Search Results - "Lombroso, Sonia I."

Cell-Type-Specific Epigenetic Editing at the Fosb Gene Controls Susceptibility to Social Defeat Stress by Hamilton, Peter J, Burek, Dominika J, Lombroso, Sonia I, Neve, Rachael L, Robison, Alfred J, Nestler, Eric J, Heller, Elizabeth A

“…Chronic social defeat stress regulates the expression of Fosb in the nucleus accumbens (NAc) to promote the cell-type-specific accumulation of ΔFosB in the two…”
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Nr4a1 suppresses cocaine-induced behavior via epigenetic regulation of homeostatic target genes by Carpenter, Marco D., Hu, Qiwen, Bond, Allison M., Lombroso, Sonia I., Czarnecki, Kyle S., Lim, Carissa J., Song, Hongjun, Wimmer, Mathieu E., Pierce, R. Christopher, Heller, Elizabeth A.

“…Endogenous homeostatic mechanisms can restore normal neuronal function following cocaine-induced neuroadaptations. Such mechanisms may be exploited to develop…”
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CRISPR generation of CSF1R-G795A human microglia for robust microglia replacement in a chimeric mouse model by Chadarevian, Jean Paul, Davtyan, Hayk, Lombroso, Sonia I., Bennett, F. Chris, Blurton-Jones, Mathew

“…Chimeric mouse models have recently been developed to study human microglia in vivo. However, widespread engraftment of donor microglia within the adult brain…”
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Chromatin-mediated alternative splicing regulates cocaine-reward behavior by Xu, Song-Jun, Lombroso, Sonia I., Fischer, Delaney K., Carpenter, Marco D., Marchione, Dylan M., Hamilton, Peter J., Lim, Carissa J., Neve, Rachel L., Garcia, Benjamin A., Wimmer, Mathieu E., Pierce, R. Christopher, Heller, Elizabeth A.

“…Neuronal alternative splicing is a key gene regulatory mechanism in the brain. However, the spliceosome machinery is insufficient to fully specify splicing…”
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Engineering an inhibitor-resistant human CSF1R variant for microglia replacement by Chadarevian, Jean Paul, Lombroso, Sonia I, Peet, Graham C, Hasselmann, Jonathan, Tu, Christina, Marzan, Dave E, Capocchi, Joia, Purnell, Freddy S, Nemec, Kelsey M, Lahian, Alina, Escobar, Adrian, England, Whitney, Chaluvadi, Sai, O'Brien, Carleigh A, Yaqoob, Fazeela, Aisenberg, William H, Porras-Paniagua, Matias, Bennett, Mariko L, Davtyan, Hayk, Spitale, Robert C, Blurton-Jones, Mathew, Bennett, F Chris

“…Hematopoietic stem cell transplantation (HSCT) can replace endogenous microglia with circulation-derived macrophages but has high mortality. To mitigate the…”
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Targeted Epigenetic Remodeling of the Cdk5 Gene in Nucleus Accumbens Regulates Cocaine- and Stress-Evoked Behavior by Heller, Elizabeth A, Hamilton, Peter J, Burek, Dominika D, Lombroso, Sonia I, Peña, Catherine J, Neve, Rachael L, Nestler, Eric J

“…Recent studies have implicated epigenetic remodeling in brain reward regions following psychostimulant or stress exposure. It has only recently become possible…”
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Sex-Specific Regulation of Fear Memory by Targeted Epigenetic Editing of Cdk5 by Sase, Ajinkya S., Lombroso, Sonia I., Santhumayor, Brandon A., Wood, Rozalyn R., Lim, Carissa J., Neve, Rachael L., Heller, Elizabeth A.

“…Sex differences in the expression and prevalence of trauma- and stress-related disorders have led to a growing interest in the sex-specific molecular and…”
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