Search Results - "Lomme, R."

Prevention of postsurgical adhesions using an ultrapure alginate-based gel by Chaturvedi, A. A., Lomme, R. M. L. M., Hendriks, T., van Goor, H.

“…Background Postoperative adhesion formation is a common consequence of abdominal surgery, and constitutes a major source of morbidity and mortality. This study…”
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Bioinspired coupled helical coils for soft tissue engineering of tubular structures – Improved mechanical behavior of tubular collagen type I templates by Janke, H.P., Bohlin, J., Lomme, R.M.L.M., Mihaila, S.M., Hilborn, J., Feitz, W.F.J., Oosterwijk, E.

“…[Display omitted] The design of constructs for tubular tissue engineering is challenging. Most biomaterials need to be reinforced with supporting structures…”
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Diclofenac causes more leakage than naproxen in anastomoses in the small intestine of the rat by van der Vijver, R. J., van Laarhoven, C. J. H. M., Lomme, R. M. L. M., Hendriks, T.

“…Background Non-steroid anti-inflammatory drugs such as the cyclooxygenase isoenzyme inhibitors diclofenac and naproxen are increasingly used for perioperative…”
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Intraoperative hyperthermic intraperitoneal chemotherapy after cytoreductive surgery for peritoneal carcinomatosis in an experimental model by Klaver, Y. L. B., Hendriks, T., Lomme, R. M. L. M., Rutten, H. J. T., Bleichrodt, R. P., de Hingh, I. H. J. T.

“…Background: The combination of cytoreductive surgery (CS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is the treatment of choice for selected…”
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Matrix metalloproteinase 2 and 9 activity in patients with colorectal cancer liver metastasis by Waas, E. T., Wobbes, T., Lomme, R. M. L. M., DeGroot, J., Ruers, T., Hendriks, T.

“…Background: Matrix metalloproteinases (MMPs) have been reported to play an important role in tumour cell invasion and metastasis. The bioactivity of MMPs in…”
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The Effects of Adjuvant Experimental Radioimmunotherapy and Hyperthermic Intraperitoneal Chemotherapy on Intestinal and Abdominal Healing after Cytoreductive Surgery for Peritoneal Carcinomatosis in the Rat by Aarts, F., Bleichrodt, R. P., de Man, B., Lomme, R., Boerman, O. C., Hendriks, T.

“…Background Cytoreductive surgery (CS) followed by hyperthermic intraperitoneal chemotherapy (HIPEC) results in limited survival benefit and high morbidity and…”
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Selective cyclo-oxygenase 2 inhibition affects ileal but not colonic anastomotic healing in the early postoperative period by de Hingh, I. H. J. T., van Goor, H., de Man, B. M., Lomme, R. M. L. M., Bleichrodt, R. P., Hendriks, T.

“…Background: Selective cyclo‐oxygenase 2 (COX‐2) inhibitors are increasingly prescribed in the perioperative period. Recent recognition of a possible role for…”
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Early Anastomotic Repair in the Rat Intestine is Affected by Transient Preoperative Mesenteric Ischemia by Posma, L. A. E., Bleichrodt, R. P., Lomme, R. M. L. M., de Man, B. M., van Goor, H., Hendriks, T.

“…Introduction During bowel surgery, perioperative blood loss and hypotension can lead to transient intestinal ischemia. Recent preclinical studies reveal that…”
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Perioperative Pain Relief by a COX-2 Inhibitor Affects Ileal Repair and Provides a Model for Anastomotic Leakage in the Intestine by van der Vijver, R. J., van Laarhoven, C. J. H. M., de Man, B. M., Lomme, R. M. L. M., Hendriks, T.

“…The authors examined the potential of the cyclooxygenase 2 (COX-2) inhibitor carprofen to reproducibly induce anastomotic leakage. In experiment 1, an…”
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Colonic anastomotic strength and matrix metalloproteinase activity in an experimental model of bacterial peritonitis by de Hingh, I. H. J. T., de Man, B. M., Lomme, R. M. L. M., van Goor, H., Hendriks, T.

