Search Results - "Long, Alexandra S"

Quantitative Interpretation of Genetic Toxicity Dose‐Response Data for Risk Assessment and Regulatory Decision‐Making: Current Status and Emerging Priorities by White, Paul A., Long, Alexandra S., Johnson, George E.

“…The screen‐and‐bin approach for interpretation of genotoxicity data is predicated on three false assumptions: that genotoxicants are rare, that genotoxicity…”
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Cancer Risk Assessment of Polycyclic Aromatic Hydrocarbon Contaminated Soils Determined Using Bioassay-Derived Levels of Benzo[a]pyrene Equivalents by Lemieux, Christine L, Long, Alexandra S, Lambert, Iain B, Lundstedt, Staffan, Tysklind, Mats, White, Paul A

“…Here we evaluate the excess lifetime cancer risk (ELCR) posed by 10 PAH-contaminated soils using (i) the currently advocated, targeted chemical-specific…”
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Mitochondrial DNA exhibits resistance to induced point and deletion mutations by Valente, William J, Ericson, Nolan G, Long, Alexandra S, White, Paul A, Marchetti, Francesco, Bielas, Jason H

“…The accumulation of somatic mitochondrial DNA (mtDNA) mutations contributes to the pathogenesis of human disease. Currently, mitochondrial mutations are…”
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Tissue-specific in vivo genetic toxicity of nine polycyclic aromatic hydrocarbons assessed using the Muta™Mouse transgenic rodent assay by Long, Alexandra S., Lemieux, Christine L., Arlt, Volker M., White, Paul A.

“…Test batteries to screen chemicals for mutagenic hazard include several endpoints regarded as effective for detecting genotoxic carcinogens. Traditional in…”
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Quantitative in vitro to in vivo extrapolation of genotoxicity data provides protective estimates of in vivo dose by Beal, Marc A., Audebert, Marc, Barton‐Maclaren, Tara, Battaion, Hannah, Bemis, Jeffrey C., Cao, Xuefei, Chen, Connie, Dertinger, Stephen D., Froetschl, Roland, Guo, Xiaoqing, Johnson, George, Hendriks, Giel, Khoury, Laure, Long, Alexandra S., Pfuhler, Stefan, Settivari, Raja S., Wickramasuriya, Shamika, White, Paul

“…Genotoxicity assessment is a critical component in the development and evaluation of chemicals. Traditional genotoxicity assays (i.e., mutagenicity,…”
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Development and application of consensus in silico models for advancing high-throughput toxicological predictions by Collins, Sean P, Mailloux, Brandon, Kulkarni, Sunil, Gagné, Matthew, Long, Alexandra S, Barton-Maclaren, Tara S

“…Computational toxicology models have been successfully implemented to prioritize and screen chemicals. There are numerous (quantitative) structure-activity…”
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A comparison of transgenic rodent mutation and in vivo comet assay responses for 91 chemicals by Kirkland, David, Levy, Dan D., LeBaron, Matthew J., Aardema, Marilyn J., Beevers, Carol, Bhalli, Javed, Douglas, George R., Escobar, Patricia A., Farabaugh, Christopher S., Guerard, Melanie, Johnson, George E., Kulkarni, Rohan, Le Curieux, Frank, Long, Alexandra S., Lott, Jasmin, Lovell, David P., Luijten, Mirjam, Marchetti, Francesco, Nicolette, John J., Pfuhler, Stefan, Roberts, Daniel J., Stankowski, Leon F., Thybaud, Veronique, Weiner, Sandy K., Williams, Andrew, Witt, Kristine L., Young, Robert

“…•In vivo comet assay compared with transgenic rodent assay for 91 chemicals.•Comparison focussed on evaluation of in vivo genotoxicity per se.•Fair to good…”
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Application of a new approach methodology (NAM)-based strategy for genotoxicity assessment of data-poor compounds by Fortin, Anne-Marie V, Long, Alexandra S, Williams, Andrew, Meier, Matthew J, Cox, Julie, Pinsonnault, Claire, Yauk, Carole L, White, Paul A

“…The conventional battery for genotoxicity testing is not well suited to assessing the large number of chemicals needing evaluation. Traditional tests lack…”
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In Vitro Mammalian Mutagenicity of Complex Polycyclic Aromatic Hydrocarbon Mixtures in Contaminated Soils by Lemieux, Christine L, Long, Alexandra S, Lambert, Iain B, Lundstedt, Staffan, Tysklind, Mats, White, Paul A

“…This study employed an in vitro version of the lacZ transgenic rodent mutation assay to assess the mutagenicity of nonpolar neutral and semipolar aromatic soil…”
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Carcinogenicity of occupational exposure as a firefighter by Demers, Paul A, DeMarini, David M, Fent, Kenneth W, Glass, Deborah C, Hansen, Johnni, Adetona, Olorunfemi, Andersen, Maria HG, Freeman, Laura E Beane, Caban-Martinez, Alberto J, Daniels, Robert D, Driscoll, Timothy R, Goodrich, Jaclyn M, Graber, Judith M, Kirkham, Tracy L, Kjaerheim, Kristina, Kriebel, David, Long, Alexandra S, Main, Luana C, Oliveira, Marta, Peters, Susan, Teras, Lauren R, Watkins, Emily R, Burgess, Jefferey L, Stec, Anna A, White, Paul A, DeBono, Nathan L, Benbrahim-Tallaa, Lamia, de Conti, Aline, El Ghissassi, Fatiha, Grosse, Yann, Stayner, Leslie T, Suonio, Eero, Viegas, Susana, Wedekind, Roland, Boucheron, Pauline, Hosseini, Bayan, Kim, Joanne, Zahed, Hana, Mattock, Heidi, Madia, Federica, Schubauer-Berigan, Mary K

