Search Results - "Longmire, Tyler A."

Efficient Derivation of Purified Lung and Thyroid Progenitors from Embryonic Stem Cells by Longmire, Tyler A., Ikonomou, Laertis, Hawkins, Finn, Christodoulou, Constantina, Cao, Yuxia, Jean, J.C., Kwok, Letty W., Mou, Hongmei, Rajagopal, Jayaraj, Shen, Steven S., Dowton, Anne A., Serra, Maria, Weiss, Daniel J., Green, Michael D., Snoeck, Hans-Willem, Ramirez, Maria I., Kotton, Darrell N.

“…Two populations of Nkx2-1+ progenitors in the developing foregut endoderm give rise to the entire postnatal lung and thyroid epithelium, but little is known…”
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Mouse ES and iPS cells can form similar definitive endoderm despite differences in imprinted genes by Christodoulou, Constantina, Longmire, Tyler A, Shen, Steven S, Bourdon, Alice, Sommer, Cesar A, Gadue, Paul, Spira, Avrum, Gouon-Evans, Valerie, Murphy, George J, Mostoslavsky, Gustavo, Kotton, Darrell N

“…The directed differentiation of iPS and ES cells into definitive endoderm (DE) would allow the derivation of otherwise inaccessible progenitors for endodermal…”
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Phase I/Ib Clinical Trial of Sabatolimab, an Anti-TIM-3 Antibody, Alone and in Combination with Spartalizumab, an Anti-PD-1 Antibody, in Advanced Solid Tumors by Curigliano, Giuseppe, Gelderblom, Hans, Mach, Nicolas, Doi, Toshihiko, Tai, David, Forde, Patrick M, Sarantopoulos, John, Bedard, Philippe L, Lin, Chia-Chi, Hodi, F Stephen, Wilgenhof, Sofie, Santoro, Armando, Sabatos-Peyton, Catherine A, Longmire, Tyler A, Xyrafas, Alexandros, Sun, Haiying, Gutzwiller, Sabine, Manenti, Luigi, Naing, Aung

“…Sabatolimab (MBG453) and spartalizumab are mAbs that bind T-cell immunoglobulin domain and mucin domain-3 (TIM-3) and programmed death-1 (PD-1), respectively…”
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Inhibition of MDM2 Promotes Antitumor Responses in p53 Wild-Type Cancer Cells through Their Interaction with the Immune and Stromal Microenvironment by Wang, Hui Qin, Mulford, Iain J., Sharp, Fiona, Liang, Jinsheng, Kurtulus, Sema, Trabucco, Gina, Quinn, David S., Longmire, Tyler A., Patel, Nidhi, Patil, Roshani, Shirley, Matthew D., Chen, Yan, Wang, Hao, Ruddy, David A., Fabre, Claire, Williams, Juliet A., Hammerman, Peter S., Mataraza, Jennifer, Platzer, Barbara, Halilovic, Ensar

“…Abstract p53 is a transcription factor that plays a central role in guarding the genomic stability of cells through cell-cycle arrest or induction of…”
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Correction: Phase I/Ib Clinical Trial of Sabatolimab, an Anti-TIM-3 Antibody, Alone and in Combination with Spartalizumab, an Anti-PD-1 Antibody, in Advanced Solid Tumors by Curigliano, Giuseppe, Curigliano, Hans, Mach, Nicolas, Doi, Toshihiko, Tai, David, Forde, Patrick M, Sarantopoulos, John, Bedard, Philippe L, Lin, Chia-Chi, Hodi, F Stephen, Wilgenhof, Sofie, Santoro, Armando, Sabatos-Peyton, Catherine A, Longmire, Tyler A, Xyrafas, Alexandros, Sun, Haiying, Gutzwiller, Sabine, Manenti, Luigi, Naing, Aung

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Excision of Reprogramming Transgenes Improves the Differentiation Potential of iPS Cells Generated with a Single Excisable Vector by Sommer, Cesar A., Sommer, Andreia Gianotti, Longmire, Tyler A., Christodoulou, Constantina, Thomas, Dolly D., Gostissa, Monica, Alt, Fred W., Murphy, George J., Kotton, Darrell N., Mostoslavsky, Gustavo

“…The residual presence of integrated transgenes following the derivation of induced pluripotent stem (iPS) cells is highly undesirable. Here we demonstrate…”
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Mouse ESC Differentiation to Nkx2.1+ Lung and Thyroid Progenitors by Tyler Longmire, Laertis Ikonomou, Darrell Kotton

“…The de novo derivation of lung progenitors from pluripotent stem cells provides the opportunity to model early lung development in vitro and allows easy access…”
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Inhibition of MDM2 promotes anti-tumor responses in p53 wild-type cancer cells through their interaction with the immune and stromal microenvironment by Wang, Hui Qin, Mulford, Iain J, Sharp, Fiona, Liang, Jinsheng, Kurtulus, Sema, Trabucco, Gina, Quinn, David S, Longmire, Tyler A, Patel, Nidhi, Patil, Roshani, Shirley, Matthew D, Chen, Yan, Wang, Hao, Ruddy, David A, Fabre, Claire, Williams, Juliet A, Hammerman, Peter S, Mataraza, Jennifer, Platzer, Barbara, Halilovic, Ensar

“…p53 is a transcription factor that plays a central role in guarding the genomic stability of cells through cell cycle arrest or induction of apoptosis…”
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