pathway metabolites farnesyl pyrophosphate (FPP) and…”
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Statins and prostate cancer—hype or hope? The biological perspective by Longo, Joseph, Freedland, Stephen J., Penn, Linda Z., Hamilton, Robert J.

“…Growing evidence suggests that men prescribed a statin for cholesterol control have a lower risk of advanced prostate cancer (PCa) and improved treatment…”
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PYGBacking on glycogen metabolism to fuel early memory T cell recall responses by Longo, Joseph, Watson, McLane J, Vos, Matthew J, Williams, Kelsey S, Jones, Russell G

“…Zhang et al. (2022) show that TCR signaling promotes the phosphorylation and activation of glycogen phosphorylase B (PYGB) in CD8 memory T (Tmem) cells…”
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Benchmark CFD validation data for surface combatant 5415 in PMM maneuvers – Part I: Force/moment/motion measurements by Yoon, Hyunse, Simonsen, Claus D., Benedetti, Lanfranco, Longo, Joseph, Toda, Yasuyuki, Stern, Frederick

“…Part I of this two-part paper presents benchmark CFD validation force/moment/motion measurements for surface combatant 5415 in planar-motion-mechanism (PMM)…”
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Ketolysis drives CD8+ T cell effector function through effects on histone acetylation by Luda, Katarzyna M., Longo, Joseph, Kitchen-Goosen, Susan M., Duimstra, Lauren R., Ma, Eric H., Watson, McLane J., Oswald, Brandon M., Fu, Zhen, Madaj, Zachary, Kupai, Ariana, Dickson, Bradley M., DeCamp, Lisa M., Dahabieh, Michael S., Compton, Shelby E., Teis, Robert, Kaymak, Irem, Lau, Kin H., Kelly, Daniel P., Puchalska, Patrycja, Williams, Kelsey S., Krawczyk, Connie M., Lévesque, Dominique, Boisvert, François-Michel, Sheldon, Ryan D., Rothbart, Scott B., Crawford, Peter A., Jones, Russell G.

“…Environmental nutrient availability influences T cell metabolism, impacting T cell function and shaping immune outcomes. Here, we identified ketone bodies…”
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