Search Results - "Lomax, Margaret I."

Induction of Heat Shock Proteins by Hyperthermia and Noise Overstimulation in Hsf1−/− Mice by Gong, Tzy-Wen, Fairfield, Damon A., Fullarton, Lynne, Dolan, David F., Altschuler, Richard A., Kohrman, David C., Lomax, Margaret I.

“…Diverse cellular and environmental stresses can activate the heat shock response, an evolutionarily conserved mechanism to protect proteins from denaturation…”
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Hsp70 Inhibits Aminoglycoside-Induced Hair Cell Death and is Necessary for the Protective Effect of Heat Shock by Taleb, Mona, Brandon, Carlene S., Lee, Fu-Shing, Lomax, Margaret I., Dillmann, Wolfgang H., Cunningham, Lisa L.

“…Sensory hair cells of the inner ear are sensitive to death from aging, noise trauma, and ototoxic drugs. Ototoxic drugs include the aminoglycoside antibiotics…”
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Heat shock factor 1-deficient mice exhibit decreased recovery of hearing following noise overstimulation by Fairfield, Damon A., Lomax, Margaret I., Dootz, Gary A., Chen, Shu, Galecki, Andrzej T., Benjamin, Ivor J., Dolan, David F., Altschuler, Richard A.

“…Heat shock proteins (Hsps) can enhance cell survival in response to stress. Heat shock factor 1 (Hsf1) is the major transcription factor that regulates…”
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Expression of ZIC genes in the development of the chick inner ear and nervous system by Warner, Stephen J., Hutson, Mary R., Oh, Seung‐Ha, Gerlach‐Bank, Lisa M., Lomax, Margaret I., Barald, Kate F.

“…ZIC genes, vertebrate homologues of the Drosophila pair‐rule gene odd‐paired (opa), function in embryonic pattern formation, in the early stages of central…”
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Induction of heat shock protein 32 (Hsp32) in the rat cochlea following hyperthermia by Fairfield, Damon A., Kanicki, Ariane C., Lomax, Margaret I., Altschuler, Richard A.

“…The genes for heat shock proteins (Hsps) can be upregulated in response to cellular trauma, resulting in enhanced cell survival and protection. Hsp32, also…”
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Glial cell line-derived neurotrophic factor (GDNF) and its receptor complex are expressed in the auditory nerve of the mature rat cochlea by Stöver, Timo, Nam, Young-Jae, Gong, Tzy-Wen L., Lomax, Margaret I., Altschuler, Richard A.

“…Glial cell line-derived neurotrophic factor (GDNF) is a survival factor for many neuronal cell types which signals through a heterodimer receptor consisting of…”
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Noise overstimulation induces immediate early genes in the rat cochlea by Cho, Younsook, Gong, Tzy-Wen L., Kanicki, Ariane, Altschuler, Richard A., Lomax, Margaret I.

“…In mammals, exposure to intense noise produces a permanent hearing loss called permanent threshold shift (PTS), whereas a moderate noise produces only a…”
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Differential display and gene arrays to examine auditory plasticity by Lomax, Margaret I, Huang, Li, Cho, Younsook, Gong, Tzy-Wen L, Altschuler, Richard A

“…Differential gene expression forms the basis for development, differentiation, regeneration, and plasticity of tissues and organs. We describe two methods to…”
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Expression and localization of heat shock factor (Hsf) 1 in the rodent cochlea by Fairfield, Damon A, Kanicki, Ariane C, Lomax, Margaret I, Altschuler, Richard A

“…Activation of heat shock factors (Hsfs) is one of the potential mechanisms for regulating the transcription of the heat shock proteins (Hsps) and certain other…”
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Molecular evolution of cytochrome c oxidase subunit IV: evidence for positive selection in simian primates by Wu, W, Goodman, M, Lomax, M I, Grossman, L I

“…Cytochrome c oxidase (COX) is a multi-subunit enzyme complex that catalyzes the final step of electron transfer through the respiratory chain on the…”
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Deafness‐related plasticity in the inferior colliculus: gene expression profiling following removal of peripheral activity by Holt, Avril Genene, Asako, Mikiya, Lomax, Catherine A., MacDonald, James W., Tong, Ling, Lomax, Margaret I., Altschuler, Richard A.

