Search Results - "Lone, Nazir A"

Trigonelline prevents high cholesterol and high fat diet induced hepatic lipid accumulation and lipo-toxicity in C57BL/6J mice, via restoration of hepatic autophagy by Sharma, Love, Lone, Nazir A., Knott, Rachel M., Hassan, Adil, Abdullah, Tasduq

“…Non-alcoholic fatty liver disease (NAFLD) is often linked with impaired hepatic autophagy. Here, we studied the alterations in hepatocellular autophagy by high…”
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Trigonelline, a naturally occurring alkaloidal agent protects ultraviolet-B (UV-B) irradiation induced apoptotic cell death in human skin fibroblasts via attenuation of oxidative stress, restoration of cellular calcium homeostasis and prevention of endoplasmic reticulum (ER) stress by Lone A, Nazir, Malik A, Tanveer, Naikoo H, Shahid, Raghu R, Sharma, A Tasduq, Sheikh

“…It has been widely reported that ultraviolet-B (UV-B) radiation is the main extrinsic etiological agent that causes skin photodamage. UV-B exposure mediated…”
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Trigonelline, a plant derived alkaloid prevents ultraviolet-B-induced oxidative DNA damage in primary human dermal fibroblasts and BALB/c mice via modulation of phosphoinositide 3-kinase-Akt-Nrf2 signalling axis by Tanveer, Malik A., Rashid, Haroon, Nazir, Lone A., Archoo, Sajida, Shahid, Naiku H., Ragni, Gupta, Umar, Sheikh A., Tasduq, Sheikh A.

“…DNA is the main target for UV-B-irradiation-induced skin photodamage and accounts for 90 % of all the non-melanoma skin cancers. In this study, we explored the…”
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Inhibition of Ultraviolet‐B Radiation Induced Photodamage by Trigonelline Through Modulation of Mitogen Activating Protein Kinases and Nuclear Factor‐κB Signaling Axis in Skin by A. Nazir, Lone, Tanveer, Malik A., Umar, Sheikh A., Love, Sharma, Divya, Gupta, Tasduq, Sheikh A.

“…Cutaneous photodamage is incited via exposure of ultraviolet‐B (UV‐B) radiation to skin, characterized by the manifestation of oxidative stress, inflammation,…”
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Chemical chaperone 4-phenyl butyric acid (4-PBA) reduces hepatocellular lipid accumulation and lipotoxicity through induction of autophagy[S] by Nissar, Ashraf U., Sharma, Love, Mudasir, Malik A., Nazir, Lone A., Umar, Sheikh A., Sharma, Parduman R., Vishwakarma, Ram A., Tasduq, Sheikh A.

“…Defective autophagy has been linked to lipotoxicity in several cellular models. We aimed to investigate autophagy in lipid-stimulated hepatoma (Huh7) cells and…”
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A Potent Inhibitor of Phosphoinositide 3-Kinase (PI3K) and Mitogen Activated Protein (MAP) Kinase Signalling, Quercetin (3, 3', 4', 5, 7-Pentahydroxyflavone) Promotes Cell Death in Ultraviolet (UV)-B-Irradiated B16F10 Melanoma Cells by Rafiq, Rather A, Quadri, Afnan, Nazir, Lone A, Peerzada, Kaiser, Ganai, Bashir A, Tasduq, Sheikh A

“…Ultraviolet (UV) radiation-induced skin damage contributes strongly to the formation of melanoma, a highly lethal form of skin cancer. Quercetin (Qu), the most…”
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Glycyrrhizic Acid Prevents Oxidative Stress Mediated DNA Damage Response through Modulation of Autophagy in Ultraviolet-B-Irradiated Human Primary Dermal Fibroblasts by Umar, Sheikh A, Tanveer, Malik A, Nazir, Lone A, Divya, Gupta, Vishwakarma, Ram A, Tasduq, Sheikh A

“…Excessive exposure to UV radiation negatively affects the human skin, characterized by photo-damage (premature aging & carcinogenesis). UV-B radiation causes…”
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Synthesis and anti-melanoma effect of 3-O-prenyl glycyrrhetinic acid against B16F10 cells via induction of endoplasmic reticulum stress-mediated autophagy through ERK/AKT signaling pathway by Nazir, Lone A., Shahid, Naikoo H., Amit, Kumar, Umar, Sheikh A., Rajni, Sharma, Bharate, Sandip, Sangwan, Pyare L., Tasduq, Sheikh Abdullah

“…Melanoma is an aggressive form of cancer with poor prognosis and survival rates and limited therapeutic options. Here, we report the anti-melanoma effect of…”
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Glycyrrhizic acid prevents ultraviolet-B-induced photodamage: a role for mitogen-activated protein kinases, nuclear factor kappa B and mitochondrial apoptotic pathway by Afnan, Quadri, Kaiser, Peerzada J., Rafiq, Rather A., Nazir, Lone A., Bhushan, Shashi, Bhardwaj, Subhash C., Sandhir, Rajat, Tasduq, Sheikh A.

