Search Results - "Long, Carole A"

Safety and immunogenicity of a plant-produced Pfs25 virus-like particle as a transmission blocking vaccine against malaria: A Phase 1 dose-escalation study in healthy adults by Chichester, Jessica A., Green, Brian J., Jones, R. Mark, Shoji, Yoko, Miura, Kazutoyo, Long, Carole A., Lee, Cynthia K., Ockenhouse, Christian F., Morin, Merribeth J., Streatfield, Stephen J., Yusibov, Vidadi

“…•Report of a Phase I clinical trial to assess a malaria transmission blocking vaccine.•P. falciparum Pfs25 virus-like particle produced under cGMP in a…”
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Enhancing immunogenicity and transmission-blocking activity of malaria vaccines by fusing Pfs25 to IMX313 multimerization technology by Li, Yuanyuan, Leneghan, Darren B., Miura, Kazutoyo, Nikolaeva, Daria, Brian, Iona J., Dicks, Matthew D. J., Fyfe, Alex J., Zakutansky, Sarah E., de Cassan, Simone, Long, Carole A., Draper, Simon J., Hill, Adrian V. S., Hill, Fergal, Biswas, Sumi

“…Transmission-blocking vaccines (TBV) target the sexual-stages of the malaria parasite in the mosquito midgut and are widely considered to be an essential tool…”
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Neutralizing and interfering human antibodies define the structural and mechanistic basis for antigenic diversion by Patel, Palak N., Dickey, Thayne H., Hopp, Christine S., Diouf, Ababacar, Tang, Wai Kwan, Long, Carole A., Miura, Kazutoyo, Crompton, Peter D., Tolia, Niraj H.

“…Defining mechanisms of pathogen immune evasion and neutralization are critical to develop potent vaccines and therapies. Merozoite Surface Protein 1 (MSP-1) is…”
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A Universal Plug-and-Display Vaccine Carrier Based on HBsAg VLP to Maximize Effective Antibody Response by Marini, Arianna, Zhou, Yu, Li, Yuanyuan, Taylor, Iona J, Leneghan, Darren B, Jin, Jing, Zaric, Marija, Mekhaiel, David, Long, Carole A, Miura, Kazutoyo, Biswas, Sumi

“…Development of effective malaria vaccines requires delivery platforms to enhance the immunogenicity and efficacy of the target antigens. This is particularly…”
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RTP4 inhibits IFN-I response and enhances experimental cerebral malaria and neuropathology by He, Xiao, Ashbrook, Alison W., Du, Yang, Wu, Jian, Hoffmann, Hans-Heinrich, Zhang, Cui, Xia, Lu, Peng, Yu-Chih, Tumas, Keyla C., Singh, Brajesh K., Qi, Chen-feng, Myers, Timothy G., Long, Carole A., Liu, Chengyu, Wang, Rongfu, Rice, Charles M., Su, Xin-zhuan

“…Infection by malaria parasites triggers dynamic immune responses leading to diverse symptoms and pathologies; however, the molecular mechanisms responsible for…”
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Structure-based design of a strain transcending AMA1-RON2L malaria vaccine by Patel, Palak N., Dickey, Thayne H., Diouf, Ababacar, Salinas, Nichole D., McAleese, Holly, Ouahes, Tarik, Long, Carole A., Miura, Kazutoyo, Lambert, Lynn E., Tolia, Niraj H.

“…Apical membrane antigen 1 (AMA1) is a key malaria vaccine candidate and target of neutralizing antibodies. AMA1 binds to a loop in rhoptry neck protein 2…”
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Transmission-blocking activity is determined by transmission-reducing activity and number of control oocysts in Plasmodium falciparum standard membrane-feeding assay by Miura, Kazutoyo, Swihart, Bruce J, Deng, Bingbing, Zhou, Luwen, Pham, Thao P, Diouf, Ababacar, Burton, Timothy, Fay, Michael P, Long, Carole A

“…Abstract Malaria transmission-blocking vaccines (TBVs) are potentially helpful tools for malaria eradication. The standard membrane-feeding assay (SMFA) is…”
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Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies by Ko, Kuang-Ting, Lennartz, Frank, Mekhaiel, David, Guloglu, Bora, Marini, Arianna, Deuker, Danielle J., Long, Carole A., Jore, Matthijs M., Miura, Kazutoyo, Biswas, Sumi, Higgins, Matthew K.

“…An effective malaria vaccine remains a global health priority and vaccine immunogens which prevent transmission of the parasite will have important roles in…”
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Nanoassembly routes stimulate conflicting antibody quantity and quality for transmission-blocking malaria vaccines by Leneghan, Darren B., Miura, Kazutoyo, Taylor, Iona J., Li, Yuanyuan, Jin, Jing, Brune, Karl D., Bachmann, Martin F., Howarth, Mark, Long, Carole A., Biswas, Sumi

“…Vaccine development efforts have recently focused on enabling strong immune responses to poorly immunogenic antigens, via display on multimerisation scaffolds…”
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Structure guided mimicry of an essential P. falciparum receptor-ligand complex enhances cross neutralizing antibodies by Yanik, Sean, Venkatesh, Varsha, Parker, Michelle L., Ramaswamy, Raghavendran, Diouf, Ababacar, Sarkar, Deepti, Miura, Kazutoyo, Long, Carole A., Boulanger, Martin J., Srinivasan, Prakash

“…Invasion of human erythrocytes by Plasmodium falciparum ( Pf ) merozoites relies on the interaction between two parasite proteins: apical membrane antigen 1…”
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Qualification of standard membrane-feeding assay with Plasmodium falciparum malaria and potential improvements for future assays by Miura, Kazutoyo, Deng, Bingbing, Tullo, Gregory, Diouf, Ababacar, Moretz, Samuel E, Locke, Emily, Morin, Merribeth, Fay, Michael P, Long, Carole A

“…Vaccines that interrupt malaria transmission are of increasing interest and a robust functional assay to measure this activity would promote their development…”
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Immunization with a functional protein complex required for erythrocyte invasion protects against lethal malaria by Srinivasan, Prakash, Ekanem, Emmanuel, Diouf, Ababacar, Tonkin, Michelle L., Miura, Kazutoyo, Boulanger, Martin J., Long, Carole A., Narum, David L., Miller, Louis H.

