Search Results - "Longley, Clifford"

Novel Prodrugs of SN38 Using Multiarm Poly(ethylene glycol) Linkers by Zhao, Hong, Rubio, Belen, Sapra, Puja, Wu, Dechun, Reddy, Prasanna, Sai, Prakash, Martinez, Anthony, Gao, Ying, Lozanguiez, Yoany, Longley, Clifford, Greenberger, Lee M, Horak, Ivan D

“…CPT-11, also known as irinotecan, is a prodrug that is approved for the treatment of advanced colorectal cancer. The active metabolite of CPT-11, SN38…”
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Novel Delivery of SN38 Markedly Inhibits Tumor Growth in Xenografts, Including a Camptothecin-11–Refractory Model by SAPRA, Puja, HONG ZHAO, MEHLIG, Mary, MALABY, Jennifer, KRAFT, Patricia, LONGLEY, Clifford, GREENBERGER, Lee M, HORAK, Ivan D

“…Purpose: Clinical development of SN38, the active metabolite of camptothecin-11 (CPT-11), has been hampered due to its poor solubility. We have developed a…”
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Biodistribution and excretion of radiolabeled 40 kDa polyethylene glycol following intravenous administration in mice by Longley, Clifford B, Zhao, Hong, Lozanguiez, Yoany L, Conover, Charles D

“…The pharmacokinetics, excretion, and tissue distribution of [(14)C]-labeled polyethylene glycol-alanine (PEG-Ala) were determined after slow bolus…”
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Expanding the Roles for Pregnane X Receptor in Cancer: Proliferation and Drug Resistance in Ovarian Cancer by GUPTA, Divya, VENKATESH, Madhukumar, HONGWEI WANG, KIM, Sean, SINZ, Michael, GOLDBERG, Gary L, WHITNEY, Kathleen, LONGLEY, Clifford, MANI, Sridhar

“…Purpose: We examined the presence of the pregnane X receptor (PXR) and its effects on ovarian cancer cells after activation by its cognate ligand. Experimental…”
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High-Dose Mannose-Binding Lectin Therapy for Ebola Virus Infection by Michelow, Ian C., Lear, Calli, Scully, Corinne, Prugar, Laura I., Longley, Clifford B., Yantosca, L. Michael, Ji, Xin, Karpel, Marshall, Brudner, Matthew, Takahashi, Kazue, Spear, Gregory T., Ezekowitz, R. Alan B., Schmidt, Emmett V., Olinger, Gene G.

“…Mannose-binding lectin (MBL) targets diverse microorganisms for phagocytosis and complement-mediated lysis by binding specific surface glycans. Although…”
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Utility of Poly(ethylene glycol) Conjugation To Create Prodrugs of Amphotericin B by Conover, Charles D, Zhao, Hong, Longley, Clifford B, Shum, Kwok L, Greenwald, Richard B

“…This paper reports on the synthesis, safety, and efficacy of a series of water-soluble derivatives of poly(ethylene glycol) (PEG)-conjugated amphotericin B…”
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Chlorobiphenyl-desleucyl-vancomycin inhibits the transglycosylation process required for peptidoglycan synthesis in bacteria in the absence of dipeptide binding by Goldman, Robert C, Baizman, Eugene R, Longley, Clifford B, Branstrom, Arthur A

“…Novel glycopeptide analogs are known that have activity on vancomycin resistant enterococci despite the fact that the primary site for drug interaction, d-ala-…”
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Antibacterial activity of synthetic analogues based on the disaccharide structure of moenomycin, an inhibitor of bacterial transglycosylase by Baizman, Eugene R, Branstrom, Arthur A, Longley, Clifford B, Allanson, Nigel, Sofia, Michael J, Gange, David, Goldman, Robert C

“…Advanced Medicine East Inc., 8 Clarke Drive, Cranbury, NJ 08512, USA 1 Author for correspondence: Eugene R. Baizman. Tel: +1 609 655 6925. Fax: +1 609 655…”
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Synthesis and Mode of Action of Hydrophobic Derivatives of the Glycopeptide Antibiotic Eremomycin and Des-(N-methyl-d-leucyl)eremomycin against Glycopeptide-Sensitive and -Resistant Bacteria by Printsevskaya, Svetlana S, Pavlov, Andrey Y, Olsufyeva, Evgenia N, Mirchink, Elena P, Isakova, Elena B, Reznikova, Marina I, Goldman, Robert C, Branstrom, Arthur A, Baizman, Eugene R, Longley, Clifford B, Sztaricskai, Ferenc, Batta, Gyula, Preobrazhenskaya, Maria N

“…Des-(N-methyl-d-leucyl)eremomycin was obtained by Edman degradation of eremomycin. Derivatives with a hydrophobic substituent at the exterior of the molecule…”
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Chlorobiphenyl-desleucyl-vancomycin inhibits the transglycosylation process required for peptidoglycan synthesis in bacteria in the absence of dipeptide binding by Goldman, Robert C., Baizman, Eugene R., Longley, Clifford B., Branstrom, Arthur A.