“…The inferior colliculus (IC) is a major center of integration in the ascending as well as descending auditory pathways, where both excitatory and inhibitory…”
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Identification and Characterization of Choline Transporter-Like Protein 2, an Inner Ear Glycoprotein of 68 and 72 kDa That Is the Target of Antibody-Induced Hearing Loss by Nair, Thankam S, Kozma, Kelley E, Hoefling, Nickoleta L, Kommareddi, Pavan K, Ueda, Yo, Gong, Tzy-Wen, Lomax, Margaret I, Lansford, Christopher D, Telian, Steven A, Satar, Bulent, Arts, H. Alexander, El-Kashlan, Hussam K, Berryhill, Wayne E, Raphael, Yehoash, Carey, Thomas E

“…The Kresge Hearing Research Institute-3 (KHRI-3) antibody binds to a guinea pig inner ear supporting cell antigen (IESCA) and causes hearing loss. To gain…”
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5′ region of the COX4 gene contains a novel overlapping gene, NOC4 by Bachman, N J, Wu, W, Schmidt, T R, Grossman, L I, Lomax, M I

“…We identified a novel human gene, NOC4 (Neighbor Of COX4), located 5′ to COX4, the gene for cytochrome c oxidase subunit IV, on Chr16q32-ter. Transcripts from…”
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DFNA25, a Novel Locus for Dominant Nonsyndromic Hereditary Hearing Impairment, Maps to 12q21-24 by Greene, Charles C., McMillan, Pamella M., Barker, Susan E., Kurnool, Purnima, Lomax, Margaret I., Burmeister, Margit, Lesperance, Marci M.

“…Using linkage analysis, we identified a novel dominant locus, DFNA25, for delayed-onset, progressive, high-frequency, nonsyndromic sensorineural hearing loss…”
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Age-related changes in cochlear gene expression in normal and shaker 2 mice by Gong, Tzy-Wen L, Karolyi, I Jill, Macdonald, James, Beyer, Lisa, Raphael, Yehoash, Kohrman, David C, Camper, Sally A, Lomax, Margaret I

“…The vertebrate cochlea is a complex organ optimized for sound transduction. Auditory hair cells, with their precisely arranged stereocilia bundles, transduce…”
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Characterization of the human UBE3B gene: structure, expression, evolution, and alternative splicing by Gong, Tzy-Wen L, Huang, Li, Warner, Steven J, Lomax, Margaret I

“…E3 ubiquitin ligases target proteins for degradation by adding ubiquitin residues. We characterized full-length cDNAs for human and mouse UBE3B, a novel…”
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WDR1 colocalizes with ADF and actin in the normal and noise-damaged chick cochlea by Oh, Seung-Ha, Adler, Henry J., Raphael, Yehoash, Lomax, Margaret I.

“…Auditory hair cells of birds, unlike hair cells in the mammalian organ of Corti, can regenerate following sound‐induced loss. We have identified several genes…”
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Gene expression profiles of the rat cochlea, cochlear nucleus, and inferior colliculus by Cho, Younsook, Gong, Tzy-Wen L, Stöver, Timo, Lomax, Margaret I, Altschuler, Richard A

“…High-throughput DNA microarray technology allows for the assessment of large numbers of genes and can reveal gene expression in a specific region, differential…”
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MACF1 gene structure: a hybrid of plectin and dystrophin by Gong, Tzy-Wen L, Besirli, Cagri G, Lomax, Margaret I

“…Mammalian MACF1 (Macrophin1; previously named ACF7) is a giant cytoskeletal linker protein with three known isoforms that arise by alternative splicing. We…”
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Constitutive expression of Hsp27 in the rat cochlea by Leonova, Elena V., Fairfield, Damon A., Lomax, Margaret I., Altschuler, Richard A.

“…Heat shock protein-27 (Hsp27) is known to function as both a stress-inducible molecular chaperone and regulator of actin polymerization. For many cells in the…”
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