Search Results - "Long, Jianyin"

Drp1S600 phosphorylation regulates mitochondrial fission and progression of nephropathy in diabetic mice by Galvan, Daniel L, Long, Jianyin, Green, Nathanael, Chang, Benny H, Lin, Jamie S, Schumacker, Paul, Truong, Luan D, Overbeek, Paul, Danesh, Farhad R

“…Phosphorylation of Dynamin-related protein1 (Drp1) represents an important regulatory mechanism for mitochondrial fission. Here we established the role of Drp1…”
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Identification of MicroRNA-93 as a Novel Regulator of Vascular Endothelial Growth Factor in Hyperglycemic Conditions by Long, Jianyin, Wang, Yin, Wang, Wenjian, Chang, Benny H.J., Danesh, Farhad R.

“…Vascular endothelial growth factor (VEGF) is a dimeric glycoprotein that plays a crucial role in microvascular complications of diabetes, including diabetic…”
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miR-93 regulates Msk2-mediated chromatin remodelling in diabetic nephropathy by Badal, Shawn S., Wang, Yin, Long, Jianyin, Corcoran, David L., Chang, Benny H., Truong, Luan D., Kanwar, Yashpal S., Overbeek, Paul A., Danesh, Farhad R.

“…How the kidney responds to the metabolic cues from the environment remains a central question in kidney research. This question is particularly relevant to the…”
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NDUFS4 regulates cristae remodeling in diabetic kidney disease by Mise, Koki, Long, Jianyin, Galvan, Daniel L., Ye, Zengchun, Fan, Guizhen, Sharma, Rajesh, Serysheva, Irina I., Moore, Travis I., Jeter, Collene R., Anna Zal, M., Araki, Motoo, Wada, Jun, Schumacker, Paul T., Chang, Benny H., Danesh, Farhad R.

“…The mitochondrial electron transport chain (ETC) is a highly adaptive process to meet metabolic demands of the cell, and its dysregulation has been associated…”
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Publisher Correction: NDUFS4 regulates cristae remodeling in diabetic kidney disease by Mise, Koki, Long, Jianyin, Galvan, Daniel L., Ye, Zengchun, Fan, Guizhen, Sharma, Rajesh, Serysheva, Irina I., Moore, Travis I., Jeter, Collene R., Anna Zal, M., Araki, Motoo, Wada, Jun, Schumacker, Paul T., Chang, Benny H., Danesh, Farhad R.

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Long noncoding RNA Tug1 regulates mitochondrial bioenergetics in diabetic nephropathy by Long, Jianyin, Badal, Shawn S, Ye, Zengchun, Wang, Yin, Ayanga, Bernard A, Galvan, Daniel L, Green, Nathanael H, Chang, Benny H, Overbeek, Paul A, Danesh, Farhad R

“…The regulatory roles of long noncoding RNAs (lncRNAs) in transcriptional coactivators are still largely unknown. Here, we have shown that the peroxisome…”
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PGC1α is required for the renoprotective effect of lncRNA Tug1 in vivo and links Tug1 with urea cycle metabolites by Li, Li, Long, Jianyin, Mise, Koki, Galvan, Daniel L., Overbeek, Paul A., Tan, Lin, Kumar, Shwetha V., Chan, Wai Kin, Lorenzi, Phillip L., Chang, Benny H., Danesh, Farhad R.

“…lncRNA taurine-upregulated gene 1 (Tug1) is a promising therapeutic target in the progression of diabetic nephropathy (DN), but the molecular basis of its…”
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MicroRNA-22 Is a Master Regulator of Bone Morphogenetic Protein-7/6 Homeostasis in the Kidney by Long, Jianyin, Badal, Shawn S., Wang, Yin, Chang, Benny H.J., Rodriguez, Antony, Danesh, Farhad R.

