Search Results - "Lomakin, Yakov"

Deconvolution of B cell receptor repertoire in multiple sclerosis patients revealed a delay in tBreg maturation by Lomakin, Yakov A., Zvyagin, Ivan V., Ovchinnikova, Leyla A., Kabilov, Marsel R., Staroverov, Dmitriy B., Mikelov, Artem, Tupikin, Alexey E., Zakharova, Maria Y., Bykova, Nadezda A., Mukhina, Vera S., Favorov, Alexander V., Ivanova, Maria, Simaniv, Taras, Rubtsov, Yury P., Chudakov, Dmitriy M., Zakharova, Maria N., Illarioshkin, Sergey N., Belogurov, Alexey A., Gabibov, Alexander G.

“…BackgroundB lymphocytes play a pivotal regulatory role in the development of the immune response. It was previously shown that deficiency in B regulatory cells…”
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Extracellular Vesicles in Chronic Demyelinating Diseases: Prospects in Treatment and Diagnosis of Autoimmune Neurological Disorders by Ovchinnikova, Leyla A, Zalevsky, Arthur O, Lomakin, Yakov A

“…Extracellular vesicles (EVs) represent membrane-enclosed structures that are likely to be secreted by all living cell types in the animal organism, including…”
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Peptides Against Autoimmune Neurodegeneration by Stepanov, Alexey, Lomakin, Yakov, Gabibov, Alexander, Belogurov, Alexey

“…The mammalian immune system is a nearly perfect defensive system polished by a hundred million years of evolution. Unique flexibility and adaptivity have…”
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Reprogramming Extracellular Vesicles for Protein Therapeutics Delivery by Ovchinnikova, Leyla A, Terekhov, Stanislav S, Ziganshin, Rustam H, Bagrov, Dmitriy V, Filimonova, Ioanna N, Zalevsky, Arthur O, Lomakin, Yakov A

“…Delivering protein therapeutics specifically into target cells and tissues is a promising avenue in medicine. Advancing this process will significantly enhance…”
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Exhaustive Search of the Receptor Ligands by the CyCLOPS (Cytometry Cell-Labeling Operable Phage Screening) Technique by Ishina, Irina A, Filimonova, Ioanna N, Zakharova, Maria Y, Ovchinnikova, Leyla A, Mamedov, Azad E, Lomakin, Yakov A, Belogurov, Jr, Alexey A

“…Effective and versatile screening of the peptide ligands capable of selectively binding to diverse receptors is in high demand for the state-of-the-art…”
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Liquid drop of DNA libraries reveals total genome information by Terekhov, Stanislav S., Eliseev, Igor E., Ovchinnikova, Leyla A., Kabilov, Marsel R., Prjibelski, Andrey D., Tupikin, Alexey E., Smirnov, Ivan V., Belogurov, Alexey A., Severinov, Konstantin V., Lomakin, Yakov A., Altman, Sidney, Gabibov, Alexander G.

“…Conventional “bulk” PCR often yields inefficient and nonuniform amplification of complex templates in DNA libraries, introducing unwanted biases. Amplification…”
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Autoantibodies from SLE patients induce programmed cell death in murine fibroblast cells through interaction with TNFR1 receptor by Sharapova, Tatiana N., Romanova, Elena A., Soshnikova, Natalia V., Belogurov, Alexey A., Lomakin, Yakov A., Sashchenko, Lidia P., Yashin, Denis V.

“…Various pathological processes are known to be associated with the production of IgG autoantibodies, which have high affinity for self-antigens and often cause…”
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Probing Surface Membrane Receptors Using Engineered Bacteriophage Bioconjugates by Lomakin, Yakov A, Kaminskaya, Alena N, Stepanov, Alexey V, Shmidt, Anna A, Gabibov, Alexander G, Belogurov, Alexey A

“…Specific recognition of ligands by surface receptors of eukaryotic cells is a fundamental process in sensing of the exogenous environment, including…”
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The Pathogenesis of the Demyelinating Form of Guillain-Barre Syndrome (GBS): Proteo-peptidomic and Immunological Profiling of Physiological Fluids by Ziganshin, Rustam H., Ivanova, Olga M., Lomakin, Yakov A., Belogurov, Alexey A., Kovalchuk, Sergey I., Azarkin, Igor V., Arapidi, Georgij P., Anikanov, Nikolay A., Shender, Victoria O., Piradov, Mikhail A., Suponeva, Natalia A., Vorobyeva, Anna A., Gabibov, Alexander G., Ivanov, Vadim T., Govorun, Vadim M.

