Search Results - "Lombard, D."

SIRT6 in DNA repair, metabolism and ageing by Lombard, D. B., Schwer, B., Alt, F. W., Mostoslavsky, R.

“… Ageing, or increased mortality with time, coupled with physiologic decline, is a nearly universal yet poorly understood biological phenomenon. Studies in…”
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DNA Repair, Genome Stability, and Aging by Lombard, David B., Chua, Katrin F., Mostoslavsky, Raul, Franco, Sonia, Gostissa, Monica, Alt, Frederick W.

“…Aging can be defined as progressive functional decline and increasing mortality over time. Here, we review evidence linking aging to nuclear DNA lesions: DNA…”
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Nijmegen breakage syndrome disease protein and MRE11 at PML nuclear bodies and meiotic telomeres by LOMBARD, D. B, GUARENTE, L

“…Nijmegen breakage syndrome is a disease characterized by immunodeficiency, genomic instability, and cancer susceptibility. The gene product defective in…”
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Custom real-time ultrasonic instrumentation for simultaneous mixture and flow analysis of binary gases in the CERN ATLAS experiment by Alhroob, M., Battistin, M., Berry, S., Bitadze, A., Bonneau, P., Boyd, G., Crespo-Lopez, O., Degeorge, C., Deterre, C., Di Girolamo, B., Doubek, M., Favre, G., Hallewell, G., Hasib, A., Katunin, S., Lombard, D., Madsen, A., McMahon, S., Nagai, K., O'Rourke, A., Pearson, B., Robinson, D., Rossi, C., Rozanov, A., Stanecka, E., Strauss, M., Vacek, V., Vaglio, R., Young, J., Zwalinski, L.

“…Custom ultrasonic instruments have been developed for simultaneous monitoring of binary gas mixture and flow in the ATLAS Inner Detector. Sound transit times…”
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Invasive rat establishment and changes in small mammal populations on Caribbean Islands following two hurricanes by Shiels, Aaron B., Lombard, Claudia D., Shiels, Laura, Hillis-Starr, Zandy

“…Invasive mammals, particularly black rats (Rattus rattus), house mice (Mus musculus), and mongoose (Herpestes auropunctatus) are established on many tropical…”
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A South African family with the mitochondrial A1555G mutation on haplogroup L0d by Human, H., Lombard, D., de Jong, G., Bardien, S.

“…The most common mutation associated with aminoglycoside-induced deafness is A1555G and it has been found in diverse populations worldwide. In the present study…”
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A Custom Online Ultrasonic Gas Mixture Analyzer With Simultaneous Flowmetry, Developed for the Upgraded Evaporative Cooling System of the ATLAS Silicon Tracker by Bates, R., Battistin, M., Berry, S., Berthoud, J., Bitadze, A., Bonneau, P., Botelho-Direito, J., Bousson, N., Boyd, G., Bozza, G., Da Riva, E., Crespo-Lopez, O., Degeorge, C., Deterre, C., DiGirolamo, B., Doubek, M., Favre, G., Godlewski, J., Hallewell, G., Katunin, S., Langevin, N., Lombard, D., Mathieu, M., McMahon, S., Nagai, K., Robinson, D., Rossi, C., Rozanov, A., Vacek, V., Vitek, M., Zwalinski, L.

“…We describe a combined ultrasonic instrument for continuous gas flow measurement and simultaneous real-time binary gas mixture analysis. In the instrument,…”
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Factors Associated with Smokeless Tobacco Use among Pregnant Women in Rural Areas of the Southern Terai, Nepal by Singh, J K, Acharya, D, Kadel, R, Adhikari, S, Lombard, D, Koirala, S, Paudel, R

“…Tobacco use among women during pregnancy leading to poor maternal and child health outcomes has been well documented. However, factors influencing use of…”
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Comparison of histological measures of skin photoaging by Hughes, M C, Bredoux, C, Salas, F, Lombard, D, Strutton, G M, Fourtanier, A, Green, A C

“…Dermal elastosis is considered the histological 'gold standard' for evaluation of skin photoaging, but the relation of the level of dermal elastosis to other…”
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A broad-spectrum sunscreen prevents cumulative damage from repeated exposure to sub-erythemal solar ultraviolet radiation representative of temperate latitudes by Seité, S, Christiaens, F, Bredoux, C, Compan, D, Zucchi, H, Lombard, D, Fourtanier, A, Young, AR

