Search Results - "Long, C."
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A long-term study of AAV gene therapy in dogs with hemophilia A identifies clonal expansions of transduced liver cells
Published in Nature biotechnology (01-01-2021)“…Nine dogs with hemophilia A were treated with adeno-associated viral (AAV) gene therapy and followed for up to 10 years. Administration of AAV8 or AAV9 vectors…”
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The SR protein family of splicing factors: master regulators of gene expression
Published in Biochemical journal (01-01-2009)“…The SR protein family comprises a number of phylogenetically conserved and structurally related proteins with a characteristic domain rich in arginine and…”
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When complexity science meets implementation science: a theoretical and empirical analysis of systems change
Published in BMC medicine (30-04-2018)“…Implementation science has a core aim - to get evidence into practice. Early in the evidence-based medicine movement, this task was construed in linear terms,…”
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Drought Induced Changes in Growth, Osmolyte Accumulation and Antioxidant Metabolism of Three Maize Hybrids
Published in Frontiers in plant science (06-02-2017)“…Consequences of drought stress in crop production systems are perhaps more deleterious than other abiotic stresses under changing climatic scenarios…”
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Finding forced trends in oceanic oxygen
Published in Global biogeochemical cycles (01-02-2016)“…Anthropogenically forced trends in oceanic dissolved oxygen are evaluated in Earth system models in the context of natural variability. A large ensemble of a…”
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Young researchers series #8
Published in Trends in cell biology (01-04-2023)Get full text
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Shape optimization of pulsatile ventricular assist devices using FSI to minimize thrombotic risk
Published in Computational mechanics (01-10-2014)“…In this paper we perform shape optimization of a pediatric pulsatile ventricular assist device (PVAD). The device simulation is carried out using…”
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Pretreatment neutrophil-to-lymphocyte ratio and mutational burden as biomarkers of tumor response to immune checkpoint inhibitors
Published in Nature communications (01-02-2021)“…Treatment with immune checkpoint inhibitors (ICI) has demonstrated clinical benefit for a wide range of cancer types. Because only a subset of patients…”
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The association between tumor mutational burden and prognosis is dependent on treatment context
Published in Nature genetics (01-01-2021)“…In multiple cancer types, high tumor mutational burden (TMB) is associated with longer survival after treatment with immune checkpoint inhibitors (ICIs). The…”
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Patient‐reported outcome measures (PROMs): A review of generic and condition‐specific measures and a discussion of trends and issues
Published in Health expectations : an international journal of public participation in health care and health policy (01-08-2021)“…Background Patient‐reported outcome measures (PROMs) are questionnaires that collect health outcomes directly from the people who experience them. This review…”
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Ube2V2 Is a Rosetta Stone Bridging Redox and Ubiquitin Codes, Coordinating DNA Damage Responses
Published in ACS central science (28-02-2018)“…Posttranslational modifications (PTMs) are the lingua franca of cellular communication. Most PTMs are enzyme-orchestrated. However, the reemergence of…”
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Asymptomatic humans transmit dengue virus to mosquitoes
Published in Proceedings of the National Academy of Sciences - PNAS (24-11-2015)“…Three-quarters of the estimated 390 million dengue virus (DENV) infections each year are clinically inapparent. People with inapparent dengue virus infections…”
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Bridges, brokers and boundary spanners in collaborative networks: a systematic review
Published in BMC health services research (30-04-2013)“…Bridges, brokers and boundary spanners facilitate transactions and the flow of information between people or groups who either have no physical or cognitive…”
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Fluid–structure interaction simulation of pulsatile ventricular assist devices
Published in Computational mechanics (01-11-2013)“…In this paper we present a collection of fluid–structure interaction (FSI) computational techniques that enable realistic simulation of pulsatile Ventricular…”
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Computation of residence time in the simulation of pulsatile ventricular assist devices
Published in Computational mechanics (01-10-2014)“…A continuum-based model of particle residence time for moving-domain fluid mechanics and fluid–structure interaction (FSI) computations is proposed, analyzed,…”
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Salpingectomy for the Primary Prevention of Ovarian Cancer: A Systematic Review
Published in JAMA surgery (01-11-2023)“…Most ovarian cancers originate in the fimbriated end of the fallopian tube. This has led to the hypothesis that surgical resection of the fallopian tubes at…”
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Upper ocean O2 trends: 1958–2015
Published in Geophysical research letters (16-05-2017)“…Historic observations of dissolved oxygen (O2) in the ocean are analyzed to quantify multidecadal trends and variability from 1958 to 2015. Additional quality…”
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Local negative permittivity and topological phase transition in polar skyrmions
Published in Nature materials (01-02-2021)“…Topological solitons such as magnetic skyrmions have drawn attention as stable quasi-particle-like objects. The recent discovery of polar vortices and…”
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Guidelines for Family-Centered Care in the Neonatal, Pediatric, and Adult ICU
Published in Critical care medicine (01-01-2017)“…To provide clinicians with evidence-based strategies to optimize the support of the family of critically ill patients in the ICU. We used the Council of…”
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