Search Results - "Long, Justin"

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies by Long, Justin M., Holtzman, David M.

“…Alzheimer disease (AD) is a heterogeneous disease with a complex pathobiology. The presence of extracellular β-amyloid deposition as neuritic plaques and…”
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Novel upregulation of amyloid-β precursor protein (APP) by microRNA-346 via targeting of APP mRNA 5′-untranslated region: Implications in Alzheimer’s disease by Long, Justin M., Maloney, Bryan, Rogers, Jack T., Lahiri, Debomoy K.

“…In addition to the devastating symptoms of dementia, Alzheimer’s disease (AD) is characterized by accumulation of the processing products of the amyloid-β (Aβ)…”
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MicroRNA-339-5p Down-regulates Protein Expression of β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 (BACE1) in Human Primary Brain Cultures and Is Reduced in Brain Tissue Specimens of Alzheimer Disease Subjects by Long, Justin M., Ray, Balmiki, Lahiri, Debomoy K.

“…Alzheimer disease (AD) results, in part, from the excess accumulation of the amyloid-β (Aβ) peptide as neuritic plaques in the brain. The short Aβ peptide is…”
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MicroRNA-153 Physiologically Inhibits Expression of Amyloid-β Precursor Protein in Cultured Human Fetal Brain Cells and Is Dysregulated in a Subset of Alzheimer Disease Patients by Long, Justin M., Ray, Balmiki, Lahiri, Debomoy K.

“…Regulation of amyloid-β (Aβ) precursor protein (APP) expression is complex. MicroRNAs (miRNAs) are expected to participate in the molecular network that…”
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The Role of Augmented Intelligence (AI) in Detecting and Preventing the Spread of Novel Coronavirus by Long, Justin B., Ehrenfeld, Jesse M.

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Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model by Shi, Yang, Manis, Melissa, Long, Justin, Wang, Kairuo, Sullivan, Patrick M, Remolina Serrano, Javier, Hoyle, Rosa, Holtzman, David M

“…Chronic activation of brain innate immunity is a prominent feature of Alzheimer's disease (AD) and primary tauopathies. However, to what degree innate immunity…”
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MicroRNA-101 downregulates Alzheimer’s amyloid-β precursor protein levels in human cell cultures and is differentially expressed by Long, Justin M., Lahiri, Debomoy K.

“…► MiR-101 inhibits expression of reporter under control of APP 3′-UTR in human cells. ► MiR-101 mediates this effect through one of two predicted target sites…”
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Increased secreted amyloid precursor protein-α (sAPPα) in severe autism: proposal of a specific, anabolic pathway and putative biomarker by Ray, Balmiki, Long, Justin M, Sokol, Deborah K, Lahiri, Debomoy K

“…Autism is a neurodevelopmental disorder characterized by deficits in verbal communication, social interactions, and the presence of repetitive, stereotyped and…”
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Autoimmune Dementia by Long, Justin M, Day, Gregory S

“…Dementia refers to an acquired syndrome of intraindividual cognitive decline that ultimately interferes with an individual's ability to manage their usual…”
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Regulation of astrocyte lipid metabolism and ApoE secretionby the microglial oxysterol, 25-hydroxycholesterol by Cashikar, Anil G, Toral-Rios, Danira, Timm, David, Romero, Johnathan, Strickland, Michael, Long, Justin M, Han, Xianlin, Holtzman, David M, Paul, Steven M

“…Neuroinflammation, a major hallmark of Alzheimer's disease and several other neurological and psychiatric disorders, is often associated with dysregulated…”
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Complications in Pediatric Regional Anesthesia: An Analysis of More than 100,000 Blocks from the Pediatric Regional Anesthesia Network by Walker, Benjamin J, Long, Justin B, Sathyamoorthy, Madhankumar, Birstler, Jennifer, Wolf, Christine, Bosenberg, Adrian T, Flack, Sean H, Krane, Elliot J, Sethna, Navil F, Suresh, Santhanam, Taenzer, Andreas H, Polaner, David M, Martin, Lynn, Anderson, Corrie, Sunder, Rani, Adams, Trevor, Martin, Lizabeth, Pankovich, Martha, Sawardekar, Amod, Birmingham, Patrick, Marcelino, Ryan, Ramarmurthi, R.J, Szmuk, Peter, Ungar, Galit Kastner, Lozano, Sara, Boretsky, Karen, Jain, Ranu, Matuszczak, Maria, Petersen, Timothy R, Dillow, Jennifer, Power, Robert, Nguyen, Kim, Lee, Benjamin H, Chan, Lisa, Pineda, Jorge, Hutchins, Jacob, Mendoza, Kimberly, Spisak, Kristen, Shah, Aali, DelPizzo, Kathryn, Dong, Naomi, Yalamanchili, Vidya, Venable, Claudia, Williams, Cassandra Armstead, Chaudahari, Reena, Ohkawa, Susumu, Usljebrka, Helga, Bhalla, Tarun, Vanzillotta, Pedro Paulo, Apiliogullari, Seza, Franklin, Andrew D, Ando, Akiko, Pestieau, Sophie R, Wright, Caroline, Rosenbloom, Julia, Anderson, Tony

