Search Results - "Lombard, D. B."

SIRT6 in DNA repair, metabolism and ageing by Lombard, D. B., Schwer, B., Alt, F. W., Mostoslavsky, R.

“… Ageing, or increased mortality with time, coupled with physiologic decline, is a nearly universal yet poorly understood biological phenomenon. Studies in…”
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Nijmegen breakage syndrome disease protein and MRE11 at PML nuclear bodies and meiotic telomeres by LOMBARD, D. B, GUARENTE, L

“…Nijmegen breakage syndrome is a disease characterized by immunodeficiency, genomic instability, and cancer susceptibility. The gene product defective in…”
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DNA Repair, Genome Stability, and Aging by Lombard, David B., Chua, Katrin F., Mostoslavsky, Raul, Franco, Sonia, Gostissa, Monica, Alt, Frederick W.

“…Aging can be defined as progressive functional decline and increasing mortality over time. Here, we review evidence linking aging to nuclear DNA lesions: DNA…”
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Uncovering of Functional Alternative CTLA-4 Counter-Receptor in B7-Deficient Mice by Freeman, Gordon J., Borriello, Frank, Hodes, Richard J., Reiser, Hans, Hathcock, Karen S., Laszlo, Gloria, McKnight, Andrew J., Kim, Jinny, Du, Lina, Lombard, David B., Gray, Gary S., Nadler, Lee M., Sharpe, Arlene H.

“…B7 delivers a costimulatory signal through CD28, resulting in interleukin-2 secretion and T cell proliferation. Blockade of this pathway results in T cell…”
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Characterization of CTLA-4 structure and expression on human T cells by Lindsten, T, Lee, KP, Harris, ES, Petryniak, B, Craighead, N, Reynolds, PJ, Lombard, DB, Freeman, GJ, Nadler, LM, Gray, GS

“…CTLA-4 is an adhesion receptor expressed on activated T cells. The amino acid sequence of CTLA-4 is related to CD28, and although the function of CTLA-4…”
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Cloning the gene for Werner syndrome: a disease with many symptoms of premature aging by Lombard, David B., Guarente, Leonard

“…Werner syndrome is a rare human genetic disease with many symptoms resembling premature aging. The gene defective in individuals with Werner syndrome has…”
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Association of the bloom syndrome protein with topoisomerase IIIα in somatic and meiotic cells by JOHNSON, F. B, LOMBARD, D. B, NEFF, N. F, MASTRANGELO, M.-A, DEWOLF, W, ELLIS, N. A, MARCINIAK, R. A, YIZHONG YIN, JAENISCH, R, GUARENTE, L

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Mutations in the WRN Gene in Mice Accelerate Mortality in a p53-Null Background by Lombard, David B., Beard, Caroline, Johnson, Brad, Marciniak, Robert A., Dausman, Jessie, Bronson, Roderick, Buhlmann, Janet E., Lipman, Ruth, Curry, Ruth, Sharpe, Arlene, Jaenisch, Rudolf, Guarente, Leonard

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Nucleolar Localization of the Werner Syndrome Protein in Human Cells by Marciniak, Robert A., Lombard, David B., Johnson, F. Bradley, Guarente, Leonard

“…Werner Syndrome (WS) is a human genetic disorder with many features of premature aging. The gene defective in WS (WRN) has been cloned and encodes a protein…”
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Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7 by FREEMAN, G. J, GRAY, G. S, GIMMI, C. D, LOMBARD, D. B, LIANG-JI ZHOU, WHITE, M, FINGEROTH, J. D, GRIBBEN, J. G, NADLER, L. M

“…Following occupancy of the T cell receptor by antigen, T cell proliferation and lymphokine production are determined by a second costimulatory signal delivered…”
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CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production by Freeman, GJ, Lombard, DB, Gimmi, CD, Brod, SA, Lee, K, Laning, JC, Hafler, DA, Dorf, ME, Gray, GS, Reiser, H

“…Ag-presenting cells provide at least two distinct signals for T cell activation. T cell receptor-dependent stimulation is provided by presentation of a…”
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Analysis of the Role of RecQ Helicases in RNAi in Mammals by Stein, Paula, Svoboda, Petr, Stumpo, Deborah J., Blackshear, Perry J., Lombard, David B., Johnson, Brad, Schultz, Richard M.