“…Abstract Novel glycopeptide analogs are known that have activity on vancomycin resistant enterococci despite the fact that the primary site for drug…”
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An unexpected amide bond cleavage: poly (ethylene glycol) transport forms of vancomycin. 2 by Greenwald, Richard B., Zhao, Hong, Peng, Ping, Longley, Clifford B., Dai, Qing-Hong, Xia, Jing, Martinez, Anthony

“…PEG-amide vancomycin derivatives (V 3 position) have been synthesized and found to behave as prodrugs in vivo, demonstrating anti-microbial activity in mice…”
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Differential antibacterial activity of moenomycin analogues on gram-positive bacteria by Goldman, Robert C, Baizman, Eugene R, Branstrom, Arthur A, Longley, Clifford B

“…The moenomycin trisaccharide degradation product and synthetic disaccharide analogues based on the disaccharide core were bactericidal to Gram-positive…”
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PEG prodrugs of 6-mercaptopurine for parenteral administration using benzyl elimination of thiols by Choe, Yun H, Greenwald, Richard B, Conover, Charles D, Zhao, Hong, Longley, Clifford B, Guan, Shuiyun, Zhao, Qiuxia, Xia, Jing

“…6-Mercaptopurine (6-MP) is an orally administered, water-insoluble purine analog that is effective against acute lymphatic leukemia. Oral absorption of 6-MP,…”
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Tumor Imaging with Technetium-99m-Labeled Hydrazinonicotinamide-Fab' Conjugates by Ultee, Michiel E, Bridger, Gary J, Abrams, Michael J, Longley, Clifford B, Burton, Charlotte A, Larsen, Scott K, Henson, Geoffrey W, Padmanabhan, Sreenivasan, Gaul, Forrest E, Schwartz, David A

“…This study compares the in vivo properties of direct versus indirect 99mTc-labeling for two Fab' fragments from antibodies that recognize tumor-associated…”
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Intestinal transport of gentamicin with a novel, glycosteroid drug transport agent by Axelrod, H. R., Kim, J. S., Longley, C. B., Lipka, E., Amidon, G. L., Kakarla, R., Hui, Y. W., Weber, S. J., Choe, S., Sofia, M. J.

“…PURPOSE: The objective was to investigate the ability of a glycosteroid (TC002) to increase the oral bioavailability of gentamicin. METHODS: Admixtures of…”
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Structure-function engineering of interferon-beta-1b for improving stability, solubility, potency, immunogenicity, and pharmacokinetic properties by site-selective mono-PEGylation by Basu, Amartya, Yang, Karen, Wang, Maoliang, Liu, Sam, Chintala, Ramesh, Palm, Thomas, Zhao, Hong, Peng, Ping, Wu, Dechun, Zhang, Zhenfan, Hua, Jack, Hsieh, Ming-Ching, Zhou, John, Petti, Gerald, Li, Xiguang, Janjua, Ahsen, Mendez, Magda, Liu, Jun, Longley, Clifford, Zhang, Zhihua, Mehlig, Mary, Borowski, Virna, Viswanathan, Manickam, Filpula, David

“…Recombinant interferon-beta-1b (IFN-beta-1b) is used clinically in the treatment of multiple sclerosis. In common with many biological ligands, IFN-beta-1b…”
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High-level conjugation of chelating agents onto immunoglobulins: use of an intermediary poly(L-lysine)-diethylenetriaminepentaacetic acid carrier by Manabe, Y, Longley, C, Furmanski, P

“…Diethylenetriaminepentaacetic acid (DTPA), a strong chelating agent, was covalently linked to murine monoclonal anti-HLA IgG1 antibody (H-1) with the use of…”
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A Comparison of Cleavable and Noncleavable Hydrazinopyridine Linkers for the 99mTc Labeling of Fab‘ Monoclonal Antibody Fragments by Bridger, Gary J, Abrams, Michael J, Padmanabhan, Sreenivasan, Gaul, Forrest, Larsen, Scott, Henson, Geoffrey W, Schwartz, David A, Longley, Clifford B, Burton, Charlotte A, Ultee, Michiel E

“…The design and synthesis of hydrazinopyridine bifunctional chelating agents (BCA's) featuring amide, ester, and disulfide groups are described. The BCA's…”
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Releasable PEGylation of Mesothelin Targeted Immunotoxin SS1P Achieves Single Dosage Complete Regression of a Human Carcinoma in Mice by Filpula, David, Yang, Karen, Basu, Amartya, Hassan, Raffit, Xiang, Laiman, Zhang, Zhenfan, Wang, Maoliang, Wang, Qing-cheng, Ho, Mitchell, Beers, Richard, Zhao, Hong, Peng, Ping, Zhou, John, Li, Xiguang, Petti, Gerald, Janjua, Ahsen, Liu, Jun, Wu, Dechun, Yu, Deshan, Zhang, Zhihua, Longley, Clifford, FitzGerald, David, Kreitman, Robert J, Pastan, Ira

“…Recombinant immunotoxins exhibit targeting and cytotoxic functions needed for cell-specific destruction. However, antitumor efficacy, safety, and…”
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Tailoring structure–function and pharmacokinetic properties of single‐chain Fv proteins by site‐specific PEGylation by Yang, Karen, Basu, Amartya, Wang, Maoliang, Chintala, Ramesh, Hsieh, Ming‐Ching, Liu, Sam, Hua, Jack, Zhang, Zhenfan, Zhou, John, Li, Mark, Phyu, Hnin, Petti, Gerald, Mendez, Magda, Janjua, Haleema, Peng, Ping, Longley, Clifford, Borowski, Virna, Mehlig, Mary, Filpula, David

“…The utility of single‐chain Fv proteins as therapeutic agents would be realized if the circulating lives of these minimal antigen‐binding polypeptides could be…”
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