Search Results - "Longhino, Laura"
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The Luxembourg Parkinson's Study: A Comprehensive Approach for Stratification and Early Diagnosis
Published in Frontiers in aging neuroscience (29-10-2018)“…While genetic advances have successfully defined part of the complexity in Parkinson's disease (PD), the clinical characterization of phenotypes remains…”
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Parkinson's disease-associated alterations of the gut microbiome predict disease-relevant changes in metabolic functions
Published in BMC biology (09-06-2020)“…Parkinson's disease (PD) is a systemic disease clinically defined by the degeneration of dopaminergic neurons in the brain. While alterations in the gut…”
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Similar α-Synuclein staining in the colon mucosa in patients with Parkinson's disease and controls
Published in Movement disorders (01-10-2016)“…ABSTRACT Background The gut is proposed as a starting point of idiopathic IPD, but the presence of α‐synuclein in the IPD colon mucosa is debated. Objectives…”
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Similar [alpha]-Synuclein staining in the colon mucosa in patients with Parkinson's disease and controls
Published in Movement disorders (01-10-2016)“…Background The gut is proposed as a starting point of idiopathic IPD, but the presence of [alpha]-synuclein in the IPD colon mucosa is debated. Objectives The…”
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Mixed effects models but not t-tests or linear regression detect progression of apathy in Parkinson's disease over seven years in a cohort: a comparative analysis
Published in BMC medical research methodology (24-08-2024)“…While there is an interest in defining longitudinal change in people with chronic illness like Parkinson's disease (PD), statistical analysis of longitudinal…”
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Levodopa-induced dyskinesia in Parkinson's disease: Insights from cross-cohort prognostic analysis using machine learning
Published in Parkinsonism & related disorders (01-09-2024)“…Prolonged levodopa treatment in Parkinson's disease (PD) often leads to motor complications, including levodopa-induced dyskinesia (LID). Despite continuous…”
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Cardiovascular history and risk of idiopathic Parkinson's disease: a cross-sectional observational study
Published in BMC neuroscience (08-07-2024)“…Parkinson's disease (PD), while often associated with its distinctive motor symptoms, can also exert a notable impact on the cardiovascular system due to the…”
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Enteric neurons reveal substantial ex vivo mitochondrial changes in Parkinson’s disease (P1.010)
Published in Neurology (18-04-2017)“…Abstract only…”
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Education as Risk Factor of Mild Cognitive Impairment: The Link to the Gut Microbiome
Published in The journal of prevention of Alzheimer's disease (2024)“…Background With differences apparent in the gut microbiome in mild cognitive impairment (MCI) and dementia, and risk factors of dementia linked to alterations…”
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Age at onset as stratifier in idiopathic Parkinson’s disease – effect of ageing and polygenic risk score on clinical phenotypes
Published in NPJ Parkinson's Disease (09-08-2022)“…Several phenotypic differences observed in Parkinson’s disease (PD) patients have been linked to age at onset (AAO). We endeavoured to find out whether these…”
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Gut microbiome is not associated with mild cognitive impairment in Parkinson’s disease
Published in NPJ Parkinson's Disease (06-04-2024)“…Gut microbiome differences between people with Parkinson’s disease (PD) and control subjects without Parkinsonism are widely reported, but potential…”
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Converging peripheral blood microRNA profiles in Parkinson's disease and progressive supranuclear palsy
Published in Brain communications (2024)“…MicroRNAs act via targeted suppression of messenger RNA translation in the DNA-RNA-protein axis. The dysregulation of microRNA(s) reflects the epigenetic…”
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Platelet mitochondrial membrane potential in Parkinson's disease
Published in Annals of clinical and translational neurology (01-01-2015)“…Objective Mitochondrial dysfunction is a hallmark of idiopathic Parkinson's disease (IPD), which has been reported not to be restricted to striatal neurons…”
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