“…Background: Clinical studies report conflicting results on the safety of primary intestinal anastomoses in the presence of peritonitis, and comprehensive…”
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Experimental study of diclofenac and its biliary metabolites on anastomotic healing by Yauw, S T K, Lomme, R M L M, van den Broek, P, Greupink, R, Russel, F G M, van Goor, H

“…Diclofenac increases the risk of anastomotic leakage, but the underlying mechanism is unknown. As diclofenac is excreted largely as biliary metabolites, the…”
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Tissue levels of active matrix metalloproteinase-2 and -9 in colorectal cancer by WAAS, E. T, LOMME, Rmlm, DEGROOT, J, WOBBES, Th, HENDRIKS, T

“…The bioactivity of matrix metalloproteinases was studied in tissues from colorectal cancer patients by means of both quantitative gelatin zymography and a…”
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Circulating gelatinases and tissue inhibitor of metalloproteinase-1 in colorectal cancer metastatic liver disease by Waas, E.T., Wobbes, Th, Ruers, T., Lomme, R.M.L.M., Hendriks, T.

“…The degradation of the extracellular matrix is intrinsic to the invasion and progression of cancer. Matrix metalloproteinase (MMP)-2 and -9 and their natural…”
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The matrix metalloproteinase inhibitor BB-94 improves the strength of intestinal anastomoses in the rat by DE HINGH, I. H. J. T, SIEMONSMA, M. A, DE MAN, B. M, LOMME, R. M. L. M, HENDRIKS, T

“…The strength of intestinal anastomoses is relatively low in the first days after operation, possibly as a result of localized degradation of the supporting…”
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Increased expression of matrix metalloproteinases in the murine zymosan-induced multiple organ dysfunction syndrome by Volman, TJH, Goris, RJA, Lomme, RMLM, DeGroot, J, Verhofstad, Albert AJ, Hendriks, T

“…Matrix metalloproteinases (MMPs) have been implicated as mediators of tissue damage in several inflammatory diseases. Since the multiple organ dysfunction…”
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Circulating matrix metalloproteinase-9 is transiently elevated after colorectal surgery by DE HINGH, I. H. J. T, WAAS, E. T, LOMME, R. M. L. M, WOBBES, T, HENDRIKS, T

“…Plasma levels of matrix metalloproteinases (MMPs) may yield important information in patients suffering from colorectal cancer but the effect of surgery, a…”
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No detrimental effects of repeated laparotomies on early healing of experimental intestinal anastomoses by DE HINGH, I. H. J. T, VAN GOOR, H, DE MAN, B. M, LOMME, R. M. L. M, BLEICHRODT, R. P, HENDRIKS, T

“…Little is known about the impact of repeated laparotomies on intestinal anastomotic healing. While experimental data are completely lacking, the sparse data…”
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Plasma gelatinase activity does not reflect disease activity after operation for colorectal cancer by Waas, E T, Wobbes, Th, Lomme, R M L M, Hendriks, T

“…To investigate if plasma matrix metalloproteinase (MMP)-2 or -9 are better markers for disease activity than carcinoembryonic antigen (CEA) in the…”
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Microbial Glucuronidase Inhibition Reduces Severity of Diclofenac-Induced Anastomotic Leak in Rats by Yauw, Simon T K, Arron, Melissa, Lomme, Roger M L M, van den Broek, Petra, Greupink, Rick, Bhatt, Aadra P, Redinbo, Matthew R, van Goor, Harry

“…The non-steroidal anti-inflammatory drug diclofenac has been associated with intestinal anastomotic leakage, although the underlying pathophysiology is…”
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A SHORT DELAY IN ADMINISTRATION OF EVEROLIMUS RESULTS IN NORMALIZED WOUND HEALING IN A RAT-BOWEL ANASTOMOSIS MODEL: 1652 by Willems, M, Hendriks, T, de Man, B, Lomme, R, van der Vliet, J A.

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