Search Results - "Lomax, Jo E"

Cytosolic Delivery of Proteins by Bioreversible Esterification by Mix, Kalie A, Lomax, Jo E, Raines, Ronald T

“…Cloaking its carboxyl groups with a hydrophobic moiety is shown to enable a protein to enter the cytosol of a mammalian cell. Diazo compounds derived from…”
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Comparative functional analysis of ribonuclease 1 homologs: molecular insights into evolving vertebrate physiology by Lomax, Jo E, Eller, Chelcie H, Raines, Ronald T

“…Pancreatic-type ribonucleases (ptRNases) comprise a class of highly conserved secretory endoribonucleases in vertebrates. The prototype of this enzyme family…”
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Boronic Acid for the Traceless Delivery of Proteins into Cells by Andersen, Kristen A, Smith, Thomas P, Lomax, Jo E, Raines, Ronald T

“…The use of exogenous proteins as intracellular probes and therapeutic agents is in its infancy. A major hurdle has been the delivery of native proteins to an…”
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Diazo compounds for the bioreversible esterification of proteins by McGrath, Nicholas A, Andersen, Kristen A, Davis, Amy K F, Lomax, Jo E, Raines, Ronald T

“…A diazo compound is shown to convert carboxylic acids to esters efficiently in an aqueous environment. The basicity of the diazo compound is critical: low…”
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Phenotype of ribonuclease 1 deficiency in mice by Garnett, Emily R, Lomax, Jo E, Mohammed, Bassem M, Gailani, David, Sheehan, John P, Raines, Ronald T

“…Biological roles for extracellular RNA (eRNA) have become apparent. For example, eRNA can induce contact activation in blood via activation of the plasma…”
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Bovine Brain Ribonuclease Is the Functional Homolog of Human Ribonuclease 1 by Eller, Chelcie H., Lomax, Jo E., Raines, Ronald T.

“…Mounting evidence suggests that human pancreatic ribonuclease (RNase 1) plays important roles in vivo, ranging from regulating blood clotting and inflammation…”
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Functional Evolution of Ribonuclease Inhibitor: Insights from Birds and Reptiles by Lomax, Jo E., Bianchetti, Christopher M., Chang, Aram, Phillips, George N., Fox, Brian G., Raines, Ronald T.

“…Ribonuclease inhibitor (RI) is a conserved protein of the mammalian cytosol. RI binds with high affinity to diverse secretory ribonucleases (RNases) and…”
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Rational design and evaluation of mammalian ribonuclease cytotoxins by Lomax, Jo E, Eller, Chelcie H, Raines, Ronald T

“…Mammalian pancreatic-type ribonucleases (ptRNases) comprise an enzyme family that is remarkably well suited for therapeutic exploitation. ptRNases are robust…”
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Diazo compounds for the bioreversible esterification of proteinsElectronic supplementary information (ESI) available: Experimental procedures, analytical data, and spectral data for novel compounds. See DOI: 10.1039/c4sc01768d by McGrath, Nicholas A, Andersen, Kristen A, Davis, Amy K. F, Lomax, Jo E, Raines, Ronald T

“…A diazo compound is shown to convert carboxylic acids to esters efficiently in an aqueous environment. The basicity of the diazo compound is critical: low…”
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Diazo compounds for the bioreversible esterification of proteins† †Electronic supplementary information (ESI) available: Experimental procedures, analytical data, and spectral data for novel compounds. See DOI: 10.1039/c4sc01768d Click here for additional data file by McGrath, Nicholas A., Andersen, Kristen A., Davis, Amy K. F., Lomax, Jo E., Raines, Ronald T.

“…A diazo compound is shown to convert carboxylic acids to esters efficiently in an aqueous environment. A diazo compound is shown to convert carboxylic acids to…”
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