“…In June, 2022, 25 scientists from eight countries met at the International Agency for Research on Cancer (IARC) in Lyon, France, to finalise their evaluation…”
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Molecular Compositions, Mutagenicity, and Mutation Spectra of Atmospheric Oxidation Products of Alkenes and Dienes Initiated by NOx + UV or Ozone: A Structure–Activity Analysis by Lewandowski, Michael, Riedel, Theran P., Krug, Jonathan D., Kleindienst, Tadeusz E., Meier, Matthew J., Long, Alexandra S., Warren, Sarah H., DeMarini, David M.

“…Photooxidation products resulting from volatile organic compounds (VOCs) reacting with sunlight are important contributors to gas-phase air pollution. We…”
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2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD)-Inducible Poly-ADP-Ribose Polymerase (TIPARP/PARP7) Catalytic Mutant Mice (TiparpH532A) Exhibit Increased Sensitivity to TCDD-Induced Hepatotoxicity and Lethality by Hutin, David, Long, Alexandra S, Sugamori, Kim, Shao, Peng, Singh, Sachin Kumar, Rasmussen, Marit, Olafsen, Ninni Elise, Pettersen, Solveig, Grimaldi, Giulia, Grant, Denis M, Matthews, Jason

“…Abstract 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly-adenosine diphosphate (ADP)-ribose polymerase (TIPARP/PARP7), an aryl hydrocarbon receptor…”
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Benchmark dose analyses of multiple genetic toxicity endpoints permit robust, cross-tissue comparisons of MutaMouse responses to orally delivered benzo[a]pyrene by Long, Alexandra S., Wills, John W., Krolak, Dorothy, Guo, Matthew, Dertinger, Stephen D., Arlt, Volker M., White, Paul A.

“…Genetic damage is a key event in tumorigenesis, and chemically induced genotoxic effects are a human health concern. Although genetic toxicity data have…”
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Interpretation of in vitro concentration-response data for risk assessment and regulatory decision-making: Report from the 2022 IWGT quantitative analysis expert working group meeting by Beal, Marc A, Chen, Guangchao, Dearfield, Kerry L, Gi, Min, Gollapudi, Bhaskar, Heflich, Robert H, Horibata, Katsuyoshi, Long, Alexandra S, Lovell, David P, Parsons, Barbara L, Pfuhler, Stefan, Wills, John, Zeller, Andreas, Johnson, George, White, Paul A

“…Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non-animal…”
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Establishing a quantitative framework for regulatory interpretation of genetic toxicity dose–response data: Margin of exposure case study of 48 compounds with both in vivo mutagenicity and carcinogenicity dose–response data by Chepelev, Nikolai, Long, Alexandra S., Beal, Marc, Barton‐Maclaren, Tara, Johnson, George, Dearfield, Kerry L., Roberts, Daniel J., Benthem, Jan, White, Paul

“…Quantitative relationships between carcinogenic potency and mutagenic potency have been previously examined using a benchmark dose (BMD)‐based approach. We…”
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Empirical analysis of BMD metrics in genetic toxicology part II: in vivo potency comparisons to promote reductions in the use of experimental animals for genetic toxicity assessment by Wills, John W, Long, Alexandra S, Johnson, George E, Bemis, Jeffrey C, Dertinger, Stephen D, Slob, Wout, White, Paul A

“…Genotoxicity tests have traditionally been used only for hazard identification, with qualitative dichotomous groupings being used to identify compounds that…”
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Genetic Toxicity of Complex Mixtures of Polycyclic Aromatic Hydrocarbons: Evaluating Dose-Additivity in a Transgenic Mouse Model by Long, Alexandra S, Lemieux, Christine L, Gagné, Rémi, Lambert, Iain B, White, Paul A

“…This study evaluates the risk assessment approach currently employed for polycyclic aromatic hydrocarbon (PAH)-contaminated media, wherein carcinogenic hazards…”
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Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT) by Parsons, Barbara L, Beal, Marc A, Dearfield, Kerry L, Douglas, George R, Gi, Min, Gollapudi, B Bhaskar, Heflich, Robert H, Horibata, Katsuyoshi, Kenyon, Michelle, Long, Alexandra S, Lovell, David P, Lynch, Anthony M, Myers, Meagan B, Pfuhler, Stefan, Vespa, Alisa, Zeller, Andreas, Johnson, George E, White, Paul A

“…Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose-response curve (e.g., benchmark dose) by a…”
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In vitro mutagenicity of selected environmental carcinogens and their metabolites in MutaMouse FE1 lung epithelial cells by Hölzl-Armstrong, Lisa, Nævisdal, Andrea, Cox, Julie A, Long, Alexandra S, Chepelev, Nikolai L, Phillips, David H, White, Paul A, Arlt, Volker M

“…Abstract Chemicals in commerce or under development must be assessed for genotoxicity; assessment is generally conducted using validated assays (e.g. Tk mouse…”
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Oral exposure to commercially available coal tar-based pavement sealcoat induces murine genetic damage and mutations by Long, Alexandra S., Watson, Margaret, Arlt, Volker M., White, Paul A.

“…Coal tar (CT) is a thick black liquid produced as a by‐product of coal carbonization to produce coke or manufactured gas. It is comprised a complex mixture of…”
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