“…Background  We have previously shown the detrimental effects of 19 sub‐erythemal exposures to daily ultraviolet radiation (DUVR, which mimics non‐extreme…”
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Identification of a common founder couple for 40 South African Afrikaner families with Parkinson's disease by Geldenhuys, Gerhard, Glanzmann, Brigitte, Lombard, Debbie, Boolay, Sihaam, Carr, Jonathan, Bardien, Soraya

“…Afrikaners are a unique ethnic group in South Africa (SA) with well-documented ancestral records spanning a period of over 350 years. They are mainly descended…”
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Factors influencing the development of early- or late-onset Parkinson's disease in a cohort of South African patients by DER MERWE, C. Van, HAYLETT, W, HARVEY, J, LOMBARD, D, BARDIEN, S, CARR, J

“…Neurodegenerative disorders such as Parkinson's disease (PD) contribute significantly to global disease burden. PD can be categorised into early-onset PD…”
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Novel non-sense GCH1 mutation in a South African family diagnosed with dopa-responsive dystonia by Bardien, S., Keyser, R., Lombard, D., Du Plessis, M., Human, H., Carr, J.

“…Background:  Dopa‐responsive dystonia (DRD), a movement disorder characterized by onset in early childhood and a dramatic response to low doses of levodopa,…”
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Uncovering of Functional Alternative CTLA-4 Counter-Receptor in B7-Deficient Mice by Freeman, Gordon J., Borriello, Frank, Hodes, Richard J., Reiser, Hans, Hathcock, Karen S., Laszlo, Gloria, McKnight, Andrew J., Kim, Jinny, Du, Lina, Lombard, David B., Gray, Gary S., Nadler, Lee M., Sharpe, Arlene H.

“…B7 delivers a costimulatory signal through CD28, resulting in interleukin-2 secretion and T cell proliferation. Blockade of this pathway results in T cell…”
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Global analysis of the effect of local climate on the hatchling output of leatherback turtles by Santidrián Tomillo, Pilar, Saba, Vincent S., Lombard, Claudia D., Valiulis, Jennifer M., Robinson, Nathan J., Paladino, Frank V., Spotila, James R., Fernández, Carlos, Rivas, Marga L., Tucek, Jenny, Nel, Ronel, Oro, Daniel

“…The most recent climate change projections show a global increase in temperatures along with precipitation changes throughout the 21 st century. However,…”
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Characterization of CTLA-4 structure and expression on human T cells by Lindsten, T, Lee, KP, Harris, ES, Petryniak, B, Craighead, N, Reynolds, PJ, Lombard, DB, Freeman, GJ, Nadler, LM, Gray, GS

“…CTLA-4 is an adhesion receptor expressed on activated T cells. The amino acid sequence of CTLA-4 is related to CD28, and although the function of CTLA-4…”
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Production of tropical copepods in Kingston Harbour, Jamaica : the importance of small species by HOPCROFT, R. R, ROFF, J. C, LOMBARD, D

“…The copepod community observed during an 18-month period at the mouth of eutrophic Kingston Harbour, Jamaica, was dominated by small species of Parvocalanus,…”
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The methyl binding domain 3/nucleosome remodelling and deacetylase complex regulates neural cell fate determination and terminal differentiation in the cerebral cortex by Knock, Erin, Pereira, João, Lombard, Patrick D, Dimond, Andrew, Leaford, Donna, Livesey, Frederick J, Hendrich, Brian

“…Chromatin-modifying complexes have key roles in regulating various aspects of neural stem cell biology, including self-renewal and neurogenesis. The methyl…”
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Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7 by FREEMAN, G. J, GRAY, G. S, GIMMI, C. D, LOMBARD, D. B, LIANG-JI ZHOU, WHITE, M, FINGEROTH, J. D, GRIBBEN, J. G, NADLER, L. M

“…Following occupancy of the T cell receptor by antigen, T cell proliferation and lymphokine production are determined by a second costimulatory signal delivered…”
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Association of the bloom syndrome protein with topoisomerase IIIα in somatic and meiotic cells by JOHNSON, F. B, LOMBARD, D. B, NEFF, N. F, MASTRANGELO, M.-A, DEWOLF, W, ELLIS, N. A, MARCINIAK, R. A, YIZHONG YIN, JAENISCH, R, GUARENTE, L

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