Search Results - "Long, Vatana"

MGD011, A CD19 x CD3 Dual-Affinity Retargeting Bi-specific Molecule Incorporating Extended Circulating Half-life for the Treatment of B-Cell Malignancies by Liu, Liqin, Lam, Chia-Ying K, Long, Vatana, Widjaja, Lusiana, Yang, Yinhua, Li, Hua, Jin, Linda, Burke, Steve, Gorlatov, Sergey, Brown, Jennifer, Alderson, Ralph, Lewis, Margaret D, Nordstrom, Jeffrey L, Koenig, Scott, Moore, Paul A, Johnson, Syd, Bonvini, Ezio

“…CD19, a B-cell lineage-specific marker, is highly represented in B-cell malignancies and an attractive target for therapeutic interventions. MGD011 is a CD19 x…”
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Development of MGD007, a gpA33 x CD3-Bispecific DART Protein for T-Cell Immunotherapy of Metastatic Colorectal Cancer by Moore, Paul A, Shah, Kalpana, Yang, Yinhua, Alderson, Ralph, Roberts, Penny, Long, Vatana, Liu, Daorong, Li, Jonathan C, Burke, Steve, Ciccarone, Valentina, Li, Hua, Fieger, Claudia B, Hooley, Jeff, Easton, Ann, Licea, Monica, Gorlatov, Sergey, King, Kathy L, Young, Peter, Adami, Arash, Loo, Deryk, Chichili, Gurunadh R, Liu, Liqin, Smith, Douglas H, Brown, Jennifer G, Chen, Francine Z, Koenig, Scott, Mather, Jennie, Bonvini, Ezio, Johnson, Syd

“…We have developed MGD007 (anti-glycoprotein A33 x anti-CD3), a DART protein designed to redirect T cells to target gpA33 expressing colon cancer. The gpA33…”
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BLyS inhibition eliminates primary B cells but leaves natural and acquired humoral immunity intact by Scholz, Jean L, Crowley, Jenni E, Tomayko, Mary M, Steinel, Natalie, O'Neill, Patrick J, Quinn, William J. III, Goenka, Radhika, Miller, Juli P, Cho, Yun Hee, Long, Vatana, Ward, Chris, Migone, Thi-Sau, Shlomchik, Mark J, Cancro, Michael P

“…We have used an inhibiting antibody to determine whether preimmune versus antigen-experienced B cells differ in their requisites for BLyS, a cytokine that…”
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682 Antibody-mediated blockade of interleukin-10 receptor-alpha promotes the activation of immune cells from in vitro dissociated tumor samples by Berezhnoy, Alexey, Shah, Kalpana, Liu, Daorong, Lung, Peter, Long, Vatana, Stahl, Kurt, Smith, Douglas, Chen, Francine, Li, Hua, Li, Jonathan, Alderson, Ralph, Ciccarone, Valentina, Tamura, James, Bonvini, Ezio, Diedrich, Gundo, Moore, Paul

“…BackgroundInterleukin-10 (IL-10) is a multifunctional cytokine that can mediate immune suppression or activation depending on the immunological context. Mouse…”
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Abstract 1772: Immunotherapy of colorectal cancer by the T-cell targeted DART® protein MGD007: Cellular mechanisms of action by Moore, Paul A., Yang, Yinhua, Shah, Kalpana, Liu, Daorong, Long, Vatana, Smith, Douglas H., Pan, Zhuangyu, Alderson, Ralph, Liu, Liqin, Johnson, Syd, Bonvini, Ezio

“…Introduction MGD007 (glycoprotein A33 x CD3), a DART protein designed to redirect T cells to target gpA33-expressing colon cancer, is presently undergoing…”
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Abstract 1560: Selection of a bispecific trivalent HER2 x CD137 TRIDENT format providing optimal tumor-anchored immune co-stimulation by Liu, Liqin, Lam, Chia-Ying K., Alderson, Ralph, Long, Vatana, Yang, Yinhua, Burns, Robert, Widjaja, Lusiana, Li, Jonathan, Wolf, Christina, Ciccarone, Valentina, Tamura, James, Diedrich, Gundo, Bonvini, Ezio, Johnson, Syd, Moore, Paul A.

“…Introduction: CD137 (4-1BB) signaling provides co-stimulation of CD8 or NK cells following antigen or FcγR engagement, respectively. Efforts to leverage CD137…”
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Abstract 554: Tumor-antigen 5T4-dependent activation of the CD137 costimulatory pathway by bispecific 5T4 x CD137 x CD137 TRIDENT™ molecules by Liu, Liqin, Huang, Ling, Long, Vatana, Yang, Yinhua, Burns, Robert, Li, Jonathan, DiChiara, Jennifer, Xu, Qihong, Whiddon, Arin, Lam, Chia-Ying K, Tamura, Jim, Ciccarone, Valentina, Johnson, Syd, Bonvini, Ezio, Moore, Paul

“…Introduction: Trophoblast glycoprotein 5T4 is expressed on the cell surface of multiple cancers yet sparingly on normal adult tissues. CD137 (4-1BB) is a…”
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Abstract 3642: Tumor-antigen expression-dependent activation of the CD137 costimulatory pathway by bispecific DART® proteins by Liu, Liqin, Lam, Chia-Ying K., Long, Vatana, Widjaja, Lusiana, Yang, Yinhua, Shah, Kalpana, Smith, Doug, Pan, Joanna, Johnson, Syd, Bonvini, Ezio, Moore, Paul

“…Introduction: CD137 (4-1BB) is a co-stimulatory molecule expressed by activated T and NK cells that, upon interaction with its CD137 ligand, further supports…”
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MGD011, Humanized CD19 x CD3 DART® Protein with Enhanced Pharmacokinetic Properties, Demonstrates Potent T-Cell Mediated Anti-Tumor Activity in Preclinical Models and Durable B-Cell Depletion in Cynomolgus Monkeys Following Once-a-Week Dosing by Liu, Liqin, Lam, Annie, Alderson, Ralph, Yang, Yinhua, Li, Hua, Long, Vatana, Gorlatov, Sergey, Burke, Steve, Ciccarone, Valentina, Nordstrom, Jeffrey, Johnson, Syd, Moore, Paul, Bonvini, Ezio

“…CD19, a lymphocyte-specific marker expressed from early B-lymphocyte development through mature memory B cells, is highly represented in B-cell malignancies,…”
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BLyS Neutralization Ablates Primary But Not Memory B Cell Pools by Crowley, Jenni, Scholz, Jean L., Tomayko, Mary, Steinel, Natalie, O'Neill, Patrick J., Miller, Juli P., Cho, Yun Hee, Long, Vatana, Ward, Chris, Migone, Thi‐Sau, Shlomchik, Mark J., Cancro, Michael P.

“…The cytokine BLyS (B lymphocyte stimulator) interacts with three receptors – BR3, TACI, and BCMA – to regulate the composition and size of peripheral B cell…”
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