“…Acute inflammatory demyelinating polyneuropathy (AIDP) - the main form of Guillain-Barre syndrome—is a rare and severe disorder of the peripheral nervous…”
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Two-dimensional high-throughput on-cell screening of immunoglobulins against broad antigen repertoires by Lomakin, Yakov A., Ovchinnikova, Leyla A., Terekhov, Stanislav S., Dzhelad, Samir S., Yaroshevich, Igor, Mamedov, Ilgar, Smirnova, Anastasia, Grigoreva, Tatiana, Eliseev, Igor E., Filimonova, Ioanna N., Mokrushina, Yuliana A., Abrikosova, Victoria, Rubtsova, Maria P., Kostin, Nikita N., Simonova, Maria A., Bobik, Tatiana V., Aleshenko, Natalia L., Alekhin, Alexander I., Boitsov, Vitali M., Zhang, Hongkai, Smirnov, Ivan V., Rubtsov, Yuri P., Gabibov, Alexander G.

“…Identifying high-affinity antibodies in human serum is challenging due to extremely low number of circulating B cells specific to the desired antigens. Delays…”
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Exposure to the Epstein-Barr Viral Antigen Latent Membrane Protein 1 Induces Myelin-Reactive Antibodies In Vivo by Lomakin, Yakov, Arapidi, Georgii Pavlovich, Chernov, Alexander, Ziganshin, Rustam, Tcyganov, Evgenii, Lyadova, Irina, Butenko, Ivan Olegovich, Osetrova, Maria, Ponomarenko, Natalia, Telegin, Georgy, Govorun, Vadim Markovich, Gabibov, Alexander, Belogurov, Jr, Alexey

“…Multiple sclerosis (MS) is an autoimmune chronic inflammatory disease of the central nervous system (CNS). Cross-reactivity of neuronal proteins with exogenous…”
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Administration of Myelin Basic Protein Peptides Encapsulated in Mannosylated Liposomes Normalizes Level of Serum TNF-α and IL-2 and Chemoattractants CCL2 and CCL4 in Multiple Sclerosis Patients by Gabibov, A. G., Genkin, Dmitry, Okunola, John, Zakharov, Konstantin, Stepanov, Alexey, Glagoleva, Irina, Belogurov, Alexey, Lomakin, Yakov, Smirnov, Ivan

“…We have previously shown that immunodominant MBP peptides encapsulated in mannosylated liposomes (Xemys) effectively suppressed experimental allergic…”
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Combinatorial antibody library from multiple sclerosis patients reveals antibodies that cross‐react with myelin basic protein and EBV antigen by Gabibov, Alexander G., Belogurov, Alexey A., Lomakin, Yakov A., Zakharova, Maria Yu, Avakyan, Marat E., Dubrovskaya, Viktorya V., Smirnov, Ivan V., Ivanov, Alexis S., Molnar, Andrey A., Gurtsevitch, Vladimir E., Diduk, Sergey V., Smirnova, Ksenia V., Avalle, Bérangère, Sharanova, Svetlana N., Tramontano, Alfonso, Friboulet, Alain, Boyko, Alexey N., Ponomarenko, Natalia A., Tikunova, Nina V.

“…ABSTRACT Multiple sclerosis (MS) is a widespread neurodegenerative autoimmune disease with unknown etiology. It is increasingly evident that, together with…”
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Drift of the Subgingival Periodontal Microbiome during Chronic Periodontitis in Type 2 Diabetes Mellitus Patients by Balmasova, Irina P, Olekhnovich, Evgenii I, Klimina, Ksenia M, Korenkova, Anna A, Vakhitova, Maria T, Babaev, Elmar A, Ovchinnikova, Leyla A, Lomakin, Yakov A, Smirnov, Ivan V, Tsarev, Victor N, Mkrtumyan, Ashot M, Belogurov, Jr, Alexey A, Gabibov, Alexander G, Ilina, Elena N, Arutyunov, Sergey D

“…Since periodontitis and type 2 diabetes mellitus are complex diseases, a thorough understanding of their pathogenesis requires knowing the relationship of…”
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Divergent Immunomodulation Capacity of Individual Myelin Peptides-Components of Liposomal Therapeutic against Multiple Sclerosis by Ivanova, Vilena V, Khaiboullina, Svetlana F, Gomzikova, Marina O, Martynova, Ekaterina V, Ferreira, André M, Garanina, Ekaterina E, Sakhapov, Damir I, Lomakin, Yakov A, Khaibullin, Timur I, Granatov, Evgenii V, Khabirov, Farit A, Rizvanov, Albert A, Gabibov, Alexander, Belogurov, Jr, Alexey

