Search Results - "Long, Eric O."

Negative signaling by inhibitory receptors: the NK cell paradigm by Long, Eric O

“…Receptors carrying immunoreceptor tyrosine-based inhibition motifs (ITIMs) in their cytoplasmic tail control a vast array of cellular responses, ranging from…”
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Cellular senescence induced by CD158d reprograms natural killer cells to promote vascular remodeling by Rajagopalan, Sumati, Long, Eric O

“…Natural killer (NK) cells, which have an essential role in immune defense, also contribute to reproductive success. NK cells are abundant at the maternal–fetal…”
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Controlling Natural Killer Cell Responses: Integration of Signals for Activation and Inhibition by Long, Eric O, Sik Kim, Hun, Liu, Dongfang, Peterson, Mary E, Rajagopalan, Sumati

“…Understanding how signals are integrated to control natural killer (NK) cell responsiveness in the absence of antigen-specific receptors has been a challenge,…”
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Cytotoxic immunological synapses by Dustin, Michael L, Long, Eric O

“…One of the most fundamental activities of the adaptive immune system is to kill infected cells and tumor cells. Two distinct pathways mediate this process,…”
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Interleukin-2 Activity Can Be Fine Tuned with Engineered Receptor Signaling Clamps by Mitra, Suman, Ring, Aaron M., Amarnath, Shoba, Spangler, Jamie B., Li, Peng, Ju, Wei, Fischer, Suzanne, Oh, Jangsuk, Spolski, Rosanne, Weiskopf, Kipp, Kohrt, Holbrook, Foley, Jason E., Rajagopalan, Sumati, Long, Eric O., Fowler, Daniel H., Waldmann, Thomas A., Garcia, K. Christopher, Leonard, Warren J.

“…Interleukin-2 (IL-2) regulates lymphocyte function by signaling through heterodimerization of the IL-2Rβ and γc receptor subunits. IL-2 is of considerable…”
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NK Cells Equipped With a Chimeric Antigen Receptor That Overcomes Inhibition by HLA Class I for Adoptive Transfer of CAR-NK Cells by Zhuang, Xiaoxuan, Long, Eric O

“…Dominant inhibitory receptors for HLA class I (HLA-I) endow NK cells with high intrinsic responsiveness, a process termed licensing or education, but hinder…”
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Regulation of human NK-cell cytokine and chemokine production by target cell recognition by Fauriat, Cyril, Long, Eric O., Ljunggren, Hans-Gustaf, Bryceson, Yenan T.

“…Natural killer (NK)–cell recognition of infected or neoplastic cells can induce cytotoxicity and cytokine secretion. So far, it has been difficult to assess…”
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Genome-Wide CRISPR Screen Reveals Cancer Cell Resistance to NK Cells Induced by NK-Derived IFN-γ by Zhuang, Xiaoxuan, Veltri, Daniel P, Long, Eric O

“…The anti-leukemia activity of NK cells helps prevent relapse during hematopoietic stem cell transplantation (HSCT) in leukemia patients. However, the factors…”
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The Adaptor Protein Crk Controls Activation and Inhibition of Natural Killer Cells by Liu, Dongfang, Peterson, Mary E., Long, Eric O.

“…Natural killer (NK) cell inhibitory receptors recruit tyrosine phosphatases to prevent activation, induce phosphorylation and dissociation of the small adaptor…”
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Synergy among receptors on resting NK cells for the activation of natural cytotoxicity and cytokine secretion by Bryceson, Yenan T., March, Michael E., Ljunggren, Hans-Gustaf, Long, Eric O.

“…Freshly isolated, resting natural killer (NK) cells are generally less lytic against target cells than in vitro interleukin 2 (IL-2)-activated NK cells. To…”
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Activation, coactivation, and costimulation of resting human natural killer cells by Bryceson, Yenan T., March, Michael E., Ljunggren, Hans-Gustaf, Long, Eric O.

“…Natural killer (NK) cells possess potent perforin‐ and interferon‐γ‐dependent effector functions that are tightly regulated. Inhibitory receptors for major…”
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Minimal requirement for induction of natural cytotoxicity and intersection of activation signals by inhibitory receptors by Bryceson, Yenan T., Ljunggren, Hans-Gustaf, Long, Eric O.

“…Natural killer (NK) cells provide innate control of infected and neoplastic cells. Multiple receptors have been implicated in natural cytotoxicity, but their…”
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Inhibitory Receptor Signaling via Tyrosine Phosphorylation of the Adaptor Crk by Peterson, Mary E., Long, Eric O.

“…Many cellular responses, such as autoimmunity and cytotoxicity, are controlled by receptors with cytoplasmic immunoreceptor tyrosine-based inhibition motifs…”
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REGULATION OF IMMUNE RESPONSES THROUGH INHIBITORY RECEPTORS by Long, Eric O

“…Major histocompatibility complex class I-specific inhibitory receptors on natural killer cells prevent the lysis of healthy autologous cells. The outcome of…”
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NK cells inhibit Plasmodium falciparum growth in red blood cells via antibody-dependent cellular cytotoxicity by Arora, Gunjan, Hart, Geoffrey T, Manzella-Lapeira, Javier, Doritchamou, Justin Ya, Narum, David L, Thomas, L Michael, Brzostowski, Joseph, Rajagopalan, Sumati, Doumbo, Ogobara K, Traore, Boubacar, Miller, Louis H, Pierce, Susan K, Duffy, Patrick E, Crompton, Peter D, Desai, Sanjay A, Long, Eric O

“…Antibodies acquired naturally through repeated exposure to are essential in the control of blood-stage malaria. Antibody-dependent functions may include…”
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NK cell-induced damage to P.falciparum-infected erythrocytes requires ligand-specific recognition and releases parasitophorous vacuoles that are phagocytosed by monocytes in the presence of immune IgG by Sekar, Padmapriya, Rajagopalan, Sumati, Shabani, Estela, Kanjee, Usheer, Schureck, Marc A, Arora, Gunjan, Peterson, Mary E, Traore, Boubacar, Crompton, Peter D, Duraisingh, Manoj T, Desai, Sanjay A, Long, Eric O

“…Natural killer (NK) cells lyse virus-infected cells and transformed cells through polarized delivery of lytic effector molecules into target cells. We have…”
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Functional genomics identifies N-acetyllactosamine extension of complex N-glycans as a mechanism to evade lysis by natural killer cells by Zhuang, Xiaoxuan, Woods, James, Ji, Yanlong, Scheich, Sebastian, Mo, Fei, Rajagopalan, Sumati, Coulibaly, Zana A., Voss, Matthias, Urlaub, Henning, Staudt, Louis M., Pan, Kuan-Ting, Long, Eric O.

“…Natural killer (NK) cells are primary defenders against cancer precursors, but cancer cells can persist by evading immune surveillance. To investigate the…”
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A signaling network stimulated by β2 integrin promotes the polarization of lytic granules in cytotoxic cells by Zhang, Minggang, March, Michael E, Lane, William S, Long, Eric O

“…Cytotoxic lymphocytes kill target cells through the polarized release of the contents of intracellular perforin-containing granules. In natural killer (NK)…”
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Understanding how combinations of HLA and KIR genes influence disease by Rajagopalan, Sumati, Long, Eric O

“…Combinations of HLA and killer cell immunoglobulin-like receptor (KIR) genes have been associated with diseases as diverse as autoimmunity, viral infections,…”
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Line of attack: NK cell specificity and integration of signals by Bryceson, Yenan T, Long, Eric O

“…Natural killer (NK) cells possess potent cytolytic activity and secrete immune modulating cytokines. The large repertoire of NK cell receptors provides…”
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