Search Results - "London, Robert E."

The structural basis of XRCC1-mediated DNA repair by London, Robert E.

“…Scaffold proteins play a central role in DNA repair by recruiting and organizing sets of enzymes required to perform multi-step repair processes. X-ray cross…”
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ZATT (ZNF451)–mediated resolution of topoisomerase 2 DNA-protein cross-links by Schellenberg, Matthew J., Lieberman, Jenna Ariel, Herrero-Ruiz, Andrés, Butler, Logan R., Williams, Jason G., Muñoz-Cabello, Ana M., Mueller, Geoffrey A., London, Robert E., Cortés-Ledesma, Felipe, Williams, R. Scott

“…Topoisomerase 2 (TOP2) DNA transactions proceed via formation of the TOP2 cleavage complex (TOP2cc), a covalent enzyme-DNA reaction intermediate that is…”
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Multiple roles of Bet v 1 ligands in allergen stabilization and modulation of endosomal protease activity by Soh, Wai Tuck, Aglas, Lorenz, Mueller, Geoffrey A., Gilles, Stefanie, Weiss, Richard, Scheiblhofer, Sandra, Huber, Sara, Scheidt, Tamara, Thompson, Peter M., Briza, Peter, London, Robert E., Traidl‐Hoffmann, Claudia, Cabrele, Chiara, Brandstetter, Hans, Ferreira, Fatima

“…Background Over 100 million people worldwide suffer from birch pollen allergy. Bet v 1 has been identified as the major birch pollen allergen. However, the…”
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Phosphopeptide interactions of the Nbs1 N-terminal FHA-BRCT1/2 domains by Kim, Kyungmin, Kirby, Thomas W., Perera, Lalith, London, Robert E.

“…Human Nbs1, a component of the MRN complex involved in DNA double strand break repair, contains a concatenated N-terminal FHA-BRCT1/2 sequence that supports…”
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APE2 Zf-GRF facilitates 3′-5′ resection of DNA damage following oxidative stress by Wallace, Bret D., Berman, Zachary, Mueller, Geoffrey A., Lin, Yunfeng, Chang, Timothy, Andres, Sara N., Wojtaszek, Jessica L., DeRose, Eugene F., Appel, C. Denise, London, Robert E., Yan, Shan, Williams, R. Scott

“…The Xenopus laevis APE2 (apurinic/apyrimidinic endonuclease 2) nuclease participates in 3′-5′ nucleolytic resection of oxidative DNA damage and activation of…”
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The novel structure of the cockroach allergen Bla g 1 has implications for allergenicity and exposure assessment by Mueller, Geoffrey A., PhD, Pedersen, Lars C., PhD, Lih, Fred B., BA, Glesner, Jill, BS, Moon, Andrea F., MS, Chapman, Martin D., PhD, Tomer, Kenneth B., PhD, London, Robert E., PhD, Pomés, Anna, PhD

“…Background Sensitization to cockroach allergens is a major risk factor for asthma. The cockroach allergen Bla g 1 has multiple repeats of approximately 100…”
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Analysis of glutathione S-transferase allergen cross-reactivity in a North American population: Relevance for molecular diagnosis by Mueller, Geoffrey A., PhD, Pedersen, Lars C., PhD, Glesner, Jill, BS, Edwards, Lori L., BS, Zakzuk, Josefina, MD, PhD, London, Robert E., PhD, Arruda, L. Karla, MD, PhD, Chapman, Martin D., PhD, Caraballo, Luis, MD, PhD, Pomés, Anna, PhD

“…Background It is not clear whether cross-reactivity or cosensitization to glutathione S-transferases (GSTs) occurs in tropical and subtropical environments. In…”
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Solution Structure of the Dickerson DNA Dodecamer Containing a Single Ribonucleotide by DeRose, Eugene F, Perera, Lalith, Murray, Michael S, Kunkel, Thomas A, London, Robert E

“…Ribonucleotides are frequently incorporated into DNA during replication. They are recognized and processed by several cellular enzymes, and their continued…”
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Oxidation state of the XRCC1 N-terminal domain regulates DNA polymerase β binding affinity by Cuneo, Matthew J, London, Robert E

“…Formation of a complex between the XRCC1 N-terminal domain (NTD) and DNA polymerase β (Pol β) is central to base excision repair of damaged DNA. Two crystal…”
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Structural Maturation of HIV-1 Reverse Transcriptase-A Metamorphic Solution to Genomic Instability by London, Robert E

“…Human immunodeficiency virus 1 (HIV-1) reverse transcriptase (RT)-a critical enzyme of the viral life cycle-undergoes a complex maturation process, required so…”
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XRCC1 – Strategies for coordinating and assembling a versatile DNA damage response by London, Robert E.