“…Accumulating evidence suggests that microRNAs (miRNAs) contribute to a myriad of kidney diseases. However, the regulatory role of miRNAs on the key molecules…”
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Pc2-mediated Sumoylation of Smad-interacting Protein 1 Attenuates Transcriptional Repression of E-cadherin by Long, Jianyin, Zuo, Dongmei, Park, Morag

“…Epithelial-mesenchymal transition (EMT) is important in embryonic development and tumorigenesis. Smad-interacting protein 1 (SIP1) can induce EMT by repressing…”
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Repression of Smad4 transcriptional activity by SUMO modification by Long, Jianyin, Wang, Guannan, He, Dongming, Liu, Fang

“…Smad4 plays a key role in TGF-beta (transforming growth factor beta)/Smad-mediated transcriptional responses. We show that Smad4 is sumoylated both in vivo and…”
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BCL6 Represses Smad Signaling in Transforming Growth Factor-β Resistance by DEGANG WANG, JIANYIN LONG, FANGYAN DAI, MIN LIANG, FENG, Xin-Hua, XIA LIN

“…Transforming growth factor-beta (TGF-beta) controls a wide spectrum of cellular processes. Deregulation of TGF-beta signaling contributes to the pathogenesis…”
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Repression of Smad Transcriptional Activity by PIASy, an Inhibitor of Activated STAT by Long, Jianyin, Matsuura, Isao, He, Dongming, Wang, Guannan, Shuai, Ke, Liu, Fang

“…Smad proteins mediate transforming growth factor β (TGF-β)-inducible transcriptional responses. Protein inhibitor of activated signal transducer and activator…”
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Activation of Smad Transcriptional Activity by Protein Inhibitor of Activated STAT3 (PIAS3) by Long, Jianyin, Wang, Guannan, Matsuura, Isao, He, Dongming, Liu, Fang

“…Smad proteins play pivotal roles in mediating the transforming growth factor β(TGF-β) transcriptional responses. We show in this report that PIAS3, a member of…”
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Tamoxifen-inducible podocyte-specific iCre recombinase transgenic mouse provides a simple approach for modulation of podocytes in vivo by Wang, Jinrong, Wang, Yin, Long, Jianyin, Chang, Benny H.J., Wilson, Mathew H., Overbeek, Paul, Danesh, Farhad R.

“…We report the generation and initial characterization of a mouse line expressing tamoxifen‐inducible improved Cre (iCre) recombinase (iCre‐ERT2) under the…”
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The Smad3 linker region contains a transcriptional activation domain by Wang, Guannan, Long, Jianyin, Matsuura, Isao, He, Dongming, Liu, Fang

“…Transforming growth factor-beta (TGF-beta)/Smads regulate a wide variety of biological responses through transcriptional regulation of target genes. Smad3…”
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Transforming Growth Factor β -Inducible Independent Binding of SMAD to the Smad7 Promoter by Denissova, Natalia G., Pouponnot, Celio, Long, Jianyin, He, Dongming, Liu, Fang

“…SMAD proteins can mediate transforming growth factor β (TGF-β )-inducible transcriptional responses. Whereas SMAD can recognize specific DNA sequences, it is…”
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Promises and challenges of miRNA therapeutics by Long, Jianyin, Danesh, Farhad R

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Values and Limitations of Targeting lncRNAs in Diabetic Nephropathy by Long, Jianyin, Danesh, Farhad R

“…Long and Danesh explore the values and limitations of targeting IncRNAs in diabetic nephropathy. They cite a study which describes the characterization of a…”
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NDUFS4 Regulates Cristae Remodeling in Diabetic Kidney Disease: FR-OR38 by Mise, Koki, Long, Jianyin, Wada, Jun, Chang, Benny B., Danesh, Farhad R.

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The Transcription Factor ChREBP Links Mitochondrial Lipidomes to Mitochondrial Morphology and Progression of Diabetic Kidney Disease: FR-OR39 by Long, Jianyin, Li, Li, Mise, Koki, Chang, Benny B., Danesh, Farhad R.

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