“…An essential step in the invasion of red blood cells (RBCs) by Plasmodium falciparum (Pf) merozoites is the binding of rhoptry neck protein 2 (RON2) to the…”
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Maintaining immunogenicity of blood stage and sexual stage subunit malaria vaccines when formulated in combination by Parzych, Elizabeth M, Miura, Kazutoyo, Long, Carole A, Burns, Jr, James M

“…Eradication of Plasmodium falciparum malaria will likely require a multivalent vaccine, but the development of a highly efficacious subunit-based formulation…”
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A defined mechanistic correlate of protection against Plasmodium falciparum malaria in non-human primates by Douglas, Alexander D., Baldeviano, G. Christian, Jin, Jing, Miura, Kazutoyo, Diouf, Ababacar, Zenonos, Zenon A., Ventocilla, Julio A., Silk, Sarah E., Marshall, Jennifer M., Alanine, Daniel G. W., Wang, Chuan, Edwards, Nick J., Leiva, Karina P., Gomez-Puerta, Luis A., Lucas, Carmen M., Wright, Gavin J., Long, Carole A., Royal, Joseph M., Draper, Simon J.

“…Malaria vaccine design and prioritization has been hindered by the lack of a mechanistic correlate of protection. We previously demonstrated a strong…”
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Phase Ia clinical evaluation of the safety and immunogenicity of the Plasmodium falciparum blood-stage antigen AMA1 in ChAd63 and MVA vaccine vectors by Sheehy, Susanne H, Duncan, Christopher J A, Elias, Sean C, Biswas, Sumi, Collins, Katharine A, O'Hara, Geraldine A, Halstead, Fenella D, Ewer, Katie J, Mahungu, Tabitha, Spencer, Alexandra J, Miura, Kazutoyo, Poulton, Ian D, Dicks, Matthew D J, Edwards, Nick J, Berrie, Eleanor, Moyle, Sarah, Colloca, Stefano, Cortese, Riccardo, Gantlett, Katherine, Long, Carole A, Lawrie, Alison M, Gilbert, Sarah C, Doherty, Tom, Nicosia, Alfredo, Hill, Adrian V S, Draper, Simon J

“…Traditionally, vaccine development against the blood-stage of Plasmodium falciparum infection has focused on recombinant protein-adjuvant formulations in order…”
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Functional Comparison of Plasmodium falciparum Transmission-Blocking Vaccine Candidates by the Standard Membrane-Feeding Assay by Miura, Kazutoyo, Takashima, Eizo, Deng, Bingbing, Tullo, Gregory, Diouf, Ababacar, Moretz, Samuel E, Nikolaeva, Daria, Diakite, Mahamadou, Fairhurst, Rick M, Fay, Michael P, Long, Carole A, Tsuboi, Takafumi

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody by Douglas, Alexander D., Williams, Andrew R., Illingworth, Joseph J., Kamuyu, Gathoni, Biswas, Sumi, Goodman, Anna L., Wyllie, David H., Crosnier, Cécile, Miura, Kazutoyo, Wright, Gavin J., Long, Carole A., Osier, Faith H., Marsh, Kevin, Turner, Alison V., Hill, Adrian V.S., Draper, Simon J.

“…Current vaccine strategies against the asexual blood stage of Plasmodium falciparum are mostly focused on well-studied merozoite antigens that induce immune…”
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A human-serum-free medium can induce more infectious P. falciparum gametocytes than a conventional human-serum-containing medium by Miura, Kazutoyo, Deng, Bingbing, Varadharajan Suresh, Ragavan, Gebremicale, Yonas T., Zhou, Luwen, Pham, Thao P., Roche, Kyle, Diouf, Ababacar, Lovell, Jonathan F., Julien, Jean-Philippe, Long, Carole A.

“…Malaria remains a global health problem, and the standard membrane feeding assay (SMFA) is a key functional assay for development of new interventions to stop…”
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Enhancing blockade of Plasmodium falciparum erythrocyte invasion: assessing combinations of antibodies against PfRH5 and other merozoite antigens by Williams, Andrew R, Douglas, Alexander D, Miura, Kazutoyo, Illingworth, Joseph J, Choudhary, Prateek, Murungi, Linda M, Furze, Julie M, Diouf, Ababacar, Miotto, Olivo, Crosnier, Cécile, Wright, Gavin J, Kwiatkowski, Dominic P, Fairhurst, Rick M, Long, Carole A, Draper, Simon J

“…No vaccine has yet proven effective against the blood-stages of Plasmodium falciparum, which cause the symptoms and severe manifestations of malaria. We…”
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Immunoscreening of Plasmodium falciparum proteins expressed in a wheat germ cell-free system reveals a novel malaria vaccine candidate by Morita, Masayuki, Takashima, Eizo, Ito, Daisuke, Miura, Kazutoyo, Thongkukiatkul, Amporn, Diouf, Ababacar, Fairhurst, Rick M., Diakite, Mahamadou, Long, Carole A., Torii, Motomi, Tsuboi, Takafumi

“…The number of malaria vaccine candidates in preclinical and clinical development is limited. To identify novel blood-stage malaria vaccine candidates, we…”
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