“…X-ray cross complementing protein 1 (XRCC1) is a DNA repair scaffold that supports base excision repair and single strand break repair, and is also a…”
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Nuclear Localization of the DNA Repair Scaffold XRCC1: Uncovering the Functional Role of a Bipartite NLS by Kirby, Thomas W., Gassman, Natalie R., Smith, Cassandra E., Pedersen, Lars C., Gabel, Scott A., Sobhany, Mack, Wilson, Samuel H., London, Robert E.

“…We have characterized the nuclear localization signal (NLS) of XRCC1 structurally using X-ray crystallography and functionally using fluorescence imaging…”
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Targeting the Structural Maturation Pathway of HIV-1 Reverse Transcriptase by Kirby, Thomas W, Gabel, Scott A, DeRose, Eugene F, Perera, Lalith, Krahn, Juno M, Pedersen, Lars C, London, Robert E

“…Formation of active HIV-1 reverse transcriptase (RT) proceeds via a structural maturation process that involves subdomain rearrangements and formation of an…”
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The structure of the dust mite allergen Der p 7 reveals similarities to innate immune proteins by Mueller, Geoffrey A., PhD, Edwards, Lori L., BS, Aloor, Jim J., PhD, Fessler, Michael B., MD, Glesner, Jill, BS, Pomés, Anna, PhD, Chapman, Martin D., PhD, London, Robert E., PhD, Pedersen, Lars C., PhD

“…Background Sensitization to house dust mite allergens is strongly correlated with asthma. Der p 7 elicits strong IgE antibody and T-cell responses in patients…”
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Are dust mite allergens more abundant and/or more stable than other Dermatophagoides pteronyssinus proteins? by Ogburn, Ryenne N., BS, Randall, Thomas A., PhD, Xu, Yingrong, BS, Roberts, Julia H., BS, Mebrahtu, Betelihem, Karnuta, Jaret M, Rider, S. Dean, PhD, Kissling, Grace E., PhD, London, Robert E., PhD, Pomés, Anna, PhD, Arlian, Larry, PhD, Fitzgerald, Michael C., PhD, Mueller, Geoffrey A., PhD

“…[...]many are outliers in the quartile analysis of the DP transcriptome. Other influences on sensitization include additional environmental exposures,…”
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The aminosalicylate - folate connection by London, Robert E

“…Two aminosalicylate isomers have been found to possess useful pharmacological behavior: -aminosalicylate (PAS, 4AS) is an anti-tubercular agent that targets ,…”
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Selective unfolding of one Ribonuclease H domain of HIV reverse transcriptase is linked to homodimer formation by Zheng, Xunhai, Pedersen, Lars C., Gabel, Scott A., Mueller, Geoffrey A., Cuneo, Matthew J., DeRose, Eugene F., Krahn, Juno M., London, Robert E.

“…HIV-1 reverse transcriptase (RT), a critical enzyme of the HIV life cycle and an important drug target, undergoes complex and largely uncharacterized…”
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Proteases of Dermatophagoides pteronyssinus by Randall, Thomas A, London, Robert E, Fitzgerald, Michael C, Mueller, Geoffrey A

“…Since the discovery that Der p 1 is a cysteine protease, the role of proteolytic activity in allergic sensitization has been explored. There are many allergens…”
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HIV-1 Reverse Transcriptase: A Metamorphic Protein with Three Stable States by London, Robert E.

“…There has been a steadily increasing appreciation of the fact that the relationship between protein sequence and structure is often sufficiently ambiguous to…”
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Asymmetric conformational maturation of HIV-1 reverse transcriptase by Zheng, Xunhai, Perera, Lalith, Mueller, Geoffrey A, DeRose, Eugene F, London, Robert E

“…HIV-1 reverse transcriptase utilizes a metamorphic polymerase domain that is able to adopt two alternate structures that fulfill catalytic and structural…”
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