“…Glycyrrhizic acid (GA), a natural triterpene, has received attention as an agent that has protective effects against chronic diseases including ultraviolet…”
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Mortality benefit of vasopressor and inotropic agents in septic shock: A Bayesian network meta-analysis of randomized controlled trials by Oba, Yuji, MD, FCCP, Lone, Nazir A., MD, MPH

“…Abstract Objective The choice of vasopressor in septic shock has been a matter of debate. The purpose of this study was to systematically review overall…”
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Efficacy and safety of roflumilast in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis by Oba, Yuji, Lone, Nazir A

“…Roflumilast, a phosphodiesterase 4 inhibitor, has been shown to improve lung function and reduce exacerbation rates, but is associated with adverse events…”
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Comparative efficacy of long-acting muscarinic antagonists in preventing COPD exacerbations: a network meta-analysis and meta-regression by Oba, Yuji, Lone, Nazir A

“…We hypothesized a class effect of currently available long-acting muscarinic antagonists (LAMAs; i.e., tiotropium as a dry powder inhaler or a soft mist…”
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Cardiovascular Safety of Roflumilast by Oba, Yuji, MD, Lone, Nazir A., MD

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Cardiac lymphangioma presenting as intrapericardial cystic mass by Lone, Nazir A, Naikoo, Bashir A, Khan, Naseer A

“…Cystic lymphangioma usually confined to head and neck is a well-recognized tumor that occurs during childhood. However, a cardiac lymphangioma is exceptionally…”
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Inhibition of melanogenesis by 3-(1′-methyltetrahydropyridinyl)-2,4-6-trihydroxy acetophenone via suppressing the activity of cAMP response element-binding protein (CREB) and nuclear exclusion of CREB-regulated transcription coactivator 1 (CRTC1) by Naikoo, Shahid H., Rashid, Haroon, Kumar, Sanjay, Archoo, Sajida, Sheikh, Umar A., Lone, Nazir A., Singh, Parvinder P., Tasduq, Sheikh A.

“…Exposure to Ultraviolet radiation or α-melanocyte-stimulating hormone (α-MSH) stimulates the Cyclic Adenosine Monophosphate/Protein Kinase A signalling…”
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Anti-inflammatory potential of hentriacontane in LPS stimulated RAW 264.7 cells and mice model by Khajuria, Vidushi, Gupta, Shilpa, Sharma, Neha, Kumar, Ashok, Lone, Nazir A, Khullar, Mowkshi, Dutt, Prabhu, Sharma, Parduman Raj, Bhagat, Asha, Ahmed, Zabeer

“…Graphical abstract…”
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Concomitant Pulmonary Aspergillosis Following Severe COVID-19 by Munir, Ahmad, Dahhan, Hadi, Huda, Zoha, Lone, Nazir A

“…This case report discusses an atypical complication of COVID-19 pneumonia in a 68-year-old male patient, distinguished by the development of cavitary lung…”
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The amino analogue of β-boswellic acid efficiently attenuates the release of pro-inflammatory mediators than its parent compound through the suppression of NF-κB/IκBα signalling axis by Gupta, Shilpa, Ahsan, Aitizaz Ul, Wani, Abubakar, Khajuria, Vidushi, Nazir, Lone A., Sharma, Simmi, Bhagat, Asha, Raj Sharma, Parduman, Bhardwaj, Subhash, Peerzada, Kaiser J., Ali Shah, Bhahwal, Ahmed, Zabeer

“…[Display omitted] •Comparative study of β-boswellic acid and its analogue, BA-25 for anti-inflammatory potential.•BA-25 strongly inhibits the expression iNOS,…”
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Comparative efficacy of inhaled corticosteroid and long-acting beta agonist combinations in preventing COPD exacerbations: a Bayesian network meta-analysis by Oba, Yuji, Lone, Nazir A

“…A combination therapy with inhaled corticosteroid (ICS) and a long-acting beta agonist (LABA) is recommended in severe chronic obstructive pulmonary disease…”
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Tumor Heterogeneity Shapes Survival Dynamics in Drug-Treated Cells, Revealing Size-Drifting Subpopulations by Vangala, Venugopal, Chen, Yu-Chi, Dinavahi, Saketh S., Gowda, Krishne, Lone, Nazir A., Herlyn, Meenhard, Drabick, Joseph, Helm, Klaus, Zhu, Jiyue, Neves, Rogerio I., Sharma, Arun K., Berg, Arthur, Archetti, Marco, Amin, Shantu, Schell, Todd D., Robertson, Gavin P.

“…The goal of this project was to demonstrate that subpopulations of cells in tumors can uniquely fluctuate in size in response to environmental conditions…”
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