“…WHAT WE ALREADY KNOW ABOUT THIS TOPIC WHAT THIS ARTICLE TELLS US THAT IS NEW BACKGROUND:Complications in pediatric regional anesthesia are rare, so a large…”
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Response to Dr Visoiu concerning ‘ultrasound-guided bilateral rectus sheath block with and without dexmedetomidine in pediatric umbilical hernia repairs: a retrospective interrupted time series analysis’ by Hartzell, Cheryl J, Long, Justin B, Austin, Thomas

“…Correspondence to Cheryl J Hartzell, Anesthesiology, Emory University School of Medicine, Atlanta, GA 30322, USA; cheryl.hartzell@emory.edu To the Editor We…”
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Postoperative Hematocrit and Adverse Outcomes in Pediatric Cardiac Surgery Patients: A Cross-Sectional Study From the Society of Thoracic Surgeons and Congenital Cardiac Anesthesia Society Database Collaboration by Long, Justin B., Engorn, Branden M., Hill, Kevin D., Feng, Liqi, Chiswell, Karen, Jacobs, Marshall L., Jacobs, Jeffrey P., Goswami, Dheeraj

“…We sought to examine potential associations between pediatric postcardiac surgical hematocrit values and postoperative complications or mortality. A…”
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Lessons from a BACE1 inhibitor trial: Off-site but not off base by Lahiri, Debomoy K, Maloney, Bryan, Long, Justin M, Greig, Nigel H

“…Abstract Alzheimer's disease (AD) is characterized by formation of neuritic plaque primarily composed of a small filamentous protein called amyloid-β peptide…”
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Preclinical Alzheimer's disease biomarkers accurately predict cognitive and neuropathological outcomes by Long, Justin M, Coble, Dean W, Xiong, Chengjie, Schindler, Suzanne E, Perrin, Richard J, Gordon, Brian A, Benzinger, Tammie L S, Grant, Elizabeth, Fagan, Anne M, Harari, Oscar, Cruchaga, Carlos, Holtzman, David M, Morris, John C

“…Alzheimer's disease biomarkers are widely accepted as surrogate markers of underlying neuropathological changes. However, few studies have evaluated whether…”
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Cerebral angiography, blood flow and vascular reactivity in progressive hypertension by Li, Yunxia, Shen, Qiang, Huang, Shiliang, Li, Wei, Muir, Eric R., Long, Justin A., Duong, Timothy Q.

“…Chronic hypertension alters cerebral vascular morphology, cerebral blood flow (CBF), cerebrovascular reactivity, and increses susceptibility to neurological…”
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Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy by Toral-Rios, Danira, Long, Justin M, Ulrich, Jason D, Yu, Jinsheng, Strickland, Michael R, Han, Xianlin, Holtzman, David M, Cashikar, Anil G, Paul, Steven M

“…Alzheimer's disease (AD) is characterized by amyloid plaques and neurofibrillary tangles, in addition to neuroinflammation and changes in brain lipid…”
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Transversus Abdominis Plane Block in Children: A Multicenter Safety Analysis of 1994 Cases from the PRAN (Pediatric Regional Anesthesia Network) Database by Long, Justin B., Birmingham, Patrick K., De Oliveira, Gildasio S., Schaldenbrand, Katie M., Suresh, Santhanam

“…BACKGROUND:Currently, there is not enough evidence to support the safety of the transversus abdominis plane (TAP) block when used to ameliorate postoperative…”
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Advances in microRNA experimental approaches to study physiological regulation of gene products implicated in CNS disorders by Long, Justin M., Lahiri, Debomoy K.

“…The central nervous system (CNS) is a remarkably complex organ system, requiring an equally complex network of molecular pathways controlling the multitude of…”
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Ultrasound-guided bilateral rectus sheath block with and without dexmedetomidine in pediatric umbilical hernia repairs: a retrospective interrupted time series analysis by Hartzell, Cheryl J, Long, Justin B, White, William M, Machado, Daniel, Austin, Thomas M

“…In order to control for both potential confounding variables and underlying temporal trends in the outcomes, interrupted time series analyses5 were performed…”
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