“…The identity of mammalian genes involved in RNA interference (RNAi), the targeted sequence-specific mRNA degradation by double-stranded RNA (dsRNA), is poorly…”
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Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6 by Mostoslavsky, Raul, Chua, Katrin F., Lombard, David B., Pang, Wendy W., Fischer, Miriam R., Gellon, Lionel, Liu, Pingfang, Mostoslavsky, Gustavo, Franco, Sonia, Murphy, Michael M., Mills, Kevin D., Patel, Parin, Hsu, Joyce T., Hong, Andrew L., Ford, Ethan, Cheng, Hwei-Ling, Kennedy, Caitlin, Nunez, Nomeli, Bronson, Roderick, Frendewey, David, Auerbach, Wojtek, Valenzuela, David, Karow, Margaret, Hottiger, Michael O., Hursting, Stephen, Barrett, J. Carl, Guarente, Leonard, Mulligan, Richard, Demple, Bruce, Yancopoulos, George D., Alt, Frederick W.

“…The Sir2 histone deacetylase functions as a chromatin silencer to regulate recombination, genomic stability, and aging in budding yeast. Seven mammalian Sir2…”
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H2AX Prevents DNA Breaks from Progressing to Chromosome Breaks and Translocations by Franco, Sonia, Gostissa, Monica, Zha, Shan, Lombard, David B., Murphy, Michael M., Zarrin, Ali A., Yan, Catherine, Tepsuporn, Suprawee, Morales, Julio C., Adams, Melissa M., Lou, Zhenkun, Bassing, Craig H., Manis, John P., Chen, Junjie, Carpenter, Phillip B., Alt, Frederick W.

“…Histone H2AX promotes DNA double-strand break (DSB) repair and immunoglobulin heavy chain (IgH) class switch recombination (CSR) in B-lymphocytes. CSR requires…”
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Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress by Chua, Katrin F., Mostoslavsky, Raul, Lombard, David B., Pang, Wendy W., Saito, Shin’ichi, Franco, Sonia, Kaushal, Dhruv, Cheng, Hwei-Ling, Fischer, Miriam R., Stokes, Nicole, Murphy, Michael M., Appella, Ettore, Alt, Frederick W.

“…The Saccharomyces cerevisiae chromatin silencing factor Sir2 suppresses genomic instability and extends replicative life span. In contrast, we find that mouse…”
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Telomere Shortening Exposes Functions for the Mouse Werner and Bloom Syndrome Genes by Du, Xiaobing, Shen, Johnny, Kugan, Nishan, Furth, Emma E., Lombard, David B., Cheung, Catherine, Pak, Sally, Luo, Guangbin, Pignolo, Robert J., DePinho, Ronald A., Guarente, Leonard, Johnson, F. Brad

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NEW VALUES IN TRADITIONAL FORMS A STUDY IN MENANDER'S 'ASPIS' by Lombard, D. B.

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CHARLES AUGUST VAN ROOY†: 15.01.1923–15.07.1998 by Lombard, D B

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Charles August van Rooy (15.01.1923-15.07.1998) by Lombard, D B

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Congenital adrenal hyperplasia with associated giant adrenal myelolipoma, testicular adrenal rest tumors and primary pigmented nodular adrenocortical disease: A case report and brief review of the literature by Jacobson, Aaron, Koberlein, Elaine, Thomay, Alan, Lombard, Cara B, Adelanwa, Ayodele, Lakhani, Dhairya A, Smith, Kelly T.

“…Congenital adrenal hyperplasia is an autosomal recessive disease most commonly associated with 21-hydroxylase deficiency, an enzyme integral in the…”
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