“…Multiple sclerosis (MS) is an autoimmune disease characterized by demyelination and consequent neuron injury. Although the pathogenesis of MS is largely…”
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Heavy-light chain interrelations of MS-associated immunoglobulins probed by deep sequencing and rational variation by Lomakin, Yakov A, Zakharova, Maria Yu, Stepanov, Alexey V, Dronina, Maria A, Smirnov, Ivan V, Bobik, Tatyana V, Pyrkov, Andrey Yu, Tikunova, Nina V, Sharanova, Svetlana N, Boitsov, Vitali M, Vyazmin, Sergey Yu, Kabilov, Marsel R, Tupikin, Alexey E, Krasnov, Alexey N, Bykova, Nadezda A, Medvedeva, Yulia A, Fridman, Marina V, Favorov, Alexander V, Ponomarenko, Natalia A, Dubina, Michael V, Boyko, Alexey N, Vlassov, Valentin V, Belogurov, Jr, Alexey A, Gabibov, Alexander G

“…The mechanisms triggering most of autoimmune diseases are still obscure. Autoreactive B cells play a crucial role in the development of such pathologies and,…”
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Single-Molecule Interactions of a Monoclonal Anti-DNA Antibody with DNA by Nevzorova, Tatiana A., Zhao, Qingze, Lomakin, Yakov A., Ponomareva, Anastasia A., Mukhitov, Alexander R., Purohit, Prashant K., Weisel, John W., Litvinov, Rustem I.

“…Interactions of DNA with proteins are essential for key biological processes and have both a fundamental and practical significance. In particular, DNA binding…”
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Clinical and experimental studies of multiple sclerosis in Russia: experience of the leading national research centers by Zavalishin, Igor A, Belogurov, Alexey A., Jr, Lomakin, Yakov A, Ponomarenko, Natalia A, Morozova, Sofia N, Suslina, Zinaida A, Piradov, Michael A, Illarioshkin, Sergey N, Gabibov, Alexander G

“…Mechanisms of axonal damage and adaptive capacity in multiple sclerosis (MS), including cortical reorganization, have been actively studied in recent years…”
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Exposure to the Epstein-Barr viral antigen induces affinity-maturated anti-myelin antibodies by Lomakin, Yakov Anatol’evich, Belogurov, Alexey

“…Multiple Sclerosis (MS) is an autoimmune chronic inflammatory disease of central nervous system (CNS). Cross-reactivity of neuronal proteins with exogenous…”
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Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)–Specific T Cells and Antibodies in Coronavirus Disease 2019 (COVID-19) Protection: A Prospective Study by Molodtsov, Ivan A, Kegeles, Evgenii, Mitin, Alexander N, Mityaeva, Olga, Musatova, Oksana E, Panova, Anna E, Pashenkov, Mikhail V, Peshkova, Iuliia O, Alsalloum, Almaqdad, Asaad, Walaa, Budikhina, Anna S, Deryabin, Alexander S, Dolzhikova, Inna V, Filimonova, Ioanna N, Gracheva, Alexandra N, Ivanova, Oxana I, Kizilova, Anastasia, Komogorova, Viktoria V, Komova, Anastasia, Kompantseva, Natalia I, Kucheryavykh, Ekaterina, Lagutkin, Denis А, Lomakin, Yakov A, Maleeva, Alexandra V, Maryukhnich, Elena V, Mohammad, Afraa, Murugin, Vladimir V, Murugina, Nina E, Navoikova, Anna, Nikonova, Margarita F, Ovchinnikova, Leyla A, Panarina, Yana, Pinegina, Natalia V, Potashnikova, Daria M, Romanova, Elizaveta V, Saidova, Aleena A, Sakr, Nawar, Samoilova, Anastasia G, Serdyuk, Yana, Shakirova, Naina T, Sharova, Nina I, Sheetikov, Saveliy A, Shemetova, Anastasia F, Shevkova, Liudmila V, Shpektor, Alexander V, Trufanova, Anna, Tvorogova, Anna V, Ukrainskaya, Valeria M, Vinokurov, Anatoliy S, Vorobyeva, Daria A, Zornikova, Ksenia V, Efimov, Grigory A, Khaitov, Musa R, Kofiadi, Ilya A, Komissarov, Alexey A, Logunov, Denis Y, Naigovzina, Nelli B, Rubtsov, Yury P, Vasilyeva, Irina A, Volchkov, Pavel, Vasilieva, Elena

“…In a prospective study involving 5340 individuals, humoral and cellular responses revealed magnitude-dependent protection from COVID-19. Antibodies alone…”
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